RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AD34_LEIMA

TriTrypDb:

LmjF.27.0570 , LMJLV39_270011100 , LMJSD75_270011000

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD34

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.480
CLV_NRD_NRD_1	160	162	PF00675	0.402
CLV_NRD_NRD_1	19	21	PF00675	0.568
CLV_NRD_NRD_1	232	234	PF00675	0.586
CLV_NRD_NRD_1	303	305	PF00675	0.773
CLV_NRD_NRD_1	345	347	PF00675	0.761
CLV_NRD_NRD_1	424	426	PF00675	0.563
CLV_NRD_NRD_1	453	455	PF00675	0.453
CLV_NRD_NRD_1	461	463	PF00675	0.404
CLV_NRD_NRD_1	475	477	PF00675	0.419
CLV_NRD_NRD_1	515	517	PF00675	0.618
CLV_PCSK_FUR_1	473	477	PF00082	0.430
CLV_PCSK_FUR_1	513	517	PF00082	0.448
CLV_PCSK_KEX2_1	112	114	PF00082	0.509
CLV_PCSK_KEX2_1	160	162	PF00082	0.402
CLV_PCSK_KEX2_1	19	21	PF00082	0.568
CLV_PCSK_KEX2_1	231	233	PF00082	0.602
CLV_PCSK_KEX2_1	303	305	PF00082	0.785
CLV_PCSK_KEX2_1	345	347	PF00082	0.761
CLV_PCSK_KEX2_1	426	428	PF00082	0.560
CLV_PCSK_KEX2_1	453	455	PF00082	0.465
CLV_PCSK_KEX2_1	473	475	PF00082	0.308
CLV_PCSK_KEX2_1	513	515	PF00082	0.452
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.570
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.560
CLV_PCSK_PC7_1	299	305	PF00082	0.571
CLV_PCSK_SKI1_1	154	158	PF00082	0.360
CLV_PCSK_SKI1_1	177	181	PF00082	0.432
CLV_PCSK_SKI1_1	20	24	PF00082	0.563
CLV_PCSK_SKI1_1	232	236	PF00082	0.596
DEG_ODPH_VHL_1	370	383	PF01847	0.525
DEG_SCF_FBW7_1	336	342	PF00400	0.624
DEG_SPOP_SBC_1	275	279	PF00917	0.551
DEG_SPOP_SBC_1	339	343	PF00917	0.629
DOC_CKS1_1	219	224	PF01111	0.675
DOC_CKS1_1	336	341	PF01111	0.625
DOC_MAPK_MEF2A_6	237	246	PF00069	0.538
DOC_PP1_RVXF_1	175	182	PF00149	0.405
DOC_PP4_FxxP_1	329	332	PF00568	0.740
DOC_PP4_FxxP_1	369	372	PF00568	0.498
DOC_PP4_FxxP_1	447	450	PF00568	0.494
DOC_USP7_MATH_1	275	279	PF00917	0.587
DOC_USP7_MATH_1	292	296	PF00917	0.657
DOC_USP7_MATH_1	35	39	PF00917	0.614
DOC_USP7_MATH_1	4	8	PF00917	0.611
DOC_USP7_MATH_1	410	414	PF00917	0.486
DOC_USP7_MATH_1	428	432	PF00917	0.436
DOC_USP7_UBL2_3	504	508	PF12436	0.410
DOC_USP7_UBL2_3	76	80	PF12436	0.282
DOC_WW_Pin1_4	10	15	PF00397	0.631
DOC_WW_Pin1_4	2	7	PF00397	0.585
DOC_WW_Pin1_4	210	215	PF00397	0.597
DOC_WW_Pin1_4	218	223	PF00397	0.605
DOC_WW_Pin1_4	238	243	PF00397	0.653
DOC_WW_Pin1_4	28	33	PF00397	0.570
DOC_WW_Pin1_4	302	307	PF00397	0.565
DOC_WW_Pin1_4	309	314	PF00397	0.572
DOC_WW_Pin1_4	335	340	PF00397	0.796
DOC_WW_Pin1_4	348	353	PF00397	0.627
LIG_14-3-3_CanoR_1	177	182	PF00244	0.399
LIG_14-3-3_CanoR_1	19	28	PF00244	0.609
LIG_14-3-3_CanoR_1	249	253	PF00244	0.750
LIG_14-3-3_CanoR_1	287	297	PF00244	0.584
LIG_14-3-3_CanoR_1	304	313	PF00244	0.628
LIG_14-3-3_CanoR_1	345	349	PF00244	0.662
LIG_14-3-3_CanoR_1	427	433	PF00244	0.499
LIG_14-3-3_CanoR_1	62	70	PF00244	0.305
LIG_14-3-3_CanoR_1	94	99	PF00244	0.361
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_FHA_1	164	170	PF00498	0.504
LIG_FHA_1	239	245	PF00498	0.597
LIG_FHA_1	275	281	PF00498	0.600
LIG_FHA_1	283	289	PF00498	0.532
LIG_FHA_1	403	409	PF00498	0.433
LIG_FHA_2	483	489	PF00498	0.440
LIG_LIR_Apic_2	328	332	PF02991	0.761
LIG_LIR_Apic_2	366	372	PF02991	0.489
LIG_LIR_Apic_2	444	450	PF02991	0.492
LIG_LIR_Gen_1	380	391	PF02991	0.425
LIG_LIR_Gen_1	39	50	PF02991	0.447
LIG_LIR_Nem_3	268	274	PF02991	0.535
LIG_LIR_Nem_3	364	370	PF02991	0.530
LIG_LIR_Nem_3	380	386	PF02991	0.455
LIG_LIR_Nem_3	39	45	PF02991	0.482
LIG_Pex14_1	118	122	PF04695	0.550
LIG_SH2_GRB2like	42	45	PF00017	0.445
LIG_SH2_SRC	42	45	PF00017	0.445
LIG_SH2_SRC	477	480	PF00017	0.496
LIG_SH2_STAP1	165	169	PF00017	0.313
LIG_SH2_STAP1	96	100	PF00017	0.473
LIG_SH2_STAT5	115	118	PF00017	0.488
LIG_SH2_STAT5	165	168	PF00017	0.403
LIG_SH2_STAT5	368	371	PF00017	0.514
LIG_SH2_STAT5	477	480	PF00017	0.450
LIG_SH2_STAT5	73	76	PF00017	0.282
LIG_SH2_STAT5	96	99	PF00017	0.396
LIG_SH3_2	14	19	PF14604	0.538
LIG_SH3_3	11	17	PF00018	0.668
LIG_SH3_3	211	217	PF00018	0.620
LIG_SH3_3	261	267	PF00018	0.534
LIG_SH3_3	29	35	PF00018	0.489
LIG_SH3_3	294	300	PF00018	0.726
LIG_SH3_3	320	326	PF00018	0.590
LIG_SH3_3	53	59	PF00018	0.370
LIG_TRAF2_1	132	135	PF00917	0.539
LIG_TRAF2_1	442	445	PF00917	0.556
LIG_TRFH_1	368	372	PF08558	0.505
LIG_WRC_WIRS_1	95	100	PF05994	0.366
MOD_CDC14_SPxK_1	5	8	PF00782	0.546
MOD_CDK_SPxK_1	2	8	PF00069	0.540
MOD_CDK_SPxxK_3	309	316	PF00069	0.599
MOD_CK1_1	2	8	PF00069	0.797
MOD_CK1_1	260	266	PF00069	0.606
MOD_CK1_1	269	275	PF00069	0.664
MOD_CK1_1	276	282	PF00069	0.560
MOD_CK1_1	305	311	PF00069	0.639
MOD_CK1_1	314	320	PF00069	0.639
MOD_CK1_1	344	350	PF00069	0.688
MOD_CK1_1	9	15	PF00069	0.644
MOD_CK2_1	292	298	PF00069	0.639
MOD_CK2_1	439	445	PF00069	0.503
MOD_CK2_1	9	15	PF00069	0.569
MOD_CK2_1	99	105	PF00069	0.455
MOD_GlcNHglycan	101	104	PF01048	0.549
MOD_GlcNHglycan	204	207	PF01048	0.646
MOD_GlcNHglycan	24	27	PF01048	0.627
MOD_GlcNHglycan	259	262	PF01048	0.656
MOD_GlcNHglycan	271	274	PF01048	0.573
MOD_GlcNHglycan	294	297	PF01048	0.772
MOD_GlcNHglycan	307	310	PF01048	0.594
