Putative radial spoke protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

radial spoke protein 3, putative

Species:

Leishmania major

UniProt:

E9AD29_LEIMA

TriTrypDb:

LmjF.27.0520 , LMJLV39_270010600 , LMJSD75_270010500

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005929	cilium	4	2
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005856	cytoskeleton	5	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9

Expansion

Sequence features

E9AD29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD29

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0009987	cellular process	1	2
GO:0048870	cell motility	2	2
GO:0060285	cilium-dependent cell motility	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.399
CLV_NRD_NRD_1	100	102	PF00675	0.232
CLV_NRD_NRD_1	108	110	PF00675	0.198
CLV_NRD_NRD_1	222	224	PF00675	0.198
CLV_NRD_NRD_1	238	240	PF00675	0.252
CLV_NRD_NRD_1	246	248	PF00675	0.207
CLV_NRD_NRD_1	56	58	PF00675	0.234
CLV_NRD_NRD_1	79	81	PF00675	0.222
CLV_NRD_NRD_1	87	89	PF00675	0.223
CLV_PCSK_KEX2_1	108	110	PF00082	0.198
CLV_PCSK_KEX2_1	222	224	PF00082	0.198
CLV_PCSK_KEX2_1	238	240	PF00082	0.199
CLV_PCSK_KEX2_1	246	248	PF00082	0.198
CLV_PCSK_KEX2_1	56	58	PF00082	0.195
CLV_PCSK_KEX2_1	79	81	PF00082	0.218
CLV_PCSK_KEX2_1	87	89	PF00082	0.177
CLV_PCSK_KEX2_1	99	101	PF00082	0.105
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.155
CLV_PCSK_SKI1_1	153	157	PF00082	0.198
CLV_PCSK_SKI1_1	318	322	PF00082	0.203
CLV_Separin_Metazoa	210	214	PF03568	0.398
DEG_Nend_UBRbox_3	1	3	PF02207	0.569
DOC_CKS1_1	111	116	PF01111	0.398
DOC_CKS1_1	154	159	PF01111	0.398
DOC_MAPK_MEF2A_6	295	304	PF00069	0.492
DOC_PP4_FxxP_1	17	20	PF00568	0.490
DOC_PP4_FxxP_1	24	27	PF00568	0.513
DOC_USP7_MATH_1	161	165	PF00917	0.398
DOC_USP7_MATH_1	32	36	PF00917	0.492
DOC_USP7_MATH_1	67	71	PF00917	0.499
DOC_USP7_UBL2_3	240	244	PF12436	0.429
DOC_WW_Pin1_4	110	115	PF00397	0.398
DOC_WW_Pin1_4	153	158	PF00397	0.406
DOC_WW_Pin1_4	63	68	PF00397	0.425
LIG_14-3-3_CanoR_1	60	65	PF00244	0.381
LIG_14-3-3_CanoR_1	88	98	PF00244	0.489
LIG_Clathr_ClatBox_1	177	181	PF01394	0.398
LIG_EVH1_2	20	24	PF00568	0.500
LIG_FHA_1	133	139	PF00498	0.492
LIG_FHA_1	145	151	PF00498	0.458
LIG_FHA_1	228	234	PF00498	0.458
LIG_FHA_2	143	149	PF00498	0.410
LIG_LIR_Apic_2	16	20	PF02991	0.525
LIG_LIR_Apic_2	26	32	PF02991	0.549
LIG_LIR_Apic_2	63	67	PF02991	0.492
LIG_LIR_Nem_3	156	162	PF02991	0.424
LIG_LIR_Nem_3	303	308	PF02991	0.427
LIG_LIR_Nem_3	46	52	PF02991	0.358
LIG_PDZ_Class_2	353	358	PF00595	0.544
LIG_PTB_Apo_2	277	284	PF02174	0.398
LIG_PTB_Apo_2	48	55	PF02174	0.315
LIG_PTB_Phospho_1	48	54	PF10480	0.315
LIG_SH2_CRK	49	53	PF00017	0.398
LIG_SH2_CRK	64	68	PF00017	0.399
LIG_SH2_PTP2	159	162	PF00017	0.411
LIG_SH2_SRC	159	162	PF00017	0.411
LIG_SH2_STAP1	54	58	PF00017	0.430
LIG_SH2_STAT3	121	124	PF00017	0.415
LIG_SH2_STAT5	130	133	PF00017	0.504
LIG_SH2_STAT5	15	18	PF00017	0.519
LIG_SH2_STAT5	159	162	PF00017	0.415
LIG_SH2_STAT5	41	44	PF00017	0.579
LIG_SH3_3	151	157	PF00018	0.411
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.398
LIG_TRAF2_1	351	354	PF00917	0.493
LIG_UBA3_1	187	194	PF00899	0.398
MOD_CDK_SPK_2	153	158	PF00069	0.412
MOD_CK1_1	39	45	PF00069	0.484
MOD_CK1_1	8	14	PF00069	0.582
MOD_CK2_1	273	279	PF00069	0.477
MOD_CK2_1	336	342	PF00069	0.526
MOD_DYRK1A_RPxSP_1	153	157	PF00069	0.398
MOD_GlcNHglycan	163	166	PF01048	0.198
MOD_GlcNHglycan	43	46	PF01048	0.642
MOD_GSK3_1	120	127	PF00069	0.469
MOD_GSK3_1	32	39	PF00069	0.635
MOD_GSK3_1	63	70	PF00069	0.416
MOD_N-GLC_1	336	341	PF02516	0.399
MOD_N-GLC_1	36	41	PF02516	0.694
MOD_NEK2_1	227	232	PF00069	0.455
MOD_NEK2_1	336	341	PF00069	0.599
MOD_NEK2_1	82	87	PF00069	0.492
MOD_NEK2_2	13	18	PF00069	0.634
MOD_PIKK_1	120	126	PF00454	0.551
MOD_PIKK_1	142	148	PF00454	0.412
MOD_PIKK_1	167	173	PF00454	0.398
MOD_PIKK_1	227	233	PF00454	0.455
MOD_PIKK_1	336	342	PF00454	0.604
MOD_PIKK_1	43	49	PF00454	0.637
MOD_PIKK_1	82	88	PF00454	0.492
MOD_PIKK_1	89	95	PF00454	0.492
MOD_PK_1	94	100	PF00069	0.411
MOD_PKA_2	39	45	PF00069	0.479
MOD_Plk_1	336	342	PF00069	0.614
MOD_Plk_1	36	42	PF00069	0.690
MOD_ProDKin_1	110	116	PF00069	0.398
MOD_ProDKin_1	153	159	PF00069	0.406
MOD_ProDKin_1	63	69	PF00069	0.425
TRG_DiLeu_BaEn_1	207	212	PF01217	0.398
TRG_DiLeu_BaEn_4	207	213	PF01217	0.398
TRG_ENDOCYTIC_2	159	162	PF00928	0.411
TRG_ENDOCYTIC_2	49	52	PF00928	0.398
TRG_ER_diArg_1	56	58	PF00400	0.398
TRG_NLS_Bipartite_1	87	103	PF00514	0.489
TRG_NLS_MonoCore_2	98	103	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.230
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.200

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF18	Leptomonas seymouri	86%	100%
A0A1X0ND20	Trypanosomatidae	66%	100%
A0A3Q8IG75	Leishmania donovani	97%	100%
A0A422NMR1	Trypanosoma rangeli	67%	100%
A4HFH8	Leishmania braziliensis	90%	100%
D0A5Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AHC2	Leishmania infantum	97%	100%
E9AYV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P12759	Chlamydomonas reinhardtii	49%	69%
Q3UFY4	Mus musculus	45%	69%
Q9DA80	Mus musculus	45%	92%
V5D5G2	Trypanosoma cruzi	67%	100%