LeishMANIAdb
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Putative ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase
Gene product:
ATPase, putative
Species:
Leishmania major
UniProt:
E9AD13_LEIMA
TriTrypDb:
LmjF.27.0360 , LMJLV39_270008600 , LMJSD75_270008600 *
Length:
656

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AD13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD13

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 520 524 PF00656 0.341
CLV_NRD_NRD_1 112 114 PF00675 0.675
CLV_NRD_NRD_1 286 288 PF00675 0.471
CLV_NRD_NRD_1 377 379 PF00675 0.575
CLV_NRD_NRD_1 483 485 PF00675 0.393
CLV_NRD_NRD_1 501 503 PF00675 0.276
CLV_NRD_NRD_1 53 55 PF00675 0.602
CLV_PCSK_FUR_1 481 485 PF00082 0.449
CLV_PCSK_KEX2_1 112 114 PF00082 0.675
CLV_PCSK_KEX2_1 377 379 PF00082 0.595
CLV_PCSK_KEX2_1 483 485 PF00082 0.417
CLV_PCSK_KEX2_1 501 503 PF00082 0.193
CLV_PCSK_KEX2_1 53 55 PF00082 0.600
CLV_PCSK_SKI1_1 104 108 PF00082 0.474
CLV_PCSK_SKI1_1 112 116 PF00082 0.560
CLV_PCSK_SKI1_1 147 151 PF00082 0.547
CLV_PCSK_SKI1_1 230 234 PF00082 0.525
CLV_PCSK_SKI1_1 342 346 PF00082 0.375
CLV_PCSK_SKI1_1 428 432 PF00082 0.339
CLV_PCSK_SKI1_1 476 480 PF00082 0.344
DEG_APCC_DBOX_1 229 237 PF00400 0.558
DEG_MDM2_SWIB_1 255 263 PF02201 0.535
DEG_Nend_Nbox_1 1 3 PF02207 0.476
DOC_CYCLIN_yCln2_LP_2 542 548 PF00134 0.449
DOC_MAPK_gen_1 481 491 PF00069 0.365
DOC_MAPK_gen_1 549 559 PF00069 0.328
DOC_MAPK_gen_1 87 94 PF00069 0.571
DOC_MAPK_MEF2A_6 305 312 PF00069 0.403
DOC_MAPK_MEF2A_6 483 491 PF00069 0.366
DOC_MAPK_MEF2A_6 552 561 PF00069 0.328
DOC_MAPK_MEF2A_6 567 575 PF00069 0.383
DOC_MAPK_MEF2A_6 610 619 PF00069 0.365
DOC_PP1_RVXF_1 386 393 PF00149 0.463
DOC_PP1_RVXF_1 405 412 PF00149 0.557
DOC_PP2B_LxvP_1 424 427 PF13499 0.446
DOC_USP7_MATH_1 159 163 PF00917 0.464
DOC_USP7_MATH_1 205 209 PF00917 0.598
DOC_USP7_MATH_1 303 307 PF00917 0.548
DOC_USP7_MATH_1 337 341 PF00917 0.463
DOC_USP7_MATH_1 446 450 PF00917 0.358
DOC_USP7_MATH_1 72 76 PF00917 0.679
DOC_WW_Pin1_4 10 15 PF00397 0.459
DOC_WW_Pin1_4 247 252 PF00397 0.490
DOC_WW_Pin1_4 422 427 PF00397 0.514
LIG_14-3-3_CanoR_1 116 122 PF00244 0.556
LIG_14-3-3_CanoR_1 147 152 PF00244 0.483
LIG_14-3-3_CanoR_1 235 245 PF00244 0.495
LIG_14-3-3_CanoR_1 391 399 PF00244 0.500
LIG_14-3-3_CanoR_1 46 50 PF00244 0.568
LIG_14-3-3_CanoR_1 513 519 PF00244 0.328
LIG_14-3-3_CanoR_1 53 62 PF00244 0.533
LIG_14-3-3_CanoR_1 622 632 PF00244 0.508
LIG_Actin_WH2_2 282 299 PF00022 0.452
LIG_Actin_WH2_2 461 478 PF00022 0.328
LIG_APCC_ABBA_1 606 611 PF00400 0.525
LIG_BRCT_BRCA1_1 245 249 PF00533 0.558
LIG_BRCT_BRCA1_1 251 255 PF00533 0.591
LIG_BRCT_BRCA1_1 56 60 PF00533 0.556
LIG_Clathr_ClatBox_1 455 459 PF01394 0.449
LIG_eIF4E_1 155 161 PF01652 0.480
LIG_FHA_1 193 199 PF00498 0.566
LIG_FHA_1 237 243 PF00498 0.577
LIG_FHA_1 260 266 PF00498 0.490
LIG_FHA_1 268 274 PF00498 0.498
LIG_FHA_1 319 325 PF00498 0.406
LIG_FHA_1 353 359 PF00498 0.506
LIG_FHA_1 36 42 PF00498 0.575
LIG_FHA_1 439 445 PF00498 0.328
LIG_FHA_1 507 513 PF00498 0.408
LIG_FHA_1 580 586 PF00498 0.499
LIG_FHA_1 624 630 PF00498 0.427
LIG_FHA_1 63 69 PF00498 0.469
LIG_FHA_2 100 106 PF00498 0.547
LIG_FHA_2 266 272 PF00498 0.550
LIG_FHA_2 366 372 PF00498 0.545
LIG_FHA_2 518 524 PF00498 0.344
LIG_FHA_2 561 567 PF00498 0.475
LIG_FHA_2 576 582 PF00498 0.314
LIG_FHA_2 637 643 PF00498 0.487
LIG_LIR_Apic_2 246 251 PF02991 0.506
LIG_LIR_Gen_1 450 461 PF02991 0.328
LIG_LIR_Gen_1 523 533 PF02991 0.475
LIG_LIR_LC3C_4 262 267 PF02991 0.462
LIG_LIR_Nem_3 450 456 PF02991 0.337
LIG_LIR_Nem_3 523 528 PF02991 0.475
LIG_NRBOX 197 203 PF00104 0.558
LIG_NRBOX 514 520 PF00104 0.328
LIG_NRBOX 570 576 PF00104 0.513
LIG_Pex14_1 245 249 PF04695 0.558
LIG_Pex14_1 632 636 PF04695 0.332
LIG_Pex14_2 255 259 PF04695 0.565
LIG_Rb_LxCxE_1 596 612 PF01857 0.309
LIG_SH2_CRK 155 159 PF00017 0.495
LIG_SH2_CRK 433 437 PF00017 0.328
LIG_SH2_NCK_1 641 645 PF00017 0.443
LIG_SH2_PTP2 130 133 PF00017 0.434
LIG_SH2_SRC 457 460 PF00017 0.344
LIG_SH2_STAP1 641 645 PF00017 0.480
LIG_SH2_STAT3 628 631 PF00017 0.542
LIG_SH2_STAT5 101 104 PF00017 0.455
LIG_SH2_STAT5 130 133 PF00017 0.416
LIG_SH2_STAT5 144 147 PF00017 0.442
LIG_SH2_STAT5 25 28 PF00017 0.525
LIG_SH2_STAT5 457 460 PF00017 0.336
LIG_SH2_STAT5 467 470 PF00017 0.344
LIG_SH2_STAT5 474 477 PF00017 0.328
LIG_SH2_STAT5 628 631 PF00017 0.516
LIG_SH3_3 105 111 PF00018 0.587
LIG_SH3_3 214 220 PF00018 0.374
LIG_SH3_3 331 337 PF00018 0.437
LIG_SH3_3 554 560 PF00018 0.316
LIG_SH3_3 66 72 PF00018 0.556
LIG_SH3_3 78 84 PF00018 0.495
LIG_Sin3_3 209 216 PF02671 0.318
LIG_SUMO_SIM_anti_2 262 268 PF11976 0.449
LIG_SUMO_SIM_anti_2 306 311 PF11976 0.396
LIG_SUMO_SIM_anti_2 493 499 PF11976 0.344
LIG_SUMO_SIM_par_1 262 268 PF11976 0.534
LIG_SUMO_SIM_par_1 397 403 PF11976 0.313
LIG_SUMO_SIM_par_1 615 621 PF11976 0.515
LIG_TRFH_1 422 426 PF08558 0.464
LIG_UBA3_1 198 207 PF00899 0.562
LIG_UBA3_1 570 577 PF00899 0.456
LIG_UBA3_1 605 610 PF00899 0.528
LIG_WW_3 425 429 PF00397 0.451
MOD_CDK_SPxK_1 422 428 PF00069 0.520
MOD_CK1_1 247 253 PF00069 0.546
MOD_CK2_1 247 253 PF00069 0.573
MOD_CK2_1 265 271 PF00069 0.430
MOD_CK2_1 365 371 PF00069 0.520
MOD_CK2_1 45 51 PF00069 0.538
MOD_CK2_1 72 78 PF00069 0.652
MOD_CK2_1 99 105 PF00069 0.514
MOD_CMANNOS 245 248 PF00535 0.357
MOD_Cter_Amidation 499 502 PF01082 0.344
MOD_GlcNHglycan 176 179 PF01048 0.683
MOD_GlcNHglycan 206 210 PF01048 0.595
MOD_GlcNHglycan 352 355 PF01048 0.581
MOD_GlcNHglycan 358 361 PF01048 0.533
MOD_GlcNHglycan 459 462 PF01048 0.336
MOD_GlcNHglycan 464 467 PF01048 0.319
MOD_GlcNHglycan 503 506 PF01048 0.437
MOD_GlcNHglycan 592 595 PF01048 0.416
MOD_GlcNHglycan 611 614 PF01048 0.460
MOD_GlcNHglycan 633 636 PF01048 0.528
MOD_GlcNHglycan 642 645 PF01048 0.519
MOD_GlcNHglycan 74 77 PF01048 0.634
MOD_GSK3_1 243 250 PF00069 0.489
MOD_GSK3_1 352 359 PF00069 0.509
MOD_GSK3_1 365 372 PF00069 0.496
MOD_GSK3_1 41 48 PF00069 0.483
MOD_GSK3_1 513 520 PF00069 0.337
MOD_GSK3_1 575 582 PF00069 0.436
MOD_GSK3_1 586 593 PF00069 0.349
MOD_GSK3_1 636 643 PF00069 0.477
MOD_LATS_1 511 517 PF00433 0.413
MOD_N-GLC_1 451 456 PF02516 0.413
MOD_NEK2_1 243 248 PF00069 0.537
MOD_NEK2_1 265 270 PF00069 0.437
MOD_NEK2_1 33 38 PF00069 0.607
MOD_NEK2_1 332 337 PF00069 0.458
MOD_NEK2_1 345 350 PF00069 0.483
MOD_NEK2_1 41 46 PF00069 0.467
MOD_NEK2_1 514 519 PF00069 0.328
MOD_NEK2_1 575 580 PF00069 0.406
MOD_NEK2_1 609 614 PF00069 0.525
MOD_NEK2_1 62 67 PF00069 0.572
MOD_NEK2_1 636 641 PF00069 0.476
MOD_NEK2_1 99 104 PF00069 0.517
MOD_NEK2_2 142 147 PF00069 0.556
MOD_PIKK_1 136 142 PF00454 0.525
MOD_PIKK_1 337 343 PF00454 0.455
MOD_PIKK_1 54 60 PF00454 0.589
MOD_PKA_1 112 118 PF00069 0.548
MOD_PKA_1 501 507 PF00069 0.437
MOD_PKA_2 112 118 PF00069 0.576
MOD_PKA_2 390 396 PF00069 0.503
MOD_PKA_2 45 51 PF00069 0.512
MOD_PKA_2 501 507 PF00069 0.390
MOD_PKA_2 566 572 PF00069 0.516
MOD_Plk_1 104 110 PF00069 0.550
MOD_Plk_1 41 47 PF00069 0.523
MOD_Plk_1 451 457 PF00069 0.413
MOD_Plk_4 238 244 PF00069 0.541
MOD_Plk_4 259 265 PF00069 0.536
MOD_Plk_4 380 386 PF00069 0.628
MOD_Plk_4 439 445 PF00069 0.319
MOD_Plk_4 45 51 PF00069 0.491
MOD_Plk_4 459 465 PF00069 0.381
MOD_Plk_4 514 520 PF00069 0.328
MOD_Plk_4 566 572 PF00069 0.472
MOD_ProDKin_1 10 16 PF00069 0.453
MOD_ProDKin_1 247 253 PF00069 0.500
MOD_ProDKin_1 422 428 PF00069 0.510
MOD_SUMO_rev_2 590 600 PF00179 0.534
TRG_DiLeu_BaEn_1 194 199 PF01217 0.555
TRG_DiLeu_BaEn_1 394 399 PF01217 0.309
TRG_DiLeu_BaEn_1 510 515 PF01217 0.449
TRG_DiLeu_LyEn_5 510 515 PF01217 0.449
TRG_ENDOCYTIC_2 130 133 PF00928 0.434
TRG_ENDOCYTIC_2 155 158 PF00928 0.513
TRG_ER_diArg_1 111 113 PF00400 0.672
TRG_ER_diArg_1 166 169 PF00400 0.563
TRG_ER_diArg_1 377 379 PF00400 0.571
TRG_ER_diArg_1 481 484 PF00400 0.449
TRG_ER_diArg_1 501 503 PF00400 0.145
TRG_ER_diArg_1 53 55 PF00400 0.608
TRG_Pf-PMV_PEXEL_1 287 292 PF00026 0.450
TRG_Pf-PMV_PEXEL_1 473 477 PF00026 0.344
TRG_Pf-PMV_PEXEL_1 583 587 PF00026 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYP0 Leptomonas seymouri 67% 97%
A0A0S4JUV1 Bodo saltans 37% 100%
A0A1X0P3W8 Trypanosomatidae 44% 100%
A0A3R7L6R6 Trypanosoma rangeli 45% 98%
A0A3S7X0E5 Leishmania donovani 92% 100%
A4HFG1 Leishmania braziliensis 86% 100%
A4I2M3 Leishmania infantum 92% 100%
D0A5N6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AYT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BSQ8 Trypanosoma cruzi 42% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS