RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD47_LEIMA

TriTrypDb:

LmjF.27.0700 , LMJLV39_270012700 , LMJSD75_270012700

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.476
CLV_NRD_NRD_1	368	370	PF00675	0.687
CLV_NRD_NRD_1	391	393	PF00675	0.665
CLV_NRD_NRD_1	428	430	PF00675	0.751
CLV_PCSK_KEX2_1	310	312	PF00082	0.464
CLV_PCSK_KEX2_1	368	370	PF00082	0.687
CLV_PCSK_KEX2_1	379	381	PF00082	0.704
CLV_PCSK_KEX2_1	391	393	PF00082	0.703
CLV_PCSK_KEX2_1	428	430	PF00082	0.745
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.464
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.682
CLV_PCSK_PC7_1	306	312	PF00082	0.470
CLV_PCSK_SKI1_1	17	21	PF00082	0.787
CLV_PCSK_SKI1_1	201	205	PF00082	0.506
CLV_PCSK_SKI1_1	310	314	PF00082	0.404
DEG_Nend_UBRbox_3	1	3	PF02207	0.839
DEG_SCF_FBW7_1	140	146	PF00400	0.811
DEG_SCF_FBW7_1	25	31	PF00400	0.696
DEG_SPOP_SBC_1	58	62	PF00917	0.688
DOC_CKS1_1	140	145	PF01111	0.710
DOC_CKS1_1	25	30	PF01111	0.706
DOC_CYCLIN_RxL_1	306	315	PF00134	0.457
DOC_MAPK_gen_1	204	212	PF00069	0.487
DOC_MAPK_gen_1	347	355	PF00069	0.498
DOC_PP1_RVXF_1	206	213	PF00149	0.424
DOC_PP1_RVXF_1	308	315	PF00149	0.448
DOC_PP2B_LxvP_1	337	340	PF13499	0.559
DOC_PP4_FxxP_1	192	195	PF00568	0.531
DOC_PP4_FxxP_1	44	47	PF00568	0.698
DOC_USP7_MATH_1	109	113	PF00917	0.727
DOC_USP7_MATH_1	118	122	PF00917	0.663
DOC_USP7_MATH_1	147	151	PF00917	0.735
DOC_USP7_MATH_1	156	160	PF00917	0.610
DOC_USP7_MATH_1	279	283	PF00917	0.476
DOC_USP7_MATH_1	349	353	PF00917	0.499
DOC_USP7_MATH_1	362	366	PF00917	0.612
DOC_USP7_MATH_1	400	404	PF00917	0.813
DOC_WW_Pin1_4	101	106	PF00397	0.694
DOC_WW_Pin1_4	133	138	PF00397	0.684
DOC_WW_Pin1_4	139	144	PF00397	0.708
DOC_WW_Pin1_4	24	29	PF00397	0.716
DOC_WW_Pin1_4	37	42	PF00397	0.538
DOC_WW_Pin1_4	48	53	PF00397	0.593
DOC_WW_Pin1_4	87	92	PF00397	0.662
LIG_14-3-3_CanoR_1	17	25	PF00244	0.701
LIG_BRCT_BRCA1_1	148	152	PF00533	0.580
LIG_Clathr_ClatBox_1	84	88	PF01394	0.787
LIG_EVH1_2	448	452	PF00568	0.711
LIG_FHA_1	189	195	PF00498	0.615
LIG_FHA_1	37	43	PF00498	0.657
LIG_FHA_2	263	269	PF00498	0.459
LIG_FHA_2	322	328	PF00498	0.475
LIG_FHA_2	434	440	PF00498	0.736
LIG_FHA_2	81	87	PF00498	0.695
LIG_GSK3_LRP6_1	37	42	PF00069	0.707
LIG_IBAR_NPY_1	125	127	PF08397	0.669
LIG_LIR_Apic_2	104	109	PF02991	0.687
LIG_LIR_Apic_2	189	195	PF02991	0.562
LIG_LIR_Gen_1	333	342	PF02991	0.601
LIG_LIR_Nem_3	333	337	PF02991	0.593
LIG_LIR_Nem_3	451	455	PF02991	0.535
LIG_SH2_CRK	106	110	PF00017	0.800
LIG_SH2_CRK	72	76	PF00017	0.683
LIG_SH2_PTP2	334	337	PF00017	0.588
LIG_SH2_SRC	437	440	PF00017	0.810
LIG_SH2_STAP1	127	131	PF00017	0.688
LIG_SH2_STAP1	437	441	PF00017	0.808
LIG_SH2_STAT3	32	35	PF00017	0.698
LIG_SH2_STAT3	447	450	PF00017	0.710
LIG_SH2_STAT3	8	11	PF00017	0.737
LIG_SH2_STAT5	127	130	PF00017	0.709
LIG_SH2_STAT5	209	212	PF00017	0.410
LIG_SH2_STAT5	292	295	PF00017	0.437
LIG_SH2_STAT5	334	337	PF00017	0.486
LIG_SH3_3	137	143	PF00018	0.630
LIG_SH3_3	214	220	PF00018	0.535
LIG_SH3_3	35	41	PF00018	0.674
LIG_SH3_3	439	445	PF00018	0.691
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.468
