Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD39_LEIMA

TriTrypDb:

LmjF.27.0620 , LMJLV39_270011600 , LMJSD75_270011500

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AD39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.659
CLV_NRD_NRD_1	230	232	PF00675	0.417
CLV_NRD_NRD_1	271	273	PF00675	0.565
CLV_PCSK_KEX2_1	230	232	PF00082	0.422
CLV_PCSK_KEX2_1	271	273	PF00082	0.565
CLV_PCSK_SKI1_1	413	417	PF00082	0.292
CLV_PCSK_SKI1_1	418	422	PF00082	0.244
DEG_SPOP_SBC_1	125	129	PF00917	0.663
DEG_SPOP_SBC_1	38	42	PF00917	0.398
DOC_MAPK_gen_1	230	238	PF00069	0.584
DOC_MAPK_MEF2A_6	251	259	PF00069	0.286
DOC_MAPK_MEF2A_6	367	375	PF00069	0.365
DOC_MAPK_MEF2A_6	418	426	PF00069	0.486
DOC_PP1_RVXF_1	90	96	PF00149	0.623
DOC_SPAK_OSR1_1	272	276	PF12202	0.291
DOC_USP7_MATH_1	153	157	PF00917	0.737
DOC_USP7_MATH_1	160	164	PF00917	0.743
DOC_USP7_MATH_1	181	185	PF00917	0.640
DOC_USP7_MATH_1	28	32	PF00917	0.532
DOC_USP7_MATH_1	38	42	PF00917	0.415
DOC_USP7_MATH_1	463	467	PF00917	0.440
DOC_USP7_UBL2_3	311	315	PF12436	0.676
DOC_WW_Pin1_4	12	17	PF00397	0.524
DOC_WW_Pin1_4	126	131	PF00397	0.720
DOC_WW_Pin1_4	177	182	PF00397	0.657
DOC_WW_Pin1_4	186	191	PF00397	0.730
DOC_WW_Pin1_4	303	308	PF00397	0.648
DOC_WW_Pin1_4	392	397	PF00397	0.624
LIG_14-3-3_CanoR_1	113	123	PF00244	0.709
LIG_14-3-3_CanoR_1	126	130	PF00244	0.705
LIG_14-3-3_CanoR_1	327	332	PF00244	0.652
LIG_APCC_ABBA_1	75	80	PF00400	0.518
LIG_BRCT_BRCA1_1	139	143	PF00533	0.608
LIG_BRCT_BRCA1_1	474	478	PF00533	0.383
LIG_CaM_IQ_9	84	100	PF13499	0.604
LIG_Clathr_ClatBox_1	297	301	PF01394	0.485
LIG_Dynein_DLC8_1	111	117	PF01221	0.649
LIG_EH1_1	291	299	PF00400	0.558
LIG_EH1_1	319	327	PF00400	0.624
LIG_eIF4E_1	292	298	PF01652	0.503
LIG_eIF4E_1	372	378	PF01652	0.365
LIG_FHA_1	115	121	PF00498	0.661
LIG_FHA_1	126	132	PF00498	0.590
LIG_FHA_1	164	170	PF00498	0.703
LIG_FHA_1	304	310	PF00498	0.682
LIG_FHA_1	328	334	PF00498	0.610
LIG_FHA_1	342	348	PF00498	0.477
LIG_FHA_1	38	44	PF00498	0.478
LIG_FHA_1	419	425	PF00498	0.300
LIG_FHA_1	53	59	PF00498	0.331
LIG_FHA_2	312	318	PF00498	0.595
LIG_FHA_2	442	448	PF00498	0.361
LIG_GBD_Chelix_1	218	226	PF00786	0.429
LIG_IRF3_LxIS_1	322	329	PF10401	0.620
LIG_LIR_Gen_1	250	261	PF02991	0.481
LIG_LIR_Gen_1	291	300	PF02991	0.595
LIG_LIR_Gen_1	344	354	PF02991	0.287
LIG_LIR_Gen_1	421	429	PF02991	0.386
LIG_LIR_Gen_1	466	474	PF02991	0.334
LIG_LIR_Gen_1	55	64	PF02991	0.391
LIG_LIR_Nem_3	239	243	PF02991	0.643
