Putative ATP-binding cassette protein subfamily D,member 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal transporter (GAT3), putative

Species:

Leishmania major

UniProt:

E9AD24_LEIMA

TriTrypDb:

LmjF.27.0470 , LMJLV39_270009700 , LMJSD75_270009700

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0005778	peroxisomal membrane	6	2
GO:0016020	membrane	2	12
GO:0020015	glycosome	7	2
GO:0020022	acidocalcisome	5	2
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AD24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD24

Function

Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	2
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0006810	transport	3	2
GO:0006869	lipid transport	5	2
GO:0006996	organelle organization	4	2
GO:0007031	peroxisome organization	5	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0015908	fatty acid transport	6	2
GO:0015909	long-chain fatty acid transport	7	2
GO:0015910	long-chain fatty acid import into peroxisome	5	2
GO:0015919	peroxisomal membrane transport	5	2
GO:0016042	lipid catabolic process	4	2
GO:0016043	cellular component organization	3	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032365	intracellular lipid transport	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0034440	lipid oxidation	5	2
GO:0042760	very long-chain fatty acid catabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0043574	peroxisomal transport	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2
GO:1902001	fatty acid transmembrane transport	5	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005215	transporter activity	1	12
GO:0005319	lipid transporter activity	2	2
GO:0005324	long-chain fatty acid transporter activity	3	2
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140359	ABC-type transporter activity	3	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.277
CLV_NRD_NRD_1	174	176	PF00675	0.479
CLV_NRD_NRD_1	255	257	PF00675	0.276
CLV_NRD_NRD_1	276	278	PF00675	0.242
CLV_NRD_NRD_1	347	349	PF00675	0.623
CLV_NRD_NRD_1	48	50	PF00675	0.601
CLV_NRD_NRD_1	635	637	PF00675	0.516
CLV_PCSK_KEX2_1	174	176	PF00082	0.476
CLV_PCSK_KEX2_1	255	257	PF00082	0.276
CLV_PCSK_KEX2_1	276	278	PF00082	0.242
CLV_PCSK_KEX2_1	347	349	PF00082	0.623
CLV_PCSK_KEX2_1	48	50	PF00082	0.601
CLV_PCSK_KEX2_1	635	637	PF00082	0.548
CLV_PCSK_PC7_1	44	50	PF00082	0.492
CLV_PCSK_SKI1_1	102	106	PF00082	0.332
CLV_PCSK_SKI1_1	238	242	PF00082	0.421
CLV_PCSK_SKI1_1	276	280	PF00082	0.265
CLV_PCSK_SKI1_1	296	300	PF00082	0.126
CLV_PCSK_SKI1_1	508	512	PF00082	0.463
CLV_PCSK_SKI1_1	597	601	PF00082	0.504
CLV_PCSK_SKI1_1	78	82	PF00082	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.726
DEG_SCF_FBW7_1	518	523	PF00400	0.193
DOC_CDC14_PxL_1	216	224	PF14671	0.315
DOC_CKS1_1	517	522	PF01111	0.301
DOC_MAPK_gen_1	607	615	PF00069	0.295
DOC_MAPK_gen_1	670	677	PF00069	0.472
DOC_MAPK_MEF2A_6	102	109	PF00069	0.358
DOC_MAPK_MEF2A_6	135	144	PF00069	0.549
DOC_MAPK_MEF2A_6	353	362	PF00069	0.341
DOC_MAPK_MEF2A_6	439	446	PF00069	0.358
DOC_PP1_RVXF_1	595	601	PF00149	0.341
DOC_PP2B_LxvP_1	493	496	PF13499	0.275
DOC_PP4_FxxP_1	217	220	PF00568	0.255
DOC_USP7_MATH_1	30	34	PF00917	0.460
DOC_USP7_MATH_1	346	350	PF00917	0.440
DOC_USP7_MATH_1	433	437	PF00917	0.441
DOC_USP7_MATH_1	513	517	PF00917	0.279
DOC_WW_Pin1_4	12	17	PF00397	0.671
DOC_WW_Pin1_4	419	424	PF00397	0.417
DOC_WW_Pin1_4	450	455	PF00397	0.331
DOC_WW_Pin1_4	509	514	PF00397	0.338
DOC_WW_Pin1_4	516	521	PF00397	0.325
DOC_WW_Pin1_4	535	540	PF00397	0.370
DOC_WW_Pin1_4	608	613	PF00397	0.295
LIG_14-3-3_CanoR_1	167	173	PF00244	0.310
LIG_14-3-3_CanoR_1	3	11	PF00244	0.562
LIG_14-3-3_CanoR_1	347	355	PF00244	0.436
LIG_14-3-3_CanoR_1	592	596	PF00244	0.263
LIG_Actin_WH2_2	224	240	PF00022	0.333
LIG_Actin_WH2_2	295	312	PF00022	0.562
LIG_Actin_WH2_2	385	402	PF00022	0.349
LIG_BRCT_BRCA1_1	168	172	PF00533	0.279
LIG_BRCT_BRCA1_1	32	36	PF00533	0.404
LIG_BRCT_BRCA1_1	505	509	PF00533	0.297
LIG_BRCT_BRCA1_1	91	95	PF00533	0.392
LIG_Clathr_ClatBox_1	443	447	PF01394	0.356
LIG_CSL_BTD_1	493	496	PF09270	0.279
LIG_eIF4E_1	359	365	PF01652	0.395
LIG_FHA_1	246	252	PF00498	0.461
LIG_FHA_1	278	284	PF00498	0.479
LIG_FHA_1	30	36	PF00498	0.406
LIG_FHA_1	482	488	PF00498	0.266
LIG_FHA_1	536	542	PF00498	0.341
LIG_FHA_1	64	70	PF00498	0.446
LIG_FHA_1	653	659	PF00498	0.296
LIG_FHA_2	184	190	PF00498	0.261
LIG_FHA_2	408	414	PF00498	0.472
LIG_FHA_2	521	527	PF00498	0.255
LIG_FHA_2	57	63	PF00498	0.423
LIG_FHA_2	624	630	PF00498	0.381
LIG_FHA_2	643	649	PF00498	0.181
LIG_GBD_Chelix_1	140	148	PF00786	0.436
LIG_IRF3_LxIS_1	298	305	PF10401	0.504
LIG_LIR_Apic_2	516	520	PF02991	0.246
LIG_LIR_Gen_1	322	330	PF02991	0.491
LIG_LIR_Gen_1	33	41	PF02991	0.298
LIG_LIR_Gen_1	331	341	PF02991	0.352
LIG_LIR_Gen_1	413	424	PF02991	0.508
LIG_LIR_Gen_1	470	478	PF02991	0.261
LIG_LIR_Gen_1	523	533	PF02991	0.311
LIG_LIR_Gen_1	68	77	PF02991	0.333
LIG_LIR_Gen_1	92	103	PF02991	0.308
LIG_LIR_Nem_3	212	218	PF02991	0.251
LIG_LIR_Nem_3	327	333	PF02991	0.490
LIG_LIR_Nem_3	33	39	PF02991	0.286
LIG_LIR_Nem_3	413	419	PF02991	0.512
LIG_LIR_Nem_3	470	476	PF02991	0.261
LIG_LIR_Nem_3	523	528	PF02991	0.311
LIG_LIR_Nem_3	579	585	PF02991	0.255
LIG_LIR_Nem_3	66	70	PF02991	0.341
LIG_LIR_Nem_3	9	14	PF02991	0.681
LIG_LIR_Nem_3	92	98	PF02991	0.310
LIG_PCNA_yPIPBox_3	369	380	PF02747	0.362
LIG_Pex14_2	172	176	PF04695	0.279
LIG_Pex14_2	375	379	PF04695	0.348
LIG_Pex14_2	95	99	PF04695	0.307
LIG_SH2_CRK	177	181	PF00017	0.294
LIG_SH2_CRK	19	23	PF00017	0.670
LIG_SH2_CRK	416	420	PF00017	0.465
LIG_SH2_CRK	517	521	PF00017	0.279
LIG_SH2_CRK	70	74	PF00017	0.255
LIG_SH2_GRB2like	282	285	PF00017	0.536
LIG_SH2_SRC	359	362	PF00017	0.378
LIG_SH2_STAP1	564	568	PF00017	0.360
LIG_SH2_STAT5	202	205	PF00017	0.261
LIG_SH2_STAT5	216	219	PF00017	0.234
LIG_SH2_STAT5	282	285	PF00017	0.511
LIG_SH2_STAT5	297	300	PF00017	0.396
LIG_SH2_STAT5	359	362	PF00017	0.328
