Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD48_LEIMA

TriTrypDb:

LmjF.27.0710 , LMJLV39_270012800 , LMJSD75_270012800

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AD48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.342
CLV_C14_Caspase3-7	315	319	PF00656	0.473
CLV_C14_Caspase3-7	51	55	PF00656	0.428
CLV_NRD_NRD_1	192	194	PF00675	0.634
CLV_NRD_NRD_1	256	258	PF00675	0.520
CLV_NRD_NRD_1	287	289	PF00675	0.397
CLV_NRD_NRD_1	63	65	PF00675	0.598
CLV_NRD_NRD_1	83	85	PF00675	0.583
CLV_PCSK_KEX2_1	191	193	PF00082	0.650
CLV_PCSK_KEX2_1	203	205	PF00082	0.443
CLV_PCSK_KEX2_1	256	258	PF00082	0.520
CLV_PCSK_KEX2_1	287	289	PF00082	0.397
CLV_PCSK_KEX2_1	63	65	PF00082	0.533
CLV_PCSK_KEX2_1	83	85	PF00082	0.568
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.443
CLV_PCSK_PC7_1	79	85	PF00082	0.573
CLV_PCSK_SKI1_1	113	117	PF00082	0.490
CLV_PCSK_SKI1_1	149	153	PF00082	0.439
CLV_PCSK_SKI1_1	345	349	PF00082	0.558
CLV_PCSK_SKI1_1	370	374	PF00082	0.453
DEG_Nend_UBRbox_1	1	4	PF02207	0.711
DOC_CKS1_1	72	77	PF01111	0.528
DOC_CYCLIN_RxL_1	367	378	PF00134	0.396
DOC_MAPK_gen_1	231	238	PF00069	0.408
DOC_MAPK_gen_1	63	72	PF00069	0.552
DOC_MAPK_MEF2A_6	208	217	PF00069	0.477
DOC_MAPK_MEF2A_6	231	238	PF00069	0.497
DOC_MAPK_RevD_3	70	84	PF00069	0.561
DOC_PP1_RVXF_1	190	197	PF00149	0.584
DOC_PP1_RVXF_1	368	375	PF00149	0.393
DOC_PP2B_LxvP_1	217	220	PF13499	0.470
DOC_PP4_FxxP_1	266	269	PF00568	0.552
DOC_USP7_MATH_1	120	124	PF00917	0.778
DOC_USP7_MATH_1	218	222	PF00917	0.569
DOC_USP7_MATH_1	298	302	PF00917	0.486
DOC_USP7_MATH_1	42	46	PF00917	0.607
DOC_USP7_MATH_1	88	92	PF00917	0.660
DOC_USP7_MATH_1	94	98	PF00917	0.613
DOC_WW_Pin1_4	2	7	PF00397	0.514
DOC_WW_Pin1_4	318	323	PF00397	0.453
DOC_WW_Pin1_4	384	389	PF00397	0.442
DOC_WW_Pin1_4	433	438	PF00397	0.381
DOC_WW_Pin1_4	71	76	PF00397	0.530
LIG_14-3-3_CanoR_1	261	265	PF00244	0.540
LIG_14-3-3_CanoR_1	415	421	PF00244	0.437
LIG_14-3-3_CanoR_1	48	54	PF00244	0.648
LIG_14-3-3_CanoR_1	67	73	PF00244	0.722
LIG_Actin_WH2_2	32	50	PF00022	0.450
LIG_BRCT_BRCA1_1	262	266	PF00533	0.476
LIG_CaM_NSCaTE_8	99	106	PF13499	0.403
LIG_deltaCOP1_diTrp_1	195	200	PF00928	0.474
LIG_deltaCOP1_diTrp_1	390	398	PF00928	0.494
LIG_FHA_1	150	156	PF00498	0.447
LIG_FHA_1	367	373	PF00498	0.408
LIG_FHA_1	375	381	PF00498	0.309
LIG_FHA_1	384	390	PF00498	0.326
LIG_FHA_1	424	430	PF00498	0.565
LIG_FHA_2	156	162	PF00498	0.535
LIG_FHA_2	242	248	PF00498	0.643
LIG_FHA_2	329	335	PF00498	0.608
LIG_FHA_2	406	412	PF00498	0.523
LIG_HP1_1	112	116	PF01393	0.491
LIG_LIR_Apic_2	263	269	PF02991	0.483
LIG_LIR_Apic_2	395	400	PF02991	0.467
LIG_LIR_Apic_2	431	437	PF02991	0.341
LIG_LIR_Gen_1	29	40	PF02991	0.573
LIG_LIR_Gen_1	74	82	PF02991	0.531
LIG_LIR_Gen_1	97	108	PF02991	0.441
LIG_LIR_Nem_3	195	199	PF02991	0.475
LIG_LIR_Nem_3	29	35	PF02991	0.535
LIG_LIR_Nem_3	426	430	PF02991	0.416
LIG_LIR_Nem_3	74	80	PF02991	0.531
LIG_LIR_Nem_3	97	103	PF02991	0.392
LIG_MAD2	233	241	PF02301	0.328
