LeishMANIAdb
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MatE family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MatE family protein
Gene product:
MatE, putative
Species:
Leishmania major
UniProt:
E9AD56_LEIMA
TriTrypDb:
LmjF.27.0790 , LMJLV39_270013600 * , LMJSD75_270013600 *
Length:
891

Annotations

LeishMANIAdb annotations

SLC47 family transporter, with potential detoxification functions

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14

Expansion

Sequence features

E9AD56
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD56

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0009987 cellular process 1 1
GO:0042908 xenobiotic transport 4 1
GO:0046618 xenobiotic export from cell 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
GO:0140115 export across plasma membrane 3 1
GO:0140352 export from cell 2 1
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 14
GO:0015291 secondary active transmembrane transporter activity 4 14
GO:0015297 antiporter activity 5 14
GO:0022804 active transmembrane transporter activity 3 14
GO:0022857 transmembrane transporter activity 2 14
GO:0042910 xenobiotic transmembrane transporter activity 3 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 15 19 PF00656 0.696
CLV_C14_Caspase3-7 254 258 PF00656 0.653
CLV_C14_Caspase3-7 318 322 PF00656 0.730
CLV_C14_Caspase3-7 62 66 PF00656 0.673
CLV_NRD_NRD_1 157 159 PF00675 0.551
CLV_NRD_NRD_1 212 214 PF00675 0.532
CLV_NRD_NRD_1 849 851 PF00675 0.400
CLV_NRD_NRD_1 86 88 PF00675 0.526
CLV_NRD_NRD_1 868 870 PF00675 0.312
CLV_NRD_NRD_1 875 877 PF00675 0.436
CLV_NRD_NRD_1 881 883 PF00675 0.461
CLV_PCSK_FUR_1 879 883 PF00082 0.463
CLV_PCSK_KEX2_1 156 158 PF00082 0.556
CLV_PCSK_KEX2_1 212 214 PF00082 0.532
CLV_PCSK_KEX2_1 277 279 PF00082 0.563
CLV_PCSK_KEX2_1 587 589 PF00082 0.344
CLV_PCSK_KEX2_1 685 687 PF00082 0.375
CLV_PCSK_KEX2_1 849 851 PF00082 0.386
CLV_PCSK_KEX2_1 875 877 PF00082 0.461
CLV_PCSK_KEX2_1 881 883 PF00082 0.507
CLV_PCSK_PC1ET2_1 277 279 PF00082 0.563
CLV_PCSK_PC1ET2_1 587 589 PF00082 0.344
CLV_PCSK_PC1ET2_1 685 687 PF00082 0.334
CLV_PCSK_SKI1_1 212 216 PF00082 0.403
CLV_PCSK_SKI1_1 278 282 PF00082 0.496
CLV_PCSK_SKI1_1 421 425 PF00082 0.525
CLV_PCSK_SKI1_1 471 475 PF00082 0.251
CLV_PCSK_SKI1_1 728 732 PF00082 0.526
CLV_PCSK_SKI1_1 869 873 PF00082 0.503
CLV_PCSK_SKI1_1 91 95 PF00082 0.467
CLV_Separin_Fungi 453 459 PF03568 0.451
CLV_Separin_Metazoa 846 850 PF03568 0.639
DEG_APCC_DBOX_1 470 478 PF00400 0.451
DEG_APCC_DBOX_1 727 735 PF00400 0.293
DEG_Kelch_actinfilin_1 802 806 PF01344 0.306
DEG_SPOP_SBC_1 21 25 PF00917 0.646
DEG_SPOP_SBC_1 71 75 PF00917 0.800
DOC_CDC14_PxL_1 731 739 PF14671 0.306
DOC_CKS1_1 548 553 PF01111 0.284
