Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AD46_LEIMA

TriTrypDb:

LmjF.27.0690 , LMJLV39_270012600 , LMJSD75_270012600

Length:

896

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

E9AD46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.443
CLV_C14_Caspase3-7	366	370	PF00656	0.428
CLV_C14_Caspase3-7	499	503	PF00656	0.390
CLV_C14_Caspase3-7	608	612	PF00656	0.461
CLV_C14_Caspase3-7	842	846	PF00656	0.727
CLV_NRD_NRD_1	167	169	PF00675	0.481
CLV_NRD_NRD_1	20	22	PF00675	0.653
CLV_NRD_NRD_1	340	342	PF00675	0.660
CLV_NRD_NRD_1	496	498	PF00675	0.699
CLV_NRD_NRD_1	516	518	PF00675	0.506
CLV_NRD_NRD_1	625	627	PF00675	0.600
CLV_PCSK_FUR_1	18	22	PF00082	0.653
CLV_PCSK_KEX2_1	20	22	PF00082	0.653
CLV_PCSK_KEX2_1	340	342	PF00082	0.660
CLV_PCSK_KEX2_1	496	498	PF00082	0.699
CLV_PCSK_KEX2_1	625	627	PF00082	0.600
CLV_PCSK_SKI1_1	210	214	PF00082	0.555
CLV_PCSK_SKI1_1	265	269	PF00082	0.553
CLV_PCSK_SKI1_1	429	433	PF00082	0.631
CLV_PCSK_SKI1_1	440	444	PF00082	0.646
CLV_PCSK_SKI1_1	630	634	PF00082	0.554
CLV_PCSK_SKI1_1	647	651	PF00082	0.325
CLV_PCSK_SKI1_1	713	717	PF00082	0.477
CLV_PCSK_SKI1_1	719	723	PF00082	0.427
CLV_PCSK_SKI1_1	818	822	PF00082	0.451
CLV_PCSK_SKI1_1	883	887	PF00082	0.449
DEG_APCC_DBOX_1	209	217	PF00400	0.388
DEG_SCF_FBW7_1	244	251	PF00400	0.390
DOC_ANK_TNKS_1	20	27	PF00023	0.441
DOC_ANK_TNKS_1	280	287	PF00023	0.424
DOC_CDC14_PxL_1	730	738	PF14671	0.651
DOC_CKS1_1	245	250	PF01111	0.382
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.347
DOC_MAPK_DCC_7	530	540	PF00069	0.413
DOC_MAPK_gen_1	625	631	PF00069	0.369
DOC_MAPK_MEF2A_6	41	49	PF00069	0.372
DOC_PP1_RVXF_1	645	651	PF00149	0.325
DOC_PP2B_LxvP_1	464	467	PF13499	0.424
DOC_PP2B_LxvP_1	653	656	PF13499	0.347
DOC_PP2B_LxvP_1	731	734	PF13499	0.624
DOC_PP4_FxxP_1	193	196	PF00568	0.431
DOC_USP7_MATH_1	24	28	PF00917	0.493
DOC_USP7_MATH_1	289	293	PF00917	0.475
DOC_USP7_MATH_1	350	354	PF00917	0.489
DOC_USP7_MATH_1	359	363	PF00917	0.453
DOC_USP7_MATH_1	458	462	PF00917	0.466
DOC_USP7_MATH_1	548	552	PF00917	0.408
DOC_USP7_MATH_1	610	614	PF00917	0.456
DOC_USP7_MATH_1	715	719	PF00917	0.673
DOC_USP7_MATH_1	829	833	PF00917	0.654
DOC_USP7_MATH_1	87	91	PF00917	0.525
DOC_WW_Pin1_4	244	249	PF00397	0.400
DOC_WW_Pin1_4	297	302	PF00397	0.473
DOC_WW_Pin1_4	533	538	PF00397	0.372
DOC_WW_Pin1_4	665	670	PF00397	0.691
DOC_WW_Pin1_4	99	104	PF00397	0.428
LIG_14-3-3_CanoR_1	135	143	PF00244	0.644
LIG_14-3-3_CanoR_1	185	193	PF00244	0.303
LIG_14-3-3_CanoR_1	323	332	PF00244	0.535
LIG_14-3-3_CanoR_1	340	347	PF00244	0.402
LIG_14-3-3_CanoR_1	363	371	PF00244	0.456
LIG_14-3-3_CanoR_1	541	547	PF00244	0.421
LIG_14-3-3_CanoR_1	625	630	PF00244	0.394
LIG_14-3-3_CanoR_1	667	676	PF00244	0.611
LIG_14-3-3_CanoR_1	747	756	PF00244	0.702
LIG_14-3-3_CanoR_1	75	80	PF00244	0.434
