Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD30_LEIMA

TriTrypDb:

LmjF.27.0530 , LMJLV39_270010700 , LMJSD75_270010600

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.672
CLV_C14_Caspase3-7	499	503	PF00656	0.699
CLV_NRD_NRD_1	113	115	PF00675	0.480
CLV_NRD_NRD_1	167	169	PF00675	0.505
CLV_NRD_NRD_1	204	206	PF00675	0.597
CLV_NRD_NRD_1	238	240	PF00675	0.649
CLV_NRD_NRD_1	309	311	PF00675	0.604
CLV_NRD_NRD_1	333	335	PF00675	0.459
CLV_NRD_NRD_1	364	366	PF00675	0.605
CLV_NRD_NRD_1	39	41	PF00675	0.505
CLV_NRD_NRD_1	541	543	PF00675	0.493
CLV_NRD_NRD_1	558	560	PF00675	0.521
CLV_NRD_NRD_1	584	586	PF00675	0.503
CLV_PCSK_FUR_1	331	335	PF00082	0.451
CLV_PCSK_KEX2_1	113	115	PF00082	0.486
CLV_PCSK_KEX2_1	157	159	PF00082	0.435
CLV_PCSK_KEX2_1	166	168	PF00082	0.515
CLV_PCSK_KEX2_1	204	206	PF00082	0.597
CLV_PCSK_KEX2_1	238	240	PF00082	0.608
CLV_PCSK_KEX2_1	309	311	PF00082	0.604
CLV_PCSK_KEX2_1	333	335	PF00082	0.459
CLV_PCSK_KEX2_1	364	366	PF00082	0.605
CLV_PCSK_KEX2_1	541	543	PF00082	0.493
CLV_PCSK_KEX2_1	558	560	PF00082	0.521
CLV_PCSK_KEX2_1	584	586	PF00082	0.504
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.403
CLV_PCSK_PC7_1	163	169	PF00082	0.466
CLV_PCSK_SKI1_1	149	153	PF00082	0.396
CLV_PCSK_SKI1_1	184	188	PF00082	0.575
CLV_PCSK_SKI1_1	365	369	PF00082	0.701
CLV_PCSK_SKI1_1	424	428	PF00082	0.606
CLV_PCSK_SKI1_1	548	552	PF00082	0.486
CLV_PCSK_SKI1_1	569	573	PF00082	0.486
CLV_PCSK_SKI1_1	579	583	PF00082	0.486
CLV_PCSK_SKI1_1	82	86	PF00082	0.386
CLV_Separin_Metazoa	70	74	PF03568	0.451
DEG_APCC_DBOX_1	148	156	PF00400	0.397
DEG_Nend_UBRbox_3	1	3	PF02207	0.577
DEG_SCF_FBW7_1	457	463	PF00400	0.634
DEG_SIAH_1	368	376	PF03145	0.560
DEG_SPOP_SBC_1	249	253	PF00917	0.602
DEG_SPOP_SBC_1	526	530	PF00917	0.578
DOC_CKS1_1	457	462	PF01111	0.620
DOC_MAPK_FxFP_2	572	575	PF00069	0.484
DOC_MAPK_gen_1	364	370	PF00069	0.545
DOC_PP2B_LxvP_1	374	377	PF13499	0.518
DOC_PP4_FxxP_1	572	575	PF00568	0.484
DOC_USP7_MATH_1	224	228	PF00917	0.731
DOC_USP7_MATH_1	240	244	PF00917	0.559
DOC_USP7_MATH_1	250	254	PF00917	0.563
DOC_USP7_MATH_1	270	274	PF00917	0.685
DOC_USP7_MATH_1	387	391	PF00917	0.592
DOC_USP7_MATH_1	410	414	PF00917	0.587
DOC_USP7_MATH_1	526	530	PF00917	0.776
DOC_USP7_UBL2_3	350	354	PF12436	0.604
DOC_WW_Pin1_4	140	145	PF00397	0.443
DOC_WW_Pin1_4	173	178	PF00397	0.575
DOC_WW_Pin1_4	211	216	PF00397	0.635
DOC_WW_Pin1_4	281	286	PF00397	0.536
DOC_WW_Pin1_4	359	364	PF00397	0.672
DOC_WW_Pin1_4	375	380	PF00397	0.489
DOC_WW_Pin1_4	381	386	PF00397	0.557
DOC_WW_Pin1_4	39	44	PF00397	0.521
DOC_WW_Pin1_4	424	429	PF00397	0.611
DOC_WW_Pin1_4	456	461	PF00397	0.621
