Tyrosine-protein phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACZ9_LEIMA

TriTrypDb:

LmjF.27.0220 , LMJLV39_270007400 , LMJSD75_270007200

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.556
CLV_NRD_NRD_1	159	161	PF00675	0.507
CLV_NRD_NRD_1	178	180	PF00675	0.386
CLV_NRD_NRD_1	281	283	PF00675	0.581
CLV_NRD_NRD_1	293	295	PF00675	0.401
CLV_NRD_NRD_1	74	76	PF00675	0.474
CLV_NRD_NRD_1	83	85	PF00675	0.427
CLV_PCSK_KEX2_1	159	161	PF00082	0.470
CLV_PCSK_KEX2_1	177	179	PF00082	0.377
CLV_PCSK_KEX2_1	20	22	PF00082	0.469
CLV_PCSK_KEX2_1	280	282	PF00082	0.595
CLV_PCSK_KEX2_1	293	295	PF00082	0.350
CLV_PCSK_KEX2_1	83	85	PF00082	0.465
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.516
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.483
CLV_PCSK_PC7_1	173	179	PF00082	0.469
CLV_PCSK_SKI1_1	116	120	PF00082	0.544
CLV_PCSK_SKI1_1	189	193	PF00082	0.488
CLV_PCSK_SKI1_1	202	206	PF00082	0.323
CLV_PCSK_SKI1_1	301	305	PF00082	0.455
CLV_PCSK_SKI1_1	75	79	PF00082	0.521
DEG_APCC_DBOX_1	115	123	PF00400	0.599
DEG_APCC_DBOX_1	74	82	PF00400	0.489
DEG_COP1_1	223	234	PF00400	0.517
DOC_CDC14_PxL_1	128	136	PF14671	0.492
DOC_CDC14_PxL_1	228	236	PF14671	0.326
DOC_CYCLIN_RxL_1	73	82	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.442
DOC_MAPK_gen_1	159	167	PF00069	0.518
DOC_MAPK_gen_1	184	193	PF00069	0.567
DOC_MAPK_gen_1	75	81	PF00069	0.463
DOC_MAPK_gen_1	83	89	PF00069	0.425
DOC_MAPK_MEF2A_6	43	51	PF00069	0.493
DOC_PP1_RVXF_1	74	81	PF00149	0.518
DOC_PP2B_LxvP_1	204	207	PF13499	0.501
DOC_PP4_FxxP_1	141	144	PF00568	0.572
DOC_USP7_MATH_1	10	14	PF00917	0.481
DOC_USP7_MATH_1	142	146	PF00917	0.553
DOC_USP7_MATH_1	245	249	PF00917	0.593
DOC_USP7_MATH_1	258	262	PF00917	0.583
DOC_USP7_MATH_1	52	56	PF00917	0.542
DOC_USP7_MATH_1	70	74	PF00917	0.276
DOC_WW_Pin1_4	29	34	PF00397	0.544
DOC_WW_Pin1_4	43	48	PF00397	0.325
LIG_14-3-3_CanoR_1	147	156	PF00244	0.517
LIG_14-3-3_CanoR_1	178	187	PF00244	0.539
LIG_Clathr_ClatBox_1	310	314	PF01394	0.586
LIG_EVH1_1	128	132	PF00568	0.469
LIG_FHA_1	285	291	PF00498	0.523
LIG_FHA_1	298	304	PF00498	0.437
LIG_FHA_1	305	311	PF00498	0.474
LIG_FHA_2	222	228	PF00498	0.683
LIG_Integrin_RGD_1	63	65	PF01839	0.497
LIG_LIR_Gen_1	166	176	PF02991	0.502
LIG_LIR_Nem_3	125	131	PF02991	0.491
LIG_LIR_Nem_3	166	172	PF02991	0.496
LIG_LYPXL_S_1	127	131	PF13949	0.510
LIG_LYPXL_yS_3	128	131	PF13949	0.515
LIG_MAD2	294	302	PF02301	0.516
LIG_MYND_1	232	236	PF01753	0.383
LIG_Pex14_1	96	100	PF04695	0.423
LIG_PTAP_UEV_1	211	216	PF05743	0.592
LIG_PTB_Apo_2	47	54	PF02174	0.489
LIG_PTB_Phospho_1	47	53	PF10480	0.481
LIG_SH2_CRK	169	173	PF00017	0.518
LIG_SH2_CRK	53	57	PF00017	0.532
LIG_SH2_NCK_1	53	57	PF00017	0.532
LIG_SH2_STAT3	104	107	PF00017	0.517
LIG_SH3_3	124	130	PF00018	0.430
LIG_SH3_3	209	215	PF00018	0.511
LIG_SH3_3	226	232	PF00018	0.475
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.567
LIG_TYR_ITIM	167	172	PF00017	0.536
LIG_TYR_ITIM	51	56	PF00017	0.531
LIG_WW_2	129	132	PF00397	0.475
MOD_CK1_1	276	282	PF00069	0.559
MOD_CK2_1	147	153	PF00069	0.478
MOD_CK2_1	245	251	PF00069	0.629
MOD_GlcNHglycan	12	15	PF01048	0.495
MOD_GlcNHglycan	149	152	PF01048	0.549
MOD_GlcNHglycan	211	215	PF01048	0.555
MOD_GlcNHglycan	260	263	PF01048	0.528
MOD_GSK3_1	16	23	PF00069	0.428
MOD_GSK3_1	265	272	PF00069	0.451
MOD_NEK2_1	122	127	PF00069	0.476
MOD_NEK2_1	165	170	PF00069	0.438
MOD_NEK2_1	221	226	PF00069	0.723
MOD_NEK2_1	274	279	PF00069	0.552
MOD_NEK2_1	79	84	PF00069	0.523
MOD_NEK2_2	52	57	PF00069	0.531
MOD_OFUCOSY	264	269	PF10250	0.407
MOD_PK_1	20	26	PF00069	0.510
MOD_PKA_1	20	26	PF00069	0.463
MOD_PKA_2	185	191	PF00069	0.574
MOD_PKA_2	20	26	PF00069	0.445
MOD_Plk_1	165	171	PF00069	0.520
MOD_Plk_4	123	129	PF00069	0.472
MOD_Plk_4	167	173	PF00069	0.496
MOD_Plk_4	230	236	PF00069	0.389
MOD_Plk_4	52	58	PF00069	0.517
MOD_Plk_4	91	97	PF00069	0.422
MOD_ProDKin_1	29	35	PF00069	0.537
MOD_ProDKin_1	43	49	PF00069	0.316
TRG_DiLeu_BaEn_1	217	222	PF01217	0.677
TRG_DiLeu_BaEn_1	305	310	PF01217	0.468
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.509
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.507
TRG_ENDOCYTIC_2	128	131	PF00928	0.489
TRG_ENDOCYTIC_2	169	172	PF00928	0.510
TRG_ENDOCYTIC_2	53	56	PF00928	0.537
TRG_ER_diArg_1	159	161	PF00400	0.510
TRG_ER_diArg_1	280	282	PF00400	0.594
TRG_ER_diArg_1	293	295	PF00400	0.353
TRG_ER_diArg_1	83	86	PF00400	0.479
TRG_NLS_Bipartite_1	159	181	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E8	Leptomonas seymouri	62%	100%
A0A0S4IST0	Bodo saltans	30%	91%
A0A1X0NLN1	Trypanosomatidae	40%	92%
A0A381MKM4	Leishmania infantum	94%	100%
A0A3S7X0D1	Leishmania donovani	94%	100%
A0A422NXN0	Trypanosoma rangeli	40%	94%
A4HFE0	Leishmania braziliensis	84%	100%
C9ZKW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
E9AYS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BBP3	Trypanosoma cruzi	39%	94%