Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD57_LEIMA

TriTrypDb:

LmjF.27.0800 , LMJLV39_270013700 , LMJSD75_270013700

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

E9AD57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.371
CLV_NRD_NRD_1	202	204	PF00675	0.432
CLV_NRD_NRD_1	278	280	PF00675	0.380
CLV_NRD_NRD_1	347	349	PF00675	0.445
CLV_NRD_NRD_1	50	52	PF00675	0.625
CLV_NRD_NRD_1	64	66	PF00675	0.754
CLV_PCSK_KEX2_1	202	204	PF00082	0.432
CLV_PCSK_KEX2_1	278	280	PF00082	0.380
CLV_PCSK_KEX2_1	347	349	PF00082	0.445
CLV_PCSK_KEX2_1	52	54	PF00082	0.619
CLV_PCSK_KEX2_1	64	66	PF00082	0.616
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.597
CLV_PCSK_SKI1_1	138	142	PF00082	0.558
CLV_PCSK_SKI1_1	171	175	PF00082	0.321
CLV_PCSK_SKI1_1	202	206	PF00082	0.420
CLV_PCSK_SKI1_1	26	30	PF00082	0.497
CLV_PCSK_SKI1_1	6	10	PF00082	0.473
DOC_CYCLIN_RxL_1	197	208	PF00134	0.427
DOC_CYCLIN_RxL_1	264	275	PF00134	0.355
DOC_MAPK_MEF2A_6	213	220	PF00069	0.460
DOC_USP7_MATH_1	103	107	PF00917	0.736
DOC_USP7_MATH_1	114	118	PF00917	0.463
DOC_USP7_MATH_1	140	144	PF00917	0.554
DOC_USP7_MATH_1	63	67	PF00917	0.596
DOC_USP7_MATH_1	75	79	PF00917	0.545
DOC_USP7_MATH_1	83	87	PF00917	0.426
DOC_WW_Pin1_4	149	154	PF00397	0.483
DOC_WW_Pin1_4	163	168	PF00397	0.554
DOC_WW_Pin1_4	26	31	PF00397	0.515
DOC_WW_Pin1_4	58	63	PF00397	0.783
LIG_14-3-3_CanoR_1	138	146	PF00244	0.466
LIG_14-3-3_CanoR_1	155	165	PF00244	0.494
LIG_14-3-3_CanoR_1	171	176	PF00244	0.484
LIG_14-3-3_CanoR_1	272	278	PF00244	0.425
LIG_14-3-3_CanoR_1	64	70	PF00244	0.596
LIG_14-3-3_CterR_2	347	352	PF00244	0.445
LIG_Actin_WH2_2	262	280	PF00022	0.417
LIG_AP2alpha_1	262	266	PF02296	0.341
LIG_Clathr_ClatBox_1	172	176	PF01394	0.321
LIG_Clathr_ClatBox_1	217	221	PF01394	0.385
LIG_FHA_1	139	145	PF00498	0.505
LIG_FHA_1	172	178	PF00498	0.388
LIG_FHA_1	235	241	PF00498	0.545
LIG_FHA_1	245	251	PF00498	0.501
LIG_FHA_1	266	272	PF00498	0.552
LIG_FHA_1	287	293	PF00498	0.406
LIG_FHA_1	312	318	PF00498	0.359
LIG_GBD_Chelix_1	269	277	PF00786	0.378
LIG_LIR_Gen_1	166	177	PF02991	0.321
LIG_LIR_Nem_3	166	172	PF02991	0.467
LIG_LIR_Nem_3	264	269	PF02991	0.429
LIG_LIR_Nem_3	74	79	PF02991	0.484
LIG_NRBOX	200	206	PF00104	0.403
LIG_Pex14_2	262	266	PF04695	0.341
LIG_Rb_LxCxE_1	174	192	PF01857	0.371
LIG_SH2_CRK	169	173	PF00017	0.233
LIG_SH2_STAT5	316	319	PF00017	0.397
LIG_SH3_3	301	307	PF00018	0.396
LIG_SUMO_SIM_anti_2	214	222	PF11976	0.317
LIG_SUMO_SIM_par_1	171	176	PF11976	0.305
