Vacuolar iron transporter 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar iron transporter 1, putative

Species:

Leishmania major

UniProt:

E9ACZ8_LEIMA

TriTrypDb:

LmjF.27.0210 , LMJLV39_270007300 , LMJSD75_270007100

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	12
GO:0020022	acidocalcisome	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ACZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ8

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	12
GO:0006875	obsolete intracellular metal ion homeostasis	6	12
GO:0006880	intracellular sequestering of iron ion	4	2
GO:0009987	cellular process	1	12
GO:0019725	cellular homeostasis	2	12
GO:0030003	intracellular monoatomic cation homeostasis	5	12
GO:0030026	intracellular manganese ion homeostasis	8	12
GO:0042592	homeostatic process	3	12
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0051179	localization	1	2
GO:0051235	maintenance of location	2	2
GO:0051238	sequestering of metal ion	3	2
GO:0051651	maintenance of location in cell	2	2
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055071	manganese ion homeostasis	9	12
GO:0055076	obsolete transition metal ion homeostasis	8	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0055082	intracellular chemical homeostasis	3	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0097577	sequestering of iron ion	3	2
GO:0098771	inorganic ion homeostasis	6	12

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005381	iron ion transmembrane transporter activity	7	2
GO:0005384	manganese ion transmembrane transporter activity	7	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0046873	metal ion transmembrane transporter activity	5	12
GO:0046915	transition metal ion transmembrane transporter activity	6	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.200
CLV_NRD_NRD_1	36	38	PF00675	0.379
CLV_PCSK_KEX2_1	121	123	PF00082	0.193
CLV_PCSK_KEX2_1	36	38	PF00082	0.369
CLV_PCSK_SKI1_1	24	28	PF00082	0.305
DOC_CDC14_PxL_1	202	210	PF14671	0.276
DOC_CYCLIN_RxL_1	143	152	PF00134	0.511
DOC_CYCLIN_RxL_1	54	65	PF00134	0.422
DOC_MAPK_gen_1	162	170	PF00069	0.407
DOC_MAPK_gen_1	189	196	PF00069	0.403
DOC_MAPK_MEF2A_6	162	170	PF00069	0.418
DOC_MAPK_MEF2A_6	240	248	PF00069	0.454
DOC_PP1_RVXF_1	144	151	PF00149	0.511
DOC_PP1_RVXF_1	55	62	PF00149	0.407
DOC_USP7_MATH_1	276	280	PF00917	0.291
DOC_USP7_MATH_1	283	287	PF00917	0.392
DOC_USP7_MATH_1	77	81	PF00917	0.242
DOC_USP7_UBL2_3	14	18	PF12436	0.561
DOC_WD40_RPTOR_TOS_1	132	138	PF00400	0.418
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BIR_III_4	184	188	PF00653	0.438
LIG_BRCT_BRCA1_1	100	104	PF00533	0.230
LIG_BRCT_BRCA1_1	197	201	PF00533	0.369
LIG_BRCT_BRCA1_1	231	235	PF00533	0.465
LIG_BRCT_BRCA1_1	57	61	PF00533	0.407
LIG_Clathr_ClatBox_1	179	183	PF01394	0.511
LIG_deltaCOP1_diTrp_1	124	132	PF00928	0.418
LIG_EH1_1	153	161	PF00400	0.422
LIG_FHA_1	282	288	PF00498	0.395
LIG_FHA_1	68	74	PF00498	0.293
LIG_FHA_1	84	90	PF00498	0.218
LIG_LIR_Gen_1	169	178	PF02991	0.466
LIG_LIR_Gen_1	198	207	PF02991	0.257
LIG_LIR_Gen_1	219	228	PF02991	0.272
LIG_LIR_Gen_1	69	78	PF02991	0.245
LIG_LIR_Nem_3	101	107	PF02991	0.218
LIG_LIR_Nem_3	169	173	PF02991	0.498
LIG_LIR_Nem_3	198	202	PF02991	0.242
LIG_LIR_Nem_3	219	223	PF02991	0.241
LIG_LIR_Nem_3	58	64	PF02991	0.273
LIG_LIR_Nem_3	69	74	PF02991	0.249
LIG_PDZ_Class_2	284	289	PF00595	0.473
LIG_Pex14_2	100	104	PF04695	0.264
LIG_Pex14_2	223	227	PF04695	0.447
LIG_SH2_SRC	210	213	PF00017	0.288
LIG_SH2_STAT5	107	110	PF00017	0.418
LIG_SH2_STAT5	210	213	PF00017	0.259
LIG_SH2_STAT5	242	245	PF00017	0.432
LIG_SH2_STAT5	55	58	PF00017	0.483
LIG_UBA3_1	207	214	PF00899	0.301
LIG_WRC_WIRS_1	196	201	PF05994	0.242
LIG_WRC_WIRS_1	264	269	PF05994	0.276
LIG_WRC_WIRS_1	68	73	PF05994	0.242
MOD_CK1_1	2	8	PF00069	0.630
MOD_CK2_1	276	282	PF00069	0.316
MOD_CK2_1	32	38	PF00069	0.523
MOD_CK2_1	48	54	PF00069	0.466
MOD_CK2_1	7	13	PF00069	0.721
MOD_GlcNHglycan	108	111	PF01048	0.207
MOD_GlcNHglycan	250	253	PF01048	0.254
MOD_GlcNHglycan	261	264	PF01048	0.262
MOD_GlcNHglycan	278	281	PF01048	0.492
MOD_GlcNHglycan	50	53	PF01048	0.391
MOD_GlcNHglycan	79	82	PF01048	0.533
MOD_GlcNHglycan	9	12	PF01048	0.434
MOD_GSK3_1	222	229	PF00069	0.406
MOD_GSK3_1	244	251	PF00069	0.456
MOD_GSK3_1	259	266	PF00069	0.263
MOD_N-GLC_1	48	53	PF02516	0.495
MOD_N-GLC_1	7	12	PF02516	0.493
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	195	200	PF00069	0.242
MOD_NEK2_1	201	206	PF00069	0.242
MOD_NEK2_1	222	227	PF00069	0.257
MOD_NEK2_1	235	240	PF00069	0.306
MOD_NEK2_1	248	253	PF00069	0.438
MOD_NEK2_1	275	280	PF00069	0.364
MOD_NEK2_1	7	12	PF00069	0.747
MOD_NEK2_1	90	95	PF00069	0.274
MOD_Plk_1	128	134	PF00069	0.511
MOD_Plk_1	2	8	PF00069	0.643
MOD_Plk_4	152	158	PF00069	0.420
MOD_Plk_4	195	201	PF00069	0.278
MOD_Plk_4	2	8	PF00069	0.545
MOD_Plk_4	229	235	PF00069	0.301
MOD_Plk_4	263	269	PF00069	0.282
MOD_Plk_4	55	61	PF00069	0.407
MOD_Plk_4	83	89	PF00069	0.220
MOD_SUMO_rev_2	161	167	PF00179	0.432
TRG_DiLeu_BaEn_1	174	179	PF01217	0.432
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.276
TRG_ER_diArg_1	121	123	PF00400	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC2	Leptomonas seymouri	77%	99%
A0A0S4J3A7	Bodo saltans	58%	100%
A0A1X0NM64	Trypanosomatidae	69%	100%
A0A3Q8IE64	Leishmania donovani	98%	100%
A0A3R7MYU7	Trypanosoma rangeli	65%	100%
A4HFD9	Leishmania braziliensis	85%	100%
A4I355	Leishmania infantum	98%	100%
C9ZKW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AE74	Leishmania major	29%	97%
E9AYS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P0DO17	Eucalyptus grandis	28%	100%
Q6ERE5	Oryza sativa subsp. japonica	30%	100%
Q6MWE5	Oryza sativa subsp. japonica	27%	100%
Q9P6J2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9ZUA5	Arabidopsis thaliana	29%	100%
V5BKT4	Trypanosoma cruzi	69%	100%