MOD_GlcNHglycan	360	363	PF01048	0.576
MOD_GlcNHglycan	421	424	PF01048	0.675
MOD_GlcNHglycan	441	444	PF01048	0.507
MOD_GSK3_1	2	9	PF00069	0.701
MOD_GSK3_1	200	207	PF00069	0.584
MOD_GSK3_1	265	272	PF00069	0.596
MOD_GSK3_1	274	281	PF00069	0.568
MOD_GSK3_1	288	295	PF00069	0.539
MOD_GSK3_1	304	311	PF00069	0.604
MOD_GSK3_1	314	321	PF00069	0.678
MOD_GSK3_1	335	342	PF00069	0.675
MOD_GSK3_1	344	351	PF00069	0.605
MOD_GSK3_1	354	361	PF00069	0.470
MOD_GSK3_1	410	417	PF00069	0.452
MOD_GSK3_1	492	499	PF00069	0.445
MOD_GSK3_1	90	97	PF00069	0.367
MOD_N-GLC_1	292	297	PF02516	0.648
MOD_N-GLC_2	44	46	PF02516	0.305
MOD_N-GLC_2	64	66	PF02516	0.183
MOD_N-GLC_2	83	85	PF02516	0.305
MOD_NEK2_1	137	142	PF00069	0.529
MOD_NEK2_1	200	205	PF00069	0.604
MOD_NEK2_1	274	279	PF00069	0.586
MOD_NEK2_1	419	424	PF00069	0.562
MOD_NEK2_1	69	74	PF00069	0.305
MOD_NEK2_2	410	415	PF00069	0.438
MOD_PIKK_1	492	498	PF00454	0.424
MOD_PKA_1	232	238	PF00069	0.596
MOD_PKA_2	232	238	PF00069	0.621
MOD_PKA_2	248	254	PF00069	0.602
MOD_PKA_2	344	350	PF00069	0.767
MOD_PKA_2	90	96	PF00069	0.370
MOD_PKB_1	400	408	PF00069	0.433
MOD_PKB_1	60	68	PF00069	0.305
MOD_Plk_1	118	124	PF00069	0.517
MOD_Plk_1	292	298	PF00069	0.650
MOD_Plk_1	317	323	PF00069	0.617
MOD_Plk_4	118	124	PF00069	0.522
MOD_Plk_4	137	143	PF00069	0.468
MOD_Plk_4	177	183	PF00069	0.384
MOD_Plk_4	204	210	PF00069	0.526
MOD_Plk_4	266	272	PF00069	0.544
MOD_ProDKin_1	10	16	PF00069	0.629
MOD_ProDKin_1	2	8	PF00069	0.590
MOD_ProDKin_1	210	216	PF00069	0.594
MOD_ProDKin_1	218	224	PF00069	0.608
MOD_ProDKin_1	238	244	PF00069	0.653
MOD_ProDKin_1	28	34	PF00069	0.568
MOD_ProDKin_1	302	308	PF00069	0.567
MOD_ProDKin_1	309	315	PF00069	0.572
MOD_ProDKin_1	335	341	PF00069	0.797
MOD_ProDKin_1	348	354	PF00069	0.626
MOD_SUMO_for_1	403	406	PF00179	0.496
MOD_SUMO_for_1	507	510	PF00179	0.451
MOD_SUMO_rev_2	101	110	PF00179	0.451
TRG_ENDOCYTIC_2	367	370	PF00928	0.527
TRG_ENDOCYTIC_2	42	45	PF00928	0.445
TRG_ER_diArg_1	110	113	PF00400	0.477
TRG_ER_diArg_1	231	233	PF00400	0.619
TRG_ER_diArg_1	453	455	PF00400	0.458
TRG_ER_diArg_1	472	475	PF00400	0.298
TRG_ER_diArg_1	512	515	PF00400	0.438
TRG_ER_diArg_1	59	62	PF00400	0.305
TRG_NLS_MonoExtN_4	109	115	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U0	Leptomonas seymouri	55%	98%
A0A3S7X0G9	Leishmania donovani	89%	100%
A4HFI3	Leishmania braziliensis	71%	100%
E9AHC7	Leishmania infantum	89%	100%
E9AYV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%