Rad60-SLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4470)/Domain of unknown function (DUF4471), putative

Species:

Leishmania major

UniProt:

E9AD36_LEIMA

TriTrypDb:

LmjF.27.0590 , LMJLV39_270011300 , LMJSD75_270011200

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AD36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD36

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0043933	protein-containing complex organization	4	11
GO:0044458	motile cilium assembly	7	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.494
CLV_C14_Caspase3-7	299	303	PF00656	0.455
CLV_C14_Caspase3-7	567	571	PF00656	0.609
CLV_NRD_NRD_1	169	171	PF00675	0.263
CLV_NRD_NRD_1	238	240	PF00675	0.466
CLV_NRD_NRD_1	343	345	PF00675	0.255
CLV_NRD_NRD_1	40	42	PF00675	0.554
CLV_NRD_NRD_1	58	60	PF00675	0.722
CLV_PCSK_FUR_1	38	42	PF00082	0.612
CLV_PCSK_KEX2_1	168	170	PF00082	0.260
CLV_PCSK_KEX2_1	343	345	PF00082	0.255
CLV_PCSK_KEX2_1	37	39	PF00082	0.505
CLV_PCSK_KEX2_1	40	42	PF00082	0.586
CLV_PCSK_KEX2_1	58	60	PF00082	0.697
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.201
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.572
CLV_PCSK_PC7_1	54	60	PF00082	0.593
CLV_PCSK_SKI1_1	150	154	PF00082	0.296
CLV_PCSK_SKI1_1	189	193	PF00082	0.269
CLV_PCSK_SKI1_1	224	228	PF00082	0.427
CLV_PCSK_SKI1_1	239	243	PF00082	0.457
DEG_APCC_DBOX_1	149	157	PF00400	0.530
DEG_APCC_DBOX_1	410	418	PF00400	0.455
DEG_SCF_FBW7_1	116	123	PF00400	0.573
DEG_SPOP_SBC_1	121	125	PF00917	0.759
DOC_CKS1_1	443	448	PF01111	0.486
DOC_CYCLIN_RxL_1	351	362	PF00134	0.534
DOC_MAPK_gen_1	326	335	PF00069	0.455
DOC_MAPK_gen_1	457	465	PF00069	0.507
DOC_MAPK_MEF2A_6	210	217	PF00069	0.486
DOC_MAPK_NFAT4_5	210	218	PF00069	0.486
DOC_PIKK_1	82	89	PF02985	0.682
DOC_PP1_RVXF_1	187	194	PF00149	0.469
DOC_PP1_RVXF_1	208	215	PF00149	0.469
DOC_PP1_RVXF_1	353	360	PF00149	0.512
DOC_PP1_RVXF_1	457	463	PF00149	0.528
DOC_USP7_MATH_1	108	112	PF00917	0.751
DOC_USP7_MATH_1	121	125	PF00917	0.697
DOC_USP7_MATH_1	144	148	PF00917	0.557
DOC_USP7_MATH_1	161	165	PF00917	0.459
DOC_USP7_MATH_1	39	43	PF00917	0.701
DOC_USP7_UBL2_3	351	355	PF12436	0.497
DOC_WW_Pin1_4	104	109	PF00397	0.726
DOC_WW_Pin1_4	116	121	PF00397	0.713
DOC_WW_Pin1_4	23	28	PF00397	0.376
DOC_WW_Pin1_4	244	249	PF00397	0.333
DOC_WW_Pin1_4	442	447	PF00397	0.469
DOC_WW_Pin1_4	493	498	PF00397	0.467
DOC_WW_Pin1_4	64	69	PF00397	0.755
DOC_WW_Pin1_4	72	77	PF00397	0.634
LIG_14-3-3_CanoR_1	154	160	PF00244	0.469
LIG_Actin_WH2_2	145	162	PF00022	0.535
LIG_APCC_ABBA_1	211	216	PF00400	0.455
LIG_APCC_ABBAyCdc20_2	210	216	PF00400	0.469
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_Clathr_ClatBox_1	212	216	PF01394	0.462
LIG_deltaCOP1_diTrp_1	20	25	PF00928	0.421
