PH domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD42_LEIMA

TriTrypDb:

LmjF.27.0650 , LMJLV39_270011900 , LMJSD75_270011800

Length:

167

Annotations

LeishMANIAdb annotations

Belongs to a unique family or proteins highly conserved in Kinetoplastida, but not seen outside that group.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AD42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.322
CLV_NRD_NRD_1	138	140	PF00675	0.344
CLV_NRD_NRD_1	17	19	PF00675	0.355
CLV_NRD_NRD_1	61	63	PF00675	0.627
CLV_PCSK_KEX2_1	120	122	PF00082	0.335
CLV_PCSK_KEX2_1	138	140	PF00082	0.344
CLV_PCSK_KEX2_1	61	63	PF00082	0.574
CLV_PCSK_SKI1_1	99	103	PF00082	0.417
DEG_APCC_DBOX_1	98	106	PF00400	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.605
DOC_MAPK_MEF2A_6	145	154	PF00069	0.594
DOC_PP4_FxxP_1	64	67	PF00568	0.431
DOC_WW_Pin1_4	90	95	PF00397	0.362
LIG_14-3-3_CanoR_1	18	28	PF00244	0.541
LIG_deltaCOP1_diTrp_1	11	20	PF00928	0.540
LIG_eIF4E_1	97	103	PF01652	0.353
LIG_FHA_1	105	111	PF00498	0.378
LIG_FHA_2	20	26	PF00498	0.535
LIG_GBD_Chelix_1	150	158	PF00786	0.428
LIG_LIR_Gen_1	147	156	PF02991	0.631
LIG_LIR_Nem_3	107	111	PF02991	0.335
LIG_LIR_Nem_3	147	152	PF02991	0.599
LIG_PCNA_yPIPBox_3	138	150	PF02747	0.650
LIG_PDZ_Class_2	162	167	PF00595	0.688
LIG_SH2_CRK	97	101	PF00017	0.313
LIG_SH2_STAT3	126	129	PF00017	0.542
LIG_SH2_STAT3	92	95	PF00017	0.357
LIG_SH2_STAT5	126	129	PF00017	0.542
LIG_SH2_STAT5	149	152	PF00017	0.625
LIG_SH2_STAT5	53	56	PF00017	0.354
LIG_SH2_STAT5	9	12	PF00017	0.540
LIG_SH2_STAT5	92	95	PF00017	0.357
LIG_SH3_3	100	106	PF00018	0.407
LIG_WRC_WIRS_1	105	110	PF05994	0.411
MOD_N-GLC_1	160	165	PF02516	0.464
MOD_NEK2_2	56	61	PF00069	0.365
MOD_PIKK_1	160	166	PF00454	0.645
MOD_Plk_1	160	166	PF00069	0.666
MOD_Plk_1	3	9	PF00069	0.577
MOD_Plk_4	104	110	PF00069	0.319
MOD_Plk_4	128	134	PF00069	0.550
MOD_ProDKin_1	90	96	PF00069	0.363
MOD_SUMO_for_1	1	4	PF00179	0.605
MOD_SUMO_rev_2	147	157	PF00179	0.704
MOD_SUMO_rev_2	71	78	PF00179	0.488
TRG_ENDOCYTIC_2	149	152	PF00928	0.624
TRG_ENDOCYTIC_2	97	100	PF00928	0.295
TRG_ER_diArg_1	120	122	PF00400	0.536
TRG_ER_diArg_1	138	140	PF00400	0.546
TRG_ER_diArg_1	60	62	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P780	Leptomonas seymouri	82%	100%
A0A0S4JRI7	Bodo saltans	62%	99%
A0A1X0P491	Trypanosomatidae	63%	99%
A0A3Q8IE57	Leishmania donovani	98%	100%
A0A422NMQ9	Trypanosoma rangeli	66%	99%
A4HFJ1	Leishmania braziliensis	92%	100%
D0A5R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	99%
E9AHD5	Leishmania infantum	98%	100%
E9AYW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%