A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | yes | yes: 5 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 5 |
NetGPI | no | yes: 0, no: 5 |
Term | Name | Level | Count |
---|---|---|---|
GO:0016020 | membrane | 2 | 1 |
GO:0110165 | cellular anatomical entity | 1 | 1 |
Related structures:
AlphaFold database: E9AD01
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_NRD_NRD_1 | 15 | 17 | PF00675 | 0.597 |
CLV_PCSK_KEX2_1 | 15 | 17 | PF00082 | 0.594 |
CLV_PCSK_KEX2_1 | 25 | 27 | PF00082 | 0.551 |
CLV_PCSK_PC1ET2_1 | 25 | 27 | PF00082 | 0.558 |
CLV_PCSK_PC7_1 | 21 | 27 | PF00082 | 0.558 |
DOC_MAPK_gen_1 | 25 | 32 | PF00069 | 0.556 |
LIG_FHA_1 | 50 | 56 | PF00498 | 0.517 |
LIG_FHA_2 | 29 | 35 | PF00498 | 0.561 |
LIG_SH2_STAP1 | 4 | 8 | PF00017 | 0.579 |
LIG_SH2_STAT5 | 4 | 7 | PF00017 | 0.581 |
LIG_TRAF2_1 | 33 | 36 | PF00917 | 0.540 |
MOD_CK1_1 | 10 | 16 | PF00069 | 0.604 |
MOD_CK2_1 | 17 | 23 | PF00069 | 0.570 |
MOD_CK2_1 | 28 | 34 | PF00069 | 0.549 |
MOD_GSK3_1 | 17 | 24 | PF00069 | 0.582 |
MOD_GSK3_1 | 2 | 9 | PF00069 | 0.606 |
MOD_GSK3_1 | 44 | 51 | PF00069 | 0.549 |
MOD_N-GLC_1 | 28 | 33 | PF02516 | 0.560 |
MOD_PKA_2 | 2 | 8 | PF00069 | 0.588 |
MOD_PKA_2 | 44 | 50 | PF00069 | 0.558 |
MOD_Plk_1 | 28 | 34 | PF00069 | 0.564 |
TRG_DiLeu_BaEn_4 | 110 | 116 | PF01217 | 0.466 |
TRG_DiLeu_BaEn_4 | 120 | 126 | PF01217 | 0.435 |
TRG_DiLeu_BaEn_4 | 130 | 136 | PF01217 | 0.442 |
TRG_DiLeu_BaEn_4 | 140 | 146 | PF01217 | 0.436 |
TRG_DiLeu_BaEn_4 | 170 | 176 | PF01217 | 0.480 |
TRG_DiLeu_BaEn_4 | 180 | 186 | PF01217 | 0.466 |
TRG_DiLeu_BaEn_4 | 190 | 196 | PF01217 | 0.485 |
TRG_DiLeu_BaEn_4 | 220 | 226 | PF01217 | 0.546 |
TRG_DiLeu_BaEn_4 | 230 | 236 | PF01217 | 0.519 |
TRG_DiLeu_BaEn_4 | 250 | 256 | PF01217 | 0.543 |
TRG_DiLeu_BaEn_4 | 260 | 266 | PF01217 | 0.528 |
TRG_DiLeu_BaEn_4 | 270 | 276 | PF01217 | 0.543 |
TRG_DiLeu_BaEn_4 | 300 | 306 | PF01217 | 0.561 |
TRG_DiLeu_BaEn_4 | 310 | 316 | PF01217 | 0.530 |
TRG_DiLeu_BaEn_4 | 350 | 356 | PF01217 | 0.524 |
TRG_DiLeu_BaEn_4 | 360 | 366 | PF01217 | 0.491 |
TRG_DiLeu_BaEn_4 | 370 | 376 | PF01217 | 0.484 |
TRG_DiLeu_BaEn_4 | 390 | 396 | PF01217 | 0.506 |
TRG_DiLeu_BaEn_4 | 410 | 416 | PF01217 | 0.500 |
TRG_DiLeu_BaEn_4 | 420 | 426 | PF01217 | 0.500 |
TRG_DiLeu_BaEn_4 | 430 | 436 | PF01217 | 0.501 |
TRG_DiLeu_BaEn_4 | 460 | 466 | PF01217 | 0.543 |
TRG_DiLeu_BaEn_4 | 470 | 476 | PF01217 | 0.522 |
TRG_DiLeu_BaEn_4 | 490 | 496 | PF01217 | 0.549 |
TRG_DiLeu_BaEn_4 | 500 | 506 | PF01217 | 0.564 |
TRG_DiLeu_BaEn_4 | 510 | 516 | PF01217 | 0.537 |
TRG_DiLeu_BaEn_4 | 550 | 556 | PF01217 | 0.540 |
TRG_DiLeu_BaEn_4 | 560 | 566 | PF01217 | 0.506 |
TRG_DiLeu_BaEn_4 | 570 | 576 | PF01217 | 0.483 |
TRG_DiLeu_BaEn_4 | 580 | 586 | PF01217 | 0.493 |
TRG_DiLeu_BaEn_4 | 590 | 596 | PF01217 | 0.493 |
TRG_DiLeu_BaEn_4 | 60 | 66 | PF01217 | 0.474 |
TRG_DiLeu_BaEn_4 | 610 | 616 | PF01217 | 0.494 |
TRG_DiLeu_BaEn_4 | 640 | 646 | PF01217 | 0.486 |
TRG_DiLeu_BaEn_4 | 690 | 696 | PF01217 | 0.451 |
TRG_DiLeu_BaEn_4 | 710 | 716 | PF01217 | 0.452 |
TRG_DiLeu_BaEn_4 | 720 | 726 | PF01217 | 0.451 |
TRG_DiLeu_BaEn_4 | 80 | 86 | PF01217 | 0.455 |
TRG_DiLeu_BaEn_4 | 90 | 96 | PF01217 | 0.435 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A3Q8IJE1 | Leishmania donovani | 62% | 78% |
A4HFE2 | Leishmania braziliensis | 88% | 79% |
A4HFE3 | Leishmania braziliensis | 85% | 100% |
A4I2L3 | Leishmania infantum | 92% | 100% |