Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD43_LEIMA

TriTrypDb:

LmjF.27.0660 , LMJLV39_270012000 , LMJSD75_270011900

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AD43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.378
CLV_MEL_PAP_1	442	448	PF00089	0.409
CLV_NRD_NRD_1	187	189	PF00675	0.491
CLV_NRD_NRD_1	360	362	PF00675	0.550
CLV_NRD_NRD_1	363	365	PF00675	0.606
CLV_NRD_NRD_1	398	400	PF00675	0.532
CLV_NRD_NRD_1	496	498	PF00675	0.477
CLV_PCSK_FUR_1	18	22	PF00082	0.618
CLV_PCSK_FUR_1	361	365	PF00082	0.468
CLV_PCSK_FUR_1	494	498	PF00082	0.525
CLV_PCSK_KEX2_1	20	22	PF00082	0.603
CLV_PCSK_KEX2_1	358	360	PF00082	0.541
CLV_PCSK_KEX2_1	363	365	PF00082	0.466
CLV_PCSK_KEX2_1	398	400	PF00082	0.532
CLV_PCSK_KEX2_1	496	498	PF00082	0.477
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.587
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.471
CLV_PCSK_PC7_1	16	22	PF00082	0.652
CLV_PCSK_PC7_1	359	365	PF00082	0.468
CLV_PCSK_PC7_1	492	498	PF00082	0.486
CLV_PCSK_SKI1_1	25	29	PF00082	0.553
CLV_PCSK_SKI1_1	399	403	PF00082	0.573
DEG_SPOP_SBC_1	199	203	PF00917	0.245
DEG_SPOP_SBC_1	234	238	PF00917	0.426
DEG_SPOP_SBC_1	273	277	PF00917	0.468
DEG_SPOP_SBC_1	280	284	PF00917	0.461
DEG_SPOP_SBC_1	340	344	PF00917	0.652
DOC_CKS1_1	488	493	PF01111	0.662
DOC_CYCLIN_RxL_1	20	29	PF00134	0.457
DOC_MAPK_gen_1	188	198	PF00069	0.318
DOC_MAPK_gen_1	494	503	PF00069	0.675
DOC_MAPK_MEF2A_6	298	307	PF00069	0.263
DOC_MAPK_MEF2A_6	450	459	PF00069	0.628
DOC_PP1_SILK_1	399	404	PF00149	0.734
DOC_PP2B_LxvP_1	196	199	PF13499	0.281
DOC_PP2B_LxvP_1	348	351	PF13499	0.675
DOC_USP7_MATH_1	155	159	PF00917	0.281
DOC_USP7_MATH_1	199	203	PF00917	0.272
DOC_USP7_MATH_1	281	285	PF00917	0.493
DOC_USP7_MATH_1	351	355	PF00917	0.677
DOC_USP7_MATH_1	368	372	PF00917	0.616
DOC_USP7_MATH_1	418	422	PF00917	0.789
DOC_USP7_MATH_1	83	87	PF00917	0.303
DOC_WW_Pin1_4	269	274	PF00397	0.485
DOC_WW_Pin1_4	387	392	PF00397	0.718
DOC_WW_Pin1_4	487	492	PF00397	0.701
LIG_14-3-3_CanoR_1	25	31	PF00244	0.445
LIG_14-3-3_CanoR_1	445	452	PF00244	0.675
LIG_14-3-3_CanoR_1	494	504	PF00244	0.684
LIG_14-3-3_CanoR_1	67	73	PF00244	0.423
LIG_BRCT_BRCA1_1	499	503	PF00533	0.713
LIG_CtBP_PxDLS_1	456	460	PF00389	0.632
LIG_deltaCOP1_diTrp_1	128	133	PF00928	0.244
LIG_eIF4E_1	225	231	PF01652	0.401
LIG_FHA_1	110	116	PF00498	0.343
LIG_FHA_1	274	280	PF00498	0.473
LIG_FHA_1	298	304	PF00498	0.317
LIG_FHA_1	452	458	PF00498	0.683
LIG_FHA_1	496	502	PF00498	0.718
LIG_FHA_1	8	14	PF00498	0.626
LIG_FHA_2	283	289	PF00498	0.562
LIG_GBD_Chelix_1	311	319	PF00786	0.370
LIG_LIR_Gen_1	306	316	PF02991	0.370
LIG_LIR_Nem_3	103	108	PF02991	0.269
LIG_LIR_Nem_3	135	141	PF02991	0.285
LIG_LIR_Nem_3	142	148	PF02991	0.301
LIG_LIR_Nem_3	300	305	PF02991	0.311
LIG_LIR_Nem_3	306	311	PF02991	0.321
LIG_SH2_CRK	19	23	PF00017	0.470
LIG_SH2_CRK	193	197	PF00017	0.317
LIG_SH2_STAP1	193	197	PF00017	0.281
LIG_SH2_STAP1	226	230	PF00017	0.390
LIG_SH2_STAP1	9	13	PF00017	0.518
LIG_SH2_STAT5	105	108	PF00017	0.279
LIG_SH2_STAT5	152	155	PF00017	0.268
LIG_SH2_STAT5	9	12	PF00017	0.531
LIG_SH3_3	385	391	PF00018	0.649
LIG_SH3_3	77	83	PF00018	0.258
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.615
LIG_SUMO_SIM_par_1	434	440	PF11976	0.663
LIG_TRAF2_1	291	294	PF00917	0.504
LIG_WRC_WIRS_1	383	388	PF05994	0.725
LIG_WW_1	462	465	PF00397	0.665
MOD_CDC14_SPxK_1	390	393	PF00782	0.674
MOD_CDK_SPK_2	487	492	PF00069	0.682