LIG_Actin_WH2_2	170	187	PF00022	0.447
LIG_Actin_WH2_2	188	205	PF00022	0.432
LIG_APCC_ABBA_1	629	634	PF00400	0.352
LIG_BIR_III_4	198	202	PF00653	0.436
LIG_BRCT_BRCA1_1	47	51	PF00533	0.359
LIG_Clathr_ClatBox_1	318	322	PF01394	0.419
LIG_Clathr_ClatBox_1	772	776	PF01394	0.661
LIG_eIF4E_1	654	660	PF01652	0.369
LIG_FHA_1	115	121	PF00498	0.369
LIG_FHA_1	181	187	PF00498	0.304
LIG_FHA_1	245	251	PF00498	0.363
LIG_FHA_1	303	309	PF00498	0.486
LIG_FHA_1	334	340	PF00498	0.460
LIG_FHA_1	362	368	PF00498	0.466
LIG_FHA_1	44	50	PF00498	0.399
LIG_FHA_1	473	479	PF00498	0.435
LIG_FHA_1	626	632	PF00498	0.461
LIG_FHA_1	634	640	PF00498	0.376
LIG_FHA_1	767	773	PF00498	0.646
LIG_FHA_1	803	809	PF00498	0.655
LIG_FHA_1	885	891	PF00498	0.635
LIG_FHA_2	103	109	PF00498	0.374
LIG_FHA_2	288	294	PF00498	0.467
LIG_FHA_2	297	303	PF00498	0.475
LIG_FHA_2	505	511	PF00498	0.402
LIG_FHA_2	566	572	PF00498	0.416
LIG_FHA_2	840	846	PF00498	0.699
LIG_FHA_2	869	875	PF00498	0.638
LIG_LIR_Apic_2	110	116	PF02991	0.304
LIG_LIR_Apic_2	192	196	PF02991	0.426
LIG_LIR_Apic_2	554	560	PF02991	0.410
LIG_LIR_Gen_1	48	58	PF02991	0.355
LIG_LIR_Gen_1	566	576	PF02991	0.466
LIG_LIR_Gen_1	671	681	PF02991	0.724
LIG_LIR_Gen_1	873	882	PF02991	0.621
LIG_LIR_Nem_3	392	398	PF02991	0.586
LIG_LIR_Nem_3	447	452	PF02991	0.425
LIG_LIR_Nem_3	48	54	PF02991	0.355
LIG_LIR_Nem_3	510	516	PF02991	0.385
LIG_LIR_Nem_3	521	527	PF02991	0.394
LIG_LIR_Nem_3	566	572	PF02991	0.451
LIG_LIR_Nem_3	600	605	PF02991	0.528
LIG_LIR_Nem_3	671	676	PF02991	0.728
LIG_LIR_Nem_3	873	878	PF02991	0.617
LIG_MAD2	223	231	PF02301	0.332
LIG_NRBOX	121	127	PF00104	0.325
LIG_OCRL_FandH_1	715	727	PF00620	0.665
LIG_PAM2_1	151	163	PF00658	0.668
LIG_PCNA_yPIPBox_3	203	213	PF02747	0.377
LIG_Pex14_1	642	646	PF04695	0.369
LIG_Pex14_2	646	650	PF04695	0.369
LIG_PTB_Apo_2	869	876	PF02174	0.623
LIG_SH2_CRK	657	661	PF00017	0.534
LIG_SH2_CRK	867	871	PF00017	0.638
LIG_SH2_NCK_1	867	871	PF00017	0.684
LIG_SH2_PTP2	113	116	PF00017	0.284
LIG_SH2_SRC	547	550	PF00017	0.441
LIG_SH2_SRC	652	655	PF00017	0.347
LIG_SH2_STAP1	383	387	PF00017	0.417
LIG_SH2_STAT3	526	529	PF00017	0.438
LIG_SH2_STAT5	113	116	PF00017	0.291
LIG_SH2_STAT5	33	36	PF00017	0.430
LIG_SH2_STAT5	395	398	PF00017	0.464
LIG_SH2_STAT5	400	403	PF00017	0.463
LIG_SH2_STAT5	526	529	PF00017	0.392
LIG_SH2_STAT5	53	56	PF00017	0.343
LIG_SH2_STAT5	557	560	PF00017	0.338
LIG_SH2_STAT5	652	655	PF00017	0.354
LIG_SH2_STAT5	7	10	PF00017	0.462
LIG_SH3_3	152	158	PF00018	0.678
LIG_SH3_3	447	453	PF00018	0.454
LIG_SH3_3	486	492	PF00018	0.416
LIG_SH3_3	61	67	PF00018	0.337
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.322
LIG_SUMO_SIM_anti_2	763	769	PF11976	0.702
LIG_SUMO_SIM_par_1	117	124	PF11976	0.355
LIG_SUMO_SIM_par_1	223	228	PF11976	0.328