LIG_SUMO_SIM_par_1	83	90	PF11976	0.681
LIG_TRAF2_1	436	439	PF00917	0.813
LIG_TRAF2_2	52	57	PF00917	0.714
LIG_TRFH_1	192	196	PF08558	0.515
MOD_CDC14_SPxK_1	90	93	PF00782	0.758
MOD_CDK_SPxK_1	87	93	PF00069	0.765
MOD_CK1_1	132	138	PF00069	0.685
MOD_CK1_1	141	147	PF00069	0.710
MOD_CK1_1	237	243	PF00069	0.802
MOD_CK1_1	246	252	PF00069	0.522
MOD_CK1_1	30	36	PF00069	0.731
MOD_CK1_1	383	389	PF00069	0.718
MOD_CK1_1	4	10	PF00069	0.781
MOD_CK2_1	262	268	PF00069	0.469
MOD_CK2_1	279	285	PF00069	0.471
MOD_CK2_1	321	327	PF00069	0.473
MOD_CK2_1	433	439	PF00069	0.818
MOD_CK2_1	448	454	PF00069	0.538
MOD_CK2_1	80	86	PF00069	0.702
MOD_Cter_Amidation	366	369	PF01082	0.772
MOD_Cter_Amidation	377	380	PF01082	0.704
MOD_GlcNHglycan	119	123	PF01048	0.717
MOD_GlcNHglycan	131	134	PF01048	0.461
MOD_GlcNHglycan	149	152	PF01048	0.733
MOD_GlcNHglycan	153	157	PF01048	0.685
MOD_GlcNHglycan	242	245	PF01048	0.692
MOD_GlcNHglycan	364	367	PF01048	0.710
MOD_GlcNHglycan	387	390	PF01048	0.696
MOD_GlcNHglycan	398	401	PF01048	0.667
MOD_GlcNHglycan	402	405	PF01048	0.566
MOD_GlcNHglycan	412	415	PF01048	0.657
MOD_GlcNHglycan	438	442	PF01048	0.702
MOD_GSK3_1	125	132	PF00069	0.770
MOD_GSK3_1	139	146	PF00069	0.718
MOD_GSK3_1	147	154	PF00069	0.700
MOD_GSK3_1	20	27	PF00069	0.728
MOD_GSK3_1	233	240	PF00069	0.749
MOD_GSK3_1	243	250	PF00069	0.565
MOD_GSK3_1	279	286	PF00069	0.453
MOD_GSK3_1	3	10	PF00069	0.698
MOD_GSK3_1	300	307	PF00069	0.429
MOD_GSK3_1	396	403	PF00069	0.814
MOD_GSK3_1	406	413	PF00069	0.496
MOD_GSK3_1	433	440	PF00069	0.817
MOD_N-GLC_1	232	237	PF02516	0.806
MOD_N-GLC_1	383	388	PF02516	0.632
MOD_N-GLC_1	4	9	PF02516	0.799
MOD_NEK2_1	1	6	PF00069	0.743
MOD_NEK2_1	129	134	PF00069	0.655
MOD_NEK2_1	138	143	PF00069	0.715
MOD_NEK2_1	152	157	PF00069	0.641
MOD_NEK2_1	188	193	PF00069	0.672
MOD_NEK2_1	262	267	PF00069	0.496
MOD_NEK2_1	304	309	PF00069	0.418
MOD_NEK2_1	408	413	PF00069	0.751
MOD_NEK2_1	59	64	PF00069	0.786
MOD_PIKK_1	30	36	PF00454	0.700
MOD_PIKK_1	406	412	PF00454	0.795
MOD_PIKK_1	7	13	PF00454	0.694
MOD_PKA_2	349	355	PF00069	0.493
MOD_PKB_1	15	23	PF00069	0.701
MOD_Plk_1	188	194	PF00069	0.595
MOD_Plk_1	247	253	PF00069	0.605
MOD_Plk_1	300	306	PF00069	0.468
MOD_Plk_1	383	389	PF00069	0.718
MOD_Plk_1	4	10	PF00069	0.743
MOD_Plk_4	300	306	PF00069	0.434
MOD_Plk_4	349	355	PF00069	0.493
MOD_ProDKin_1	101	107	PF00069	0.697
MOD_ProDKin_1	133	139	PF00069	0.688
MOD_ProDKin_1	143	149	PF00069	0.713
MOD_ProDKin_1	24	30	PF00069	0.717
MOD_ProDKin_1	37	43	PF00069	0.540
MOD_ProDKin_1	48	54	PF00069	0.594
MOD_ProDKin_1	87	93	PF00069	0.663
MOD_SUMO_rev_2	351	360	PF00179	0.518
TRG_DiLeu_BaEn_1	268	273	PF01217	0.442
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.611
TRG_ENDOCYTIC_2	209	212	PF00928	0.410
TRG_ENDOCYTIC_2	334	337	PF00928	0.588
TRG_ER_diArg_1	14	17	PF00400	0.709
TRG_ER_diArg_1	206	209	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L6	Leptomonas seymouri	59%	100%
A0A3S7X0I2	Leishmania donovani	92%	100%
A4HFJ4	Leishmania braziliensis	73%	100%
E9AHE1	Leishmania infantum	93%	100%
E9AYX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%