Sema domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD14_LEIMA

TriTrypDb:

LmjF.27.0370 , LMJLV39_270008700 , LMJSD75_270008700

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9AD14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.598
CLV_PCSK_SKI1_1	134	138	PF00082	0.563
CLV_PCSK_SKI1_1	144	148	PF00082	0.469
CLV_PCSK_SKI1_1	33	37	PF00082	0.543
CLV_PCSK_SKI1_1	8	12	PF00082	0.587
DEG_Nend_UBRbox_3	1	3	PF02207	0.666
DEG_SPOP_SBC_1	94	98	PF00917	0.648
DOC_USP7_MATH_1	130	134	PF00917	0.653
DOC_USP7_MATH_1	185	189	PF00917	0.495
DOC_USP7_MATH_1	94	98	PF00917	0.597
DOC_USP7_MATH_2	130	136	PF00917	0.421
LIG_14-3-3_CanoR_1	163	167	PF00244	0.630
LIG_BRCT_BRCA1_1	97	101	PF00533	0.564
LIG_FHA_1	72	78	PF00498	0.612
LIG_FHA_2	10	16	PF00498	0.600
LIG_FHA_2	145	151	PF00498	0.536
LIG_LIR_Apic_2	65	70	PF02991	0.709
LIG_LIR_Gen_1	14	22	PF02991	0.647
LIG_LIR_Nem_3	126	131	PF02991	0.504
LIG_LIR_Nem_3	14	20	PF02991	0.650
LIG_PCNA_yPIPBox_3	180	193	PF02747	0.562
LIG_PDZ_Class_2	189	194	PF00595	0.539
LIG_PTB_Apo_2	76	83	PF02174	0.622
LIG_PTB_Phospho_1	76	82	PF10480	0.492
LIG_Rb_LxCxE_1	31	49	PF01857	0.579
LIG_SH2_PTP2	17	20	PF00017	0.618
LIG_SH2_SRC	67	70	PF00017	0.510
LIG_SH2_STAT3	82	85	PF00017	0.565
LIG_SH2_STAT5	111	114	PF00017	0.568
LIG_SH2_STAT5	166	169	PF00017	0.560
LIG_SH2_STAT5	17	20	PF00017	0.618
LIG_SH2_STAT5	176	179	PF00017	0.521
LIG_SH2_STAT5	82	85	PF00017	0.624
LIG_SH3_4	56	63	PF00018	0.580
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.630
LIG_WRC_WIRS_1	72	77	PF05994	0.607
LIG_WRPW_2	128	131	PF00400	0.527
MOD_CK1_1	188	194	PF00069	0.564
MOD_CK2_1	144	150	PF00069	0.637
MOD_CK2_1	165	171	PF00069	0.610
MOD_CK2_1	63	69	PF00069	0.577
MOD_GlcNHglycan	101	104	PF01048	0.475
MOD_GlcNHglycan	89	92	PF01048	0.717
MOD_GSK3_1	16	23	PF00069	0.686
MOD_GSK3_1	89	96	PF00069	0.571
MOD_N-GLC_1	78	83	PF02516	0.494
MOD_NEK2_1	62	67	PF00069	0.581
MOD_NEK2_1	71	76	PF00069	0.647
MOD_PIKK_1	81	87	PF00454	0.582
MOD_PIKK_1	89	95	PF00454	0.563
MOD_PKA_1	144	150	PF00069	0.618
MOD_PKA_2	162	168	PF00069	0.602
MOD_Plk_1	78	84	PF00069	0.611
MOD_Plk_4	123	129	PF00069	0.599
MOD_Plk_4	132	138	PF00069	0.567
MOD_Plk_4	188	194	PF00069	0.600
MOD_Plk_4	78	84	PF00069	0.596
MOD_SUMO_rev_2	126	136	PF00179	0.620
MOD_SUMO_rev_2	140	147	PF00179	0.542
MOD_SUMO_rev_2	49	58	PF00179	0.596
TRG_DiLeu_BaEn_1	31	36	PF01217	0.606
TRG_ENDOCYTIC_2	17	20	PF00928	0.618
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC1	Leptomonas seymouri	67%	99%
A0A0S4JRB9	Bodo saltans	29%	100%
A0A1X0P3W2	Trypanosomatidae	35%	95%
A0A3Q8ID94	Leishmania donovani	97%	100%
A0A3R7KLB2	Trypanosoma rangeli	30%	94%
A4HFG2	Leishmania braziliensis	85%	100%
A4I2M4	Leishmania infantum	97%	100%
D0A5N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
E9AYT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%