Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD37_LEIMA

TriTrypDb:

LmjF.27.0600 , LMJLV39_270011400 , LMJSD75_270011300

Length:

988

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.567
CLV_C14_Caspase3-7	4	8	PF00656	0.663
CLV_NRD_NRD_1	325	327	PF00675	0.647
CLV_NRD_NRD_1	342	344	PF00675	0.629
CLV_NRD_NRD_1	359	361	PF00675	0.396
CLV_NRD_NRD_1	416	418	PF00675	0.565
CLV_NRD_NRD_1	435	437	PF00675	0.529
CLV_NRD_NRD_1	504	506	PF00675	0.644
CLV_NRD_NRD_1	560	562	PF00675	0.453
CLV_NRD_NRD_1	715	717	PF00675	0.543
CLV_NRD_NRD_1	730	732	PF00675	0.488
CLV_NRD_NRD_1	751	753	PF00675	0.553
CLV_NRD_NRD_1	775	777	PF00675	0.481
CLV_NRD_NRD_1	883	885	PF00675	0.716
CLV_NRD_NRD_1	982	984	PF00675	0.633
CLV_PCSK_FUR_1	323	327	PF00082	0.586
CLV_PCSK_FUR_1	340	344	PF00082	0.429
CLV_PCSK_FUR_1	698	702	PF00082	0.702
CLV_PCSK_FUR_1	713	717	PF00082	0.378
CLV_PCSK_KEX2_1	325	327	PF00082	0.633
CLV_PCSK_KEX2_1	342	344	PF00082	0.422
CLV_PCSK_KEX2_1	359	361	PF00082	0.422
CLV_PCSK_KEX2_1	416	418	PF00082	0.581
CLV_PCSK_KEX2_1	434	436	PF00082	0.539
CLV_PCSK_KEX2_1	504	506	PF00082	0.689
CLV_PCSK_KEX2_1	538	540	PF00082	0.513
CLV_PCSK_KEX2_1	562	564	PF00082	0.453
CLV_PCSK_KEX2_1	677	679	PF00082	0.754
CLV_PCSK_KEX2_1	700	702	PF00082	0.603
CLV_PCSK_KEX2_1	715	717	PF00082	0.385
CLV_PCSK_KEX2_1	729	731	PF00082	0.495
CLV_PCSK_KEX2_1	751	753	PF00082	0.553
CLV_PCSK_KEX2_1	775	777	PF00082	0.481
CLV_PCSK_KEX2_1	982	984	PF00082	0.633
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.473
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.514
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.670
CLV_PCSK_PC1ET2_1	700	702	PF00082	0.657
CLV_PCSK_PC7_1	534	540	PF00082	0.479
CLV_PCSK_SKI1_1	10	14	PF00082	0.638
CLV_PCSK_SKI1_1	302	306	PF00082	0.452
CLV_PCSK_SKI1_1	382	386	PF00082	0.497
CLV_PCSK_SKI1_1	400	404	PF00082	0.509
CLV_PCSK_SKI1_1	416	420	PF00082	0.505
CLV_PCSK_SKI1_1	421	425	PF00082	0.523
CLV_PCSK_SKI1_1	570	574	PF00082	0.459
CLV_PCSK_SKI1_1	605	609	PF00082	0.561
CLV_PCSK_SKI1_1	812	816	PF00082	0.639
CLV_PCSK_SKI1_1	970	974	PF00082	0.526
DEG_APCC_DBOX_1	604	612	PF00400	0.500
DEG_SCF_FBW7_1	649	654	PF00400	0.458
DEG_SPOP_SBC_1	77	81	PF00917	0.684
DOC_CKS1_1	190	195	PF01111	0.798
DOC_CKS1_1	648	653	PF01111	0.411