LIG_NRBOX	371	377	PF00104	0.424
LIG_Pex14_1	100	104	PF04695	0.423
LIG_SH2_CRK	434	438	PF00017	0.380
LIG_SH2_STAP1	104	108	PF00017	0.460
LIG_SH2_STAT5	142	145	PF00017	0.426
LIG_SH2_STAT5	189	192	PF00017	0.621
LIG_SH2_STAT5	397	400	PF00017	0.507
LIG_SH3_3	111	117	PF00018	0.632
LIG_SH3_3	151	157	PF00018	0.447
LIG_SH3_3	163	169	PF00018	0.547
LIG_SH3_3	191	197	PF00018	0.496
LIG_SH3_3	359	365	PF00018	0.562
LIG_SH3_3	69	75	PF00018	0.563
LIG_SUMO_SIM_par_1	211	216	PF11976	0.458
LIG_TRAF2_1	331	334	PF00917	0.548
LIG_WRC_WIRS_1	371	376	PF05994	0.371
MOD_CK1_1	321	327	PF00069	0.430
MOD_CK1_1	355	361	PF00069	0.630
MOD_CK1_1	71	77	PF00069	0.588
MOD_CK2_1	161	167	PF00069	0.602
MOD_CK2_1	328	334	PF00069	0.630
MOD_CK2_1	384	390	PF00069	0.508
MOD_CK2_1	405	411	PF00069	0.527
MOD_Cter_Amidation	254	257	PF01082	0.461
MOD_GlcNHglycan	176	179	PF01048	0.641
MOD_GlcNHglycan	26	29	PF01048	0.465
MOD_GlcNHglycan	300	303	PF01048	0.401
MOD_GlcNHglycan	90	93	PF01048	0.694
MOD_GSK3_1	120	127	PF00069	0.675
MOD_GSK3_1	20	27	PF00069	0.446
MOD_GSK3_1	260	267	PF00069	0.529
MOD_GSK3_1	352	359	PF00069	0.609
MOD_GSK3_1	366	373	PF00069	0.509
MOD_GSK3_1	416	423	PF00069	0.646
MOD_GSK3_1	429	436	PF00069	0.501
MOD_N-GLC_1	392	397	PF02516	0.451
MOD_NEK2_1	20	25	PF00069	0.342
MOD_NEK2_1	213	218	PF00069	0.468
MOD_NEK2_1	260	265	PF00069	0.433
MOD_NEK2_1	303	308	PF00069	0.344
MOD_NEK2_1	31	36	PF00069	0.489
MOD_NEK2_1	311	316	PF00069	0.382
MOD_NEK2_1	339	344	PF00069	0.564
MOD_NEK2_1	374	379	PF00069	0.342
MOD_NEK2_1	383	388	PF00069	0.379
MOD_NEK2_1	413	418	PF00069	0.507
MOD_NEK2_1	445	450	PF00069	0.671
MOD_NEK2_1	47	52	PF00069	0.690
MOD_PIKK_1	118	124	PF00454	0.544
MOD_PIKK_1	149	155	PF00454	0.461
MOD_PIKK_1	321	327	PF00454	0.430
MOD_PIKK_1	339	345	PF00454	0.434
MOD_PIKK_1	443	449	PF00454	0.691
MOD_PKA_2	260	266	PF00069	0.505
MOD_PKA_2	47	53	PF00069	0.565
MOD_Plk_1	149	155	PF00069	0.461
MOD_Plk_1	213	219	PF00069	0.473
MOD_Plk_1	241	247	PF00069	0.483
MOD_Plk_1	312	318	PF00069	0.530
MOD_Plk_2-3	405	411	PF00069	0.527
MOD_Plk_4	155	161	PF00069	0.351
MOD_Plk_4	195	201	PF00069	0.476
MOD_Plk_4	26	32	PF00069	0.491
MOD_Plk_4	370	376	PF00069	0.389
MOD_Plk_4	429	435	PF00069	0.426
MOD_Plk_4	95	101	PF00069	0.612
MOD_ProDKin_1	2	8	PF00069	0.503
MOD_ProDKin_1	318	324	PF00069	0.448
MOD_ProDKin_1	384	390	PF00069	0.449
MOD_ProDKin_1	433	439	PF00069	0.395
MOD_ProDKin_1	71	77	PF00069	0.526
TRG_ER_diArg_1	1	4	PF00400	0.670
TRG_ER_diArg_1	111	114	PF00400	0.543
TRG_ER_diArg_1	191	193	PF00400	0.482
TRG_ER_diArg_1	286	288	PF00400	0.393
TRG_NES_CRM1_1	138	150	PF08389	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU3	Leptomonas seymouri	39%	100%
A0A1X0P3Z2	Trypanosomatidae	30%	100%
A0A3Q8IPT0	Leishmania donovani	90%	100%
A0A3R7KFH1	Trypanosoma rangeli	27%	100%
D0A5R9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AHE2	Leishmania infantum	89%	91%
E9AYX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%