MOD_CDK_SPxK_1	387	393	PF00069	0.717
MOD_CDK_SPxxK_3	487	494	PF00069	0.717
MOD_CK1_1	116	122	PF00069	0.299
MOD_CK1_1	12	18	PF00069	0.515
MOD_CK1_1	123	129	PF00069	0.288
MOD_CK1_1	169	175	PF00069	0.317
MOD_CK1_1	210	216	PF00069	0.302
MOD_CK1_1	284	290	PF00069	0.516
MOD_CK1_1	342	348	PF00069	0.791
MOD_CK1_1	366	372	PF00069	0.738
MOD_CK1_1	375	381	PF00069	0.678
MOD_CK1_1	421	427	PF00069	0.679
MOD_CK1_1	477	483	PF00069	0.686
MOD_CK1_1	499	505	PF00069	0.747
MOD_CK2_1	136	142	PF00069	0.281
MOD_CK2_1	213	219	PF00069	0.458
MOD_CK2_1	282	288	PF00069	0.563
MOD_CK2_1	351	357	PF00069	0.666
MOD_Cter_Amidation	186	189	PF01082	0.481
MOD_Cter_Amidation	396	399	PF01082	0.531
MOD_GlcNHglycan	138	141	PF01048	0.486
MOD_GlcNHglycan	142	145	PF01048	0.474
MOD_GlcNHglycan	155	158	PF01048	0.433
MOD_GlcNHglycan	209	212	PF01048	0.426
MOD_GlcNHglycan	344	347	PF01048	0.502
MOD_GlcNHglycan	379	382	PF01048	0.516
MOD_GlcNHglycan	394	398	PF01048	0.435
MOD_GlcNHglycan	420	423	PF01048	0.623
MOD_GlcNHglycan	44	47	PF01048	0.596
MOD_GlcNHglycan	5	8	PF01048	0.674
MOD_GSK3_1	109	116	PF00069	0.270
MOD_GSK3_1	119	126	PF00069	0.270
MOD_GSK3_1	136	143	PF00069	0.203
MOD_GSK3_1	166	173	PF00069	0.286
MOD_GSK3_1	232	239	PF00069	0.420
MOD_GSK3_1	240	247	PF00069	0.431
MOD_GSK3_1	248	255	PF00069	0.460
MOD_GSK3_1	263	270	PF00069	0.430
MOD_GSK3_1	275	282	PF00069	0.470
MOD_GSK3_1	283	290	PF00069	0.416
MOD_GSK3_1	3	10	PF00069	0.484
MOD_GSK3_1	359	366	PF00069	0.766
MOD_GSK3_1	368	375	PF00069	0.690
MOD_GSK3_1	393	400	PF00069	0.678
MOD_GSK3_1	417	424	PF00069	0.795
MOD_GSK3_1	470	477	PF00069	0.745
MOD_GSK3_1	495	502	PF00069	0.727
MOD_GSK3_1	58	65	PF00069	0.392
MOD_N-GLC_1	375	380	PF02516	0.556
MOD_NEK2_1	109	114	PF00069	0.270
MOD_NEK2_1	11	16	PF00069	0.591
MOD_NEK2_1	115	120	PF00069	0.270
MOD_NEK2_1	264	269	PF00069	0.448
MOD_NEK2_1	451	456	PF00069	0.679
MOD_NEK2_1	474	479	PF00069	0.695
MOD_NEK2_1	495	500	PF00069	0.693
MOD_NEK2_1	62	67	PF00069	0.445
MOD_PIKK_1	421	427	PF00454	0.655
MOD_PIKK_1	477	483	PF00454	0.630
MOD_PIKK_1	62	68	PF00454	0.419
MOD_PK_1	497	503	PF00069	0.715
MOD_PKA_1	359	365	PF00069	0.751
MOD_PKA_1	496	502	PF00069	0.680
MOD_PKA_2	136	142	PF00069	0.253
MOD_PKA_2	359	365	PF00069	0.770
MOD_PKA_2	397	403	PF00069	0.735
MOD_PKA_2	444	450	PF00069	0.668
MOD_PKA_2	477	483	PF00069	0.684
MOD_PKA_2	495	501	PF00069	0.712
MOD_PKA_2	66	72	PF00069	0.430
MOD_PKB_1	361	369	PF00069	0.781
MOD_PKB_1	494	502	PF00069	0.682
MOD_Plk_1	58	64	PF00069	0.412
MOD_Plk_4	110	116	PF00069	0.411
MOD_Plk_4	297	303	PF00069	0.441
MOD_Plk_4	470	476	PF00069	0.677
MOD_Plk_4	499	505	PF00069	0.663
MOD_ProDKin_1	269	275	PF00069	0.486
MOD_ProDKin_1	387	393	PF00069	0.717
MOD_ProDKin_1	487	493	PF00069	0.699
MOD_SUMO_rev_2	293	300	PF00179	0.421
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.444
TRG_DiLeu_BaLyEn_6	465	470	PF01217	0.650
TRG_ENDOCYTIC_2	138	141	PF00928	0.415
TRG_ENDOCYTIC_2	193	196	PF00928	0.317
TRG_ENDOCYTIC_2	225	228	PF00928	0.393
TRG_ER_diArg_1	16	19	PF00400	0.522
TRG_ER_diArg_1	359	361	PF00400	0.743
TRG_ER_diArg_1	363	365	PF00400	0.652
TRG_ER_diArg_1	491	494	PF00400	0.680
TRG_ER_diArg_1	495	497	PF00400	0.666
TRG_NES_CRM1_1	434	448	PF08389	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U3	Leptomonas seymouri	25%	100%
A0A3Q8ICK3	Leishmania donovani	89%	98%
A4HJ08	Leishmania braziliensis	58%	100%
E9AHD6	Leishmania infantum	89%	98%
E9AYW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%