LIG_LIR_Nem_3	250	256	PF02991	0.462
LIG_LIR_Nem_3	344	349	PF02991	0.287
LIG_LIR_Nem_3	421	426	PF02991	0.338
LIG_LIR_Nem_3	466	471	PF02991	0.353
LIG_LIR_Nem_3	55	59	PF02991	0.420
LIG_PCNA_yPIPBox_3	409	418	PF02747	0.510
LIG_PDZ_Class_2	474	479	PF00595	0.337
LIG_Pex14_2	423	427	PF04695	0.284
LIG_Pex14_2	464	468	PF04695	0.378
LIG_PTAP_UEV_1	149	154	PF05743	0.587
LIG_REV1ctd_RIR_1	141	149	PF16727	0.613
LIG_SH2_CRK	451	455	PF00017	0.292
LIG_SH2_NCK_1	138	142	PF00017	0.654
LIG_SH2_PTP2	244	247	PF00017	0.478
LIG_SH2_PTP2	372	375	PF00017	0.354
LIG_SH2_SRC	445	448	PF00017	0.348
LIG_SH2_STAP1	292	296	PF00017	0.564
LIG_SH2_STAT5	244	247	PF00017	0.388
LIG_SH2_STAT5	258	261	PF00017	0.486
LIG_SH2_STAT5	372	375	PF00017	0.348
LIG_SH2_STAT5	379	382	PF00017	0.289
LIG_SH2_STAT5	4	7	PF00017	0.435
LIG_SH3_3	100	106	PF00018	0.680
LIG_SH3_3	128	134	PF00018	0.668
LIG_SH3_3	13	19	PF00018	0.507
LIG_SH3_3	147	153	PF00018	0.594
LIG_SH3_3	210	216	PF00018	0.624
LIG_SH3_3	349	355	PF00018	0.310
LIG_SH3_3	48	54	PF00018	0.370
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.695
LIG_SUMO_SIM_anti_2	55	63	PF11976	0.344
LIG_SUMO_SIM_par_1	298	303	PF11976	0.545
LIG_SUMO_SIM_par_1	306	314	PF11976	0.680
LIG_SUMO_SIM_par_1	329	335	PF11976	0.623
LIG_SUMO_SIM_par_1	55	63	PF11976	0.355
LIG_TYR_ITIM	366	371	PF00017	0.445
LIG_TYR_ITIM	377	382	PF00017	0.296
LIG_TYR_ITIM	449	454	PF00017	0.296
LIG_WRC_WIRS_1	357	362	PF05994	0.402
LIG_WRC_WIRS_1	53	58	PF05994	0.324
LIG_WRC_WIRS_1	84	89	PF05994	0.654
MOD_CDK_SPK_2	392	397	PF00069	0.583
MOD_CDK_SPxxK_3	392	399	PF00069	0.652
MOD_CK1_1	163	169	PF00069	0.693
MOD_CK1_1	175	181	PF00069	0.599
MOD_CK1_1	184	190	PF00069	0.668
MOD_CK1_1	31	37	PF00069	0.476
MOD_CK1_1	392	398	PF00069	0.600
MOD_CK1_1	9	15	PF00069	0.523
MOD_CK2_1	130	136	PF00069	0.681
MOD_CK2_1	285	291	PF00069	0.309
MOD_CK2_1	31	37	PF00069	0.501
MOD_CK2_1	326	332	PF00069	0.654
MOD_CK2_1	441	447	PF00069	0.385
MOD_DYRK1A_RPxSP_1	126	130	PF00069	0.636
MOD_GlcNHglycan	106	109	PF01048	0.475
MOD_GlcNHglycan	139	142	PF01048	0.436
MOD_GlcNHglycan	163	166	PF01048	0.562
MOD_GlcNHglycan	177	180	PF01048	0.395
MOD_GlcNHglycan	183	186	PF01048	0.443
MOD_GlcNHglycan	282	285	PF01048	0.293
MOD_GlcNHglycan	362	365	PF01048	0.576
MOD_GSK3_1	121	128	PF00069	0.686
MOD_GSK3_1	14	21	PF00069	0.515
MOD_GSK3_1	173	180	PF00069	0.690
MOD_GSK3_1	280	287	PF00069	0.313
MOD_GSK3_1	311	318	PF00069	0.656
MOD_GSK3_1	356	363	PF00069	0.482
MOD_GSK3_1	425	432	PF00069	0.295
MOD_GSK3_1	6	13	PF00069	0.561
MOD_GSK3_1	60	67	PF00069	0.414
MOD_N-GLC_1	31	36	PF02516	0.775
MOD_N-GLC_1	38	43	PF02516	0.605
MOD_NEK2_1	114	119	PF00069	0.547
MOD_NEK2_1	137	142	PF00069	0.601
MOD_NEK2_1	285	290	PF00069	0.309
MOD_NEK2_1	326	331	PF00069	0.648
MOD_NEK2_1	341	346	PF00069	0.531
MOD_NEK2_1	356	361	PF00069	0.238
MOD_NEK2_1	425	430	PF00069	0.311
MOD_NEK2_1	464	469	PF00069	0.398
MOD_NEK2_1	59	64	PF00069	0.324
MOD_NEK2_1	6	11	PF00069	0.506
MOD_NEK2_1	94	99	PF00069	0.585
MOD_PIKK_1	10	16	PF00454	0.431
MOD_PIKK_1	112	118	PF00454	0.694
MOD_PIKK_1	230	236	PF00454	0.590
MOD_PIKK_1	472	478	PF00454	0.292
MOD_PK_1	315	321	PF00069	0.663
MOD_PKA_1	230	236	PF00069	0.564
MOD_PKA_2	112	118	PF00069	0.696
MOD_PKA_2	125	131	PF00069	0.704
MOD_PKA_2	230	236	PF00069	0.628
MOD_PKA_2	326	332	PF00069	0.652
MOD_PKA_2	6	12	PF00069	0.434
MOD_Plk_1	31	37	PF00069	0.553
MOD_Plk_1	38	44	PF00069	0.408
MOD_Plk_2-3	441	447	PF00069	0.394
MOD_Plk_4	18	24	PF00069	0.529
MOD_Plk_4	285	291	PF00069	0.439
MOD_Plk_4	315	321	PF00069	0.598
MOD_Plk_4	335	341	PF00069	0.455
MOD_Plk_4	342	348	PF00069	0.449
MOD_Plk_4	39	45	PF00069	0.422
MOD_Plk_4	418	424	PF00069	0.458
MOD_Plk_4	429	435	PF00069	0.265
MOD_Plk_4	52	58	PF00069	0.207
MOD_Plk_4	60	66	PF00069	0.280
MOD_ProDKin_1	12	18	PF00069	0.524
MOD_ProDKin_1	126	132	PF00069	0.712
MOD_ProDKin_1	177	183	PF00069	0.654
MOD_ProDKin_1	186	192	PF00069	0.731
MOD_ProDKin_1	303	309	PF00069	0.652
MOD_ProDKin_1	392	398	PF00069	0.621
MOD_SUMO_for_1	310	313	PF00179	0.668
MOD_SUMO_rev_2	312	316	PF00179	0.646
TRG_DiLeu_BaEn_1	252	257	PF01217	0.281
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.402
TRG_ENDOCYTIC_2	243	246	PF00928	0.337
TRG_ENDOCYTIC_2	292	295	PF00928	0.588
TRG_ENDOCYTIC_2	368	371	PF00928	0.348
TRG_ENDOCYTIC_2	372	375	PF00928	0.312
TRG_ENDOCYTIC_2	379	382	PF00928	0.246
TRG_ENDOCYTIC_2	451	454	PF00928	0.397
TRG_ER_diArg_1	229	231	PF00400	0.602
TRG_ER_diArg_1	270	272	PF00400	0.369
TRG_ER_diArg_1	396	399	PF00400	0.714
TRG_NES_CRM1_1	323	335	PF08389	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L9	Leptomonas seymouri	64%	100%
A0A1X0P3Y2	Trypanosomatidae	34%	100%
A0A3S7X0H3	Leishmania donovani	94%	100%
A4HFI8	Leishmania braziliensis	75%	100%
D0A5R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AHD2	Leishmania infantum	95%	100%
E9AYW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BIJ3	Trypanosoma cruzi	34%	100%