LIG_SUMO_SIM_par_1	251	258	PF11976	0.348
LIG_SUMO_SIM_par_1	43	48	PF11976	0.364
LIG_SUMO_SIM_par_1	720	726	PF11976	0.620
LIG_SUMO_SIM_par_1	771	776	PF11976	0.624
LIG_TRAF2_1	508	511	PF00917	0.382
LIG_TRAF2_1	562	565	PF00917	0.400
LIG_TRAF2_1	871	874	PF00917	0.641
LIG_UBA3_1	595	604	PF00899	0.443
MOD_CK1_1	102	108	PF00069	0.411
MOD_CK1_1	249	255	PF00069	0.334
MOD_CK1_1	27	33	PF00069	0.489
MOD_CK1_1	296	302	PF00069	0.473
MOD_CK1_1	345	351	PF00069	0.477
MOD_CK1_1	358	364	PF00069	0.461
MOD_CK1_1	378	384	PF00069	0.509
MOD_CK1_1	402	408	PF00069	0.500
MOD_CK1_1	465	471	PF00069	0.353
MOD_CK1_1	606	612	PF00069	0.453
MOD_CK1_1	691	697	PF00069	0.670
MOD_CK1_1	735	741	PF00069	0.641
MOD_CK1_1	763	769	PF00069	0.656
MOD_CK1_1	834	840	PF00069	0.687
MOD_CK1_1	868	874	PF00069	0.647
MOD_CK2_1	11	17	PF00069	0.539
MOD_CK2_1	260	266	PF00069	0.359
MOD_CK2_1	296	302	PF00069	0.474
MOD_CK2_1	345	351	PF00069	0.495
MOD_CK2_1	504	510	PF00069	0.406
MOD_CK2_1	559	565	PF00069	0.412
MOD_CK2_1	85	91	PF00069	0.492
MOD_CK2_1	868	874	PF00069	0.647
MOD_GlcNHglycan	143	146	PF01048	0.439
MOD_GlcNHglycan	226	230	PF01048	0.524
MOD_GlcNHglycan	29	32	PF01048	0.776
MOD_GlcNHglycan	302	305	PF01048	0.610
MOD_GlcNHglycan	325	328	PF01048	0.625
MOD_GlcNHglycan	351	355	PF01048	0.715
MOD_GlcNHglycan	356	360	PF01048	0.673
MOD_GlcNHglycan	403	407	PF01048	0.663
MOD_GlcNHglycan	420	423	PF01048	0.564
MOD_GlcNHglycan	463	467	PF01048	0.596
MOD_GlcNHglycan	498	501	PF01048	0.662
MOD_GlcNHglycan	574	577	PF01048	0.574
MOD_GlcNHglycan	608	611	PF01048	0.670
MOD_GlcNHglycan	612	615	PF01048	0.690
MOD_GlcNHglycan	670	673	PF01048	0.399
MOD_GlcNHglycan	697	700	PF01048	0.480
MOD_GlcNHglycan	704	707	PF01048	0.476
MOD_GlcNHglycan	762	765	PF01048	0.437
MOD_GlcNHglycan	827	830	PF01048	0.454
MOD_GlcNHglycan	833	836	PF01048	0.468
MOD_GlcNHglycan	867	870	PF01048	0.443
MOD_GSK3_1	180	187	PF00069	0.345
MOD_GSK3_1	244	251	PF00069	0.393
MOD_GSK3_1	25	32	PF00069	0.519
MOD_GSK3_1	289	296	PF00069	0.472
MOD_GSK3_1	341	348	PF00069	0.486
MOD_GSK3_1	355	362	PF00069	0.460
MOD_GSK3_1	369	376	PF00069	0.420
MOD_GSK3_1	378	385	PF00069	0.449
MOD_GSK3_1	387	394	PF00069	0.450
MOD_GSK3_1	398	405	PF00069	0.509
MOD_GSK3_1	418	425	PF00069	0.505
MOD_GSK3_1	458	465	PF00069	0.408
MOD_GSK3_1	505	512	PF00069	0.405
MOD_GSK3_1	52	59	PF00069	0.354
MOD_GSK3_1	529	536	PF00069	0.373
MOD_GSK3_1	548	555	PF00069	0.367
MOD_GSK3_1	559	566	PF00069	0.341
MOD_GSK3_1	606	613	PF00069	0.454
MOD_GSK3_1	691	698	PF00069	0.658
MOD_GSK3_1	745	752	PF00069	0.744
MOD_GSK3_1	825	832	PF00069	0.713
MOD_GSK3_1	839	846	PF00069	0.632
MOD_N-GLC_1	379	384	PF02516	0.621
MOD_N-GLC_1	533	538	PF02516	0.572
MOD_NEK2_1	184	189	PF00069	0.346
MOD_NEK2_1	191	196	PF00069	0.391
MOD_NEK2_1	225	230	PF00069	0.322
MOD_NEK2_1	255	260	PF00069	0.356