DOC_CYCLIN_yCln2_LP_2 392 398 PF00134 0.425
DOC_CYCLIN_yCln2_LP_2 480 483 PF00134 0.222
DOC_CYCLIN_yCln2_LP_2 511 517 PF00134 0.387
DOC_CYCLIN_yCln2_LP_2 871 874 PF00134 0.688
DOC_MAPK_DCC_7 156 164 PF00069 0.739
DOC_MAPK_gen_1 156 164 PF00069 0.708
DOC_MAPK_gen_1 587 594 PF00069 0.638
DOC_MAPK_gen_1 685 692 PF00069 0.574
DOC_MAPK_gen_1 849 855 PF00069 0.587
DOC_MAPK_gen_1 87 95 PF00069 0.719
DOC_MAPK_MEF2A_6 157 166 PF00069 0.691
DOC_MAPK_MEF2A_6 471 479 PF00069 0.493
DOC_MAPK_MEF2A_6 609 616 PF00069 0.493
DOC_MAPK_MEF2A_6 685 694 PF00069 0.534
DOC_MAPK_MEF2A_6 786 794 PF00069 0.334
DOC_MAPK_NFAT4_5 609 617 PF00069 0.451
DOC_PP1_RVXF_1 218 224 PF00149 0.602
DOC_PP2B_LxvP_1 392 395 PF13499 0.306
DOC_PP2B_LxvP_1 480 483 PF13499 0.222
DOC_PP2B_LxvP_1 614 617 PF13499 0.284
DOC_PP2B_LxvP_1 871 874 PF13499 0.638
DOC_PP4_FxxP_1 123 126 PF00568 0.688
DOC_USP7_MATH_1 118 122 PF00917 0.808
DOC_USP7_MATH_1 144 148 PF00917 0.729
DOC_USP7_MATH_1 17 21 PF00917 0.822
DOC_USP7_MATH_1 396 400 PF00917 0.401
DOC_USP7_MATH_1 615 619 PF00917 0.358
DOC_USP7_MATH_1 624 628 PF00917 0.358
DOC_USP7_MATH_1 77 81 PF00917 0.738
DOC_WW_Pin1_4 175 180 PF00397 0.642
DOC_WW_Pin1_4 256 261 PF00397 0.740
DOC_WW_Pin1_4 279 284 PF00397 0.652
DOC_WW_Pin1_4 324 329 PF00397 0.699
DOC_WW_Pin1_4 459 464 PF00397 0.534
DOC_WW_Pin1_4 510 515 PF00397 0.401
DOC_WW_Pin1_4 547 552 PF00397 0.304
DOC_WW_Pin1_4 555 560 PF00397 0.435
LIG_14-3-3_CanoR_1 150 159 PF00244 0.729
LIG_14-3-3_CanoR_1 212 221 PF00244 0.714
LIG_14-3-3_CanoR_1 50 60 PF00244 0.638
LIG_14-3-3_CanoR_1 563 567 PF00244 0.279
LIG_14-3-3_CanoR_1 591 595 PF00244 0.517
LIG_14-3-3_CanoR_1 712 717 PF00244 0.267
LIG_14-3-3_CanoR_1 72 77 PF00244 0.682
LIG_14-3-3_CanoR_1 91 96 PF00244 0.784
LIG_Actin_WH2_2 540 558 PF00022 0.401
LIG_BIR_II_1 1 5 PF00653 0.782
LIG_BIR_III_4 353 357 PF00653 0.754
LIG_BRCT_BRCA1_1 398 402 PF00533 0.401
LIG_BRCT_BRCA1_1 617 621 PF00533 0.284
LIG_EH1_1 628 636 PF00400 0.342
LIG_eIF4E_1 512 518 PF01652 0.307
LIG_FHA_1 190 196 PF00498 0.674
LIG_FHA_1 328 334 PF00498 0.685
LIG_FHA_1 336 342 PF00498 0.693
LIG_FHA_1 384 390 PF00498 0.565
LIG_FHA_1 439 445 PF00498 0.364
LIG_FHA_1 542 548 PF00498 0.345
LIG_FHA_1 693 699 PF00498 0.418
LIG_FHA_1 721 727 PF00498 0.265
LIG_FHA_1 785 791 PF00498 0.307
LIG_FHA_1 793 799 PF00498 0.255
LIG_FHA_1 810 816 PF00498 0.600
LIG_FHA_2 195 201 PF00498 0.669
LIG_FHA_2 252 258 PF00498 0.742
LIG_FHA_2 60 66 PF00498 0.782
LIG_FHA_2 720 726 PF00498 0.316
LIG_GBD_Chelix_1 775 783 PF00786 0.401
LIG_IRF3_LxIS_1 236 241 PF10401 0.660
LIG_LIR_Apic_2 121 126 PF02991 0.710
LIG_LIR_Apic_2 513 519 PF02991 0.398
LIG_LIR_Apic_2 729 735 PF02991 0.342
LIG_LIR_Gen_1 388 398 PF02991 0.434
LIG_LIR_Gen_1 550 560 PF02991 0.342
LIG_LIR_Gen_1 604 612 PF02991 0.524
LIG_LIR_Gen_1 811 822 PF02991 0.542
LIG_LIR_Nem_3 388 394 PF02991 0.434
LIG_LIR_Nem_3 427 433 PF02991 0.305
LIG_LIR_Nem_3 438 442 PF02991 0.297
LIG_LIR_Nem_3 508 512 PF02991 0.299
LIG_LIR_Nem_3 550 555 PF02991 0.401
LIG_LIR_Nem_3 572 577 PF02991 0.293
LIG_LIR_Nem_3 604 608 PF02991 0.531
LIG_LIR_Nem_3 610 614 PF02991 0.527
LIG_LIR_Nem_3 746 750 PF02991 0.309
LIG_LIR_Nem_3 781 785 PF02991 0.424
LIG_LIR_Nem_3 811 817 PF02991 0.529
LIG_LIR_Nem_3 866 871 PF02991 0.686
LIG_LYPXL_yS_3 439 442 PF13949 0.284
LIG_PCNA_yPIPBox_3 576 588 PF02747 0.285
LIG_Pex14_2 111 115 PF04695 0.657
LIG_Pex14_2 747 751 PF04695 0.485
LIG_PTB_Apo_2 649 656 PF02174 0.284
LIG_REV1ctd_RIR_1 707 716 PF16727 0.341
LIG_SH2_CRK 498 502 PF00017 0.360
LIG_SH2_CRK 512 516 PF00017 0.221
LIG_SH2_CRK 564 568 PF00017 0.272
LIG_SH2_CRK 611 615 PF00017 0.534
LIG_SH2_CRK 868 872 PF00017 0.609
LIG_SH2_GRB2like 839 842 PF00017 0.546
LIG_SH2_NCK_1 679 683 PF00017 0.467
LIG_SH2_PTP2 814 817 PF00017 0.615
LIG_SH2_SRC 516 519 PF00017 0.306
LIG_SH2_SRC 679 682 PF00017 0.568
LIG_SH2_STAP1 839 843 PF00017 0.602
LIG_SH2_STAT5 110 113 PF00017 0.738
LIG_SH2_STAT5 391 394 PF00017 0.401
LIG_SH2_STAT5 417 420 PF00017 0.255
LIG_SH2_STAT5 430 433 PF00017 0.272
LIG_SH2_STAT5 516 519 PF00017 0.435
LIG_SH2_STAT5 564 567 PF00017 0.317
LIG_SH2_STAT5 732 735 PF00017 0.444
LIG_SH2_STAT5 758 761 PF00017 0.532
LIG_SH2_STAT5 782 785 PF00017 0.365
LIG_SH2_STAT5 814 817 PF00017 0.615
LIG_SH2_STAT5 843 846 PF00017 0.576
LIG_SH3_3 457 463 PF00018 0.534
LIG_SH3_3 533 539 PF00018 0.474
LIG_SH3_3 768 774 PF00018 0.382
LIG_SUMO_SIM_anti_2 630 635 PF11976 0.284
LIG_SUMO_SIM_par_1 160 165 PF11976 0.658
LIG_SUMO_SIM_par_1 191 200 PF11976 0.719
LIG_SUMO_SIM_par_1 539 544 PF11976 0.399
LIG_SUMO_SIM_par_1 578 584 PF11976 0.306
LIG_SUMO_SIM_par_1 761 767 PF11976 0.284
LIG_SUMO_SIM_par_1 801 808 PF11976 0.306
LIG_TRAF2_1 273 276 PF00917 0.699
LIG_TRAF2_1 295 298 PF00917 0.683
LIG_TYR_ITIM 389 394 PF00017 0.306
LIG_TYR_ITIM 428 433 PF00017 0.338
LIG_TYR_ITIM 437 442 PF00017 0.273
LIG_TYR_ITIM 510 515 PF00017 0.307
LIG_TYR_ITIM 562 567 PF00017 0.322
LIG_TYR_ITSM 810 817 PF00017 0.384
LIG_UBA3_1 493 500 PF00899 0.306
LIG_UBA3_1 522 528 PF00899 0.405
LIG_UBA3_1 750 756 PF00899 0.284
LIG_WRC_WIRS_1 693 698 PF05994 0.437
LIG_WRC_WIRS_1 785 790 PF05994 0.351
LIG_WW_3 872 876 PF00397 0.621
MOD_CDC14_SPxK_1 178 181 PF00782 0.606
MOD_CDK_SPxK_1 175 181 PF00069 0.606
MOD_CK1_1 114 120 PF00069 0.595
MOD_CK1_1 121 127 PF00069 0.588
MOD_CK1_1 146 152 PF00069 0.616
MOD_CK1_1 167 173 PF00069 0.510
MOD_CK1_1 2 8 PF00069 0.638
MOD_CK1_1 20 26 PF00069 0.519
MOD_CK1_1 248 254 PF00069 0.664
MOD_CK1_1 282 288 PF00069 0.572
MOD_CK1_1 336 342 PF00069 0.754
MOD_CK1_1 373 379 PF00069 0.605
MOD_CK1_1 808 814 PF00069 0.569
MOD_CK1_1 833 839 PF00069 0.697
MOD_CK1_1 851 857 PF00069 0.579
MOD_CK2_1 194 200 PF00069 0.714
MOD_CK2_1 719 725 PF00069 0.400
MOD_CK2_1 72 78 PF00069 0.627
MOD_GlcNHglycan 116 119 PF01048 0.517
MOD_GlcNHglycan 152 155 PF01048 0.528
MOD_GlcNHglycan 165 169 PF01048 0.579
MOD_GlcNHglycan 215 218 PF01048 0.662
MOD_GlcNHglycan 240 243 PF01048 0.731
MOD_GlcNHglycan 244 248 PF01048 0.751
MOD_GlcNHglycan 270 274 PF01048 0.664
MOD_GlcNHglycan 321 324 PF01048 0.596
MOD_GlcNHglycan 375 378 PF01048 0.686
MOD_GlcNHglycan 617 620 PF01048 0.287
MOD_GlcNHglycan 647 650 PF01048 0.313
MOD_GlcNHglycan 664 667 PF01048 0.350
MOD_GlcNHglycan 682 685 PF01048 0.344
MOD_GlcNHglycan 702 705 PF01048 0.347
MOD_GlcNHglycan 751 754 PF01048 0.267
MOD_GlcNHglycan 807 810 PF01048 0.463
MOD_GlcNHglycan 850 853 PF01048 0.469
MOD_GlcNHglycan 856 859 PF01048 0.516
MOD_GlcNHglycan 98 101 PF01048 0.635
MOD_GSK3_1 114 121 PF00069 0.606
MOD_GSK3_1 131 138 PF00069 0.563
MOD_GSK3_1 144 151 PF00069 0.578
MOD_GSK3_1 160 167 PF00069 0.730
MOD_GSK3_1 17 24 PF00069 0.545
MOD_GSK3_1 177 184 PF00069 0.518
MOD_GSK3_1 2 9 PF00069 0.682
MOD_GSK3_1 227 234 PF00069 0.655
MOD_GSK3_1 251 258 PF00069 0.785
MOD_GSK3_1 30 37 PF00069 0.628
MOD_GSK3_1 396 403 PF00069 0.307
MOD_GSK3_1 431 438 PF00069 0.401
MOD_GSK3_1 59 66 PF00069 0.749
MOD_GSK3_1 625 632 PF00069 0.325
MOD_GSK3_1 688 695 PF00069 0.342
MOD_GSK3_1 712 719 PF00069 0.321
MOD_GSK3_1 805 812 PF00069 0.433
MOD_GSK3_1 854 861 PF00069 0.619
MOD_GSK3_1 87 94 PF00069 0.720
MOD_LATS_1 89 95 PF00433 0.584
MOD_N-GLC_1 189 194 PF02516 0.740
MOD_NEK2_1 111 116 PF00069 0.623
MOD_NEK2_1 143 148 PF00069 0.752
MOD_NEK2_1 164 169 PF00069 0.662
MOD_NEK2_1 204 209 PF00069 0.583
MOD_NEK2_1 227 232 PF00069 0.674
MOD_NEK2_1 236 241 PF00069 0.657
MOD_NEK2_1 245 250 PF00069 0.620
MOD_NEK2_1 255 260 PF00069 0.466
MOD_NEK2_1 402 407 PF00069 0.360
MOD_NEK2_1 431 436 PF00069 0.472
MOD_NEK2_1 569 574 PF00069 0.283
MOD_NEK2_1 6 11 PF00069 0.659
MOD_NEK2_1 629 634 PF00069 0.287
MOD_NEK2_1 63 68 PF00069 0.616
MOD_NEK2_1 664 669 PF00069 0.448
MOD_NEK2_1 70 75 PF00069 0.804
MOD_NEK2_1 700 705 PF00069 0.313
MOD_NEK2_1 764 769 PF00069 0.279
MOD_NEK2_1 805 810 PF00069 0.395
MOD_NEK2_1 848 853 PF00069 0.482
MOD_NEK2_2 118 123 PF00069 0.680
MOD_NEK2_2 17 22 PF00069 0.671
MOD_PIKK_1 245 251 PF00454 0.772
MOD_PIKK_1 327 333 PF00454 0.493
MOD_PIKK_1 6 12 PF00454 0.557
MOD_PKA_1 587 593 PF00069 0.402
MOD_PKA_1 87 93 PF00069 0.608
MOD_PKA_2 135 141 PF00069 0.656
MOD_PKA_2 149 155 PF00069 0.613
MOD_PKA_2 21 27 PF00069 0.649