DOC_CKS1_1	838	843	PF01111	0.625
DOC_CYCLIN_RxL_1	379	388	PF00134	0.583
DOC_CYCLIN_RxL_1	809	819	PF00134	0.653
DOC_CYCLIN_RxL_1	965	974	PF00134	0.433
DOC_MAPK_gen_1	302	311	PF00069	0.533
DOC_MAPK_gen_1	547	557	PF00069	0.517
DOC_MAPK_MEF2A_6	759	766	PF00069	0.602
DOC_USP7_MATH_1	104	108	PF00917	0.639
DOC_USP7_MATH_1	157	161	PF00917	0.628
DOC_USP7_MATH_1	165	169	PF00917	0.598
DOC_USP7_MATH_1	172	176	PF00917	0.532
DOC_USP7_MATH_1	228	232	PF00917	0.658
DOC_USP7_MATH_1	242	246	PF00917	0.606
DOC_USP7_MATH_1	283	287	PF00917	0.616
DOC_USP7_MATH_1	477	481	PF00917	0.581
DOC_USP7_MATH_1	52	56	PF00917	0.729
DOC_USP7_MATH_1	651	655	PF00917	0.547
DOC_USP7_MATH_1	77	81	PF00917	0.712
DOC_USP7_MATH_1	777	781	PF00917	0.475
DOC_USP7_MATH_1	791	795	PF00917	0.556
DOC_USP7_MATH_1	797	801	PF00917	0.499
DOC_USP7_UBL2_3	6	10	PF12436	0.638
DOC_WW_Pin1_4	11	16	PF00397	0.737
DOC_WW_Pin1_4	140	145	PF00397	0.678
DOC_WW_Pin1_4	163	168	PF00397	0.631
DOC_WW_Pin1_4	189	194	PF00397	0.645
DOC_WW_Pin1_4	196	201	PF00397	0.676
DOC_WW_Pin1_4	332	337	PF00397	0.515
DOC_WW_Pin1_4	395	400	PF00397	0.581
DOC_WW_Pin1_4	435	440	PF00397	0.660
DOC_WW_Pin1_4	45	50	PF00397	0.657
DOC_WW_Pin1_4	5	10	PF00397	0.809
DOC_WW_Pin1_4	61	66	PF00397	0.575
DOC_WW_Pin1_4	647	652	PF00397	0.481
DOC_WW_Pin1_4	689	694	PF00397	0.688
DOC_WW_Pin1_4	837	842	PF00397	0.651
DOC_WW_Pin1_4	867	872	PF00397	0.622
DOC_WW_Pin1_4	98	103	PF00397	0.587
LIG_14-3-3_CanoR_1	138	144	PF00244	0.758
LIG_14-3-3_CanoR_1	183	189	PF00244	0.675
LIG_14-3-3_CanoR_1	342	348	PF00244	0.601
LIG_14-3-3_CanoR_1	382	387	PF00244	0.503
LIG_14-3-3_CanoR_1	400	406	PF00244	0.650
LIG_14-3-3_CanoR_1	593	597	PF00244	0.476
LIG_14-3-3_CanoR_1	628	638	PF00244	0.460
LIG_14-3-3_CanoR_1	668	676	PF00244	0.673
LIG_14-3-3_CanoR_1	730	738	PF00244	0.543
LIG_14-3-3_CanoR_1	776	786	PF00244	0.518
LIG_14-3-3_CanoR_1	817	825	PF00244	0.635
LIG_14-3-3_CanoR_1	830	838	PF00244	0.562
LIG_14-3-3_CanoR_1	910	916	PF00244	0.667
LIG_Actin_WH2_2	18	34	PF00022	0.557
LIG_BRCT_BRCA1_1	167	171	PF00533	0.644
LIG_BRCT_BRCA1_1	377	381	PF00533	0.569
LIG_BRCT_BRCA1_1	983	987	PF00533	0.515
LIG_CtBP_PxDLS_1	950	954	PF00389	0.518
LIG_eIF4E_1	568	574	PF01652	0.464
LIG_EVH1_1	146	150	PF00568	0.569
LIG_FHA_1	11	17	PF00498	0.608
LIG_FHA_1	141	147	PF00498	0.696
