Vasohibin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Vasohibin

Gene product:

Vasohibin, putative

Species:

Leishmania major

UniProt:

E9AD23_LEIMA

TriTrypDb:

LmjF.27.0460 , LMJLV39_270009600 , LMJSD75_270009600

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AD23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD23

Function

Biological processes
Term	Name	Level	Count
GO:0022603	regulation of anatomical structure morphogenesis	4	7
GO:0045765	regulation of angiogenesis	5	7
GO:0050789	regulation of biological process	2	7
GO:0050793	regulation of developmental process	3	7
GO:0051239	regulation of multicellular organismal process	3	7
GO:0065007	biological regulation	1	7
GO:1901342	regulation of vasculature development	5	7
GO:2000026	regulation of multicellular organismal development	4	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.755
CLV_NRD_NRD_1	147	149	PF00675	0.346
CLV_NRD_NRD_1	240	242	PF00675	0.672
CLV_NRD_NRD_1	320	322	PF00675	0.586
CLV_NRD_NRD_1	400	402	PF00675	0.508
CLV_NRD_NRD_1	449	451	PF00675	0.673
CLV_NRD_NRD_1	588	590	PF00675	0.806
CLV_PCSK_KEX2_1	170	172	PF00082	0.380
CLV_PCSK_KEX2_1	400	402	PF00082	0.508
CLV_PCSK_KEX2_1	417	419	PF00082	0.566
CLV_PCSK_KEX2_1	429	431	PF00082	0.683
CLV_PCSK_KEX2_1	449	451	PF00082	0.760
CLV_PCSK_KEX2_1	454	456	PF00082	0.786
CLV_PCSK_KEX2_1	470	472	PF00082	0.704
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.252
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.668
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.586
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.788
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.704
CLV_PCSK_PC7_1	450	456	PF00082	0.603
CLV_PCSK_SKI1_1	218	222	PF00082	0.788
CLV_PCSK_SKI1_1	287	291	PF00082	0.714
CLV_PCSK_SKI1_1	378	382	PF00082	0.511
CLV_PCSK_SKI1_1	423	427	PF00082	0.636
CLV_PCSK_SKI1_1	62	66	PF00082	0.318
CLV_PCSK_SKI1_1	81	85	PF00082	0.212
DEG_APCC_DBOX_1	454	462	PF00400	0.558
DEG_SPOP_SBC_1	334	338	PF00917	0.711
DOC_CKS1_1	580	585	PF01111	0.699
DOC_CKS1_1	609	614	PF01111	0.784
DOC_CYCLIN_RxL_1	212	226	PF00134	0.683
DOC_MAPK_DCC_7	470	478	PF00069	0.581
DOC_MAPK_gen_1	378	387	PF00069	0.498
DOC_MAPK_gen_1	449	460	PF00069	0.778
DOC_MAPK_gen_1	470	478	PF00069	0.593
DOC_MAPK_gen_1	69	78	PF00069	0.619
DOC_MAPK_MEF2A_6	107	116	PF00069	0.530
DOC_MAPK_MEF2A_6	470	478	PF00069	0.589
DOC_PP1_RVXF_1	379	385	PF00149	0.602
DOC_PP2B_LxvP_1	425	428	PF13499	0.734
DOC_PP2B_LxvP_1	490	493	PF13499	0.722
DOC_PP4_FxxP_1	576	579	PF00568	0.804
DOC_PP4_FxxP_1	609	612	PF00568	0.662
DOC_USP7_MATH_1	158	162	PF00917	0.619
DOC_USP7_MATH_1	248	252	PF00917	0.802
DOC_USP7_MATH_1	28	32	PF00917	0.546
DOC_USP7_MATH_1	294	298	PF00917	0.710
DOC_USP7_MATH_1	323	327	PF00917	0.730
DOC_USP7_MATH_1	438	442	PF00917	0.704
DOC_USP7_MATH_1	472	476	PF00917	0.666
DOC_USP7_MATH_1	498	502	PF00917	0.692
DOC_USP7_MATH_1	549	553	PF00917	0.770
DOC_WW_Pin1_4	229	234	PF00397	0.700
DOC_WW_Pin1_4	263	268	PF00397	0.712
DOC_WW_Pin1_4	316	321	PF00397	0.710
DOC_WW_Pin1_4	325	330	PF00397	0.749
DOC_WW_Pin1_4	407	412	PF00397	0.511
DOC_WW_Pin1_4	545	550	PF00397	0.730
DOC_WW_Pin1_4	559	564	PF00397	0.646
DOC_WW_Pin1_4	579	584	PF00397	0.699
DOC_WW_Pin1_4	608	613	PF00397	0.791
DOC_WW_Pin1_4	619	624	PF00397	0.635
LIG_14-3-3_CanoR_1	111	117	PF00244	0.538
LIG_14-3-3_CanoR_1	133	138	PF00244	0.604
LIG_14-3-3_CanoR_1	241	247	PF00244	0.611
LIG_14-3-3_CanoR_1	321	331	PF00244	0.601
LIG_14-3-3_CanoR_1	512	517	PF00244	0.610
LIG_14-3-3_CanoR_1	589	599	PF00244	0.814
LIG_14-3-3_CanoR_1	600	609	PF00244	0.619
LIG_14-3-3_CanoR_1	62	68	PF00244	0.511
LIG_Actin_WH2_2	93	109	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BIR_III_2	565	569	PF00653	0.746
LIG_BRCT_BRCA1_1	304	308	PF00533	0.727
LIG_BRCT_BRCA1_1	605	609	PF00533	0.686
LIG_BRCT_BRCA1_1	74	78	PF00533	0.619
LIG_deltaCOP1_diTrp_1	198	203	PF00928	0.546
LIG_DLG_GKlike_1	512	519	PF00625	0.571
LIG_EH_1	15	19	PF12763	0.411
LIG_eIF4E_1	125	131	PF01652	0.546
LIG_EVH1_1	24	28	PF00568	0.619
LIG_FHA_1	101	107	PF00498	0.513
LIG_FHA_1	322	328	PF00498	0.718
LIG_FHA_2	103	109	PF00498	0.619
LIG_FHA_2	188	194	PF00498	0.546
LIG_FHA_2	359	365	PF00498	0.587
LIG_FHA_2	77	83	PF00498	0.516
LIG_GBD_Chelix_1	348	356	PF00786	0.574
LIG_LIR_Apic_2	573	579	PF02991	0.711
LIG_LIR_Apic_2	606	612	PF02991	0.668
LIG_LIR_Gen_1	161	169	PF02991	0.546
LIG_LIR_Gen_1	172	181	PF02991	0.501
LIG_LIR_Gen_1	353	362	PF02991	0.476
LIG_LIR_Gen_1	56	65	PF02991	0.546
LIG_LIR_Gen_1	94	102	PF02991	0.529
LIG_LIR_Nem_3	151	157	PF02991	0.526
LIG_LIR_Nem_3	161	166	PF02991	0.546
LIG_LIR_Nem_3	172	176	PF02991	0.501
LIG_LIR_Nem_3	198	204	PF02991	0.536
LIG_LIR_Nem_3	305	311	PF02991	0.721
LIG_LIR_Nem_3	343	348	PF02991	0.524
LIG_LIR_Nem_3	353	358	PF02991	0.475
LIG_LIR_Nem_3	364	370	PF02991	0.507
LIG_LIR_Nem_3	56	60	PF02991	0.546
LIG_LIR_Nem_3	63	67	PF02991	0.546
LIG_LIR_Nem_3	94	100	PF02991	0.529
LIG_MYND_1	263	267	PF01753	0.735
LIG_MYND_1	579	583	PF01753	0.697
LIG_NRBOX	515	521	PF00104	0.571
LIG_NRP_CendR_1	624	625	PF00754	0.706
LIG_Pex14_2	609	613	PF04695	0.711
LIG_PTB_Apo_2	246	253	PF02174	0.739
LIG_Rb_LxCxE_1	86	108	PF01857	0.546
LIG_SH2_CRK	141	145	PF00017	0.546
LIG_SH2_CRK	154	158	PF00017	0.546
LIG_SH2_CRK	159	163	PF00017	0.546
LIG_SH2_CRK	345	349	PF00017	0.546
LIG_SH2_CRK	355	359	PF00017	0.409
LIG_SH2_CRK	367	371	PF00017	0.522
LIG_SH2_SRC	595	598	PF00017	0.738
LIG_SH2_STAP1	102	106	PF00017	0.619
LIG_SH2_STAP1	304	308	PF00017	0.727
LIG_SH2_STAT3	304	307	PF00017	0.571
LIG_SH2_STAT5	102	105	PF00017	0.619
LIG_SH3_3	22	28	PF00018	0.552
LIG_SH3_3	227	233	PF00018	0.631
LIG_SH3_3	261	267	PF00018	0.763
LIG_SH3_3	317	323	PF00018	0.700
LIG_SH3_3	477	483	PF00018	0.737
LIG_SH3_3	526	532	PF00018	0.672
LIG_SH3_3	577	583	PF00018	0.718
LIG_SUMO_SIM_par_1	128	134	PF11976	0.546
LIG_SUMO_SIM_par_1	2	10	PF11976	0.522
LIG_TYR_ITIM	152	157	PF00017	0.588
LIG_TYR_ITIM	55	60	PF00017	0.546
LIG_UBA3_1	180	184	PF00899	0.619
LIG_WW_3	26	30	PF00397	0.546
LIG_WW_3	268	272	PF00397	0.729
MOD_CDC14_SPxK_1	319	322	PF00782	0.624
MOD_CDC14_SPxK_1	622	625	PF00782	0.768
MOD_CDK_SPK_2	229	234	PF00069	0.662
MOD_CDK_SPK_2	316	321	PF00069	0.615
MOD_CDK_SPK_2	579	584	PF00069	0.699
MOD_CDK_SPK_2	619	624	PF00069	0.696
MOD_CDK_SPxK_1	316	322	PF00069	0.626
MOD_CDK_SPxK_1	619	625	PF00069	0.776
MOD_CK1_1	115	121	PF00069	0.546
MOD_CK1_1	232	238	PF00069	0.704
MOD_CK1_1	251	257	PF00069	0.716
MOD_CK1_1	316	322	PF00069	0.710
MOD_CK1_1	325	331	PF00069	0.749
MOD_CK1_1	410	416	PF00069	0.509
MOD_CK1_1	441	447	PF00069	0.583
MOD_CK1_1	496	502	PF00069	0.740
MOD_CK1_1	507	513	PF00069	0.679
MOD_CK1_1	524	530	PF00069	0.703
MOD_CK1_1	53	59	PF00069	0.626
MOD_CK1_1	545	551	PF00069	0.721
MOD_CK1_1	598	604	PF00069	0.722
MOD_CK1_1	72	78	PF00069	0.404
MOD_CK2_1	187	193	PF00069	0.546
MOD_CK2_1	220	226	PF00069	0.736
MOD_CK2_1	292	298	PF00069	0.790
MOD_CK2_1	358	364	PF00069	0.582
MOD_CK2_1	391	397	PF00069	0.649
MOD_CK2_1	567	573	PF00069	0.718
MOD_CK2_1	590	596	PF00069	0.821
MOD_CK2_1	76	82	PF00069	0.516
MOD_Cter_Amidation	447	450	PF01082	0.589
MOD_Cter_Amidation	468	471	PF01082	0.683
MOD_GlcNHglycan	135	138	PF01048	0.252
MOD_GlcNHglycan	243	246	PF01048	0.583
MOD_GlcNHglycan	273	277	PF01048	0.737
MOD_GlcNHglycan	286	290	PF01048	0.649
MOD_GlcNHglycan	393	396	PF01048	0.646
MOD_GlcNHglycan	40	43	PF01048	0.391
MOD_GlcNHglycan	412	415	PF01048	0.380
MOD_GlcNHglycan	438	441	PF01048	0.762
MOD_GlcNHglycan	443	446	PF01048	0.670
MOD_GlcNHglycan	498	501	PF01048	0.746
MOD_GlcNHglycan	506	509	PF01048	0.799
MOD_GlcNHglycan	516	519	PF01048	0.600
MOD_GlcNHglycan	545	548	PF01048	0.777
MOD_GlcNHglycan	603	606	PF01048	0.719
MOD_GSK3_1	144	151	PF00069	0.546
MOD_GSK3_1	212	219	PF00069	0.746
MOD_GSK3_1	228	235	PF00069	0.740
MOD_GSK3_1	248	255	PF00069	0.485
MOD_GSK3_1	281	288	PF00069	0.672
MOD_GSK3_1	292	299	PF00069	0.748
MOD_GSK3_1	309	316	PF00069	0.631
MOD_GSK3_1	321	328	PF00069	0.764
MOD_GSK3_1	329	336	PF00069	0.494
MOD_GSK3_1	436	443	PF00069	0.691
MOD_GSK3_1	498	505	PF00069	0.604
MOD_GSK3_1	514	521	PF00069	0.532
MOD_GSK3_1	545	552	PF00069	0.731
MOD_GSK3_1	554	561	PF00069	0.745
MOD_GSK3_1	595	602	PF00069	0.723
MOD_GSK3_1	603	610	PF00069	0.676
MOD_GSK3_1	72	79	PF00069	0.507
MOD_LATS_1	210	216	PF00433	0.452
MOD_LATS_1	239	245	PF00433	0.634
MOD_N-GLC_1	248	253	PF02516	0.816