LIG_SUMO_SIM_par_1	214	222	PF11976	0.317
LIG_WRC_WIRS_1	342	347	PF05994	0.443
LIG_WW_3	61	65	PF00397	0.573
MOD_CDC14_SPxK_1	152	155	PF00782	0.454
MOD_CDK_SPxK_1	149	155	PF00069	0.430
MOD_CDK_SPxK_1	58	64	PF00069	0.568
MOD_CDK_SPxxK_3	58	65	PF00069	0.712
MOD_CK1_1	110	116	PF00069	0.593
MOD_CK1_1	222	228	PF00069	0.534
MOD_CK1_1	66	72	PF00069	0.767
MOD_CK2_1	222	228	PF00069	0.650
MOD_CK2_1	285	291	PF00069	0.418
MOD_CK2_1	331	337	PF00069	0.537
MOD_CK2_1	68	74	PF00069	0.710
MOD_GlcNHglycan	105	108	PF01048	0.712
MOD_GlcNHglycan	109	112	PF01048	0.650
MOD_GlcNHglycan	158	161	PF01048	0.511
MOD_GlcNHglycan	191	194	PF01048	0.447
MOD_GlcNHglycan	221	224	PF01048	0.543
MOD_GSK3_1	103	110	PF00069	0.631
MOD_GSK3_1	138	145	PF00069	0.553
MOD_GSK3_1	156	163	PF00069	0.492
MOD_GSK3_1	205	212	PF00069	0.399
MOD_GSK3_1	234	241	PF00069	0.509
MOD_GSK3_1	286	293	PF00069	0.398
MOD_N-GLC_1	209	214	PF02516	0.426
MOD_N-GLC_1	26	31	PF02516	0.488
MOD_NEK2_1	156	161	PF00069	0.495
MOD_NEK2_1	189	194	PF00069	0.445
MOD_NEK2_1	205	210	PF00069	0.255
MOD_NEK2_1	219	224	PF00069	0.388
MOD_NEK2_1	271	276	PF00069	0.395
MOD_NEK2_1	331	336	PF00069	0.542
MOD_NEK2_1	42	47	PF00069	0.520
MOD_NEK2_1	9	14	PF00069	0.501
MOD_NEK2_2	249	254	PF00069	0.527
MOD_NEK2_2	311	316	PF00069	0.313
MOD_PIKK_1	158	164	PF00454	0.544
MOD_PIKK_1	68	74	PF00454	0.526
MOD_PKA_2	271	277	PF00069	0.388
MOD_PKA_2	63	69	PF00069	0.654
MOD_Plk_1	290	296	PF00069	0.358
MOD_Plk_1	66	72	PF00069	0.783
MOD_Plk_2-3	142	148	PF00069	0.446
MOD_Plk_4	291	297	PF00069	0.422
MOD_Plk_4	311	317	PF00069	0.395
MOD_Plk_4	341	347	PF00069	0.433
MOD_Plk_4	75	81	PF00069	0.388
MOD_Plk_4	83	89	PF00069	0.356
MOD_ProDKin_1	149	155	PF00069	0.480
MOD_ProDKin_1	163	169	PF00069	0.549
MOD_ProDKin_1	26	32	PF00069	0.507
MOD_ProDKin_1	58	64	PF00069	0.786
TRG_DiLeu_BaEn_1	327	332	PF01217	0.446
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.458
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.298
TRG_DiLeu_LyEn_5	327	332	PF01217	0.446
TRG_ENDOCYTIC_2	169	172	PF00928	0.508
TRG_ER_diArg_1	201	203	PF00400	0.433
TRG_ER_diArg_1	277	279	PF00400	0.378
TRG_ER_diArg_1	346	348	PF00400	0.451
TRG_ER_diArg_1	63	65	PF00400	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A7	Leptomonas seymouri	40%	99%
A0A1X0NS64	Trypanosomatidae	27%	100%
A0A3S7X0J8	Leishmania donovani	89%	100%
A4HFK3	Leishmania braziliensis	67%	98%
E9AHF2	Leishmania infantum	89%	89%
E9AYY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%