LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD35_LEIMA

TriTrypDb:

LmjF.27.0580 , LMJLV39_270011200 , LMJSD75_270011100

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0071011	precatalytic spliceosome	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9AD35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD35

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.423
CLV_C14_Caspase3-7	513	517	PF00656	0.412
CLV_C14_Caspase3-7	548	552	PF00656	0.322
CLV_NRD_NRD_1	189	191	PF00675	0.530
CLV_NRD_NRD_1	260	262	PF00675	0.695
CLV_NRD_NRD_1	292	294	PF00675	0.427
CLV_NRD_NRD_1	380	382	PF00675	0.338
CLV_NRD_NRD_1	385	387	PF00675	0.324
CLV_NRD_NRD_1	485	487	PF00675	0.433
CLV_PCSK_KEX2_1	189	191	PF00082	0.369
CLV_PCSK_KEX2_1	262	264	PF00082	0.689
CLV_PCSK_KEX2_1	291	293	PF00082	0.443
CLV_PCSK_KEX2_1	385	387	PF00082	0.317
CLV_PCSK_KEX2_1	485	487	PF00082	0.573
CLV_PCSK_KEX2_1	71	73	PF00082	0.719
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.689
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.719
CLV_PCSK_PC7_1	381	387	PF00082	0.306
CLV_PCSK_PC7_1	481	487	PF00082	0.528
CLV_PCSK_SKI1_1	135	139	PF00082	0.334
CLV_PCSK_SKI1_1	180	184	PF00082	0.472
CLV_PCSK_SKI1_1	593	597	PF00082	0.358
CLV_PCSK_SKI1_1	661	665	PF00082	0.484
CLV_Separin_Metazoa	497	501	PF03568	0.402
DEG_SPOP_SBC_1	234	238	PF00917	0.592
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.540
DOC_MAPK_gen_1	385	395	PF00069	0.424
DOC_MAPK_gen_1	557	566	PF00069	0.433
DOC_MAPK_MEF2A_6	560	568	PF00069	0.392
DOC_PP2B_LxvP_1	106	109	PF13499	0.324
DOC_PP2B_LxvP_1	139	142	PF13499	0.482
DOC_PP2B_LxvP_1	284	287	PF13499	0.472
DOC_PP4_FxxP_1	400	403	PF00568	0.366
DOC_USP7_MATH_1	133	137	PF00917	0.472
DOC_USP7_MATH_1	234	238	PF00917	0.778
DOC_USP7_MATH_1	247	251	PF00917	0.700
DOC_USP7_MATH_1	257	261	PF00917	0.651
DOC_USP7_MATH_1	332	336	PF00917	0.424
DOC_USP7_MATH_1	453	457	PF00917	0.412
DOC_USP7_MATH_1	517	521	PF00917	0.481
DOC_USP7_MATH_1	591	595	PF00917	0.437
DOC_USP7_MATH_1	64	68	PF00917	0.694
DOC_USP7_MATH_1	649	653	PF00917	0.354
DOC_USP7_MATH_1	79	83	PF00917	0.342
DOC_WW_Pin1_4	180	185	PF00397	0.532
DOC_WW_Pin1_4	670	675	PF00397	0.496
LIG_14-3-3_CanoR_1	189	194	PF00244	0.413
LIG_14-3-3_CanoR_1	202	209	PF00244	0.355
LIG_14-3-3_CanoR_1	248	256	PF00244	0.602
LIG_14-3-3_CanoR_1	341	349	PF00244	0.454
LIG_14-3-3_CanoR_1	404	410	PF00244	0.525
LIG_14-3-3_CanoR_1	51	60	PF00244	0.524
LIG_14-3-3_CanoR_1	565	575	PF00244	0.414
LIG_14-3-3_CanoR_1	72	78	PF00244	0.646
LIG_Actin_WH2_2	579	595	PF00022	0.437
LIG_APCC_ABBA_1	99	104	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BIR_III_2	516	520	PF00653	0.393
LIG_Clathr_ClatBox_1	146	150	PF01394	0.309
LIG_Clathr_ClatBox_1	451	455	PF01394	0.382
LIG_Clathr_ClatBox_1	654	658	PF01394	0.422