LIG_deltaCOP1_diTrp_1	306	311	PF00928	0.455
LIG_eIF4E_1	579	585	PF01652	0.473
LIG_FHA_1	315	321	PF00498	0.455
LIG_FHA_1	450	456	PF00498	0.552
LIG_FHA_1	549	555	PF00498	0.420
LIG_FHA_2	105	111	PF00498	0.767
LIG_FHA_2	565	571	PF00498	0.595
LIG_GBD_Chelix_1	234	242	PF00786	0.443
LIG_LIR_Apic_2	349	353	PF02991	0.457
LIG_LIR_Apic_2	492	497	PF02991	0.460
LIG_LIR_Apic_2	577	582	PF02991	0.431
LIG_LIR_Gen_1	254	262	PF02991	0.455
LIG_LIR_Gen_1	30	39	PF02991	0.425
LIG_LIR_Gen_1	306	313	PF02991	0.476
LIG_LIR_Gen_1	314	323	PF02991	0.435
LIG_LIR_Nem_3	174	180	PF02991	0.459
LIG_LIR_Nem_3	30	34	PF02991	0.392
LIG_LIR_Nem_3	306	310	PF02991	0.462
LIG_LIR_Nem_3	314	319	PF02991	0.446
LIG_LIR_Nem_3	379	383	PF02991	0.535
LIG_NRBOX	193	199	PF00104	0.469
LIG_PCNA_yPIPBox_3	189	202	PF02747	0.486
LIG_PCNA_yPIPBox_3	578	588	PF02747	0.471
LIG_Pex14_1	307	311	PF04695	0.455
LIG_Pex14_2	192	196	PF04695	0.469
LIG_PTB_Apo_2	371	378	PF02174	0.455
LIG_RPA_C_Fungi	91	103	PF08784	0.474
LIG_SH2_CRK	316	320	PF00017	0.308
LIG_SH2_CRK	350	354	PF00017	0.327
LIG_SH2_CRK	438	442	PF00017	0.381
LIG_SH2_CRK	494	498	PF00017	0.407
LIG_SH2_CRK	579	583	PF00017	0.421
LIG_SH2_GRB2like	298	301	PF00017	0.346
LIG_SH2_GRB2like	316	319	PF00017	0.191
LIG_SH2_SRC	440	443	PF00017	0.381
LIG_SH2_STAP1	316	320	PF00017	0.308
LIG_SH2_STAP1	348	352	PF00017	0.327
LIG_SH2_STAP1	451	455	PF00017	0.420
LIG_SH2_STAT5	178	181	PF00017	0.327
LIG_SH2_STAT5	316	319	PF00017	0.315
LIG_SH2_STAT5	415	418	PF00017	0.420
LIG_SH2_STAT5	440	443	PF00017	0.381
LIG_SH2_STAT5	451	454	PF00017	0.381
LIG_SH2_STAT5	5	8	PF00017	0.577
LIG_SH2_STAT5	531	534	PF00017	0.420
LIG_SH2_STAT5	587	590	PF00017	0.513
LIG_SH3_1	440	446	PF00018	0.420
LIG_SH3_3	176	182	PF00018	0.404
LIG_SH3_3	440	446	PF00018	0.351
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.527
LIG_SUMO_SIM_anti_2	87	95	PF11976	0.450
LIG_TRAF2_1	203	206	PF00917	0.420
LIG_TRAF2_1	254	257	PF00917	0.420
LIG_WRC_WIRS_1	252	257	PF05994	0.308
LIG_WRC_WIRS_1	377	382	PF05994	0.391
MOD_CDK_SPxxK_3	72	79	PF00069	0.690
MOD_CK1_1	111	117	PF00069	0.767
MOD_CK1_1	123	129	PF00069	0.678
MOD_CK1_1	16	22	PF00069	0.563
MOD_CK1_1	447	453	PF00069	0.351
MOD_CK1_1	67	73	PF00069	0.703
MOD_CK1_1	77	83	PF00069	0.626
MOD_CK2_1	104	110	PF00069	0.595
MOD_CK2_1	251	257	PF00069	0.308
MOD_CK2_1	77	83	PF00069	0.654
MOD_Cter_Amidation	166	169	PF01082	0.232
MOD_GlcNHglycan	110	113	PF01048	0.652
MOD_GlcNHglycan	128	131	PF01048	0.436
MOD_GlcNHglycan	163	166	PF01048	0.429
MOD_GlcNHglycan	276	280	PF01048	0.276
MOD_GlcNHglycan	361	364	PF01048	0.442
MOD_GlcNHglycan	41	44	PF01048	0.655
MOD_GlcNHglycan	446	449	PF01048	0.420
MOD_GlcNHglycan	504	507	PF01048	0.427
MOD_GlcNHglycan	64	67	PF01048	0.723
MOD_GlcNHglycan	69	72	PF01048	0.770