LIG_SH2_STAT5	426	429	PF00017	0.392
LIG_SH2_STAT5	46	49	PF00017	0.413
LIG_SH3_3	417	423	PF00018	0.474
LIG_SH3_3	531	537	PF00018	0.278
LIG_SH3_3	668	674	PF00018	0.459
LIG_SUMO_SIM_anti_2	610	618	PF11976	0.293
LIG_SUMO_SIM_par_1	37	42	PF11976	0.414
LIG_SUMO_SIM_par_1	610	618	PF11976	0.263
LIG_SUMO_SIM_par_1	640	645	PF11976	0.307
LIG_TRFH_1	509	513	PF08558	0.341
LIG_TYR_ITIM	213	218	PF00017	0.255
LIG_TYR_ITSM	521	528	PF00017	0.341
LIG_UBA3_1	364	373	PF00899	0.392
LIG_UBA3_1	489	497	PF00899	0.341
LIG_UBA3_1	657	665	PF00899	0.426
LIG_UBA3_1	94	102	PF00899	0.350
LIG_WRC_WIRS_1	330	335	PF05994	0.374
MOD_CDK_SPxxK_3	535	542	PF00069	0.304
MOD_CK1_1	245	251	PF00069	0.376
MOD_CK1_1	328	334	PF00069	0.369
MOD_CK1_1	383	389	PF00069	0.310
MOD_CK1_1	502	508	PF00069	0.360
MOD_CK1_1	516	522	PF00069	0.367
MOD_CK1_1	583	589	PF00069	0.269
MOD_CK1_1	89	95	PF00069	0.376
MOD_CK2_1	3	9	PF00069	0.562
MOD_CK2_1	520	526	PF00069	0.255
MOD_GlcNHglycan	238	241	PF01048	0.364
MOD_GlcNHglycan	32	35	PF01048	0.323
MOD_GlcNHglycan	327	330	PF01048	0.283
MOD_GlcNHglycan	497	500	PF01048	0.513
MOD_GlcNHglycan	54	57	PF01048	0.620
MOD_GlcNHglycan	565	568	PF01048	0.550
MOD_GlcNHglycan	585	588	PF01048	0.451
MOD_GlcNHglycan	88	91	PF01048	0.536
MOD_GSK3_1	142	149	PF00069	0.330
MOD_GSK3_1	194	201	PF00069	0.249
MOD_GSK3_1	241	248	PF00069	0.407
MOD_GSK3_1	263	270	PF00069	0.498
MOD_GSK3_1	325	332	PF00069	0.509
MOD_GSK3_1	383	390	PF00069	0.310
MOD_GSK3_1	403	410	PF00069	0.384
MOD_GSK3_1	411	418	PF00069	0.484
MOD_GSK3_1	424	431	PF00069	0.474
MOD_GSK3_1	495	502	PF00069	0.318
MOD_GSK3_1	509	516	PF00069	0.266
MOD_GSK3_1	52	59	PF00069	0.469
MOD_GSK3_1	576	583	PF00069	0.271
MOD_LATS_1	409	415	PF00433	0.466
MOD_N-GLC_1	368	373	PF02516	0.527
MOD_N-GLC_2	479	481	PF02516	0.479
MOD_NEK2_1	168	173	PF00069	0.332
MOD_NEK2_1	241	246	PF00069	0.423
MOD_NEK2_1	302	307	PF00069	0.541
MOD_NEK2_1	325	330	PF00069	0.444
MOD_NEK2_1	368	373	PF00069	0.326
MOD_NEK2_1	395	400	PF00069	0.322
MOD_NEK2_1	407	412	PF00069	0.411
MOD_NEK2_1	424	429	PF00069	0.476
MOD_NEK2_1	571	576	PF00069	0.326
MOD_NEK2_2	520	525	PF00069	0.315
MOD_PIKK_1	263	269	PF00454	0.541
MOD_PIKK_1	39	45	PF00454	0.521
MOD_PIKK_1	424	430	PF00454	0.479
MOD_PIKK_1	499	505	PF00454	0.360
MOD_PIKK_1	60	66	PF00454	0.486
MOD_PK_1	10	16	PF00069	0.662
MOD_PK_1	640	646	PF00069	0.305
MOD_PKA_2	166	172	PF00069	0.255
MOD_PKA_2	346	352	PF00069	0.468
MOD_PKA_2	591	597	PF00069	0.279
MOD_PKA_2	86	92	PF00069	0.371
MOD_PKB_1	165	173	PF00069	0.304
MOD_Plk_1	302	308	PF00069	0.541
MOD_Plk_1	368	374	PF00069	0.313
MOD_Plk_1	380	386	PF00069	0.276
MOD_Plk_1	395	401	PF00069	0.315
MOD_Plk_1	503	509	PF00069	0.268
MOD_Plk_1	576	582	PF00069	0.266
MOD_Plk_1	60	66	PF00069	0.433
MOD_Plk_1	617	623	PF00069	0.255
MOD_Plk_2-3	466	472	PF00069	0.313
MOD_Plk_2-3	618	624	PF00069	0.350
MOD_Plk_4	183	189	PF00069	0.277
MOD_Plk_4	329	335	PF00069	0.326
MOD_Plk_4	403	409	PF00069	0.397
MOD_Plk_4	482	488	PF00069	0.255
MOD_Plk_4	513	519	PF00069	0.250
MOD_Plk_4	520	526	PF00069	0.252
MOD_Plk_4	553	559	PF00069	0.263
MOD_Plk_4	618	624	PF00069	0.350
MOD_Plk_4	89	95	PF00069	0.371
MOD_ProDKin_1	12	18	PF00069	0.670
MOD_ProDKin_1	419	425	PF00069	0.408
MOD_ProDKin_1	450	456	PF00069	0.335
MOD_ProDKin_1	509	515	PF00069	0.338
MOD_ProDKin_1	516	522	PF00069	0.325
MOD_ProDKin_1	535	541	PF00069	0.370
MOD_ProDKin_1	608	614	PF00069	0.295
MOD_SUMO_for_1	444	447	PF00179	0.376
MOD_SUMO_rev_2	431	441	PF00179	0.367
TRG_ENDOCYTIC_2	177	180	PF00928	0.262
TRG_ENDOCYTIC_2	215	218	PF00928	0.255
TRG_ENDOCYTIC_2	275	278	PF00928	0.465
TRG_ENDOCYTIC_2	359	362	PF00928	0.338
TRG_ENDOCYTIC_2	416	419	PF00928	0.522
TRG_ENDOCYTIC_2	426	429	PF00928	0.392
TRG_ENDOCYTIC_2	525	528	PF00928	0.310
TRG_ENDOCYTIC_2	70	73	PF00928	0.279
TRG_ER_diArg_1	174	176	PF00400	0.272
TRG_ER_diArg_1	254	256	PF00400	0.476
TRG_ER_diArg_1	275	277	PF00400	0.442
TRG_ER_diArg_1	47	49	PF00400	0.402
TRG_ER_diArg_1	634	636	PF00400	0.341
TRG_ER_diArg_1	84	87	PF00400	0.341
TRG_ER_FFAT_2	512	523	PF00635	0.193
TRG_NES_CRM1_1	324	339	PF08389	0.541
TRG_NES_CRM1_1	366	381	PF08389	0.328
TRG_NES_CRM1_1	540	555	PF08389	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W7	Leptomonas seymouri	72%	100%
A0A0S4JRH8	Bodo saltans	38%	91%
A0A1X0P3R6	Trypanosomatidae	22%	100%
A0A1X0P474	Trypanosomatidae	52%	100%
A0A3Q8ICD7	Leishmania donovani	23%	82%
A0A3Q8ICJ2	Leishmania donovani	93%	100%
A0A3R7KWF0	Trypanosoma rangeli	22%	100%
A0A3S7X6Y1	Leishmania donovani	21%	100%
A0A422NTH3	Trypanosoma rangeli	51%	100%
A4HFH3	Leishmania braziliensis	81%	100%
A4HJ32	Leishmania braziliensis	22%	82%
A4HLP7	Leishmania braziliensis	21%	100%
A4I2N3	Leishmania infantum	93%	100%
A4I6L1	Leishmania infantum	23%	82%
A4I948	Leishmania infantum	21%	100%
C9ZN63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
D0A5P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A6C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D3ZHR2	Rattus norvegicus	24%	93%
E9AYU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B1K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	84%
E9B2Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	94%
F1RBC8	Danio rerio	22%	90%
O14678	Homo sapiens	23%	100%
O89016	Mus musculus	21%	100%
P16970	Rattus norvegicus	25%	100%
P28288	Homo sapiens	25%	100%
P33897	Homo sapiens	24%	92%
P34230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	81%
P41909	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	79%
P48410	Mus musculus	24%	93%
P55096	Mus musculus	26%	100%
Q4Q402	Leishmania major	21%	100%
Q55774	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
Q61285	Mus musculus	23%	93%
Q6NLC1	Arabidopsis thaliana	24%	97%
Q7JUN3	Drosophila melanogaster	24%	94%
Q8T8P3	Dictyostelium discoideum	22%	93%
Q9BHG2	Leishmania major	23%	82%
Q9QY44	Rattus norvegicus	24%	93%
Q9UBJ2	Homo sapiens	24%	93%
V5BXE1	Trypanosoma cruzi	49%	100%