Putative MP44

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative MP44

Gene product:

MP44, putative

Species:

Leishmania major

UniProt:

E9AD11_LEIMA

TriTrypDb:

LmjF.27.0340 , LMJLV39_270008400 , LMJSD75_270008300

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD11

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	9
GO:0004521	RNA endonuclease activity	5	9
GO:0004525	ribonuclease III activity	6	9
GO:0004540	RNA nuclease activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	9
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	9
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.705
CLV_NRD_NRD_1	292	294	PF00675	0.748
CLV_NRD_NRD_1	59	61	PF00675	0.438
CLV_NRD_NRD_1	72	74	PF00675	0.427
CLV_PCSK_KEX2_1	238	240	PF00082	0.599
CLV_PCSK_KEX2_1	292	294	PF00082	0.718
CLV_PCSK_KEX2_1	59	61	PF00082	0.438
CLV_PCSK_KEX2_1	72	74	PF00082	0.427
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.599
CLV_PCSK_SKI1_1	115	119	PF00082	0.531
CLV_PCSK_SKI1_1	19	23	PF00082	0.534
CLV_PCSK_SKI1_1	59	63	PF00082	0.540
CLV_PCSK_SKI1_1	65	69	PF00082	0.481
DEG_APCC_DBOX_1	112	120	PF00400	0.532
DEG_APCC_DBOX_1	14	22	PF00400	0.590
DEG_APCC_DBOX_1	64	72	PF00400	0.458
DOC_CYCLIN_RxL_1	15	24	PF00134	0.602
DOC_MAPK_gen_1	59	70	PF00069	0.474
DOC_MAPK_gen_1	72	78	PF00069	0.412
DOC_MAPK_MEF2A_6	63	70	PF00069	0.553
DOC_MAPK_NFAT4_5	63	71	PF00069	0.540
DOC_PP2B_LxvP_1	201	204	PF13499	0.547
DOC_PP4_FxxP_1	309	312	PF00568	0.613
DOC_PP4_FxxP_1	319	322	PF00568	0.581
DOC_PP4_MxPP_1	1	4	PF00568	0.765
DOC_USP7_MATH_1	156	160	PF00917	0.565
DOC_USP7_MATH_1	279	283	PF00917	0.660
DOC_USP7_MATH_1	301	305	PF00917	0.762
DOC_WW_Pin1_4	162	167	PF00397	0.720
DOC_WW_Pin1_4	25	30	PF00397	0.521
DOC_WW_Pin1_4	252	257	PF00397	0.771
LIG_14-3-3_CanoR_1	15	19	PF00244	0.506
LIG_14-3-3_CanoR_1	169	179	PF00244	0.562
LIG_14-3-3_CanoR_1	272	280	PF00244	0.642
LIG_14-3-3_CanoR_1	342	346	PF00244	0.726
LIG_14-3-3_CanoR_1	89	97	PF00244	0.562
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BIR_III_1	1	5	PF00653	0.665
LIG_BIR_III_3	1	5	PF00653	0.665
LIG_CtBP_PxDLS_1	268	272	PF00389	0.654
LIG_EH1_1	147	155	PF00400	0.594
LIG_FHA_1	112	118	PF00498	0.464
LIG_FHA_1	213	219	PF00498	0.552
LIG_FHA_1	28	34	PF00498	0.537
LIG_FHA_1	5	11	PF00498	0.690
LIG_FHA_2	272	278	PF00498	0.688
LIG_FHA_2	350	356	PF00498	0.682
LIG_FHA_2	91	97	PF00498	0.481
LIG_LIR_Apic_2	308	312	PF02991	0.667
LIG_LIR_Gen_1	224	235	PF02991	0.452
LIG_LIR_Gen_1	94	103	PF02991	0.502
LIG_LIR_Nem_3	224	230	PF02991	0.421
LIG_LIR_Nem_3	313	319	PF02991	0.581
LIG_LIR_Nem_3	94	100	PF02991	0.465
LIG_NRBOX	17	23	PF00104	0.558
LIG_PCNA_yPIPBox_3	72	82	PF02747	0.438
LIG_SH2_CRK	324	328	PF00017	0.639
LIG_SH2_CRK	74	78	PF00017	0.493
LIG_SH2_NCK_1	227	231	PF00017	0.491
LIG_SH2_STAP1	125	129	PF00017	0.594
LIG_SH2_STAT3	148	151	PF00017	0.582
LIG_SH2_STAT5	128	131	PF00017	0.523
LIG_SH2_STAT5	273	276	PF00017	0.758
LIG_SH3_1	118	124	PF00018	0.549
LIG_SH3_3	118	124	PF00018	0.549
LIG_SH3_3	226	232	PF00018	0.489
LIG_SH3_3	239	245	PF00018	0.505
LIG_SH3_3	26	32	PF00018	0.535
LIG_SH3_4	157	164	PF00018	0.496
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.583
LIG_SUMO_SIM_par_1	6	11	PF11976	0.699
LIG_TYR_ITIM	225	230	PF00017	0.427
LIG_WRC_WIRS_1	306	311	PF05994	0.676
MOD_CDK_SPK_2	252	257	PF00069	0.761
MOD_CDK_SPxxK_3	162	169	PF00069	0.704
MOD_CK1_1	247	253	PF00069	0.610
MOD_CK1_1	55	61	PF00069	0.569
MOD_CK1_1	85	91	PF00069	0.584
MOD_CK2_1	271	277	PF00069	0.660
MOD_CK2_1	90	96	PF00069	0.512
MOD_DYRK1A_RPxSP_1	162	166	PF00069	0.742
MOD_GlcNHglycan	162	165	PF01048	0.749
MOD_GlcNHglycan	347	350	PF01048	0.682
MOD_GlcNHglycan	358	361	PF01048	0.572
MOD_GSK3_1	103	110	PF00069	0.526
MOD_GSK3_1	156	163	PF00069	0.677
MOD_GSK3_1	301	308	PF00069	0.658
MOD_GSK3_1	341	348	PF00069	0.685
MOD_GSK3_1	55	62	PF00069	0.513
MOD_GSK3_1	87	94	PF00069	0.481
MOD_N-GLC_1	43	48	PF02516	0.606
MOD_N-GLC_1	91	96	PF02516	0.486
MOD_NEK2_1	103	108	PF00069	0.460
MOD_NEK2_1	14	19	PF00069	0.540
MOD_NEK2_1	170	175	PF00069	0.537
MOD_NEK2_1	271	276	PF00069	0.672
MOD_NEK2_1	52	57	PF00069	0.544
MOD_PIKK_1	247	253	PF00454	0.648
MOD_PIKK_1	27	33	PF00454	0.663
MOD_PKA_1	59	65	PF00069	0.551
MOD_PKA_2	14	20	PF00069	0.510
MOD_PKA_2	271	277	PF00069	0.667
MOD_PKA_2	310	316	PF00069	0.575
MOD_PKA_2	341	347	PF00069	0.695
MOD_PKA_2	59	65	PF00069	0.494
MOD_Plk_1	301	307	PF00069	0.761
MOD_Plk_1	340	346	PF00069	0.716
MOD_Plk_1	43	49	PF00069	0.604
MOD_Plk_4	103	109	PF00069	0.448
MOD_Plk_4	305	311	PF00069	0.670
MOD_Plk_4	349	355	PF00069	0.655
MOD_ProDKin_1	162	168	PF00069	0.711
MOD_ProDKin_1	25	31	PF00069	0.526
MOD_ProDKin_1	252	258	PF00069	0.768
MOD_SUMO_rev_2	231	240	PF00179	0.568
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.534
TRG_ENDOCYTIC_2	227	230	PF00928	0.432
TRG_ENDOCYTIC_2	316	319	PF00928	0.550
TRG_ENDOCYTIC_2	324	327	PF00928	0.539
TRG_ENDOCYTIC_2	39	42	PF00928	0.478
TRG_ENDOCYTIC_2	74	77	PF00928	0.492
TRG_ER_diArg_1	112	115	PF00400	0.441
TRG_ER_diArg_1	45	48	PF00400	0.571
TRG_ER_diArg_1	59	61	PF00400	0.352
TRG_ER_diArg_1	63	66	PF00400	0.306
TRG_ER_diArg_1	71	73	PF00400	0.420
TRG_NES_CRM1_1	231	244	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V9	Leptomonas seymouri	57%	86%
A0A1X0P3V7	Trypanosomatidae	51%	96%
A0A1X0P4R2	Trypanosomatidae	23%	91%
A0A3Q8ID52	Leishmania donovani	97%	100%
A0A3R7MNH0	Trypanosoma rangeli	52%	95%
A4HFF2	Leishmania braziliensis	89%	87%
A4I2M1	Leishmania infantum	97%	100%
D0A5N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	97%
E9AYT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%