C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACZ7_LEIMA

TriTrypDb:

LmjF.27.0200 , LMJLV39_270007200 , LMJSD75_270007000

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	11
GO:0016020	membrane	2	10
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

E9ACZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.562
CLV_NRD_NRD_1	313	315	PF00675	0.735
CLV_NRD_NRD_1	354	356	PF00675	0.536
CLV_PCSK_FUR_1	311	315	PF00082	0.730
CLV_PCSK_KEX2_1	28	30	PF00082	0.604
CLV_PCSK_KEX2_1	302	304	PF00082	0.773
CLV_PCSK_KEX2_1	311	313	PF00082	0.714
CLV_PCSK_KEX2_1	354	356	PF00082	0.518
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.790
CLV_PCSK_SKI1_1	82	86	PF00082	0.563
DEG_Nend_UBRbox_2	1	3	PF02207	0.543
DOC_MAPK_gen_1	136	144	PF00069	0.337
DOC_MAPK_gen_1	28	34	PF00069	0.353
DOC_USP7_MATH_1	126	130	PF00917	0.404
DOC_USP7_MATH_1	153	157	PF00917	0.323
DOC_WW_Pin1_4	144	149	PF00397	0.317
DOC_WW_Pin1_4	301	306	PF00397	0.617
DOC_WW_Pin1_4	317	322	PF00397	0.448
DOC_WW_Pin1_4	327	332	PF00397	0.380
DOC_WW_Pin1_4	358	363	PF00397	0.691
LIG_Actin_WH2_2	103	120	PF00022	0.403
LIG_Actin_WH2_2	153	170	PF00022	0.367
LIG_APCC_ABBA_1	84	89	PF00400	0.319
LIG_BRCT_BRCA1_1	102	106	PF00533	0.310
LIG_BRCT_BRCA1_1	270	274	PF00533	0.493
LIG_BRCT_BRCA1_1	90	94	PF00533	0.356
LIG_eIF4E_1	233	239	PF01652	0.379
LIG_FHA_1	167	173	PF00498	0.300
LIG_FHA_2	11	17	PF00498	0.358
LIG_FHA_2	145	151	PF00498	0.333
LIG_IBAR_NPY_1	164	166	PF08397	0.304
LIG_LIR_Apic_2	293	297	PF02991	0.498
LIG_LIR_Gen_1	59	69	PF02991	0.425
LIG_LIR_Nem_3	327	332	PF02991	0.522
LIG_LIR_Nem_3	59	64	PF02991	0.412
LIG_LIR_Nem_3	66	72	PF02991	0.426
LIG_LIR_Nem_3	88	93	PF02991	0.356
LIG_MLH1_MIPbox_1	90	94	PF16413	0.422
LIG_Pex14_2	90	94	PF04695	0.342
LIG_SH2_CRK	61	65	PF00017	0.354
LIG_SH2_GRB2like	61	64	PF00017	0.405
LIG_SH2_NCK_1	61	65	PF00017	0.314
LIG_SH2_PTP2	141	144	PF00017	0.410
LIG_SH2_STAP1	100	104	PF00017	0.317
LIG_SH2_STAP1	250	254	PF00017	0.396
LIG_SH2_STAP1	61	65	PF00017	0.409
LIG_SH2_STAT5	141	144	PF00017	0.410
LIG_SH2_STAT5	166	169	PF00017	0.289
LIG_SH2_STAT5	233	236	PF00017	0.344
LIG_SH2_STAT5	53	56	PF00017	0.339
LIG_SH2_STAT5	61	64	PF00017	0.313
LIG_SH3_3	282	288	PF00018	0.469
LIG_SUMO_SIM_par_1	168	175	PF11976	0.310
LIG_TYR_ITIM	139	144	PF00017	0.509
LIG_WW_3	284	288	PF00397	0.699
MOD_CDK_SPK_2	301	306	PF00069	0.714
MOD_CK1_1	59	65	PF00069	0.434
MOD_CK2_1	10	16	PF00069	0.516
MOD_CK2_1	126	132	PF00069	0.515
MOD_CK2_1	144	150	PF00069	0.401
MOD_CK2_1	191	197	PF00069	0.433
MOD_GlcNHglycan	18	21	PF01048	0.548
MOD_GlcNHglycan	256	259	PF01048	0.634
MOD_GlcNHglycan	266	269	PF01048	0.557
MOD_GlcNHglycan	333	336	PF01048	0.490
MOD_GlcNHglycan	35	38	PF01048	0.361
MOD_GlcNHglycan	88	93	PF01048	0.474
MOD_GSK3_1	12	19	PF00069	0.542
MOD_GSK3_1	250	257	PF00069	0.540
MOD_GSK3_1	264	271	PF00069	0.564
MOD_GSK3_1	286	293	PF00069	0.747
MOD_GSK3_1	327	334	PF00069	0.729
MOD_GSK3_1	52	59	PF00069	0.506
MOD_N-GLC_1	108	113	PF02516	0.356
MOD_N-GLC_1	191	196	PF02516	0.426
MOD_N-GLC_1	59	64	PF02516	0.511
MOD_NEK2_1	134	139	PF00069	0.391
MOD_NEK2_1	191	196	PF00069	0.529
MOD_NEK2_1	254	259	PF00069	0.584
MOD_NEK2_1	80	85	PF00069	0.379
MOD_PKA_2	286	292	PF00069	0.747
MOD_PKA_2	56	62	PF00069	0.446
MOD_Plk_1	108	114	PF00069	0.355
MOD_Plk_1	172	178	PF00069	0.396
MOD_Plk_1	203	209	PF00069	0.615
MOD_Plk_1	262	268	PF00069	0.644
MOD_Plk_1	73	79	PF00069	0.436
MOD_Plk_4	172	178	PF00069	0.385
MOD_Plk_4	203	209	PF00069	0.615
MOD_ProDKin_1	144	150	PF00069	0.385
MOD_ProDKin_1	301	307	PF00069	0.797
MOD_ProDKin_1	317	323	PF00069	0.570
MOD_ProDKin_1	327	333	PF00069	0.469
MOD_SUMO_rev_2	298	304	PF00179	0.802
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.704
TRG_ENDOCYTIC_2	141	144	PF00928	0.514
TRG_ENDOCYTIC_2	61	64	PF00928	0.519
TRG_ENDOCYTIC_2	87	90	PF00928	0.529
TRG_ER_diArg_1	135	138	PF00400	0.497
TRG_ER_diArg_1	28	30	PF00400	0.447
TRG_ER_diArg_1	311	314	PF00400	0.728
TRG_ER_diArg_1	354	356	PF00400	0.646
TRG_ER_diArg_1	4	7	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T9	Leptomonas seymouri	75%	97%
A0A1X0NNG2	Trypanosomatidae	47%	98%
A0A3R7NQS8	Trypanosoma rangeli	55%	99%
A0A3S7X0C2	Leishmania donovani	94%	98%
A4HFD8	Leishmania braziliensis	86%	99%
A4I356	Leishmania infantum	93%	98%
C9ZKV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AYS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
V5DCE2	Trypanosoma cruzi	56%	99%