LeishMANIAdb
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Stress-response A/B barrel domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Stress-response A/B barrel domain-containing protein
Gene product:
Stress responsive A/B Barrel Domain, putative
Species:
Leishmania major
UniProt:
E9AD52_LEIMA
TriTrypDb:
LmjF.27.0750 , LMJLV39_270013200 , LMJSD75_270013200
Length:
127

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD52
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD52

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 69 73 PF00656 0.397
CLV_PCSK_KEX2_1 46 48 PF00082 0.331
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.331
CLV_PCSK_PC7_1 42 48 PF00082 0.287
CLV_PCSK_SKI1_1 113 117 PF00082 0.331
CLV_PCSK_SKI1_1 42 46 PF00082 0.416
DEG_APCC_DBOX_1 41 49 PF00400 0.287
DEG_Nend_UBRbox_2 1 3 PF02207 0.680
DOC_ANK_TNKS_1 48 55 PF00023 0.325
DOC_CYCLIN_yCln2_LP_2 32 38 PF00134 0.331
DOC_MAPK_gen_1 110 120 PF00069 0.399
DOC_MAPK_gen_1 31 38 PF00069 0.331
LIG_14-3-3_CanoR_1 113 118 PF00244 0.331
LIG_14-3-3_CanoR_1 47 53 PF00244 0.425
LIG_APCC_ABBAyCdc20_2 33 39 PF00400 0.265
LIG_FHA_1 76 82 PF00498 0.301
LIG_FHA_2 114 120 PF00498 0.360
LIG_LIR_Gen_1 119 127 PF02991 0.481
LIG_LIR_Nem_3 119 123 PF02991 0.360
LIG_NRBOX 40 46 PF00104 0.325
LIG_PDZ_Class_1 122 127 PF00595 0.498
LIG_SH2_STAT5 106 109 PF00017 0.344
LIG_SH2_STAT5 90 93 PF00017 0.366
MOD_CK1_1 67 73 PF00069 0.410
MOD_CK2_1 106 112 PF00069 0.360
MOD_GlcNHglycan 66 69 PF01048 0.431
MOD_GlcNHglycan 72 75 PF01048 0.390
MOD_GSK3_1 60 67 PF00069 0.485
MOD_N-GLC_1 3 8 PF02516 0.461
MOD_N-GLC_1 64 69 PF02516 0.407
MOD_NEK2_1 3 8 PF00069 0.461
MOD_NEK2_1 60 65 PF00069 0.319
MOD_NEK2_1 93 98 PF00069 0.481
MOD_PKA_2 48 54 PF00069 0.331
MOD_Plk_4 113 119 PF00069 0.371
TRG_ENDOCYTIC_2 90 93 PF00928 0.407

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P783 Leptomonas seymouri 61% 99%
A0A0S4JU83 Bodo saltans 39% 100%
A0A1X0P411 Trypanosomatidae 45% 100%
A0A3R7NRY9 Trypanosoma rangeli 33% 100%
A0A3S7X0I8 Leishmania donovani 94% 100%
A4HFJ9 Leishmania braziliensis 77% 100%
E9AHE7 Leishmania infantum 94% 100%
E9AYX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5AU50 Trypanosoma cruzi 42% 100%
V5DA48 Trypanosoma cruzi 37% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS