ULP_PROTEASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD20_LEIMA

TriTrypDb:

LmjF.27.0430 , LMJLV39_270009300 , LMJSD75_270009300

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AD20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.642
CLV_C14_Caspase3-7	427	431	PF00656	0.719
CLV_C14_Caspase3-7	513	517	PF00656	0.687
CLV_NRD_NRD_1	157	159	PF00675	0.562
CLV_NRD_NRD_1	192	194	PF00675	0.594
CLV_NRD_NRD_1	20	22	PF00675	0.632
CLV_NRD_NRD_1	210	212	PF00675	0.614
CLV_NRD_NRD_1	235	237	PF00675	0.654
CLV_NRD_NRD_1	297	299	PF00675	0.684
CLV_NRD_NRD_1	322	324	PF00675	0.562
CLV_NRD_NRD_1	417	419	PF00675	0.699
CLV_NRD_NRD_1	446	448	PF00675	0.647
CLV_NRD_NRD_1	481	483	PF00675	0.650
CLV_NRD_NRD_1	495	497	PF00675	0.687
CLV_NRD_NRD_1	543	545	PF00675	0.704
CLV_NRD_NRD_1	58	60	PF00675	0.662
CLV_NRD_NRD_1	584	586	PF00675	0.668
CLV_NRD_NRD_1	90	92	PF00675	0.632
CLV_PCSK_FUR_1	204	208	PF00082	0.588
CLV_PCSK_FUR_1	493	497	PF00082	0.742
CLV_PCSK_KEX2_1	157	159	PF00082	0.593
CLV_PCSK_KEX2_1	192	194	PF00082	0.610
CLV_PCSK_KEX2_1	20	22	PF00082	0.632
CLV_PCSK_KEX2_1	206	208	PF00082	0.575
CLV_PCSK_KEX2_1	210	212	PF00082	0.600
CLV_PCSK_KEX2_1	235	237	PF00082	0.657
CLV_PCSK_KEX2_1	253	255	PF00082	0.721
CLV_PCSK_KEX2_1	296	298	PF00082	0.656
CLV_PCSK_KEX2_1	324	326	PF00082	0.553
CLV_PCSK_KEX2_1	345	347	PF00082	0.609
CLV_PCSK_KEX2_1	379	381	PF00082	0.741
CLV_PCSK_KEX2_1	412	414	PF00082	0.694
CLV_PCSK_KEX2_1	419	421	PF00082	0.635
CLV_PCSK_KEX2_1	446	448	PF00082	0.647
CLV_PCSK_KEX2_1	481	483	PF00082	0.675
CLV_PCSK_KEX2_1	495	497	PF00082	0.620
CLV_PCSK_KEX2_1	542	544	PF00082	0.706
CLV_PCSK_KEX2_1	57	59	PF00082	0.662
CLV_PCSK_KEX2_1	584	586	PF00082	0.700
CLV_PCSK_KEX2_1	608	610	PF00082	0.641
CLV_PCSK_KEX2_1	90	92	PF00082	0.624
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.663
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.721
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.553
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.609
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.741
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.707
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.624
CLV_PCSK_PC7_1	153	159	PF00082	0.540
CLV_PCSK_SKI1_1	226	230	PF00082	0.593
CLV_PCSK_SKI1_1	338	342	PF00082	0.694
CLV_PCSK_SKI1_1	384	388	PF00082	0.728
CLV_PCSK_SKI1_1	59	63	PF00082	0.631
DEG_APCC_DBOX_1	19	27	PF00400	0.710
DEG_APCC_DBOX_1	324	332	PF00400	0.616
DEG_SPOP_SBC_1	500	504	PF00917	0.741
DEG_SPOP_SBC_1	79	83	PF00917	0.568
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.690
DOC_MAPK_DCC_7	90	99	PF00069	0.727
DOC_MAPK_gen_1	136	144	PF00069	0.703
DOC_MAPK_gen_1	20	28	PF00069	0.709
DOC_MAPK_gen_1	296	302	PF00069	0.622
DOC_MAPK_gen_1	341	350	PF00069	0.609
DOC_MAPK_gen_1	384	393	PF00069	0.715
DOC_MAPK_gen_1	57	63	PF00069	0.666
DOC_MAPK_MEF2A_6	90	99	PF00069	0.727
DOC_PP1_RVXF_1	57	64	PF00149	0.634
DOC_PP1_SILK_1	97	102	PF00149	0.720
DOC_PP2B_LxvP_1	600	603	PF13499	0.634
DOC_PP4_FxxP_1	564	567	PF00568	0.537
DOC_USP7_MATH_1	125	129	PF00917	0.668
DOC_USP7_MATH_1	249	253	PF00917	0.705
DOC_USP7_MATH_1	278	282	PF00917	0.696
DOC_USP7_MATH_1	385	389	PF00917	0.782
DOC_USP7_MATH_1	414	418	PF00917	0.702
DOC_USP7_MATH_1	454	458	PF00917	0.660
DOC_USP7_MATH_1	500	504	PF00917	0.716
DOC_USP7_MATH_1	565	569	PF00917	0.560
DOC_USP7_UBL2_3	339	343	PF12436	0.640
DOC_USP7_UBL2_3	404	408	PF12436	0.714
DOC_WW_Pin1_4	13	18	PF00397	0.645
DOC_WW_Pin1_4	137	142	PF00397	0.653
DOC_WW_Pin1_4	238	243	PF00397	0.644
DOC_WW_Pin1_4	43	48	PF00397	0.625
DOC_WW_Pin1_4	563	568	PF00397	0.571
DOC_WW_Pin1_4	84	89	PF00397	0.671
DOC_WW_Pin1_4	90	95	PF00397	0.667
LIG_14-3-3_CanoR_1	210	219	PF00244	0.582
LIG_14-3-3_CanoR_1	235	241	PF00244	0.608
LIG_14-3-3_CanoR_1	254	259	PF00244	0.773
LIG_14-3-3_CanoR_1	279	283	PF00244	0.616
LIG_14-3-3_CanoR_1	413	422	PF00244	0.673
LIG_14-3-3_CanoR_1	456	465	PF00244	0.653
LIG_14-3-3_CanoR_1	471	477	PF00244	0.643
LIG_14-3-3_CanoR_1	57	62	PF00244	0.627
LIG_Actin_WH2_2	458	473	PF00022	0.544
LIG_APCC_ABBA_1	556	561	PF00400	0.650
LIG_BIR_III_4	359	363	PF00653	0.693
LIG_BRCT_BRCA1_1	430	434	PF00533	0.673
LIG_BRCT_BRCA1_1	59	63	PF00533	0.631
LIG_FHA_1	214	220	PF00498	0.525
LIG_FHA_1	3	9	PF00498	0.719
LIG_FHA_1	453	459	PF00498	0.658
LIG_FHA_2	180	186	PF00498	0.639
LIG_FHA_2	365	371	PF00498	0.744
LIG_LIR_Apic_2	561	567	PF02991	0.557
LIG_LIR_Gen_1	32	41	PF02991	0.622
LIG_LIR_Gen_1	352	360	PF02991	0.692
LIG_LIR_Gen_1	568	577	PF02991	0.556
LIG_LIR_Nem_3	32	36	PF02991	0.650
LIG_LIR_Nem_3	352	356	PF02991	0.683
LIG_MYND_1	441	445	PF01753	0.718
LIG_NRP_CendR_1	608	610	PF00754	0.641
LIG_Pex14_2	560	564	PF04695	0.575
LIG_SH2_CRK	33	37	PF00017	0.634
LIG_SH2_NCK_1	33	37	PF00017	0.653
LIG_SH2_NCK_1	76	80	PF00017	0.700
LIG_SH2_SRC	168	171	PF00017	0.548
LIG_SH2_STAP1	168	172	PF00017	0.530
LIG_SH2_STAP1	80	84	PF00017	0.807
LIG_SH2_STAT5	176	179	PF00017	0.497
LIG_SH3_1	549	555	PF00018	0.662
LIG_SH3_2	53	58	PF14604	0.639
LIG_SH3_2	85	90	PF14604	0.743
LIG_SH3_3	403	409	PF00018	0.690
LIG_SH3_3	477	483	PF00018	0.729
LIG_SH3_3	50	56	PF00018	0.601
LIG_SH3_3	522	528	PF00018	0.798
LIG_SH3_3	549	555	PF00018	0.629
LIG_SH3_3	82	88	PF00018	0.753
LIG_SH3_4	408	415	PF00018	0.601
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.775
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.596
LIG_TRAF2_1	108	111	PF00917	0.699
LIG_TRAF2_1	200	203	PF00917	0.566
LIG_WRC_WIRS_1	511	516	PF05994	0.802
LIG_WW_3	482	486	PF00397	0.688
MOD_CDC14_SPxK_1	243	246	PF00782	0.751
MOD_CDC14_SPxK_1	566	569	PF00782	0.540
MOD_CDC14_SPxK_1	87	90	PF00782	0.709
MOD_CDK_SPxK_1	240	246	PF00069	0.743
MOD_CDK_SPxK_1	563	569	PF00069	0.544
MOD_CDK_SPxK_1	84	90	PF00069	0.673
MOD_CDK_SPxxK_3	13	20	PF00069	0.641
MOD_CDK_SPxxK_3	84	91	PF00069	0.668
MOD_CK1_1	213	219	PF00069	0.571
MOD_CK1_1	29	35	PF00069	0.569
MOD_CK1_1	301	307	PF00069	0.773
MOD_CK1_1	344	350	PF00069	0.652
MOD_CK1_1	501	507	PF00069	0.763
MOD_CK1_1	512	518	PF00069	0.651
MOD_CK2_1	168	174	PF00069	0.534
MOD_CK2_1	179	185	PF00069	0.544
MOD_CK2_1	456	462	PF00069	0.733
MOD_CK2_1	500	506	PF00069	0.732
MOD_CK2_1	65	71	PF00069	0.687
MOD_Cter_Amidation	606	609	PF01082	0.711
MOD_GlcNHglycan	110	116	PF01048	0.742
MOD_GlcNHglycan	127	130	PF01048	0.665
MOD_GlcNHglycan	291	294	PF01048	0.727
MOD_GlcNHglycan	303	306	PF01048	0.623
MOD_GlcNHglycan	310	313	PF01048	0.524
MOD_GlcNHglycan	401	404	PF01048	0.784
MOD_GlcNHglycan	422	425	PF01048	0.743
MOD_GlcNHglycan	545	548	PF01048	0.746
MOD_GlcNHglycan	82	85	PF01048	0.809
MOD_GSK3_1	209	216	PF00069	0.530
MOD_GSK3_1	236	243	PF00069	0.629
MOD_GSK3_1	249	256	PF00069	0.696
MOD_GSK3_1	284	291	PF00069	0.577
MOD_GSK3_1	31	38	PF00069	0.631
MOD_GSK3_1	351	358	PF00069	0.684
MOD_GSK3_1	395	402	PF00069	0.714
MOD_GSK3_1	4	11	PF00069	0.678
MOD_GSK3_1	43	50	PF00069	0.653
MOD_GSK3_1	452	459	PF00069	0.654
MOD_GSK3_1	510	517	PF00069	0.631
MOD_GSK3_1	529	536	PF00069	0.785
MOD_GSK3_1	80	87	PF00069	0.713
MOD_LATS_1	294	300	PF00433	0.698
MOD_N-GLC_1	102	107	PF02516	0.626
MOD_N-GLC_1	254	259	PF02516	0.773
MOD_N-GLC_1	319	324	PF02516	0.710
MOD_NEK2_1	102	107	PF00069	0.696
MOD_NEK2_1	163	168	PF00069	0.652
MOD_NEK2_1	230	235	PF00069	0.526
MOD_NEK2_1	277	282	PF00069	0.663
MOD_NEK2_1	399	404	PF00069	0.790
MOD_NEK2_1	428	433	PF00069	0.686
MOD_NEK2_1	499	504	PF00069	0.811
MOD_NEK2_1	514	519	PF00069	0.562
MOD_NEK2_2	65	70	PF00069	0.784
MOD_PIKK_1	26	32	PF00454	0.521
MOD_PK_1	236	242	PF00069	0.716
MOD_PK_1	296	302	PF00069	0.775
MOD_PK_1	387	393	PF00069	0.686
MOD_PK_1	57	63	PF00069	0.631
MOD_PKA_1	210	216	PF00069	0.607
MOD_PKA_1	235	241	PF00069	0.678
MOD_PKA_1	253	259	PF00069	0.719
MOD_PKA_1	296	302	PF00069	0.704
MOD_PKA_1	543	549	PF00069	0.720
MOD_PKA_1	57	63	PF00069	0.666
MOD_PKA_2	209	215	PF00069	0.586
MOD_PKA_2	235	241	PF00069	0.632
MOD_PKA_2	253	259	PF00069	0.719
MOD_PKA_2	278	284	PF00069	0.604
MOD_PKA_2	296	302	PF00069	0.669
MOD_PKA_2	484	490	PF00069	0.734
MOD_PKA_2	543	549	PF00069	0.753
MOD_PKA_2	57	63	PF00069	0.666
MOD_PKA_2	8	14	PF00069	0.726
MOD_PKB_1	145	153	PF00069	0.580
MOD_PKB_1	296	304	PF00069	0.717
MOD_PKB_1	418	426	PF00069	0.684
MOD_PKB_1	496	504	PF00069	0.808
MOD_PKB_1	57	65	PF00069	0.635
MOD_Plk_1	102	108	PF00069	0.676
MOD_Plk_1	168	174	PF00069	0.534
MOD_Plk_1	254	260	PF00069	0.718
MOD_Plk_1	371	377	PF00069	0.786
MOD_Plk_1	395	401	PF00069	0.724
MOD_Plk_1	509	515	PF00069	0.762
MOD_Plk_1	65	71	PF00069	0.687
MOD_Plk_2-3	355	361	PF00069	0.758
MOD_Plk_2-3	510	516	PF00069	0.687
MOD_Plk_4	168	174	PF00069	0.541
MOD_Plk_4	254	260	PF00069	0.670
MOD_Plk_4	331	337	PF00069	0.612
MOD_Plk_4	395	401	PF00069	0.724
MOD_Plk_4	428	434	PF00069	0.639
MOD_Plk_4	95	101	PF00069	0.696
MOD_ProDKin_1	13	19	PF00069	0.642
MOD_ProDKin_1	137	143	PF00069	0.654
MOD_ProDKin_1	238	244	PF00069	0.647
MOD_ProDKin_1	43	49	PF00069	0.624
MOD_ProDKin_1	563	569	PF00069	0.568
MOD_ProDKin_1	84	90	PF00069	0.673
MOD_SUMO_for_1	180	183	PF00179	0.527
TRG_DiLeu_BaEn_1	439	444	PF01217	0.680
TRG_ENDOCYTIC_2	33	36	PF00928	0.604
TRG_ER_diArg_1	144	147	PF00400	0.688
TRG_ER_diArg_1	151	154	PF00400	0.602
TRG_ER_diArg_1	19	21	PF00400	0.637
TRG_ER_diArg_1	192	194	PF00400	0.610
TRG_ER_diArg_1	234	236	PF00400	0.654
TRG_ER_diArg_1	296	298	PF00400	0.682
TRG_ER_diArg_1	325	328	PF00400	0.625
TRG_ER_diArg_1	382	385	PF00400	0.693
TRG_ER_diArg_1	445	447	PF00400	0.645
TRG_ER_diArg_1	480	482	PF00400	0.678
TRG_ER_diArg_1	493	496	PF00400	0.630
TRG_ER_diArg_1	520	523	PF00400	0.819
TRG_ER_diArg_1	542	544	PF00400	0.675
TRG_ER_diArg_1	56	59	PF00400	0.622
TRG_ER_diArg_1	608	610	PF00400	0.642
TRG_NLS_Bipartite_1	323	342	PF00514	0.524
TRG_NLS_MonoExtC_3	322	327	PF00514	0.555
TRG_NLS_MonoExtN_4	323	328	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX23	Leptomonas seymouri	70%	100%
A0A1X0P3W6	Trypanosomatidae	36%	84%
A0A3Q8IE02	Leishmania donovani	95%	100%
A4HFG7	Leishmania braziliensis	84%	100%
A4I2M9	Leishmania infantum	95%	100%
E9AYU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BSQ4	Trypanosoma cruzi	35%	91%