Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD21_LEIMA

TriTrypDb:

LmjF.27.0440 , LMJLV39_270009400 , LMJSD75_270009400

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.477
CLV_C14_Caspase3-7	523	527	PF00656	0.444
CLV_NRD_NRD_1	141	143	PF00675	0.582
CLV_NRD_NRD_1	169	171	PF00675	0.636
CLV_NRD_NRD_1	324	326	PF00675	0.593
CLV_NRD_NRD_1	546	548	PF00675	0.510
CLV_PCSK_KEX2_1	128	130	PF00082	0.526
CLV_PCSK_KEX2_1	141	143	PF00082	0.546
CLV_PCSK_KEX2_1	171	173	PF00082	0.637
CLV_PCSK_KEX2_1	223	225	PF00082	0.496
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.526
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.658
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.496
CLV_PCSK_SKI1_1	142	146	PF00082	0.424
CLV_PCSK_SKI1_1	253	257	PF00082	0.533
CLV_PCSK_SKI1_1	376	380	PF00082	0.424
CLV_PCSK_SKI1_1	38	42	PF00082	0.374
CLV_PCSK_SKI1_1	399	403	PF00082	0.397
CLV_PCSK_SKI1_1	445	449	PF00082	0.481
CLV_PCSK_SKI1_1	49	53	PF00082	0.373
CLV_PCSK_SKI1_1	535	539	PF00082	0.432
CLV_PCSK_SKI1_1	78	82	PF00082	0.402
DEG_APCC_DBOX_1	312	320	PF00400	0.391
DOC_CKS1_1	379	384	PF01111	0.327
DOC_CYCLIN_RxL_1	249	257	PF00134	0.460
DOC_CYCLIN_RxL_1	370	381	PF00134	0.447
DOC_MAPK_gen_1	128	135	PF00069	0.381
DOC_MAPK_gen_1	33	43	PF00069	0.435
DOC_MAPK_MEF2A_6	313	320	PF00069	0.392
DOC_PP1_RVXF_1	76	83	PF00149	0.425
DOC_PP1_SILK_1	137	142	PF00149	0.380
DOC_PP2B_LxvP_1	12	15	PF13499	0.434
DOC_PP4_FxxP_1	379	382	PF00568	0.300
DOC_USP7_MATH_1	101	105	PF00917	0.473
DOC_USP7_MATH_1	192	196	PF00917	0.580
DOC_USP7_MATH_1	293	297	PF00917	0.426
DOC_USP7_MATH_1	343	347	PF00917	0.567
DOC_USP7_UBL2_3	535	539	PF12436	0.386
DOC_WW_Pin1_4	217	222	PF00397	0.517
DOC_WW_Pin1_4	232	237	PF00397	0.652
DOC_WW_Pin1_4	318	323	PF00397	0.346
DOC_WW_Pin1_4	364	369	PF00397	0.513
DOC_WW_Pin1_4	378	383	PF00397	0.289
DOC_WW_Pin1_4	505	510	PF00397	0.413
LIG_14-3-3_CanoR_1	399	408	PF00244	0.508
LIG_14-3-3_CanoR_1	499	509	PF00244	0.444
LIG_Actin_WH2_2	287	305	PF00022	0.485
LIG_APCC_ABBA_1	41	46	PF00400	0.414
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BRCT_BRCA1_1	320	324	PF00533	0.410
LIG_BRCT_BRCA1_1	425	429	PF00533	0.524
LIG_BRCT_BRCA1_2	320	326	PF00533	0.377
LIG_Clathr_ClatBox_1	185	189	PF01394	0.585
LIG_CtBP_PxDLS_1	15	19	PF00389	0.479
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.345
LIG_EH_1	414	418	PF12763	0.349
LIG_EH1_1	206	214	PF00400	0.488
LIG_FHA_1	217	223	PF00498	0.427
LIG_FHA_1	379	385	PF00498	0.448
LIG_FHA_1	400	406	PF00498	0.381
LIG_FHA_2	153	159	PF00498	0.608
LIG_FHA_2	329	335	PF00498	0.375
LIG_FHA_2	392	398	PF00498	0.498
LIG_LIR_Gen_1	264	272	PF02991	0.410
LIG_LIR_Gen_1	84	94	PF02991	0.465
LIG_LIR_Nem_3	264	268	PF02991	0.458
LIG_LIR_Nem_3	321	327	PF02991	0.385
LIG_LIR_Nem_3	411	417	PF02991	0.456
LIG_LIR_Nem_3	472	477	PF02991	0.550
LIG_LIR_Nem_3	84	90	PF02991	0.343
LIG_MYND_1	11	15	PF01753	0.505
LIG_MYND_1	147	151	PF01753	0.546
LIG_NBox_RRM_1	497	507	PF00076	0.409
LIG_NRBOX	224	230	PF00104	0.503
LIG_NRBOX	315	321	PF00104	0.432
LIG_SH2_CRK	265	269	PF00017	0.484
LIG_SH2_SRC	93	96	PF00017	0.426
LIG_SH2_STAP1	530	534	PF00017	0.407
LIG_SH2_STAP1	93	97	PF00017	0.434
LIG_SH2_STAT3	164	167	PF00017	0.560
LIG_SH2_STAT5	435	438	PF00017	0.558
LIG_SH3_3	356	362	PF00018	0.515
LIG_SUMO_SIM_par_1	10	17	PF11976	0.605
LIG_SUMO_SIM_par_1	224	230	PF11976	0.557
LIG_TRAF2_1	45	48	PF00917	0.416
LIG_TYR_ITIM	528	533	PF00017	0.314
LIG_WRC_WIRS_1	327	332	PF05994	0.384
MOD_CDK_SPK_2	318	323	PF00069	0.346
MOD_CDK_SPxK_1	217	223	PF00069	0.412
MOD_CDK_SPxK_1	364	370	PF00069	0.460
MOD_CDK_SPxxK_3	217	224	PF00069	0.514
MOD_CDK_SPxxK_3	318	325	PF00069	0.357
MOD_CDK_SPxxK_3	505	512	PF00069	0.413
MOD_CK1_1	2	8	PF00069	0.534
MOD_CK1_1	243	249	PF00069	0.548
MOD_CK1_1	296	302	PF00069	0.430
MOD_CK1_1	423	429	PF00069	0.497
MOD_CK1_1	464	470	PF00069	0.659
MOD_CK1_1	476	482	PF00069	0.584
MOD_CK1_1	508	514	PF00069	0.521
MOD_CK2_1	152	158	PF00069	0.520
MOD_CK2_1	227	233	PF00069	0.558
MOD_CK2_1	328	334	PF00069	0.367
MOD_CK2_1	343	349	PF00069	0.561
MOD_CK2_1	391	397	PF00069	0.502
MOD_CK2_1	42	48	PF00069	0.411
MOD_Cter_Amidation	545	548	PF01082	0.482
MOD_GlcNHglycan	23	26	PF01048	0.546
MOD_GlcNHglycan	242	245	PF01048	0.564
MOD_GlcNHglycan	295	298	PF01048	0.462
MOD_GlcNHglycan	338	341	PF01048	0.374
MOD_GlcNHglycan	426	429	PF01048	0.476
MOD_GlcNHglycan	467	470	PF01048	0.707
MOD_GlcNHglycan	502	505	PF01048	0.438
MOD_GSK3_1	1	8	PF00069	0.612
MOD_GSK3_1	203	210	PF00069	0.418
MOD_GSK3_1	240	247	PF00069	0.543
MOD_GSK3_1	292	299	PF00069	0.572
MOD_GSK3_1	420	427	PF00069	0.438
MOD_GSK3_1	460	467	PF00069	0.610
MOD_GSK3_1	469	476	PF00069	0.585
MOD_LATS_1	67	73	PF00433	0.414
MOD_N-GLC_1	122	127	PF02516	0.410
MOD_N-GLC_2	37	39	PF02516	0.476
MOD_NEK2_1	1	6	PF00069	0.592
MOD_NEK2_1	152	157	PF00069	0.572
MOD_NEK2_1	477	482	PF00069	0.603
MOD_PIKK_1	227	233	PF00454	0.490
MOD_PIKK_1	478	484	PF00454	0.535
MOD_PIKK_1	5	11	PF00454	0.591
MOD_PKA_1	170	176	PF00069	0.705
MOD_PKA_2	32	38	PF00069	0.652
MOD_PKA_2	423	429	PF00069	0.465
MOD_PKA_2	464	470	PF00069	0.681
MOD_PKA_2	486	492	PF00069	0.488
MOD_PKB_1	443	451	PF00069	0.475
MOD_Plk_1	122	128	PF00069	0.533
MOD_Plk_1	142	148	PF00069	0.338
MOD_Plk_4	122	128	PF00069	0.346
MOD_Plk_4	180	186	PF00069	0.593
MOD_Plk_4	264	270	PF00069	0.465
MOD_Plk_4	306	312	PF00069	0.380
MOD_Plk_4	370	376	PF00069	0.366
MOD_ProDKin_1	217	223	PF00069	0.516
MOD_ProDKin_1	232	238	PF00069	0.650
MOD_ProDKin_1	318	324	PF00069	0.357
MOD_ProDKin_1	364	370	PF00069	0.509
MOD_ProDKin_1	378	384	PF00069	0.289
MOD_ProDKin_1	505	511	PF00069	0.412
MOD_SUMO_for_1	51	54	PF00179	0.456
MOD_SUMO_rev_2	195	205	PF00179	0.557
TRG_DiLeu_BaEn_1	315	320	PF01217	0.319
TRG_DiLeu_BaEn_1	442	447	PF01217	0.508
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.546
TRG_DiLeu_LyEn_5	442	447	PF01217	0.328
TRG_ENDOCYTIC_2	102	105	PF00928	0.358
TRG_ENDOCYTIC_2	265	268	PF00928	0.404
TRG_ENDOCYTIC_2	530	533	PF00928	0.415
TRG_ER_diArg_1	140	142	PF00400	0.577
TRG_ER_diArg_1	169	172	PF00400	0.672
TRG_NLS_MonoExtC_3	169	174	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKI5	Leptomonas seymouri	54%	98%
A0A1X0P429	Trypanosomatidae	26%	100%
A0A3R7MVK8	Trypanosoma rangeli	26%	100%
A0A3S7X0E6	Leishmania donovani	92%	99%
A4HFG8	Leishmania braziliensis	79%	99%
A4I2N0	Leishmania infantum	92%	99%
D0A5P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
E9AYU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5DP58	Trypanosoma cruzi	27%	100%