DOC_WW_Pin1_4	463	468	PF00397	0.610
DOC_WW_Pin1_4	505	510	PF00397	0.664
LIG_14-3-3_CanoR_1	166	171	PF00244	0.646
LIG_14-3-3_CanoR_1	172	177	PF00244	0.620
LIG_14-3-3_CanoR_1	239	245	PF00244	0.661
LIG_14-3-3_CanoR_1	333	342	PF00244	0.538
LIG_14-3-3_CanoR_1	584	591	PF00244	0.489
LIG_APCC_ABBA_1	100	105	PF00400	0.374
LIG_FHA_1	409	415	PF00498	0.588
LIG_FHA_1	457	463	PF00498	0.646
LIG_FHA_1	464	470	PF00498	0.588
LIG_FHA_1	5	11	PF00498	0.474
LIG_FHA_1	530	536	PF00498	0.615
LIG_FHA_2	25	31	PF00498	0.448
LIG_FHA_2	494	500	PF00498	0.559
LIG_LIR_Apic_2	570	575	PF02991	0.484
LIG_LYPXL_SIV_4	259	267	PF13949	0.443
LIG_LYPXL_yS_3	260	263	PF13949	0.509
LIG_MYND_3	535	539	PF01753	0.589
LIG_PCNA_yPIPBox_3	541	551	PF02747	0.467
LIG_RPA_C_Fungi	537	549	PF08784	0.498
LIG_SH2_NCK_1	431	435	PF00017	0.628
LIG_SH2_PTP2	68	71	PF00017	0.371
LIG_SH2_SRC	68	71	PF00017	0.437
LIG_SH2_STAP1	298	302	PF00017	0.485
LIG_SH2_STAT5	103	106	PF00017	0.385
LIG_SH2_STAT5	225	228	PF00017	0.727
LIG_SH2_STAT5	58	61	PF00017	0.362
LIG_SH2_STAT5	68	71	PF00017	0.391
LIG_SH3_1	197	203	PF00018	0.575
LIG_SH3_1	40	46	PF00018	0.491
LIG_SH3_2	200	205	PF14604	0.572
LIG_SH3_3	197	203	PF00018	0.548
LIG_SH3_3	360	366	PF00018	0.670
LIG_SH3_3	376	382	PF00018	0.527
LIG_SH3_3	398	404	PF00018	0.707
LIG_SH3_3	40	46	PF00018	0.491
LIG_SUMO_SIM_anti_2	150	156	PF11976	0.389
LIG_SUMO_SIM_par_1	18	23	PF11976	0.364
LIG_TRAF2_1	131	134	PF00917	0.458
LIG_TRAF2_1	245	248	PF00917	0.581
LIG_TRFH_1	185	189	PF08558	0.573
LIG_UBA3_1	151	157	PF00899	0.367
LIG_UBA3_1	84	90	PF00899	0.447
MOD_CDC14_SPxK_1	470	473	PF00782	0.603
MOD_CDK_SPK_2	359	364	PF00069	0.598
MOD_CDK_SPK_2	456	461	PF00069	0.598
MOD_CDK_SPK_2	505	510	PF00069	0.652
MOD_CDK_SPxK_1	173	179	PF00069	0.567
MOD_CDK_SPxK_1	359	365	PF00069	0.674
MOD_CDK_SPxK_1	424	430	PF00069	0.632
MOD_CDK_SPxK_1	467	473	PF00069	0.608
MOD_CDK_SPxxK_3	505	512	PF00069	0.616
MOD_CK1_1	214	220	PF00069	0.555
MOD_CK1_1	243	249	PF00069	0.616
MOD_CK1_1	252	258	PF00069	0.488
MOD_CK1_1	36	42	PF00069	0.477
MOD_CK1_1	4	10	PF00069	0.390
MOD_CK1_1	463	469	PF00069	0.598
MOD_CK1_1	476	482	PF00069	0.637
MOD_CK1_1	514	520	PF00069	0.619
MOD_CK1_1	528	534	PF00069	0.533
MOD_CK2_1	128	134	PF00069	0.406
MOD_CK2_1	187	193	PF00069	0.585
MOD_CK2_1	24	30	PF00069	0.449
MOD_CK2_1	270	276	PF00069	0.549
MOD_CK2_1	480	486	PF00069	0.667
MOD_CK2_1	493	499	PF00069	0.537
MOD_Cter_Amidation	236	239	PF01082	0.592
MOD_GlcNHglycan	130	133	PF01048	0.495
MOD_GlcNHglycan	189	192	PF01048	0.612
MOD_GlcNHglycan	222	225	PF01048	0.617
MOD_GlcNHglycan	228	231	PF01048	0.664
MOD_GlcNHglycan	254	257	PF01048	0.747
MOD_GlcNHglycan	272	275	PF01048	0.375
MOD_GlcNHglycan	342	345	PF01048	0.521
MOD_GlcNHglycan	35	38	PF01048	0.560
MOD_GlcNHglycan	414	417	PF01048	0.563
MOD_GlcNHglycan	478	481	PF01048	0.603
MOD_GlcNHglycan	513	516	PF01048	0.735
MOD_GlcNHglycan	518	521	PF01048	0.579
MOD_GlcNHglycan	576	579	PF01048	0.483
MOD_GSK3_1	162	169	PF00069	0.433
MOD_GSK3_1	220	227	PF00069	0.557
MOD_GSK3_1	248	255	PF00069	0.591
MOD_GSK3_1	323	330	PF00069	0.535
MOD_GSK3_1	381	388	PF00069	0.599
MOD_GSK3_1	408	415	PF00069	0.616
MOD_GSK3_1	418	425	PF00069	0.569
MOD_GSK3_1	456	463	PF00069	0.611
MOD_GSK3_1	476	483	PF00069	0.497
MOD_GSK3_1	511	518	PF00069	0.591
MOD_GSK3_1	525	532	PF00069	0.559
MOD_N-GLC_1	467	472	PF02516	0.609
MOD_N-GLC_2	63	65	PF02516	0.392
MOD_NEK2_1	1	6	PF00069	0.469
MOD_NEK2_1	126	131	PF00069	0.403
MOD_NEK2_1	475	480	PF00069	0.618
MOD_NEK2_1	525	530	PF00069	0.556
MOD_NEK2_1	567	572	PF00069	0.493
MOD_NEK2_2	286	291	PF00069	0.499
MOD_PIKK_1	387	393	PF00454	0.794
MOD_PKA_1	166	172	PF00069	0.469
MOD_PKA_1	333	339	PF00069	0.458
MOD_PKA_2	162	168	PF00069	0.433
MOD_PKA_2	171	177	PF00069	0.500
MOD_PKA_2	270	276	PF00069	0.461
MOD_PKA_2	333	339	PF00069	0.533
MOD_PKA_2	429	435	PF00069	0.678
MOD_PKA_2	460	466	PF00069	0.772
MOD_PKA_2	583	589	PF00069	0.484
MOD_PKB_1	331	339	PF00069	0.454
MOD_Plk_1	147	153	PF00069	0.402
MOD_Plk_1	436	442	PF00069	0.617
MOD_Plk_1	567	573	PF00069	0.489
MOD_Plk_4	369	375	PF00069	0.563
MOD_ProDKin_1	140	146	PF00069	0.436
MOD_ProDKin_1	173	179	PF00069	0.578
MOD_ProDKin_1	211	217	PF00069	0.635
MOD_ProDKin_1	281	287	PF00069	0.531
MOD_ProDKin_1	359	365	PF00069	0.674
MOD_ProDKin_1	375	381	PF00069	0.493
MOD_ProDKin_1	39	45	PF00069	0.506
MOD_ProDKin_1	424	430	PF00069	0.615
MOD_ProDKin_1	456	462	PF00069	0.621
MOD_ProDKin_1	463	469	PF00069	0.613
MOD_ProDKin_1	505	511	PF00069	0.666
MOD_SUMO_rev_2	343	352	PF00179	0.576
TRG_DiLeu_BaEn_2	133	139	PF01217	0.448
TRG_DiLeu_BaEn_2	140	146	PF01217	0.390
TRG_ENDOCYTIC_2	103	106	PF00928	0.369
TRG_ENDOCYTIC_2	260	263	PF00928	0.509
TRG_ENDOCYTIC_2	298	301	PF00928	0.461
TRG_ER_diArg_1	112	114	PF00400	0.462
TRG_ER_diArg_1	166	168	PF00400	0.483
TRG_ER_diArg_1	203	205	PF00400	0.597
TRG_ER_diArg_1	331	334	PF00400	0.447
TRG_ER_diArg_1	363	365	PF00400	0.598
TRG_ER_diArg_1	449	452	PF00400	0.625
TRG_ER_diArg_1	540	542	PF00400	0.502
TRG_ER_diArg_1	583	585	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K9	Leptomonas seymouri	51%	96%
A0A3S7X0F9	Leishmania donovani	91%	100%
A4HFH9	Leishmania braziliensis	69%	100%
E9AHC3	Leishmania infantum	92%	100%
E9AYV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%