Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD09_LEIMA

TriTrypDb:

LmjF.27.0320 , LMJLV39_270008200 , LMJSD75_270008100

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AD09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD09

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.252
CLV_NRD_NRD_1	2	4	PF00675	0.528
CLV_NRD_NRD_1	232	234	PF00675	0.423
CLV_NRD_NRD_1	344	346	PF00675	0.442
CLV_NRD_NRD_1	365	367	PF00675	0.467
CLV_NRD_NRD_1	375	377	PF00675	0.385
CLV_NRD_NRD_1	413	415	PF00675	0.585
CLV_NRD_NRD_1	464	466	PF00675	0.623
CLV_NRD_NRD_1	468	470	PF00675	0.596
CLV_NRD_NRD_1	475	477	PF00675	0.503
CLV_NRD_NRD_1	486	488	PF00675	0.391
CLV_PCSK_FUR_1	462	466	PF00082	0.573
CLV_PCSK_KEX2_1	2	4	PF00082	0.528
CLV_PCSK_KEX2_1	232	234	PF00082	0.423
CLV_PCSK_KEX2_1	343	345	PF00082	0.447
CLV_PCSK_KEX2_1	365	367	PF00082	0.440
CLV_PCSK_KEX2_1	375	377	PF00082	0.324
CLV_PCSK_KEX2_1	413	415	PF00082	0.585
CLV_PCSK_KEX2_1	464	466	PF00082	0.623
CLV_PCSK_KEX2_1	468	470	PF00082	0.596
CLV_PCSK_KEX2_1	475	477	PF00082	0.503
CLV_PCSK_KEX2_1	485	487	PF00082	0.390
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.432
CLV_PCSK_PC7_1	340	346	PF00082	0.360
CLV_PCSK_PC7_1	464	470	PF00082	0.565
CLV_PCSK_SKI1_1	315	319	PF00082	0.461
CLV_PCSK_SKI1_1	344	348	PF00082	0.365
CLV_PCSK_SKI1_1	375	379	PF00082	0.421
CLV_PCSK_SKI1_1	469	473	PF00082	0.685
DEG_Nend_UBRbox_1	1	4	PF02207	0.580
DEG_SPOP_SBC_1	125	129	PF00917	0.378
DOC_CKS1_1	261	266	PF01111	0.566
DOC_CYCLIN_RxL_1	340	351	PF00134	0.451
DOC_CYCLIN_RxL_1	372	382	PF00134	0.481
DOC_MAPK_gen_1	170	180	PF00069	0.379
DOC_MAPK_gen_1	340	350	PF00069	0.430
DOC_MAPK_gen_1	365	373	PF00069	0.501
DOC_MAPK_gen_1	462	472	PF00069	0.645
DOC_MAPK_gen_1	81	90	PF00069	0.535
DOC_MAPK_MEF2A_6	16	25	PF00069	0.484
DOC_MAPK_MEF2A_6	343	350	PF00069	0.433
DOC_MAPK_NFAT4_5	343	351	PF00069	0.474
DOC_MAPK_RevD_3	217	233	PF00069	0.434
DOC_PP2B_LxvP_1	252	255	PF13499	0.546
DOC_PP4_FxxP_1	441	444	PF00568	0.496
DOC_PP4_FxxP_1	97	100	PF00568	0.478
DOC_USP7_MATH_1	10	14	PF00917	0.616
DOC_USP7_MATH_1	125	129	PF00917	0.451
DOC_USP7_MATH_1	158	162	PF00917	0.507
DOC_USP7_MATH_1	186	190	PF00917	0.574
DOC_USP7_MATH_1	28	32	PF00917	0.480
DOC_USP7_MATH_1	43	47	PF00917	0.308
DOC_USP7_MATH_1	79	83	PF00917	0.565
DOC_USP7_UBL2_3	479	483	PF12436	0.457
DOC_WW_Pin1_4	260	265	PF00397	0.568
DOC_WW_Pin1_4	385	390	PF00397	0.527
DOC_WW_Pin1_4	448	453	PF00397	0.607
DOC_WW_Pin1_4	98	103	PF00397	0.515
LIG_14-3-3_CanoR_1	115	121	PF00244	0.581
LIG_14-3-3_CanoR_1	166	170	PF00244	0.424
LIG_14-3-3_CanoR_1	303	312	PF00244	0.530
LIG_14-3-3_CanoR_1	343	349	PF00244	0.435
LIG_14-3-3_CanoR_1	403	407	PF00244	0.546
LIG_Actin_WH2_2	150	168	PF00022	0.403
LIG_Actin_WH2_2	46	61	PF00022	0.290
