Kinetoplast-associated protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein-like protein

Species:

Leishmania major

UniProt:

E9AD01_LEIMA

TriTrypDb:

LmjF.27.0240

Length:

729

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AD01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.597
CLV_PCSK_KEX2_1	15	17	PF00082	0.594
CLV_PCSK_KEX2_1	25	27	PF00082	0.551
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.558
CLV_PCSK_PC7_1	21	27	PF00082	0.558
DOC_MAPK_gen_1	25	32	PF00069	0.556
LIG_FHA_1	50	56	PF00498	0.517
LIG_FHA_2	29	35	PF00498	0.561
LIG_SH2_STAP1	4	8	PF00017	0.579
LIG_SH2_STAT5	4	7	PF00017	0.581
LIG_TRAF2_1	33	36	PF00917	0.540
MOD_CK1_1	10	16	PF00069	0.604
MOD_CK2_1	17	23	PF00069	0.570
MOD_CK2_1	28	34	PF00069	0.549
MOD_GSK3_1	17	24	PF00069	0.582
MOD_GSK3_1	2	9	PF00069	0.606
MOD_GSK3_1	44	51	PF00069	0.549
MOD_N-GLC_1	28	33	PF02516	0.560
MOD_PKA_2	2	8	PF00069	0.588
MOD_PKA_2	44	50	PF00069	0.558
MOD_Plk_1	28	34	PF00069	0.564
TRG_DiLeu_BaEn_4	110	116	PF01217	0.466
TRG_DiLeu_BaEn_4	120	126	PF01217	0.435
TRG_DiLeu_BaEn_4	130	136	PF01217	0.442
TRG_DiLeu_BaEn_4	140	146	PF01217	0.436
TRG_DiLeu_BaEn_4	170	176	PF01217	0.480
TRG_DiLeu_BaEn_4	180	186	PF01217	0.466
TRG_DiLeu_BaEn_4	190	196	PF01217	0.485
TRG_DiLeu_BaEn_4	220	226	PF01217	0.546
TRG_DiLeu_BaEn_4	230	236	PF01217	0.519
TRG_DiLeu_BaEn_4	250	256	PF01217	0.543
TRG_DiLeu_BaEn_4	260	266	PF01217	0.528
TRG_DiLeu_BaEn_4	270	276	PF01217	0.543
TRG_DiLeu_BaEn_4	300	306	PF01217	0.561
TRG_DiLeu_BaEn_4	310	316	PF01217	0.530
TRG_DiLeu_BaEn_4	350	356	PF01217	0.524
TRG_DiLeu_BaEn_4	360	366	PF01217	0.491
TRG_DiLeu_BaEn_4	370	376	PF01217	0.484
TRG_DiLeu_BaEn_4	390	396	PF01217	0.506
TRG_DiLeu_BaEn_4	410	416	PF01217	0.500
TRG_DiLeu_BaEn_4	420	426	PF01217	0.500
TRG_DiLeu_BaEn_4	430	436	PF01217	0.501
TRG_DiLeu_BaEn_4	460	466	PF01217	0.543
TRG_DiLeu_BaEn_4	470	476	PF01217	0.522
TRG_DiLeu_BaEn_4	490	496	PF01217	0.549
TRG_DiLeu_BaEn_4	500	506	PF01217	0.564
TRG_DiLeu_BaEn_4	510	516	PF01217	0.537
TRG_DiLeu_BaEn_4	550	556	PF01217	0.540
TRG_DiLeu_BaEn_4	560	566	PF01217	0.506
TRG_DiLeu_BaEn_4	570	576	PF01217	0.483
TRG_DiLeu_BaEn_4	580	586	PF01217	0.493
TRG_DiLeu_BaEn_4	590	596	PF01217	0.493
TRG_DiLeu_BaEn_4	60	66	PF01217	0.474
TRG_DiLeu_BaEn_4	610	616	PF01217	0.494
TRG_DiLeu_BaEn_4	640	646	PF01217	0.486
TRG_DiLeu_BaEn_4	690	696	PF01217	0.451
TRG_DiLeu_BaEn_4	710	716	PF01217	0.452
TRG_DiLeu_BaEn_4	720	726	PF01217	0.451
TRG_DiLeu_BaEn_4	80	86	PF01217	0.455
TRG_DiLeu_BaEn_4	90	96	PF01217	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJE1	Leishmania donovani	62%	78%
A4HFE2	Leishmania braziliensis	88%	79%
A4HFE3	Leishmania braziliensis	85%	100%
A4I2L3	Leishmania infantum	92%	100%