TSNAXIP1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD10_LEIMA

TriTrypDb:

LmjF.27.0330 , LMJLV39_270008300 , LMJSD75_270008200

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AD10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.675
CLV_C14_Caspase3-7	480	484	PF00656	0.526
CLV_NRD_NRD_1	121	123	PF00675	0.613
CLV_NRD_NRD_1	15	17	PF00675	0.472
CLV_NRD_NRD_1	162	164	PF00675	0.645
CLV_NRD_NRD_1	182	184	PF00675	0.283
CLV_NRD_NRD_1	189	191	PF00675	0.285
CLV_NRD_NRD_1	310	312	PF00675	0.494
CLV_NRD_NRD_1	342	344	PF00675	0.540
CLV_NRD_NRD_1	371	373	PF00675	0.650
CLV_NRD_NRD_1	44	46	PF00675	0.475
CLV_NRD_NRD_1	618	620	PF00675	0.456
CLV_NRD_NRD_1	772	774	PF00675	0.427
CLV_NRD_NRD_1	782	784	PF00675	0.359
CLV_PCSK_FUR_1	159	163	PF00082	0.648
CLV_PCSK_KEX2_1	15	17	PF00082	0.472
CLV_PCSK_KEX2_1	161	163	PF00082	0.568
CLV_PCSK_KEX2_1	182	184	PF00082	0.325
CLV_PCSK_KEX2_1	189	191	PF00082	0.325
CLV_PCSK_KEX2_1	310	312	PF00082	0.547
CLV_PCSK_KEX2_1	371	373	PF00082	0.559
CLV_PCSK_KEX2_1	46	48	PF00082	0.471
CLV_PCSK_KEX2_1	617	619	PF00082	0.486
CLV_PCSK_KEX2_1	718	720	PF00082	0.593
CLV_PCSK_KEX2_1	772	774	PF00082	0.407
CLV_PCSK_KEX2_1	782	784	PF00082	0.342
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.547
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.471
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.593
CLV_PCSK_SKI1_1	205	209	PF00082	0.284
CLV_PCSK_SKI1_1	219	223	PF00082	0.319
CLV_PCSK_SKI1_1	48	52	PF00082	0.467
CLV_PCSK_SKI1_1	598	602	PF00082	0.340
CLV_PCSK_SKI1_1	605	609	PF00082	0.356
CLV_PCSK_SKI1_1	637	641	PF00082	0.498
CLV_PCSK_SKI1_1	72	76	PF00082	0.595
CLV_Separin_Metazoa	61	65	PF03568	0.615
DEG_APCC_DBOX_1	597	605	PF00400	0.390
DEG_MDM2_SWIB_1	692	700	PF02201	0.402
DEG_Nend_Nbox_1	1	3	PF02207	0.440
DEG_SPOP_SBC_1	154	158	PF00917	0.552
DOC_CYCLIN_RxL_1	529	539	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	534	540	PF00134	0.384
DOC_MAPK_gen_1	122	128	PF00069	0.606
DOC_MAPK_gen_1	530	538	PF00069	0.402
DOC_MAPK_gen_1	617	625	PF00069	0.470
DOC_MAPK_gen_1	772	780	PF00069	0.382
DOC_MAPK_MEF2A_6	170	177	PF00069	0.380
DOC_MAPK_MEF2A_6	530	538	PF00069	0.450
DOC_MAPK_MEF2A_6	617	625	PF00069	0.288
DOC_PP2B_LxvP_1	131	134	PF13499	0.529
DOC_PP2B_LxvP_1	534	537	PF13499	0.396
DOC_PP2B_PxIxI_1	752	758	PF00149	0.476
DOC_SPAK_OSR1_1	663	667	PF12202	0.489
DOC_USP7_MATH_1	14	18	PF00917	0.467
DOC_USP7_MATH_1	154	158	PF00917	0.625
DOC_USP7_MATH_1	166	170	PF00917	0.535
DOC_USP7_MATH_1	19	23	PF00917	0.448
DOC_USP7_MATH_1	193	197	PF00917	0.435
DOC_USP7_MATH_1	338	342	PF00917	0.513
DOC_USP7_MATH_1	41	45	PF00917	0.479
DOC_USP7_MATH_1	477	481	PF00917	0.716
DOC_USP7_MATH_1	554	558	PF00917	0.615
DOC_USP7_MATH_1	63	67	PF00917	0.629
DOC_USP7_MATH_1	652	656	PF00917	0.363
DOC_WW_Pin1_4	550	555	PF00397	0.356
DOC_WW_Pin1_4	781	786	PF00397	0.379
LIG_14-3-3_CanoR_1	107	113	PF00244	0.615
LIG_14-3-3_CanoR_1	122	127	PF00244	0.439
LIG_14-3-3_CanoR_1	137	146	PF00244	0.586
LIG_14-3-3_CanoR_1	355	359	PF00244	0.532
LIG_14-3-3_CanoR_1	371	376	PF00244	0.497
LIG_14-3-3_CanoR_1	47	57	PF00244	0.533
LIG_14-3-3_CanoR_1	479	483	PF00244	0.614
LIG_14-3-3_CanoR_1	532	537	PF00244	0.466
LIG_14-3-3_CanoR_1	663	667	PF00244	0.448
LIG_14-3-3_CanoR_1	719	725	PF00244	0.463
LIG_14-3-3_CanoR_1	72	80	PF00244	0.656
LIG_14-3-3_CanoR_1	772	781	PF00244	0.408
LIG_Actin_WH2_2	252	267	PF00022	0.413
LIG_Actin_WH2_2	608	626	PF00022	0.426
LIG_Actin_WH2_2	693	708	PF00022	0.416
LIG_APCC_ABBA_1	201	206	PF00400	0.360
LIG_BRCT_BRCA1_1	124	128	PF00533	0.552
LIG_BRCT_BRCA1_1	416	420	PF00533	0.572
LIG_Clathr_ClatBox_1	302	306	PF01394	0.502
LIG_CtBP_PxDLS_1	609	613	PF00389	0.465
LIG_CtBP_PxDLS_1	785	789	PF00389	0.476
LIG_DCNL_PONY_1	1	4	PF03556	0.440
LIG_EH1_1	418	426	PF00400	0.459
LIG_FHA_1	420	426	PF00498	0.529
LIG_FHA_1	49	55	PF00498	0.538
LIG_FHA_1	504	510	PF00498	0.642
LIG_FHA_1	524	530	PF00498	0.552
LIG_FHA_1	537	543	PF00498	0.400
LIG_FHA_1	702	708	PF00498	0.368
LIG_FHA_1	726	732	PF00498	0.443
LIG_FHA_1	758	764	PF00498	0.519
LIG_FHA_1	774	780	PF00498	0.360
LIG_FHA_2	250	256	PF00498	0.362
LIG_FHA_2	292	298	PF00498	0.534
LIG_FHA_2	311	317	PF00498	0.587
LIG_Integrin_RGD_1	36	38	PF01839	0.486
LIG_LIR_Gen_1	125	136	PF02991	0.543
LIG_LIR_Gen_1	206	215	PF02991	0.308
LIG_LIR_Gen_1	374	381	PF02991	0.643
LIG_LIR_Gen_1	641	652	PF02991	0.406
LIG_LIR_Gen_1	685	692	PF02991	0.333
LIG_LIR_Gen_1	740	749	PF02991	0.527
LIG_LIR_Nem_3	125	131	PF02991	0.551
LIG_LIR_Nem_3	206	211	PF02991	0.295
LIG_LIR_Nem_3	216	221	PF02991	0.288
LIG_LIR_Nem_3	374	378	PF02991	0.597
LIG_LIR_Nem_3	641	647	PF02991	0.412
LIG_LIR_Nem_3	685	691	PF02991	0.405
LIG_LIR_Nem_3	740	746	PF02991	0.527
LIG_PDZ_Class_2	786	791	PF00595	0.518
LIG_Pex14_2	204	208	PF04695	0.433
LIG_Pex14_2	211	215	PF04695	0.391
LIG_Pex14_2	562	566	PF04695	0.438
LIG_Pex14_2	640	644	PF04695	0.409
LIG_Pex14_2	688	692	PF04695	0.499
LIG_PTAP_UEV_1	89	94	PF05743	0.559
LIG_SH2_CRK	218	222	PF00017	0.300
LIG_SH2_CRK	743	747	PF00017	0.431
LIG_SH2_NCK_1	375	379	PF00017	0.612
LIG_SH2_PTP2	745	748	PF00017	0.434
LIG_SH2_SRC	247	250	PF00017	0.404
LIG_SH2_STAP1	229	233	PF00017	0.291
LIG_SH2_STAP1	416	420	PF00017	0.572
LIG_SH2_STAT5	247	250	PF00017	0.392
LIG_SH2_STAT5	687	690	PF00017	0.415
LIG_SH2_STAT5	743	746	PF00017	0.468
LIG_SH3_2	59	64	PF14604	0.565
LIG_SH3_3	109	115	PF00018	0.671
LIG_SH3_3	142	148	PF00018	0.648
LIG_SH3_3	24	30	PF00018	0.463
LIG_SH3_3	505	511	PF00018	0.601
LIG_SH3_3	56	62	PF00018	0.621
LIG_SH3_3	67	73	PF00018	0.747
LIG_SH3_3	87	93	PF00018	0.691
LIG_SUMO_SIM_par_1	301	306	PF11976	0.551
LIG_SUMO_SIM_par_1	753	758	PF11976	0.528
LIG_TRAF2_1	281	284	PF00917	0.362
LIG_TRAF2_1	784	787	PF00917	0.431
LIG_TRFH_1	100	104	PF08558	0.689
LIG_UBA3_1	261	265	PF00899	0.413
LIG_UBA3_1	302	310	PF00899	0.558
LIG_WRC_WIRS_1	208	213	PF05994	0.358
LIG_WW_3	61	65	PF00397	0.615
MOD_CK1_1	22	28	PF00069	0.462
MOD_CK1_1	301	307	PF00069	0.492
MOD_CK1_1	332	338	PF00069	0.621
MOD_CK1_1	467	473	PF00069	0.686
MOD_CK1_1	545	551	PF00069	0.537
MOD_CK1_1	626	632	PF00069	0.527
MOD_CK1_1	683	689	PF00069	0.472
MOD_CK1_1	747	753	PF00069	0.404
MOD_CK1_1	91	97	PF00069	0.594
MOD_CK2_1	249	255	PF00069	0.429
MOD_CK2_1	291	297	PF00069	0.505
MOD_CK2_1	310	316	PF00069	0.555
MOD_CK2_1	666	672	PF00069	0.548
MOD_CK2_1	755	761	PF00069	0.516
MOD_CK2_1	781	787	PF00069	0.421
MOD_DYRK1A_RPxSP_1	550	554	PF00069	0.346
MOD_GlcNHglycan	279	282	PF01048	0.378
MOD_GlcNHglycan	330	334	PF01048	0.586
MOD_GlcNHglycan	466	469	PF01048	0.683
MOD_GlcNHglycan	523	526	PF01048	0.602
MOD_GlcNHglycan	629	632	PF01048	0.401
MOD_GlcNHglycan	720	723	PF01048	0.416
MOD_GlcNHglycan	756	760	PF01048	0.444
MOD_GlcNHglycan	90	93	PF01048	0.633
MOD_GSK3_1	118	125	PF00069	0.639
MOD_GSK3_1	19	26	PF00069	0.452
MOD_GSK3_1	264	271	PF00069	0.313
MOD_GSK3_1	532	539	PF00069	0.491
MOD_GSK3_1	550	557	PF00069	0.363
MOD_GSK3_1	623	630	PF00069	0.445
MOD_GSK3_1	662	669	PF00069	0.512
MOD_GSK3_1	683	690	PF00069	0.460
MOD_GSK3_1	757	764	PF00069	0.538
MOD_N-GLC_1	268	273	PF02516	0.413
MOD_NEK2_1	264	269	PF00069	0.371
MOD_NEK2_1	394	399	PF00069	0.690
MOD_NEK2_1	523	528	PF00069	0.527
MOD_NEK2_1	542	547	PF00069	0.259
MOD_NEK2_1	584	589	PF00069	0.546
MOD_NEK2_1	623	628	PF00069	0.467
MOD_NEK2_1	662	667	PF00069	0.466
MOD_NEK2_1	774	779	PF00069	0.420
MOD_NEK2_2	687	692	PF00069	0.400
MOD_PIKK_1	247	253	PF00454	0.413
MOD_PIKK_1	346	352	PF00454	0.620
MOD_PIKK_1	566	572	PF00454	0.513
MOD_PIKK_1	747	753	PF00454	0.373
MOD_PKA_1	122	128	PF00069	0.634
MOD_PKA_1	310	316	PF00069	0.545
MOD_PKA_1	371	377	PF00069	0.572
MOD_PKA_1	440	446	PF00069	0.592
MOD_PKA_1	718	724	PF00069	0.439
MOD_PKA_2	14	20	PF00069	0.457
MOD_PKA_2	310	316	PF00069	0.524
MOD_PKA_2	338	344	PF00069	0.538
MOD_PKA_2	354	360	PF00069	0.410
MOD_PKA_2	371	377	PF00069	0.614
MOD_PKA_2	394	400	PF00069	0.617
MOD_PKA_2	478	484	PF00069	0.625
MOD_PKA_2	623	629	PF00069	0.482
MOD_PKA_2	63	69	PF00069	0.728
MOD_PKA_2	662	668	PF00069	0.430
MOD_PKA_2	718	724	PF00069	0.439
MOD_PKA_2	774	780	PF00069	0.419
MOD_Plk_1	268	274	PF00069	0.394
MOD_Plk_1	554	560	PF00069	0.638
MOD_Plk_1	652	658	PF00069	0.424
MOD_Plk_1	683	689	PF00069	0.479
MOD_Plk_2-3	249	255	PF00069	0.365
MOD_Plk_4	207	213	PF00069	0.358
MOD_Plk_4	220	226	PF00069	0.220
MOD_Plk_4	298	304	PF00069	0.487
MOD_Plk_4	394	400	PF00069	0.473
MOD_Plk_4	542	548	PF00069	0.511
MOD_Plk_4	683	689	PF00069	0.446
MOD_Plk_4	741	747	PF00069	0.494
MOD_Plk_4	774	780	PF00069	0.414
MOD_ProDKin_1	550	556	PF00069	0.362
MOD_ProDKin_1	781	787	PF00069	0.391
MOD_SUMO_rev_2	216	221	PF00179	0.488
TRG_DiLeu_BaEn_2	517	523	PF01217	0.562
TRG_DiLeu_BaEn_2	683	689	PF01217	0.434
TRG_ENDOCYTIC_2	218	221	PF00928	0.284
TRG_ENDOCYTIC_2	375	378	PF00928	0.693
TRG_ENDOCYTIC_2	743	746	PF00928	0.534
TRG_ER_diArg_1	159	162	PF00400	0.648
TRG_ER_diArg_1	181	183	PF00400	0.325
TRG_ER_diArg_1	188	190	PF00400	0.325
TRG_ER_diArg_1	370	372	PF00400	0.664
TRG_ER_diArg_1	42	45	PF00400	0.481
TRG_ER_diArg_1	617	619	PF00400	0.489
TRG_ER_diArg_1	667	670	PF00400	0.472
TRG_ER_diArg_1	771	773	PF00400	0.446
TRG_ER_diArg_1	781	783	PF00400	0.423
TRG_NES_CRM1_1	235	249	PF08389	0.430
TRG_NES_CRM1_1	695	709	PF08389	0.319
TRG_NLS_MonoCore_2	44	49	PF00514	0.473
TRG_NLS_MonoExtN_4	43	50	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY0	Leptomonas seymouri	55%	100%
A0A0S4ISJ1	Bodo saltans	25%	94%
A0A1X0ND09	Trypanosomatidae	33%	100%
A0A3S7X0D8	Leishmania donovani	95%	100%
A0A422NTD8	Trypanosoma rangeli	33%	100%
A4HFF1	Leishmania braziliensis	78%	100%
A4I2M0	Leishmania infantum	95%	100%
E9AYT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DP68	Trypanosoma cruzi	32%	100%