LIG_FHA_1	32	38	PF00498	0.686
LIG_FHA_1	386	392	PF00498	0.609
LIG_FHA_1	496	502	PF00498	0.532
LIG_FHA_2	409	415	PF00498	0.476
LIG_FHA_2	630	636	PF00498	0.476
LIG_FHA_2	767	773	PF00498	0.569
LIG_FHA_2	79	85	PF00498	0.702
LIG_FHA_2	959	965	PF00498	0.592
LIG_GSK3_LRP6_1	189	194	PF00069	0.572
LIG_KLC1_Yacidic_2	293	297	PF13176	0.581
LIG_LIR_Gen_1	403	413	PF02991	0.484
LIG_LIR_Gen_1	633	644	PF02991	0.473
LIG_LIR_Nem_3	378	384	PF02991	0.519
LIG_LIR_Nem_3	403	409	PF02991	0.493
LIG_LIR_Nem_3	567	572	PF02991	0.478
LIG_LIR_Nem_3	633	639	PF02991	0.475
LIG_MYND_1	144	148	PF01753	0.582
LIG_SH2_CRK	569	573	PF00017	0.460
LIG_SH2_GRB2like	130	133	PF00017	0.595
LIG_SH2_NCK_1	410	414	PF00017	0.551
LIG_SH2_SRC	130	133	PF00017	0.595
LIG_SH2_SRC	295	298	PF00017	0.483
LIG_SH2_STAP1	243	247	PF00017	0.645
LIG_SH2_STAP1	337	341	PF00017	0.514
LIG_SH2_STAP1	478	482	PF00017	0.615
LIG_SH2_STAT3	744	747	PF00017	0.631
LIG_SH2_STAT5	295	298	PF00017	0.562
LIG_SH2_STAT5	410	413	PF00017	0.561
LIG_SH2_STAT5	744	747	PF00017	0.631
LIG_SH2_STAT5	778	781	PF00017	0.443
LIG_SH3_1	326	332	PF00018	0.520
LIG_SH3_1	658	664	PF00018	0.566
LIG_SH3_1	884	890	PF00018	0.650
LIG_SH3_2	147	152	PF14604	0.621
LIG_SH3_2	887	892	PF14604	0.649
LIG_SH3_3	141	147	PF00018	0.685
LIG_SH3_3	187	193	PF00018	0.771
LIG_SH3_3	326	332	PF00018	0.520
LIG_SH3_3	43	49	PF00018	0.757
LIG_SH3_3	658	664	PF00018	0.522
LIG_SH3_3	835	841	PF00018	0.692
LIG_SH3_3	884	890	PF00018	0.650
LIG_SH3_3	898	904	PF00018	0.539
LIG_SH3_3	913	919	PF00018	0.609
LIG_SUMO_SIM_anti_2	635	641	PF11976	0.460
LIG_SUMO_SIM_par_1	382	388	PF11976	0.575
LIG_SUMO_SIM_par_1	497	503	PF11976	0.521
LIG_SUMO_SIM_par_1	788	794	PF11976	0.500
LIG_TRAF2_1	314	317	PF00917	0.530
MOD_CDC14_SPxK_1	438	441	PF00782	0.609
MOD_CDK_SPK_2	395	400	PF00069	0.581
MOD_CDK_SPK_2	5	10	PF00069	0.664
MOD_CDK_SPK_2	61	66	PF00069	0.575
MOD_CDK_SPxK_1	435	441	PF00069	0.605
MOD_CDK_SPxxK_3	837	844	PF00069	0.639
MOD_CK1_1	107	113	PF00069	0.621
MOD_CK1_1	14	20	PF00069	0.771
MOD_CK1_1	160	166	PF00069	0.730
MOD_CK1_1	181	187	PF00069	0.700
MOD_CK1_1	500	506	PF00069	0.475
MOD_CK1_1	672	678	PF00069	0.668
MOD_CK1_1	688	694	PF00069	0.510
MOD_CK1_1	76	82	PF00069	0.619
MOD_CK1_1	765	771	PF00069	0.571
MOD_CK1_1	936	942	PF00069	0.724
MOD_CK2_1	167	173	PF00069	0.587
MOD_CK2_1	249	255	PF00069	0.674
MOD_CK2_1	408	414	PF00069	0.477
MOD_CK2_1	609	615	PF00069	0.569
MOD_CK2_1	629	635	PF00069	0.310
MOD_CK2_1	766	772	PF00069	0.579
MOD_CK2_1	78	84	PF00069	0.740
MOD_CK2_1	823	829	PF00069	0.657
MOD_CK2_1	949	955	PF00069	0.613
MOD_CK2_1	957	963	PF00069	0.459
MOD_Cter_Amidation	72	75	PF01082	0.683
MOD_Cter_Amidation	882	885	PF01082	0.658
MOD_DYRK1A_RPxSP_1	837	841	PF00069	0.657
MOD_GlcNHglycan	159	162	PF01048	0.658
MOD_GlcNHglycan	173	177	PF01048	0.654
MOD_GlcNHglycan	180	183	PF01048	0.684
MOD_GlcNHglycan	244	247	PF01048	0.716
MOD_GlcNHglycan	273	276	PF01048	0.698
MOD_GlcNHglycan	461	464	PF01048	0.664
MOD_GlcNHglycan	512	515	PF01048	0.566
MOD_GlcNHglycan	653	656	PF01048	0.530
MOD_GlcNHglycan	671	674	PF01048	0.483
MOD_GlcNHglycan	680	683	PF01048	0.578
MOD_GlcNHglycan	687	690	PF01048	0.518
MOD_GlcNHglycan	69	72	PF01048	0.776
MOD_GlcNHglycan	75	78	PF01048	0.729
MOD_GlcNHglycan	779	782	PF01048	0.564
MOD_GlcNHglycan	799	802	PF01048	0.443
MOD_GlcNHglycan	832	835	PF01048	0.721
MOD_GlcNHglycan	845	849	PF01048	0.564
MOD_GlcNHglycan	855	858	PF01048	0.614
MOD_GlcNHglycan	877	880	PF01048	0.669
MOD_GlcNHglycan	904	907	PF01048	0.700
MOD_GlcNHglycan	913	916	PF01048	0.616
MOD_GlcNHglycan	935	938	PF01048	0.676
MOD_GlcNHglycan	983	986	PF01048	0.647
MOD_GSK3_1	10	17	PF00069	0.751
MOD_GSK3_1	156	163	PF00069	0.746
MOD_GSK3_1	178	185	PF00069	0.694
MOD_GSK3_1	213	220	PF00069	0.737
MOD_GSK3_1	238	245	PF00069	0.693
MOD_GSK3_1	256	263	PF00069	0.549
MOD_GSK3_1	26	33	PF00069	0.700
MOD_GSK3_1	271	278	PF00069	0.702
MOD_GSK3_1	477	484	PF00069	0.580
MOD_GSK3_1	647	654	PF00069	0.541
MOD_GSK3_1	685	692	PF00069	0.683
MOD_GSK3_1	73	80	PF00069	0.667
MOD_GSK3_1	762	769	PF00069	0.457
MOD_GSK3_1	791	798	PF00069	0.632
MOD_GSK3_1	824	831	PF00069	0.705
MOD_GSK3_1	849	856	PF00069	0.689
MOD_GSK3_1	858	865	PF00069	0.580
MOD_GSK3_1	94	101	PF00069	0.688
MOD_N-GLC_1	131	136	PF02516	0.641
MOD_N-GLC_1	804	809	PF02516	0.582
MOD_N-GLC_2	59	61	PF02516	0.734
MOD_NEK2_1	201	206	PF00069	0.667
MOD_NEK2_1	260	265	PF00069	0.524
MOD_NEK2_1	31	36	PF00069	0.644
MOD_NEK2_1	804	809	PF00069	0.582
MOD_NEK2_1	851	856	PF00069	0.651
MOD_NEK2_1	935	940	PF00069	0.556
MOD_NEK2_2	256	261	PF00069	0.503
MOD_NEK2_2	401	406	PF00069	0.547
MOD_PIKK_1	213	219	PF00454	0.764
MOD_PIKK_1	26	32	PF00454	0.635
MOD_PIKK_1	265	271	PF00454	0.656
MOD_PIKK_1	724	730	PF00454	0.507
MOD_PKA_1	342	348	PF00069	0.465
MOD_PKA_1	366	372	PF00069	0.486
MOD_PKA_1	724	730	PF00069	0.493
MOD_PKA_2	182	188	PF00069	0.675
MOD_PKA_2	31	37	PF00069	0.619
MOD_PKA_2	342	348	PF00069	0.510
MOD_PKA_2	592	598	PF00069	0.514
MOD_PKA_2	766	772	PF00069	0.523
MOD_PKA_2	816	822	PF00069	0.658
MOD_PKA_2	981	987	PF00069	0.588
MOD_PKB_1	340	348	PF00069	0.463
MOD_PKB_1	729	737	PF00069	0.499
MOD_PKB_1	828	836	PF00069	0.713
MOD_Plk_1	742	748	PF00069	0.722
MOD_Plk_1	804	810	PF00069	0.497
MOD_Plk_1	94	100	PF00069	0.791
MOD_Plk_2-3	408	414	PF00069	0.467
MOD_Plk_2-3	481	487	PF00069	0.555
MOD_Plk_2-3	949	955	PF00069	0.557
MOD_Plk_4	401	407	PF00069	0.577
MOD_Plk_4	949	955	PF00069	0.557
MOD_ProDKin_1	140	146	PF00069	0.680
MOD_ProDKin_1	163	169	PF00069	0.635
MOD_ProDKin_1	189	195	PF00069	0.640
MOD_ProDKin_1	196	202	PF00069	0.674
MOD_ProDKin_1	332	338	PF00069	0.512
MOD_ProDKin_1	395	401	PF00069	0.576
MOD_ProDKin_1	435	441	PF00069	0.661
MOD_ProDKin_1	45	51	PF00069	0.657
MOD_ProDKin_1	5	11	PF00069	0.810
MOD_ProDKin_1	61	67	PF00069	0.577
MOD_ProDKin_1	647	653	PF00069	0.486
MOD_ProDKin_1	689	695	PF00069	0.687
MOD_ProDKin_1	837	843	PF00069	0.644
MOD_ProDKin_1	867	873	PF00069	0.623
MOD_ProDKin_1	98	104	PF00069	0.584
MOD_SUMO_for_1	537	540	PF00179	0.543
MOD_SUMO_for_1	699	702	PF00179	0.661
MOD_SUMO_rev_2	420	425	PF00179	0.550
TRG_DiLeu_BaEn_1	615	620	PF01217	0.486
TRG_DiLeu_BaEn_1	949	954	PF01217	0.560
TRG_DiLeu_BaLyEn_6	749	754	PF01217	0.623
TRG_ENDOCYTIC_2	569	572	PF00928	0.470
TRG_ER_diArg_1	323	326	PF00400	0.586
TRG_ER_diArg_1	340	343	PF00400	0.434
TRG_ER_diArg_1	358	360	PF00400	0.495
TRG_ER_diArg_1	434	436	PF00400	0.728
TRG_ER_diArg_1	504	506	PF00400	0.677
TRG_ER_diArg_1	561	564	PF00400	0.476
TRG_ER_diArg_1	712	715	PF00400	0.557
TRG_ER_diArg_1	729	731	PF00400	0.495
TRG_ER_diArg_1	750	752	PF00400	0.558
TRG_ER_diArg_1	774	776	PF00400	0.485
TRG_ER_diArg_1	965	968	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7NHW7	Trypanosoma rangeli	30%	100%
A0A3S7X0G5	Leishmania donovani	88%	100%
A4HFI6	Leishmania braziliensis	68%	100%
E9AHD0	Leishmania infantum	88%	100%
E9AYW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%