MOD_PKA_2 236 242 PF00069 0.742
MOD_PKA_2 255 261 PF00069 0.462
MOD_PKA_2 42 48 PF00069 0.738
MOD_PKA_2 562 568 PF00069 0.319
MOD_PKA_2 587 593 PF00069 0.459
MOD_PKA_2 6 12 PF00069 0.789
MOD_PKA_2 71 77 PF00069 0.656
MOD_PKA_2 848 854 PF00069 0.459
MOD_Plk_1 17 23 PF00069 0.744
MOD_Plk_1 251 257 PF00069 0.726
MOD_Plk_1 336 342 PF00069 0.478
MOD_Plk_1 370 376 PF00069 0.693
MOD_Plk_1 624 630 PF00069 0.284
MOD_Plk_2-3 370 376 PF00069 0.693
MOD_Plk_2-3 625 631 PF00069 0.307
MOD_Plk_2-3 720 726 PF00069 0.306
MOD_Plk_2-3 827 833 PF00069 0.675
MOD_Plk_4 118 124 PF00069 0.681
MOD_Plk_4 204 210 PF00069 0.675
MOD_Plk_4 30 36 PF00069 0.634
MOD_Plk_4 336 342 PF00069 0.508
MOD_Plk_4 404 410 PF00069 0.284
MOD_Plk_4 431 437 PF00069 0.399
MOD_Plk_4 562 568 PF00069 0.325
MOD_Plk_4 578 584 PF00069 0.375
MOD_Plk_4 629 635 PF00069 0.284
MOD_Plk_4 688 694 PF00069 0.307
MOD_Plk_4 712 718 PF00069 0.395
MOD_Plk_4 764 770 PF00069 0.315
MOD_ProDKin_1 175 181 PF00069 0.555
MOD_ProDKin_1 256 262 PF00069 0.686
MOD_ProDKin_1 279 285 PF00069 0.558
MOD_ProDKin_1 324 330 PF00069 0.631
MOD_ProDKin_1 459 465 PF00069 0.401
MOD_ProDKin_1 510 516 PF00069 0.401
MOD_ProDKin_1 547 553 PF00069 0.304
MOD_ProDKin_1 555 561 PF00069 0.431
MOD_SUMO_for_1 273 276 PF00179 0.671
MOD_SUMO_for_1 586 589 PF00179 0.512
TRG_DiLeu_BaEn_1 276 281 PF01217 0.539
TRG_DiLeu_BaEn_1 729 734 PF01217 0.370
TRG_DiLeu_BaEn_3 504 510 PF01217 0.306
TRG_ENDOCYTIC_2 145 148 PF00928 0.588
TRG_ENDOCYTIC_2 391 394 PF00928 0.306
TRG_ENDOCYTIC_2 430 433 PF00928 0.305
TRG_ENDOCYTIC_2 439 442 PF00928 0.259
TRG_ENDOCYTIC_2 498 501 PF00928 0.418
TRG_ENDOCYTIC_2 512 515 PF00928 0.210
TRG_ENDOCYTIC_2 564 567 PF00928 0.318
TRG_ENDOCYTIC_2 60 63 PF00928 0.656
TRG_ENDOCYTIC_2 611 614 PF00928 0.340
TRG_ENDOCYTIC_2 785 788 PF00928 0.421
TRG_ENDOCYTIC_2 814 817 PF00928 0.385
TRG_ENDOCYTIC_2 868 871 PF00928 0.608
TRG_ER_diArg_1 156 158 PF00400 0.712
TRG_ER_diArg_1 211 213 PF00400 0.678
TRG_ER_diArg_1 848 850 PF00400 0.477
TRG_ER_diArg_1 874 876 PF00400 0.577
TRG_ER_diArg_1 879 882 PF00400 0.628
TRG_Pf-PMV_PEXEL_1 213 218 PF00026 0.491
TRG_Pf-PMV_PEXEL_1 500 504 PF00026 0.306

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I703 Leptomonas seymouri 67% 97%
A0A1X0P466 Trypanosomatidae 42% 100%
A0A3Q8ID83 Leishmania donovani 91% 100%
A0A3Q8II95 Leishmania donovani 21% 100%
A0A422NN08 Trypanosoma rangeli 45% 100%
A4HN33 Leishmania braziliensis 24% 100%
A4IBQ2 Leishmania infantum 21% 100%
E9AFI7 Leishmania major 23% 100%
E9AHF1 Leishmania infantum 91% 100%
E9AYY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B6P2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 100%
V5BE59 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS