Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD38_LEIMA

TriTrypDb:

LmjF.27.0610 , LMJLV39_270011500 , LMJSD75_270011400

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AD38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.427
CLV_NRD_NRD_1	168	170	PF00675	0.574
CLV_NRD_NRD_1	181	183	PF00675	0.554
CLV_NRD_NRD_1	198	200	PF00675	0.480
CLV_NRD_NRD_1	206	208	PF00675	0.548
CLV_NRD_NRD_1	238	240	PF00675	0.580
CLV_NRD_NRD_1	267	269	PF00675	0.622
CLV_NRD_NRD_1	303	305	PF00675	0.523
CLV_NRD_NRD_1	372	374	PF00675	0.461
CLV_NRD_NRD_1	378	380	PF00675	0.475
CLV_NRD_NRD_1	389	391	PF00675	0.372
CLV_NRD_NRD_1	433	435	PF00675	0.741
CLV_NRD_NRD_1	99	101	PF00675	0.500
CLV_PCSK_KEX2_1	110	112	PF00082	0.486
CLV_PCSK_KEX2_1	168	170	PF00082	0.490
CLV_PCSK_KEX2_1	238	240	PF00082	0.636
CLV_PCSK_KEX2_1	303	305	PF00082	0.568
CLV_PCSK_KEX2_1	324	326	PF00082	0.475
CLV_PCSK_KEX2_1	378	380	PF00082	0.481
CLV_PCSK_KEX2_1	389	391	PF00082	0.507
CLV_PCSK_KEX2_1	433	435	PF00082	0.671
CLV_PCSK_KEX2_1	446	448	PF00082	0.625
CLV_PCSK_KEX2_1	99	101	PF00082	0.487
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.568
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.494
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.746
CLV_PCSK_SKI1_1	303	307	PF00082	0.466
CLV_PCSK_SKI1_1	349	353	PF00082	0.551
CLV_PCSK_SKI1_1	41	45	PF00082	0.536
DOC_CKS1_1	442	447	PF01111	0.495
DOC_CYCLIN_RxL_1	38	48	PF00134	0.542
DOC_MAPK_gen_1	324	332	PF00069	0.538
DOC_MAPK_gen_1	446	454	PF00069	0.517
DOC_MAPK_MEF2A_6	446	454	PF00069	0.517
DOC_USP7_MATH_1	380	384	PF00917	0.475
DOC_USP7_MATH_1	419	423	PF00917	0.585
DOC_USP7_MATH_1	450	454	PF00917	0.624
DOC_USP7_UBL2_3	17	21	PF12436	0.623
DOC_USP7_UBL2_3	208	212	PF12436	0.648
DOC_USP7_UBL2_3	241	245	PF12436	0.706
DOC_WW_Pin1_4	441	446	PF00397	0.739
DOC_WW_Pin1_4	453	458	PF00397	0.577
DOC_WW_Pin1_4	6	11	PF00397	0.711
LIG_14-3-3_CanoR_1	111	119	PF00244	0.472
LIG_14-3-3_CanoR_1	250	255	PF00244	0.637
LIG_14-3-3_CanoR_1	433	442	PF00244	0.680
LIG_14-3-3_CanoR_1	63	67	PF00244	0.440
LIG_14-3-3_CanoR_1	76	83	PF00244	0.475
LIG_FHA_1	168	174	PF00498	0.672
LIG_FHA_1	350	356	PF00498	0.522
LIG_FHA_1	55	61	PF00498	0.560
LIG_FHA_2	333	339	PF00498	0.418
LIG_FHA_2	435	441	PF00498	0.587
LIG_HP1_1	450	454	PF01393	0.495
LIG_LIR_Gen_1	435	442	PF02991	0.659
LIG_LIR_Nem_3	32	36	PF02991	0.404
LIG_LIR_Nem_3	435	439	PF02991	0.658
LIG_MYND_1	6	10	PF01753	0.586
LIG_NRBOX	39	45	PF00104	0.525
LIG_PCNA_yPIPBox_3	310	322	PF02747	0.548
LIG_PDZ_Class_2	457	462	PF00595	0.596
LIG_RPA_C_Fungi	364	376	PF08784	0.566
LIG_SH2_SRC	354	357	PF00017	0.488
LIG_SH2_STAP1	197	201	PF00017	0.607
LIG_SH2_STAP1	33	37	PF00017	0.440
LIG_SH2_STAP1	97	101	PF00017	0.583
LIG_SH2_STAT3	150	153	PF00017	0.612
LIG_SH2_STAT3	299	302	PF00017	0.473
LIG_SH2_STAT3	36	39	PF00017	0.491
LIG_SH2_STAT5	299	302	PF00017	0.577
LIG_SH2_STAT5	354	357	PF00017	0.558
LIG_SH2_STAT5	36	39	PF00017	0.491
LIG_SH3_3	439	445	PF00018	0.596
LIG_SH3_3	449	455	PF00018	0.487
LIG_SUMO_SIM_par_1	450	456	PF11976	0.539
LIG_TRAF2_1	164	167	PF00917	0.600
LIG_TRAF2_1	309	312	PF00917	0.432
LIG_TRAF2_1	335	338	PF00917	0.555
LIG_ULM_U2AF65_1	238	243	PF00076	0.703
MOD_CDK_SPK_2	441	446	PF00069	0.568
MOD_CDK_SPxK_1	441	447	PF00069	0.566
MOD_CDK_SPxK_1	6	12	PF00069	0.721
MOD_CK1_1	11	17	PF00069	0.697
MOD_CK1_1	237	243	PF00069	0.727
MOD_CK1_1	432	438	PF00069	0.705
MOD_CK1_1	453	459	PF00069	0.650
MOD_CK2_1	161	167	PF00069	0.612
MOD_CK2_1	332	338	PF00069	0.552
MOD_CK2_1	434	440	PF00069	0.672
MOD_CK2_1	453	459	PF00069	0.645
MOD_GlcNHglycan	68	71	PF01048	0.511
MOD_GlcNHglycan	77	80	PF01048	0.513
MOD_GSK3_1	11	18	PF00069	0.660
MOD_GSK3_1	246	253	PF00069	0.623
MOD_GSK3_1	419	426	PF00069	0.629
MOD_GSK3_1	62	69	PF00069	0.540
MOD_N-GLC_1	380	385	PF02516	0.542
MOD_NEK2_1	402	407	PF00069	0.464
MOD_NEK2_1	44	49	PF00069	0.592
MOD_NEK2_1	66	71	PF00069	0.509
MOD_PIKK_1	263	269	PF00454	0.592
MOD_PIKK_1	349	355	PF00454	0.525
MOD_PIKK_1	382	388	PF00454	0.366
MOD_PIKK_1	419	425	PF00454	0.652
MOD_PK_1	250	256	PF00069	0.701
MOD_PKA_1	110	116	PF00069	0.401
MOD_PKA_1	21	27	PF00069	0.595
MOD_PKA_2	110	116	PF00069	0.439
MOD_PKA_2	167	173	PF00069	0.662
MOD_PKA_2	234	240	PF00069	0.616
MOD_PKA_2	432	438	PF00069	0.684
MOD_PKA_2	62	68	PF00069	0.440
MOD_PKA_2	75	81	PF00069	0.484
MOD_Plk_1	155	161	PF00069	0.603
MOD_Plk_1	380	386	PF00069	0.443
MOD_Plk_4	155	161	PF00069	0.582
MOD_Plk_4	250	256	PF00069	0.703
MOD_ProDKin_1	441	447	PF00069	0.736
MOD_ProDKin_1	453	459	PF00069	0.577
MOD_ProDKin_1	6	12	PF00069	0.712
MOD_SUMO_for_1	244	247	PF00179	0.699
MOD_SUMO_for_1	407	410	PF00179	0.543
MOD_SUMO_rev_2	11	19	PF00179	0.557
MOD_SUMO_rev_2	138	144	PF00179	0.537
MOD_SUMO_rev_2	226	231	PF00179	0.725
MOD_SUMO_rev_2	287	294	PF00179	0.589
TRG_DiLeu_BaEn_1	301	306	PF01217	0.467
TRG_DiLeu_BaEn_1	356	361	PF01217	0.480
TRG_DiLeu_LyEn_5	301	306	PF01217	0.467
TRG_DiLeu_LyEn_5	356	361	PF01217	0.375
TRG_ER_diArg_1	168	171	PF00400	0.568
TRG_ER_diArg_1	303	305	PF00400	0.569
TRG_ER_diArg_1	388	390	PF00400	0.500
TRG_ER_diArg_1	99	101	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN1	Leptomonas seymouri	59%	100%
A0A1X0P3Z6	Trypanosomatidae	30%	100%
A0A3Q8IE88	Leishmania donovani	92%	100%
A0A3R7MQZ8	Trypanosoma rangeli	32%	100%
A4HFI7	Leishmania braziliensis	73%	99%
D0A5R3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AHD1	Leishmania infantum	93%	100%
E9AYW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BE50	Trypanosoma cruzi	29%	100%