LIG_BIR_III_2	250	254	PF00653	0.529
LIG_BRCT_BRCA1_1	127	131	PF00533	0.413
LIG_BRCT_BRCA1_1	308	312	PF00533	0.466
LIG_deltaCOP1_diTrp_1	194	201	PF00928	0.415
LIG_FHA_1	256	262	PF00498	0.700
LIG_FHA_1	296	302	PF00498	0.436
LIG_FHA_1	345	351	PF00498	0.358
LIG_FHA_1	395	401	PF00498	0.472
LIG_FHA_1	472	478	PF00498	0.558
LIG_FHA_1	52	58	PF00498	0.454
LIG_FHA_2	101	107	PF00498	0.606
LIG_FHA_2	195	201	PF00498	0.599
LIG_FHA_2	268	274	PF00498	0.456
LIG_FHA_2	319	325	PF00498	0.469
LIG_FHA_2	330	336	PF00498	0.511
LIG_LIR_Apic_2	439	444	PF02991	0.489
LIG_LIR_Apic_2	448	452	PF02991	0.521
LIG_LIR_Apic_2	95	100	PF02991	0.469
LIG_LIR_Gen_1	128	139	PF02991	0.399
LIG_LIR_Gen_1	273	284	PF02991	0.257
LIG_LIR_Gen_1	390	400	PF02991	0.486
LIG_LIR_Gen_1	82	93	PF02991	0.355
LIG_LIR_Nem_3	167	172	PF02991	0.319
LIG_LIR_Nem_3	273	279	PF02991	0.262
LIG_LIR_Nem_3	390	395	PF02991	0.407
LIG_LIR_Nem_3	82	88	PF02991	0.532
LIG_LRP6_Inhibitor_1	477	483	PF00058	0.503
LIG_NBox_RRM_1	313	323	PF00076	0.384
LIG_PCNA_yPIPBox_3	214	223	PF02747	0.454
LIG_PCNA_yPIPBox_3	429	442	PF02747	0.420
LIG_REV1ctd_RIR_1	310	319	PF16727	0.379
LIG_SH2_CRK	169	173	PF00017	0.468
LIG_SH2_NCK_1	202	206	PF00017	0.500
LIG_SH2_SRC	333	336	PF00017	0.493
LIG_SH2_SRC	85	88	PF00017	0.318
LIG_SH2_STAP1	126	130	PF00017	0.452
LIG_SH2_STAP1	333	337	PF00017	0.489
LIG_SH2_STAP1	424	428	PF00017	0.541
LIG_SH2_STAP1	85	89	PF00017	0.370
LIG_SH2_STAT3	304	307	PF00017	0.414
LIG_SH2_STAT5	126	129	PF00017	0.418
LIG_SH2_STAT5	304	307	PF00017	0.499
LIG_SH2_STAT5	363	366	PF00017	0.533
LIG_SH2_STAT5	481	484	PF00017	0.477
LIG_SH3_3	324	330	PF00018	0.541
LIG_SH3_CIN85_PxpxPR_1	452	457	PF14604	0.676
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.412
LIG_SUMO_SIM_anti_2	370	375	PF11976	0.471
LIG_SUMO_SIM_par_1	21	27	PF11976	0.466
LIG_SUMO_SIM_par_1	429	434	PF11976	0.621
LIG_TRAF2_1	208	211	PF00917	0.697
LIG_TRAF2_1	270	273	PF00917	0.340
LIG_TRAF2_1	332	335	PF00917	0.513
LIG_TYR_ITIM	157	162	PF00017	0.419
LIG_TYR_ITIM	83	88	PF00017	0.319
LIG_UBA3_1	419	427	PF00899	0.524
LIG_UBA3_1	89	98	PF00899	0.365
LIG_WW_3	465	469	PF00397	0.545
MOD_CDK_SPK_2	452	457	PF00069	0.643
MOD_CK1_1	108	114	PF00069	0.673
MOD_CK1_1	121	127	PF00069	0.420
MOD_CK1_1	190	196	PF00069	0.670
MOD_CK1_1	29	35	PF00069	0.461
MOD_CK1_1	409	415	PF00069	0.713
MOD_CK2_1	116	122	PF00069	0.529
MOD_CK2_1	178	184	PF00069	0.434
MOD_CK2_1	194	200	PF00069	0.484
MOD_CK2_1	267	273	PF00069	0.473
MOD_CK2_1	318	324	PF00069	0.491
MOD_CK2_1	329	335	PF00069	0.520
MOD_GlcNHglycan	12	15	PF01048	0.685
MOD_GlcNHglycan	122	126	PF01048	0.471
MOD_GlcNHglycan	128	131	PF01048	0.434
MOD_GlcNHglycan	264	267	PF01048	0.677
MOD_GlcNHglycan	27	31	PF01048	0.617
MOD_GlcNHglycan	308	311	PF01048	0.482
MOD_GlcNHglycan	334	338	PF01048	0.480
MOD_GlcNHglycan	350	353	PF01048	0.457
MOD_GlcNHglycan	45	48	PF01048	0.282
MOD_GSK3_1	105	112	PF00069	0.737
MOD_GSK3_1	121	128	PF00069	0.375
MOD_GSK3_1	186	193	PF00069	0.612
MOD_GSK3_1	26	33	PF00069	0.539
MOD_GSK3_1	289	296	PF00069	0.439
MOD_GSK3_1	299	306	PF00069	0.402
MOD_GSK3_1	329	336	PF00069	0.646
MOD_GSK3_1	344	351	PF00069	0.446
MOD_GSK3_1	379	386	PF00069	0.492
MOD_GSK3_1	402	409	PF00069	0.614
MOD_GSK3_1	448	455	PF00069	0.667
MOD_GSK3_1	471	478	PF00069	0.570
MOD_N-GLC_1	51	56	PF02516	0.294
MOD_NEK2_1	165	170	PF00069	0.493
MOD_NEK2_1	178	183	PF00069	0.499
MOD_NEK2_1	26	31	PF00069	0.528
MOD_NEK2_1	289	294	PF00069	0.265
MOD_NEK2_1	348	353	PF00069	0.463
MOD_NEK2_1	74	79	PF00069	0.409
MOD_NEK2_2	30	35	PF00069	0.344
MOD_NEK2_2	394	399	PF00069	0.486
MOD_NEK2_2	79	84	PF00069	0.373
MOD_NEK2_2	92	97	PF00069	0.253
MOD_PIKK_1	267	273	PF00454	0.370
MOD_PIKK_1	303	309	PF00454	0.398
MOD_PIKK_1	406	412	PF00454	0.564
MOD_PK_1	429	435	PF00069	0.600
MOD_PKA_1	344	350	PF00069	0.346
MOD_PKA_1	475	481	PF00069	0.485
MOD_PKA_2	165	171	PF00069	0.501
MOD_PKA_2	267	273	PF00069	0.501
MOD_PKA_2	344	350	PF00069	0.466
MOD_PKA_2	402	408	PF00069	0.550
MOD_PKA_2	475	481	PF00069	0.493
MOD_Plk_1	105	111	PF00069	0.734
MOD_Plk_1	121	127	PF00069	0.298
MOD_Plk_1	209	215	PF00069	0.676
MOD_Plk_1	383	389	PF00069	0.332
MOD_Plk_2-3	105	111	PF00069	0.700
MOD_Plk_2-3	329	335	PF00069	0.520
MOD_Plk_4	318	324	PF00069	0.430
MOD_ProDKin_1	260	266	PF00069	0.567
MOD_ProDKin_1	385	391	PF00069	0.518
MOD_ProDKin_1	448	454	PF00069	0.610
MOD_ProDKin_1	98	104	PF00069	0.526
MOD_SUMO_rev_2	439	448	PF00179	0.545
TRG_DiLeu_BaEn_2	271	277	PF01217	0.419
TRG_DiLeu_BaEn_2	436	442	PF01217	0.493
TRG_DiLeu_BaEn_4	272	278	PF01217	0.271
TRG_ENDOCYTIC_2	159	162	PF00928	0.462
TRG_ENDOCYTIC_2	169	172	PF00928	0.252
TRG_ENDOCYTIC_2	85	88	PF00928	0.318
TRG_ER_diArg_1	1	3	PF00400	0.530
TRG_ER_diArg_1	231	233	PF00400	0.423
TRG_ER_diArg_1	343	345	PF00400	0.368
TRG_ER_diArg_1	364	366	PF00400	0.413
TRG_ER_diArg_1	374	376	PF00400	0.314
TRG_ER_diArg_1	413	415	PF00400	0.585
TRG_ER_diArg_1	461	464	PF00400	0.638
TRG_ER_diArg_1	467	469	PF00400	0.599
TRG_ER_diArg_1	475	477	PF00400	0.493
TRG_NLS_Bipartite_1	468	489	PF00514	0.553
TRG_NLS_MonoCore_2	484	489	PF00514	0.452
TRG_NLS_MonoExtN_4	483	489	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S3	Leptomonas seymouri	58%	100%
A0A1X0P4N9	Trypanosomatidae	34%	100%
A0A3R7KSE1	Trypanosoma rangeli	36%	100%
A0A3S7X0E2	Leishmania donovani	93%	100%
A4HFF0	Leishmania braziliensis	80%	100%
A4I2L9	Leishmania infantum	93%	100%
D0A5N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AYT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BSR3	Trypanosoma cruzi	35%	100%