Acyl carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl carrier protein, mitochondrial, putative

Species:

Leishmania major

UniProt:

E9AD06_LEIMA

TriTrypDb:

LmjF.27.0290 , LMJLV39_270007900 , LMJSD75_270007800

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005747	mitochondrial respiratory chain complex I	4	2
GO:0005759	mitochondrial matrix	5	2
GO:0030964	NADH dehydrogenase complex	3	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0045271	respiratory chain complex I	4	2
GO:0070013	intracellular organelle lumen	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990204	oxidoreductase complex	3	2
GO:1990351	transporter complex	2	2

Expansion

Sequence features

E9AD06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD06

PDB structure(s): 2m5r_A , 5zws_A , 5zws_B , 5zwt_A , 5zwt_B , 7am2_CC

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006631	fatty acid metabolic process	4	11
GO:0006633	fatty acid biosynthetic process	5	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016053	organic acid biosynthetic process	4	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046394	carboxylic acid biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0072330	monocarboxylic acid biosynthetic process	6	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000035	acyl binding	2	2
GO:0000036	acyl carrier activity	3	2
GO:0005488	binding	1	2
GO:0044620	ACP phosphopantetheine attachment site binding	3	2
GO:0051192	prosthetic group binding	2	2
GO:0140104	molecular carrier activity	1	2
GO:0140414	phosphopantetheine-dependent carrier activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.482
CLV_C14_Caspase3-7	86	90	PF00656	0.482
CLV_NRD_NRD_1	7	9	PF00675	0.713
CLV_PCSK_KEX2_1	7	9	PF00082	0.808
CLV_PCSK_PC7_1	3	9	PF00082	0.829
CLV_PCSK_SKI1_1	12	16	PF00082	0.823
DEG_Nend_UBRbox_3	1	3	PF02207	0.727
DOC_PP2B_LxvP_1	123	126	PF13499	0.482
DOC_USP7_MATH_1	22	26	PF00917	0.771
DOC_USP7_UBL2_3	83	87	PF12436	0.482
DOC_WW_Pin1_4	91	96	PF00397	0.474
LIG_14-3-3_CanoR_1	23	31	PF00244	0.804
LIG_FHA_1	74	80	PF00498	0.335
LIG_Integrin_RGD_1	32	34	PF01839	0.596
LIG_LIR_Nem_3	13	18	PF02991	0.790
LIG_SH2_STAT3	142	145	PF00017	0.553
LIG_SH2_STAT5	142	145	PF00017	0.548
LIG_SH2_STAT5	67	70	PF00017	0.509
LIG_SUMO_SIM_anti_2	107	112	PF11976	0.482
LIG_SUMO_SIM_par_1	120	127	PF11976	0.471
LIG_WRC_WIRS_1	42	47	PF05994	0.829
MOD_CK1_1	61	67	PF00069	0.751
MOD_CK1_1	91	97	PF00069	0.354
MOD_GlcNHglycan	12	15	PF01048	0.829
MOD_GlcNHglycan	34	37	PF01048	0.757
MOD_GlcNHglycan	52	55	PF01048	0.574
MOD_GlcNHglycan	63	66	PF01048	0.648
MOD_GSK3_1	41	48	PF00069	0.700
MOD_GSK3_1	69	76	PF00069	0.581
MOD_N-GLC_1	10	15	PF02516	0.834
MOD_NEK2_1	45	50	PF00069	0.687
MOD_PIKK_1	22	28	PF00454	0.826
MOD_PK_1	132	138	PF00069	0.335
MOD_PKA_2	22	28	PF00069	0.818
MOD_Plk_1	10	16	PF00069	0.834
MOD_Plk_4	41	47	PF00069	0.840
MOD_ProDKin_1	91	97	PF00069	0.324
TRG_ER_diArg_1	38	41	PF00400	0.596
TRG_ER_diArg_1	6	8	PF00400	0.829

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S1	Leptomonas seymouri	83%	100%
A0A0S4KI16	Bodo saltans	76%	100%
A0A1X0NLX3	Trypanosomatidae	62%	100%
A0A3Q8ICI1	Leishmania donovani	93%	100%
A0A422NXN1	Trypanosoma rangeli	62%	100%
A4HFE7	Leishmania braziliensis	87%	100%
A4I2L8	Leishmania infantum	93%	100%
C9ZKW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AYT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P11943	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	45%	100%
P32463	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P52413	Cuphea lanceolata	34%	100%
P53665	Arabidopsis thaliana	50%	100%