LIG_CSL_BTD_1	671	674	PF09270	0.376
LIG_deltaCOP1_diTrp_1	272	279	PF00928	0.616
LIG_deltaCOP1_diTrp_1	627	636	PF00928	0.463
LIG_eIF4E_1	102	108	PF01652	0.334
LIG_FHA_1	177	183	PF00498	0.596
LIG_FHA_1	189	195	PF00498	0.494
LIG_FHA_1	404	410	PF00498	0.400
LIG_FHA_1	474	480	PF00498	0.429
LIG_FHA_1	618	624	PF00498	0.418
LIG_FHA_2	113	119	PF00498	0.431
LIG_FHA_2	166	172	PF00498	0.538
LIG_FHA_2	546	552	PF00498	0.581
LIG_FHA_2	565	571	PF00498	0.316
LIG_LIR_Apic_2	520	526	PF02991	0.465
LIG_LIR_Gen_1	115	125	PF02991	0.299
LIG_LIR_Gen_1	326	332	PF02991	0.504
LIG_LIR_Gen_1	362	368	PF02991	0.294
LIG_LIR_Gen_1	370	378	PF02991	0.274
LIG_LIR_Gen_1	633	643	PF02991	0.490
LIG_LIR_Gen_1	92	103	PF02991	0.349
LIG_LIR_Nem_3	115	120	PF02991	0.356
LIG_LIR_Nem_3	223	227	PF02991	0.669
LIG_LIR_Nem_3	277	282	PF02991	0.486
LIG_LIR_Nem_3	326	330	PF02991	0.479
LIG_LIR_Nem_3	362	366	PF02991	0.301
LIG_LIR_Nem_3	370	375	PF02991	0.271
LIG_LIR_Nem_3	463	469	PF02991	0.352
LIG_LIR_Nem_3	594	599	PF02991	0.418
LIG_LIR_Nem_3	633	639	PF02991	0.452
LIG_LIR_Nem_3	92	98	PF02991	0.350
LIG_LRP6_Inhibitor_1	45	51	PF00058	0.345
LIG_PCNA_yPIPBox_3	135	147	PF02747	0.464
LIG_Pex14_1	275	279	PF04695	0.614
LIG_Pex14_1	372	376	PF04695	0.316
LIG_SH2_CRK	466	470	PF00017	0.400
LIG_SH2_CRK	47	51	PF00017	0.488
LIG_SH2_CRK	523	527	PF00017	0.484
LIG_SH2_NCK_1	523	527	PF00017	0.342
LIG_SH2_PTP2	155	158	PF00017	0.469
LIG_SH2_SRC	102	105	PF00017	0.366
LIG_SH2_STAP1	117	121	PF00017	0.293
LIG_SH2_STAP1	685	689	PF00017	0.446
LIG_SH2_STAT5	102	105	PF00017	0.347
LIG_SH2_STAT5	155	158	PF00017	0.469
LIG_SH2_STAT5	466	469	PF00017	0.504
LIG_SH2_STAT5	527	530	PF00017	0.407
LIG_SH2_STAT5	575	578	PF00017	0.473
LIG_SH3_3	146	152	PF00018	0.307
LIG_SH3_3	236	242	PF00018	0.590
LIG_SUMO_SIM_anti_2	312	319	PF11976	0.366
LIG_SUMO_SIM_anti_2	652	658	PF11976	0.368
LIG_SUMO_SIM_par_1	652	658	PF11976	0.342
LIG_TRAF2_1	311	314	PF00917	0.455
LIG_TYR_ITIM	45	50	PF00017	0.390
LIG_TYR_ITIM	464	469	PF00017	0.328
LIG_TYR_ITSM	113	120	PF00017	0.430
LIG_UBA3_1	193	198	PF00899	0.405
MOD_CK1_1	3	9	PF00069	0.647
MOD_CK1_1	539	545	PF00069	0.644
MOD_CK1_1	54	60	PF00069	0.580
MOD_CK2_1	112	118	PF00069	0.432
MOD_CK2_1	165	171	PF00069	0.570
MOD_CK2_1	246	252	PF00069	0.520
MOD_CK2_1	307	313	PF00069	0.513
MOD_CK2_1	91	97	PF00069	0.416
MOD_Cter_Amidation	69	72	PF01082	0.591
MOD_GlcNHglycan	249	252	PF01048	0.664
MOD_GlcNHglycan	309	312	PF01048	0.554
MOD_GlcNHglycan	321	324	PF01048	0.263
MOD_GlcNHglycan	400	403	PF01048	0.359
MOD_GlcNHglycan	444	447	PF01048	0.489
MOD_GlcNHglycan	470	473	PF01048	0.313
MOD_GlcNHglycan	593	596	PF01048	0.439
MOD_GlcNHglycan	646	649	PF01048	0.414
MOD_GlcNHglycan	650	654	PF01048	0.258
MOD_GlcNHglycan	68	71	PF01048	0.668
MOD_GlcNHglycan	685	688	PF01048	0.426
MOD_GlcNHglycan	73	76	PF01048	0.664
MOD_GSK3_1	172	179	PF00069	0.642
MOD_GSK3_1	247	254	PF00069	0.799
MOD_GSK3_1	3	10	PF00069	0.649
MOD_GSK3_1	347	354	PF00069	0.400
MOD_GSK3_1	411	418	PF00069	0.361
MOD_GSK3_1	529	536	PF00069	0.665
MOD_GSK3_1	66	73	PF00069	0.528
MOD_GSK3_1	666	673	PF00069	0.485
MOD_NEK2_1	393	398	PF00069	0.384
MOD_NEK2_1	415	420	PF00069	0.371
MOD_NEK2_1	468	473	PF00069	0.349
MOD_NEK2_1	553	558	PF00069	0.360
MOD_NEK2_1	643	648	PF00069	0.496
MOD_NEK2_1	666	671	PF00069	0.395
MOD_NEK2_1	91	96	PF00069	0.438
MOD_NEK2_2	608	613	PF00069	0.281
MOD_NEK2_2	619	624	PF00069	0.286
MOD_PIKK_1	517	523	PF00454	0.378
MOD_PIKK_1	546	552	PF00454	0.429
MOD_PIKK_1	672	678	PF00454	0.520
MOD_PKA_1	189	195	PF00069	0.319
MOD_PKA_1	71	77	PF00069	0.708
MOD_PKA_2	188	194	PF00069	0.421
MOD_PKA_2	201	207	PF00069	0.334
MOD_PKA_2	247	253	PF00069	0.797
MOD_PKA_2	264	270	PF00069	0.426
MOD_PKA_2	340	346	PF00069	0.478
MOD_PKA_2	350	356	PF00069	0.520
MOD_PKA_2	403	409	PF00069	0.516
MOD_PKA_2	564	570	PF00069	0.405
MOD_PKA_2	643	649	PF00069	0.481
MOD_PKA_2	71	77	PF00069	0.655
MOD_Plk_1	234	240	PF00069	0.746
MOD_Plk_1	251	257	PF00069	0.507
MOD_Plk_1	539	545	PF00069	0.538
MOD_Plk_1	649	655	PF00069	0.352
MOD_Plk_4	112	118	PF00069	0.391
MOD_Plk_4	189	195	PF00069	0.321
MOD_Plk_4	264	270	PF00069	0.615
MOD_Plk_4	275	281	PF00069	0.506
MOD_Plk_4	405	411	PF00069	0.413
MOD_Plk_4	475	481	PF00069	0.245
MOD_Plk_4	598	604	PF00069	0.466
MOD_Plk_4	608	614	PF00069	0.244
MOD_Plk_4	678	684	PF00069	0.412
MOD_ProDKin_1	180	186	PF00069	0.519
MOD_ProDKin_1	670	676	PF00069	0.500
MOD_SUMO_rev_2	110	115	PF00179	0.454
MOD_SUMO_rev_2	228	234	PF00179	0.573
TRG_DiLeu_BaEn_4	122	128	PF01217	0.343
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.418
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.332
TRG_ENDOCYTIC_2	117	120	PF00928	0.342
TRG_ENDOCYTIC_2	155	158	PF00928	0.336
TRG_ENDOCYTIC_2	24	27	PF00928	0.346
TRG_ENDOCYTIC_2	466	469	PF00928	0.432
TRG_ENDOCYTIC_2	47	50	PF00928	0.388
TRG_ER_diArg_1	290	293	PF00400	0.437
TRG_ER_diArg_1	384	386	PF00400	0.335
TRG_NES_CRM1_1	97	111	PF08389	0.430
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM3	Leptomonas seymouri	63%	100%
A0A1X0P521	Trypanosomatidae	31%	100%
A0A3R7KHV4	Trypanosoma rangeli	33%	100%
A0A3S5H7H4	Leishmania donovani	93%	100%
A4HFI4	Leishmania braziliensis	78%	100%
D0A5R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AHC8	Leishmania infantum	94%	100%
E9AYV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q2TAY7	Homo sapiens	24%	100%
Q2TBS9	Bos taurus	24%	100%
Q3UKJ7	Mus musculus	24%	100%
Q5ZME8	Gallus gallus	24%	100%
Q6NRT3	Xenopus laevis	24%	100%
Q6P4J8	Xenopus tropicalis	24%	100%
Q76B40	Cricetulus griseus	24%	100%
Q7ZVA0	Danio rerio	23%	100%
Q99M63	Rattus norvegicus	24%	100%
V5B9I2	Trypanosoma cruzi	33%	100%