MOD_GSK3_1	104	111	PF00069	0.757
MOD_GSK3_1	116	123	PF00069	0.702
MOD_GSK3_1	271	278	PF00069	0.402
MOD_GSK3_1	324	331	PF00069	0.311
MOD_GSK3_1	390	397	PF00069	0.333
MOD_GSK3_1	489	496	PF00069	0.302
MOD_GSK3_1	67	74	PF00069	0.691
MOD_LATS_1	388	394	PF00433	0.327
MOD_N-GLC_1	353	358	PF02516	0.308
MOD_NEK2_1	13	18	PF00069	0.570
MOD_NEK2_1	152	157	PF00069	0.451
MOD_NEK2_1	197	202	PF00069	0.327
MOD_NEK2_1	265	270	PF00069	0.379
MOD_NEK2_1	335	340	PF00069	0.291
MOD_NEK2_1	359	364	PF00069	0.383
MOD_NEK2_1	486	491	PF00069	0.303
MOD_NEK2_1	92	97	PF00069	0.586
MOD_NEK2_2	403	408	PF00069	0.308
MOD_PIKK_1	111	117	PF00454	0.689
MOD_PIKK_1	265	271	PF00454	0.358
MOD_PIKK_1	381	387	PF00454	0.363
MOD_PIKK_1	45	51	PF00454	0.761
MOD_PIKK_1	489	495	PF00454	0.306
MOD_PKA_2	328	334	PF00069	0.327
MOD_PKA_2	39	45	PF00069	0.632
MOD_PKA_2	391	397	PF00069	0.420
MOD_Plk_1	335	341	PF00069	0.305
MOD_Plk_1	353	359	PF00069	0.314
MOD_Plk_4	197	203	PF00069	0.351
MOD_Plk_4	30	36	PF00069	0.497
MOD_Plk_4	413	419	PF00069	0.420
MOD_Plk_4	495	501	PF00069	0.409
MOD_Plk_4	580	586	PF00069	0.467
MOD_ProDKin_1	104	110	PF00069	0.729
MOD_ProDKin_1	116	122	PF00069	0.714
MOD_ProDKin_1	23	29	PF00069	0.373
MOD_ProDKin_1	244	250	PF00069	0.327
MOD_ProDKin_1	442	448	PF00069	0.327
MOD_ProDKin_1	493	499	PF00069	0.325
MOD_ProDKin_1	64	70	PF00069	0.757
MOD_ProDKin_1	72	78	PF00069	0.630
MOD_SUMO_rev_2	254	260	PF00179	0.355
MOD_SUMO_rev_2	553	559	PF00179	0.558
TRG_DiLeu_BaEn_1	138	143	PF01217	0.451
TRG_DiLeu_BaEn_1	208	213	PF01217	0.308
TRG_DiLeu_BaEn_1	315	320	PF01217	0.420
TRG_DiLeu_BaEn_1	85	90	PF01217	0.643
TRG_DiLeu_BaEn_1	9	14	PF01217	0.603
TRG_DiLeu_BaEn_2	514	520	PF01217	0.308
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.419
TRG_ENDOCYTIC_2	316	319	PF00928	0.308
TRG_ENDOCYTIC_2	415	418	PF00928	0.308
TRG_ENDOCYTIC_2	438	441	PF00928	0.308
TRG_ER_diArg_1	169	171	PF00400	0.319
TRG_ER_diArg_1	342	344	PF00400	0.308
TRG_ER_diArg_1	38	41	PF00400	0.596
TRG_ER_diArg_1	389	392	PF00400	0.351
TRG_NLS_MonoCore_2	36	41	PF00514	0.537
TRG_NLS_MonoExtC_3	36	41	PF00514	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILC1	Leptomonas seymouri	68%	100%
A0A1X0P5D9	Trypanosomatidae	50%	100%
A0A3R7RLZ6	Trypanosoma rangeli	53%	100%
A0A3S7X0G7	Leishmania donovani	94%	100%
A4HFI5	Leishmania braziliensis	83%	100%
D0A5R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3ZCM9	Rattus norvegicus	28%	100%
E9AHC9	Leishmania infantum	93%	100%
E9AYW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
F1MLB4	Bos taurus	31%	100%
F6S9E6	Xenopus tropicalis	27%	100%
Q32NQ7	Xenopus laevis	27%	100%
Q3UYV8	Mus musculus	29%	100%
Q8N9W5	Homo sapiens	30%	100%
Q95K25	Macaca fascicularis	29%	100%
V5AU25	Trypanosoma cruzi	60%	100%