MOD_N-GLC_1	421	426	PF02516	0.532
MOD_N-GLC_1	436	441	PF02516	0.732
MOD_NEK2_1	100	105	PF00069	0.521
MOD_NEK2_1	144	149	PF00069	0.543
MOD_NEK2_1	220	225	PF00069	0.694
MOD_NEK2_1	252	257	PF00069	0.742
MOD_NEK2_1	285	290	PF00069	0.789
MOD_NEK2_1	502	507	PF00069	0.644
MOD_NEK2_1	599	604	PF00069	0.793
MOD_NEK2_1	93	98	PF00069	0.546
MOD_NEK2_2	102	107	PF00069	0.619
MOD_NEK2_2	158	163	PF00069	0.619
MOD_NEK2_2	421	426	PF00069	0.473
MOD_PIKK_1	10	16	PF00454	0.537
MOD_PIKK_1	100	106	PF00454	0.546
MOD_PK_1	50	56	PF00069	0.619
MOD_PKA_1	148	154	PF00069	0.546
MOD_PKA_1	241	247	PF00069	0.689
MOD_PKA_1	321	327	PF00069	0.597
MOD_PKA_1	449	455	PF00069	0.751
MOD_PKA_2	240	246	PF00069	0.612
MOD_PKA_2	28	34	PF00069	0.546
MOD_PKA_2	38	44	PF00069	0.546
MOD_PKA_2	391	397	PF00069	0.572
MOD_PKA_2	449	455	PF00069	0.751
MOD_PKA_2	599	605	PF00069	0.761
MOD_Plk_1	192	198	PF00069	0.546
MOD_Plk_1	216	222	PF00069	0.713
MOD_Plk_1	248	254	PF00069	0.739
MOD_Plk_1	281	287	PF00069	0.619
MOD_Plk_1	314	320	PF00069	0.703
MOD_Plk_1	421	427	PF00069	0.479
MOD_Plk_1	493	499	PF00069	0.702
MOD_Plk_1	93	99	PF00069	0.543
MOD_Plk_2-3	567	573	PF00069	0.703
MOD_Plk_4	148	154	PF00069	0.589
MOD_Plk_4	158	164	PF00069	0.546
MOD_Plk_4	486	492	PF00069	0.733
MOD_Plk_4	72	78	PF00069	0.526
MOD_Plk_4	93	99	PF00069	0.546
MOD_ProDKin_1	229	235	PF00069	0.698
MOD_ProDKin_1	263	269	PF00069	0.709
MOD_ProDKin_1	316	322	PF00069	0.710
MOD_ProDKin_1	325	331	PF00069	0.749
MOD_ProDKin_1	407	413	PF00069	0.510
MOD_ProDKin_1	545	551	PF00069	0.730
MOD_ProDKin_1	559	565	PF00069	0.648
MOD_ProDKin_1	579	585	PF00069	0.699
MOD_ProDKin_1	608	614	PF00069	0.789
MOD_ProDKin_1	619	625	PF00069	0.637
MOD_SUMO_for_1	116	119	PF00179	0.546
MOD_SUMO_rev_2	179	185	PF00179	0.619
MOD_SUMO_rev_2	410	419	PF00179	0.628
MOD_SUMO_rev_2	463	472	PF00179	0.670
MOD_SUMO_rev_2	587	592	PF00179	0.578
TRG_DiLeu_BaEn_2	42	48	PF01217	0.619
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.466
TRG_ENDOCYTIC_2	125	128	PF00928	0.533
TRG_ENDOCYTIC_2	141	144	PF00928	0.443
TRG_ENDOCYTIC_2	154	157	PF00928	0.504
TRG_ENDOCYTIC_2	159	162	PF00928	0.504
TRG_ENDOCYTIC_2	173	176	PF00928	0.522
TRG_ENDOCYTIC_2	345	348	PF00928	0.502
TRG_ENDOCYTIC_2	355	358	PF00928	0.473
TRG_ENDOCYTIC_2	367	370	PF00928	0.514
TRG_ENDOCYTIC_2	57	60	PF00928	0.546
TRG_ER_diArg_1	132	135	PF00400	0.546
TRG_ER_diArg_1	194	197	PF00400	0.452
TRG_ER_diArg_1	400	402	PF00400	0.508
TRG_ER_diArg_1	623	625	PF00400	0.687
TRG_NLS_Bipartite_1	417	433	PF00514	0.490
TRG_NLS_MonoExtN_4	426	433	PF00514	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY3	Leptomonas seymouri	48%	94%
A0A3Q8IE45	Leishmania donovani	87%	100%
A4HFH0	Leishmania braziliensis	72%	99%
A4I2N2	Leishmania infantum	87%	100%
E9AYU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%