Conserved plasma membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD03_LEIMA

TriTrypDb:

LmjF.27.0260 , LMJLV39_270007700 , LMJSD75_270007600

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AD03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.682
CLV_NRD_NRD_1	290	292	PF00675	0.579
CLV_NRD_NRD_1	93	95	PF00675	0.474
CLV_PCSK_KEX2_1	106	108	PF00082	0.317
CLV_PCSK_KEX2_1	93	95	PF00082	0.474
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.314
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.470
CLV_PCSK_SKI1_1	136	140	PF00082	0.350
CLV_PCSK_SKI1_1	213	217	PF00082	0.419
CLV_PCSK_SKI1_1	281	285	PF00082	0.466
CLV_PCSK_SKI1_1	95	99	PF00082	0.347
DEG_APCC_DBOX_1	93	101	PF00400	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.419
DEG_SPOP_SBC_1	172	176	PF00917	0.681
DOC_CYCLIN_RxL_1	92	99	PF00134	0.590
DOC_MAPK_gen_1	93	102	PF00069	0.548
DOC_MAPK_MEF2A_6	93	102	PF00069	0.598
DOC_PP4_FxxP_1	116	119	PF00568	0.606
DOC_USP7_MATH_1	172	176	PF00917	0.686
DOC_USP7_MATH_1	186	190	PF00917	0.580
DOC_USP7_MATH_1	248	252	PF00917	0.708
DOC_USP7_MATH_1	81	85	PF00917	0.481
DOC_WW_Pin1_4	301	306	PF00397	0.723
LIG_14-3-3_CanoR_1	171	181	PF00244	0.603
LIG_14-3-3_CanoR_1	3	11	PF00244	0.459
LIG_BIR_III_4	269	273	PF00653	0.606
LIG_FHA_1	143	149	PF00498	0.645
LIG_FHA_1	182	188	PF00498	0.627
LIG_FHA_1	221	227	PF00498	0.608
LIG_FHA_1	250	256	PF00498	0.661
LIG_FHA_1	293	299	PF00498	0.692
LIG_FHA_1	37	43	PF00498	0.333
LIG_FHA_1	77	83	PF00498	0.444
LIG_FHA_2	129	135	PF00498	0.551
LIG_FHA_2	252	258	PF00498	0.623
LIG_Integrin_RGD_1	277	279	PF01839	0.431
LIG_IRF3_LxIS_1	146	151	PF10401	0.585
LIG_LIR_Gen_1	205	215	PF02991	0.543
LIG_LIR_Gen_1	257	267	PF02991	0.582
LIG_LIR_Nem_3	164	168	PF02991	0.592
LIG_LIR_Nem_3	205	211	PF02991	0.537
LIG_LIR_Nem_3	257	263	PF02991	0.558
LIG_MYND_1	285	289	PF01753	0.703
LIG_SH2_CRK	165	169	PF00017	0.635
LIG_SH2_STAP1	142	146	PF00017	0.511
LIG_SH2_STAP1	208	212	PF00017	0.602
LIG_SH2_STAT5	238	241	PF00017	0.546
LIG_SH3_3	193	199	PF00018	0.581
LIG_SH3_3	8	14	PF00018	0.483
LIG_SH3_4	284	291	PF00018	0.732
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.448
LIG_SUMO_SIM_anti_2	174	184	PF11976	0.620
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.572
LIG_SUMO_SIM_par_1	143	151	PF11976	0.649
LIG_SUMO_SIM_par_1	225	231	PF11976	0.595
LIG_SUMO_SIM_par_1	78	84	PF11976	0.291
LIG_UBA3_1	211	216	PF00899	0.609
MOD_CK1_1	128	134	PF00069	0.505
MOD_CK1_1	174	180	PF00069	0.656
MOD_CK1_1	200	206	PF00069	0.592
MOD_CK1_1	251	257	PF00069	0.623
MOD_CK1_1	27	33	PF00069	0.441
MOD_CK1_1	293	299	PF00069	0.738
MOD_CK2_1	128	134	PF00069	0.554
MOD_CK2_1	174	180	PF00069	0.676
MOD_CK2_1	251	257	PF00069	0.645
MOD_CK2_1	29	35	PF00069	0.440
MOD_CK2_1	293	299	PF00069	0.770
MOD_CK2_1	50	56	PF00069	0.424
MOD_Cter_Amidation	104	107	PF01082	0.476
MOD_GlcNHglycan	110	113	PF01048	0.408
MOD_GlcNHglycan	202	205	PF01048	0.318
MOD_GlcNHglycan	295	298	PF01048	0.545
MOD_GlcNHglycan	31	34	PF01048	0.646
MOD_GSK3_1	138	145	PF00069	0.625
MOD_GSK3_1	24	31	PF00069	0.348
MOD_GSK3_1	249	256	PF00069	0.629
MOD_GSK3_1	76	83	PF00069	0.376
MOD_NEK2_1	148	153	PF00069	0.589
MOD_NEK2_1	173	178	PF00069	0.601
MOD_NEK2_1	181	186	PF00069	0.638
MOD_NEK2_1	202	207	PF00069	0.575
MOD_NEK2_1	4	9	PF00069	0.357
MOD_PKA_2	273	279	PF00069	0.640
MOD_PKA_2	290	296	PF00069	0.768
MOD_Plk_1	128	134	PF00069	0.560
MOD_Plk_1	142	148	PF00069	0.647
MOD_Plk_2-3	253	259	PF00069	0.629
MOD_Plk_2-3	50	56	PF00069	0.424
MOD_Plk_4	17	23	PF00069	0.366
MOD_Plk_4	197	203	PF00069	0.573
MOD_Plk_4	207	213	PF00069	0.495
MOD_ProDKin_1	301	307	PF00069	0.719
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.612
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.621
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.602
TRG_ENDOCYTIC_2	165	168	PF00928	0.621
TRG_ENDOCYTIC_2	208	211	PF00928	0.519
TRG_NLS_MonoExtN_4	289	295	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX16	Leptomonas seymouri	43%	95%
A0A1X0NLT3	Trypanosomatidae	25%	91%
A0A3Q8IE36	Leishmania donovani	91%	100%
A0A3R7M6X5	Trypanosoma rangeli	26%	93%
A4HFE5	Leishmania braziliensis	74%	100%
A4I2L5	Leishmania infantum	91%	100%
C9ZKW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	84%
E9AYS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%