Amastin_surface_glycoprotein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania major

UniProt:

E9AD31_LEIMA

TriTrypDb:

LmjF.27.0540 , LMJLV39_270010800 , LMJSD75_270010700

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

E9AD31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD31

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	39	43	PF00082	0.569
CLV_PCSK_SKI1_1	59	63	PF00082	0.508
DEG_Nend_UBRbox_3	1	3	PF02207	0.649
DEG_SCF_FBW7_2	26	32	PF00400	0.422
DOC_CKS1_1	26	31	PF01111	0.419
DOC_MAPK_MEF2A_6	142	149	PF00069	0.525
DOC_PP4_FxxP_1	31	34	PF00568	0.389
DOC_SPAK_OSR1_1	64	68	PF12202	0.298
DOC_USP7_MATH_1	73	77	PF00917	0.337
DOC_USP7_MATH_1	90	94	PF00917	0.359

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T4	Leptomonas seymouri	52%	100%
A0A1X0NW81	Trypanosomatidae	34%	100%
A0A3S7X0F7	Leishmania donovani	94%	100%
A4HFI0	Leishmania braziliensis	68%	100%
C9ZWE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	93%
E9AHC4	Leishmania infantum	94%	100%
E9AYV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%

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