MOD_NEK2_1	332	337	PF00069	0.450
MOD_NEK2_1	355	360	PF00069	0.512
MOD_NEK2_1	374	379	PF00069	0.466
MOD_NEK2_1	391	396	PF00069	0.419
MOD_NEK2_1	477	482	PF00069	0.411
MOD_NEK2_1	56	61	PF00069	0.362
MOD_NEK2_1	563	568	PF00069	0.422
MOD_NEK2_1	572	577	PF00069	0.400
MOD_NEK2_1	688	693	PF00069	0.635
MOD_NEK2_1	822	827	PF00069	0.600
MOD_PIKK_1	135	141	PF00454	0.703
MOD_PIKK_1	345	351	PF00454	0.454
MOD_PIKK_1	369	375	PF00454	0.482
MOD_PIKK_1	766	772	PF00454	0.675
MOD_PK_1	75	81	PF00069	0.440
MOD_PKA_1	340	346	PF00069	0.419
MOD_PKA_1	496	502	PF00069	0.492
MOD_PKA_1	625	631	PF00069	0.337
MOD_PKA_2	184	190	PF00069	0.454
MOD_PKA_2	340	346	PF00069	0.435
MOD_PKA_2	359	365	PF00069	0.600
MOD_PKA_2	496	502	PF00069	0.492
MOD_PKA_2	624	630	PF00069	0.401
MOD_PKA_2	702	708	PF00069	0.647
MOD_PKA_2	74	80	PF00069	0.420
MOD_PKA_2	865	871	PF00069	0.744
MOD_Plk_1	107	113	PF00069	0.288
MOD_Plk_1	191	197	PF00069	0.406
MOD_Plk_1	255	261	PF00069	0.357
MOD_Plk_1	293	299	PF00069	0.420
MOD_Plk_1	34	40	PF00069	0.426
MOD_Plk_1	350	356	PF00069	0.515
MOD_Plk_1	379	385	PF00069	0.473
MOD_Plk_1	391	397	PF00069	0.422
MOD_Plk_1	509	515	PF00069	0.356
MOD_Plk_1	873	879	PF00069	0.633
MOD_Plk_2-3	11	17	PF00069	0.511
MOD_Plk_2-3	565	571	PF00069	0.389
MOD_Plk_4	114	120	PF00069	0.374
MOD_Plk_4	151	157	PF00069	0.668
MOD_Plk_4	173	179	PF00069	0.469
MOD_Plk_4	249	255	PF00069	0.332
MOD_Plk_4	45	51	PF00069	0.376
MOD_Plk_4	509	515	PF00069	0.375
MOD_Plk_4	542	548	PF00069	0.420
MOD_Plk_4	552	558	PF00069	0.361
MOD_Plk_4	597	603	PF00069	0.429
MOD_Plk_4	618	624	PF00069	0.602
MOD_Plk_4	763	769	PF00069	0.661
MOD_ProDKin_1	244	250	PF00069	0.394
MOD_ProDKin_1	297	303	PF00069	0.469
MOD_ProDKin_1	533	539	PF00069	0.373
MOD_ProDKin_1	665	671	PF00069	0.691
MOD_ProDKin_1	99	105	PF00069	0.425
MOD_SUMO_for_1	820	823	PF00179	0.654
TRG_DiLeu_BaEn_1	726	731	PF01217	0.597
TRG_DiLeu_BaEn_1	757	762	PF01217	0.635
TRG_DiLeu_BaEn_2	724	730	PF01217	0.660
TRG_DiLeu_BaEn_4	873	879	PF01217	0.633
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.671
TRG_ENDOCYTIC_2	513	516	PF00928	0.379
TRG_ENDOCYTIC_2	53	56	PF00928	0.362
TRG_ENDOCYTIC_2	569	572	PF00928	0.462
TRG_ENDOCYTIC_2	657	660	PF00928	0.534
TRG_ENDOCYTIC_2	714	717	PF00928	0.777
TRG_ENDOCYTIC_2	867	870	PF00928	0.644
TRG_ER_diArg_1	18	21	PF00400	0.454
TRG_ER_diArg_1	339	341	PF00400	0.458
TRG_ER_diArg_1	495	497	PF00400	0.477
TRG_NES_CRM1_1	124	134	PF08389	0.493
TRG_NES_CRM1_1	245	257	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	583	588	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE25	Leptomonas seymouri	43%	95%
A0A3Q8IDB5	Leishmania donovani	89%	98%
A4HFJ3	Leishmania braziliensis	67%	97%
E9AHE0	Leishmania infantum	89%	98%
E9AYX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%