Putative heat shock protein DNAJ

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein DNAJ, putative

Species:

Leishmania major

UniProt:

E9AD18_LEIMA

TriTrypDb:

LmjF.27.0410 , LMJLV39_270009100 , LMJSD75_270009100

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AD18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD18

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006458	'de novo' protein folding	3	2
GO:0009987	cellular process	1	2
GO:0042026	protein refolding	3	2
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.612
CLV_C14_Caspase3-7	201	205	PF00656	0.580
CLV_NRD_NRD_1	213	215	PF00675	0.420
CLV_NRD_NRD_1	5	7	PF00675	0.468
CLV_NRD_NRD_1	73	75	PF00675	0.236
CLV_PCSK_FUR_1	206	210	PF00082	0.427
CLV_PCSK_FUR_1	70	74	PF00082	0.244
CLV_PCSK_KEX2_1	208	210	PF00082	0.494
CLV_PCSK_KEX2_1	213	215	PF00082	0.458
CLV_PCSK_KEX2_1	5	7	PF00082	0.426
CLV_PCSK_KEX2_1	72	74	PF00082	0.236
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.422
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.288
CLV_PCSK_PC7_1	209	215	PF00082	0.459
CLV_PCSK_SKI1_1	131	135	PF00082	0.302
CLV_PCSK_SKI1_1	176	180	PF00082	0.387
CLV_PCSK_SKI1_1	208	212	PF00082	0.434
CLV_PCSK_SKI1_1	38	42	PF00082	0.208
DEG_Nend_UBRbox_3	1	3	PF02207	0.555
DOC_PP4_FxxP_1	252	255	PF00568	0.683
DOC_SPAK_OSR1_1	209	213	PF12202	0.673
DOC_USP7_MATH_1	220	224	PF00917	0.590
DOC_USP7_UBL2_3	33	37	PF12436	0.400
DOC_WW_Pin1_4	269	274	PF00397	0.621
LIG_14-3-3_CanoR_1	176	182	PF00244	0.729
LIG_14-3-3_CanoR_1	209	213	PF00244	0.592
LIG_14-3-3_CanoR_1	214	220	PF00244	0.592
LIG_BRCT_BRCA1_1	103	107	PF00533	0.705
LIG_BRCT_BRCA1_1	248	252	PF00533	0.665
LIG_FHA_1	183	189	PF00498	0.670
LIG_FHA_1	282	288	PF00498	0.266
LIG_FHA_2	199	205	PF00498	0.595
LIG_FHA_2	225	231	PF00498	0.606
LIG_FHA_2	26	32	PF00498	0.504
LIG_LIR_Apic_2	249	255	PF02991	0.684
LIG_LIR_Gen_1	16	25	PF02991	0.425
LIG_LIR_Gen_1	289	299	PF02991	0.279
LIG_LIR_Gen_1	61	71	PF02991	0.434
LIG_LIR_Nem_3	127	133	PF02991	0.494
LIG_LIR_Nem_3	140	146	PF02991	0.507
LIG_LIR_Nem_3	16	21	PF02991	0.401
LIG_LIR_Nem_3	172	178	PF02991	0.605
LIG_LIR_Nem_3	289	295	PF02991	0.246
LIG_LIR_Nem_3	54	60	PF02991	0.409
LIG_LIR_Nem_3	61	67	PF02991	0.417
LIG_NRBOX	286	292	PF00104	0.327
LIG_PCNA_yPIPBox_3	14	24	PF02747	0.465
LIG_Pex14_2	130	134	PF04695	0.490
LIG_Pex14_2	175	179	PF04695	0.586
LIG_SH2_CRK	18	22	PF00017	0.377
LIG_SH2_CRK	64	68	PF00017	0.400
LIG_SH2_NCK_1	64	68	PF00017	0.442
LIG_SH2_SRC	116	119	PF00017	0.667
LIG_SH2_STAT3	76	79	PF00017	0.574
LIG_SH2_STAT5	202	205	PF00017	0.623
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.331
LIG_SUMO_SIM_par_1	283	289	PF11976	0.379
LIG_TRAF2_1	122	125	PF00917	0.515
LIG_WRPW_2	175	178	PF00400	0.591
MOD_CK1_1	101	107	PF00069	0.649
MOD_CK1_1	180	186	PF00069	0.638
MOD_CK1_1	9	15	PF00069	0.576
MOD_CK1_1	93	99	PF00069	0.623
MOD_CK2_1	119	125	PF00069	0.526
MOD_CK2_1	224	230	PF00069	0.652
MOD_CK2_1	25	31	PF00069	0.400
MOD_CK2_1	36	42	PF00069	0.400
MOD_Cter_Amidation	206	209	PF01082	0.430
MOD_GlcNHglycan	100	103	PF01048	0.432
MOD_GlcNHglycan	38	41	PF01048	0.204
MOD_GlcNHglycan	60	63	PF01048	0.297
MOD_GlcNHglycan	92	95	PF01048	0.420
MOD_GSK3_1	164	171	PF00069	0.650
MOD_GSK3_1	177	184	PF00069	0.555
MOD_GSK3_1	198	205	PF00069	0.668
MOD_GSK3_1	220	227	PF00069	0.611
MOD_GSK3_1	265	272	PF00069	0.622
MOD_GSK3_1	281	288	PF00069	0.212
MOD_GSK3_1	58	65	PF00069	0.473
MOD_N-GLC_1	220	225	PF02516	0.388
MOD_N-GLC_1	246	251	PF02516	0.407
MOD_NEK2_1	181	186	PF00069	0.706
MOD_NEK2_1	197	202	PF00069	0.577
MOD_NEK2_1	304	309	PF00069	0.274
MOD_NEK2_1	90	95	PF00069	0.591
MOD_PIKK_1	247	253	PF00454	0.698
MOD_PIKK_1	25	31	PF00454	0.467
MOD_PIKK_1	257	263	PF00454	0.619
MOD_PK_1	56	62	PF00069	0.457
MOD_PKA_1	208	214	PF00069	0.655
MOD_PKA_2	208	214	PF00069	0.603
MOD_Plk_1	197	203	PF00069	0.588
MOD_Plk_1	220	226	PF00069	0.630
MOD_Plk_2-3	198	204	PF00069	0.590
MOD_Plk_4	286	292	PF00069	0.233
MOD_Plk_4	304	310	PF00069	0.234
MOD_Plk_4	62	68	PF00069	0.467
MOD_ProDKin_1	269	275	PF00069	0.616
MOD_SUMO_rev_2	26	35	PF00179	0.400
TRG_DiLeu_BaEn_4	147	153	PF01217	0.570
TRG_ENDOCYTIC_2	118	121	PF00928	0.555
TRG_ENDOCYTIC_2	18	21	PF00928	0.402
TRG_ENDOCYTIC_2	64	67	PF00928	0.400
TRG_ER_diArg_1	212	214	PF00400	0.656
TRG_ER_diArg_1	232	235	PF00400	0.519
TRG_ER_diArg_1	5	7	PF00400	0.669
TRG_NES_CRM1_1	127	140	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD75	Leptomonas seymouri	77%	85%
A0A0S4JV26	Bodo saltans	41%	87%
A0A1X0P3X0	Trypanosomatidae	54%	88%
A0A3S5IRT6	Trypanosoma rangeli	52%	85%
A0A3S7X0F2	Leishmania donovani	95%	67%
A4HFG5	Leishmania braziliensis	83%	85%
A4I2M7	Leishmania infantum	95%	85%
B7KEJ8	Gloeothece citriformis (strain PCC 7424)	30%	86%
D0A5P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	87%
E9AYU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	85%
V5BN28	Trypanosoma cruzi	51%	78%