RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

E9AD12_LEIMA

TriTrypDb:

LmjF.27.0350 , LMJLV39_270008500 , LMJSD75_270008500

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

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Expansion

Sequence features

E9AD12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD12

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	11
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.555
CLV_NRD_NRD_1	165	167	PF00675	0.569
CLV_NRD_NRD_1	318	320	PF00675	0.521
CLV_NRD_NRD_1	377	379	PF00675	0.539
CLV_PCSK_KEX2_1	165	167	PF00082	0.569
CLV_PCSK_KEX2_1	318	320	PF00082	0.521
CLV_PCSK_KEX2_1	376	378	PF00082	0.565
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.565
CLV_PCSK_SKI1_1	145	149	PF00082	0.480
CLV_PCSK_SKI1_1	215	219	PF00082	0.395

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I589	Leptomonas seymouri	69%	97%
A0A1X0P421	Trypanosomatidae	39%	100%
A0A3Q8IG64	Leishmania donovani	93%	100%
A0A3R7NWC3	Trypanosoma rangeli	42%	100%
A4HFG0	Leishmania braziliensis	77%	100%
A4I2M2	Leishmania infantum	93%	100%
D0A5N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AYT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BXF1	Trypanosoma cruzi	42%	100%

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