Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACZ4_LEIMA

TriTrypDb:

LmjF.27.0170 , LMJLV39_270006900 , LMJSD75_270006700

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.550
CLV_NRD_NRD_1	161	163	PF00675	0.711
CLV_NRD_NRD_1	17	19	PF00675	0.625
CLV_NRD_NRD_1	95	97	PF00675	0.688
CLV_PCSK_FUR_1	15	19	PF00082	0.677
CLV_PCSK_KEX2_1	17	19	PF00082	0.632
CLV_PCSK_KEX2_1	358	360	PF00082	0.770
CLV_PCSK_KEX2_1	95	97	PF00082	0.688
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.770
CLV_PCSK_SKI1_1	18	22	PF00082	0.613
CLV_PCSK_SKI1_1	23	27	PF00082	0.599
CLV_PCSK_SKI1_1	35	39	PF00082	0.495
CLV_PCSK_SKI1_1	443	447	PF00082	0.374
DEG_Nend_UBRbox_3	1	3	PF02207	0.574
DEG_SPOP_SBC_1	37	41	PF00917	0.400
DOC_CYCLIN_RxL_1	382	392	PF00134	0.427
DOC_MAPK_gen_1	358	368	PF00069	0.503
DOC_MAPK_MEF2A_6	361	370	PF00069	0.517
DOC_MAPK_RevD_3	149	164	PF00069	0.448
DOC_PP1_RVXF_1	383	390	PF00149	0.251
DOC_PP2B_LxvP_1	246	249	PF13499	0.457
DOC_PP2B_LxvP_1	425	428	PF13499	0.618
DOC_USP7_MATH_1	212	216	PF00917	0.478
DOC_USP7_MATH_1	319	323	PF00917	0.498
DOC_USP7_MATH_1	350	354	PF00917	0.492
DOC_USP7_MATH_1	60	64	PF00917	0.379
DOC_WW_Pin1_4	223	228	PF00397	0.437
DOC_WW_Pin1_4	368	373	PF00397	0.428
LIG_14-3-3_CanoR_1	301	308	PF00244	0.347
LIG_14-3-3_CanoR_1	347	357	PF00244	0.563
LIG_14-3-3_CanoR_1	391	396	PF00244	0.362
LIG_14-3-3_CanoR_1	415	419	PF00244	0.666
LIG_BRCT_BRCA1_1	187	191	PF00533	0.371
LIG_BRCT_BRCA1_1	43	47	PF00533	0.435
LIG_Clathr_ClatBox_1	201	205	PF01394	0.398
LIG_Clathr_ClatBox_1	406	410	PF01394	0.342
LIG_Clathr_ClatBox_1	87	91	PF01394	0.453
LIG_CtBP_PxDLS_1	153	157	PF00389	0.437
LIG_eIF4E_1	433	439	PF01652	0.701
LIG_FHA_1	123	129	PF00498	0.437
LIG_FHA_1	228	234	PF00498	0.440
LIG_FHA_1	24	30	PF00498	0.503
LIG_FHA_1	365	371	PF00498	0.433
LIG_FHA_1	377	383	PF00498	0.395
LIG_FHA_1	394	400	PF00498	0.192
LIG_FHA_1	411	417	PF00498	0.402
LIG_FHA_1	461	467	PF00498	0.534
LIG_FHA_1	77	83	PF00498	0.415
LIG_FHA_2	156	162	PF00498	0.461
LIG_LIR_Gen_1	240	251	PF02991	0.399
LIG_LIR_Gen_1	341	350	PF02991	0.408
LIG_LIR_Gen_1	392	401	PF02991	0.362
LIG_LIR_Nem_3	240	246	PF02991	0.385
LIG_LIR_Nem_3	341	346	PF02991	0.375
LIG_LIR_Nem_3	392	398	PF02991	0.298
LIG_Pex14_2	389	393	PF04695	0.273
LIG_Rb_LxCxE_1	196	216	PF01857	0.375
LIG_SH2_PTP2	343	346	PF00017	0.377
LIG_SH2_STAT5	219	222	PF00017	0.329
LIG_SH2_STAT5	265	268	PF00017	0.333
LIG_SH2_STAT5	28	31	PF00017	0.454
LIG_SH2_STAT5	343	346	PF00017	0.381
LIG_SH2_STAT5	377	380	PF00017	0.368
LIG_SH2_STAT5	64	67	PF00017	0.322
LIG_SH2_STAT5	86	89	PF00017	0.345
LIG_SH3_3	254	260	PF00018	0.503
LIG_SH3_3	310	316	PF00018	0.417
LIG_SH3_3	415	421	PF00018	0.604
LIG_SUMO_SIM_anti_2	396	403	PF11976	0.354
LIG_SUMO_SIM_par_1	119	125	PF11976	0.399
LIG_SUMO_SIM_par_1	228	235	PF11976	0.415
LIG_SUMO_SIM_par_1	363	369	PF11976	0.472
LIG_SUMO_SIM_par_1	396	403	PF11976	0.402
LIG_TRAF2_1	353	356	PF00917	0.523
LIG_WRC_WIRS_1	390	395	PF05994	0.415
MOD_CK1_1	114	120	PF00069	0.304
MOD_CK1_1	129	135	PF00069	0.473
MOD_CK1_1	193	199	PF00069	0.391
MOD_CK1_1	270	276	PF00069	0.410
MOD_CK1_1	39	45	PF00069	0.400
MOD_CK1_1	49	55	PF00069	0.326
MOD_CK1_1	70	76	PF00069	0.370
MOD_CK1_1	80	86	PF00069	0.384
MOD_CK1_1	94	100	PF00069	0.461
MOD_CK2_1	107	113	PF00069	0.507
MOD_CK2_1	155	161	PF00069	0.458
MOD_CK2_1	223	229	PF00069	0.436
MOD_CK2_1	350	356	PF00069	0.484
MOD_GlcNHglycan	109	112	PF01048	0.782
MOD_GlcNHglycan	113	116	PF01048	0.752
MOD_GlcNHglycan	128	131	PF01048	0.649
MOD_GlcNHglycan	195	198	PF01048	0.568
MOD_GlcNHglycan	207	211	PF01048	0.629
MOD_GlcNHglycan	249	252	PF01048	0.662
MOD_GlcNHglycan	269	272	PF01048	0.471
MOD_GlcNHglycan	280	283	PF01048	0.573
MOD_GlcNHglycan	326	329	PF01048	0.594
MOD_GlcNHglycan	348	351	PF01048	0.702
MOD_GlcNHglycan	352	355	PF01048	0.767
MOD_GlcNHglycan	402	405	PF01048	0.335
MOD_GlcNHglycan	449	452	PF01048	0.418
MOD_GlcNHglycan	454	457	PF01048	0.389
MOD_GlcNHglycan	57	60	PF01048	0.627
MOD_GSK3_1	107	114	PF00069	0.537
MOD_GSK3_1	122	129	PF00069	0.389
MOD_GSK3_1	223	230	PF00069	0.430
MOD_GSK3_1	232	239	PF00069	0.379
MOD_GSK3_1	302	309	PF00069	0.423
MOD_GSK3_1	319	326	PF00069	0.438
MOD_GSK3_1	338	345	PF00069	0.370
MOD_GSK3_1	346	353	PF00069	0.460
MOD_GSK3_1	35	42	PF00069	0.387
MOD_GSK3_1	364	371	PF00069	0.409
MOD_GSK3_1	389	396	PF00069	0.408
MOD_GSK3_1	410	417	PF00069	0.611
MOD_GSK3_1	76	83	PF00069	0.391
MOD_GSK3_1	94	101	PF00069	0.417
MOD_N-GLC_1	309	314	PF02516	0.595
MOD_N-GLC_1	70	75	PF02516	0.534
MOD_N-GLC_1	77	82	PF02516	0.512
MOD_NEK2_1	154	159	PF00069	0.434
MOD_NEK2_1	185	190	PF00069	0.380
MOD_NEK2_1	342	347	PF00069	0.360
MOD_NEK2_1	366	371	PF00069	0.423
MOD_NEK2_1	389	394	PF00069	0.373
MOD_NEK2_1	400	405	PF00069	0.227
MOD_NEK2_1	414	419	PF00069	0.545
MOD_NEK2_1	55	60	PF00069	0.448
MOD_NEK2_1	76	81	PF00069	0.334
MOD_NEK2_2	213	218	PF00069	0.482
MOD_PIKK_1	114	120	PF00454	0.384
MOD_PIKK_1	94	100	PF00454	0.549
MOD_PKA_1	163	169	PF00069	0.485
MOD_PKA_2	111	117	PF00069	0.350
MOD_PKA_2	346	352	PF00069	0.488
MOD_PKA_2	414	420	PF00069	0.650
MOD_PKA_2	91	97	PF00069	0.508
MOD_PKA_2	98	104	PF00069	0.520
MOD_Plk_1	154	160	PF00069	0.448
MOD_Plk_1	21	27	PF00069	0.466
MOD_Plk_1	227	233	PF00069	0.471
MOD_Plk_1	309	315	PF00069	0.407
MOD_Plk_1	49	55	PF00069	0.410
MOD_Plk_2-3	155	161	PF00069	0.458
MOD_Plk_2-3	8	14	PF00069	0.476
MOD_Plk_4	136	142	PF00069	0.335
MOD_Plk_4	155	161	PF00069	0.383
MOD_Plk_4	270	276	PF00069	0.349
MOD_Plk_4	338	344	PF00069	0.392
MOD_Plk_4	42	48	PF00069	0.454
MOD_Plk_4	49	55	PF00069	0.396
MOD_Plk_4	60	66	PF00069	0.210
MOD_ProDKin_1	223	229	PF00069	0.447
MOD_ProDKin_1	368	374	PF00069	0.435
MOD_SUMO_for_1	29	32	PF00179	0.490
MOD_SUMO_rev_2	155	165	PF00179	0.476
TRG_DiLeu_BaEn_1	402	407	PF01217	0.378
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.400
TRG_ENDOCYTIC_2	343	346	PF00928	0.382
TRG_ER_diArg_1	15	18	PF00400	0.439
TRG_NLS_MonoExtC_3	357	363	PF00514	0.560
TRG_NLS_MonoExtN_4	357	362	PF00514	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF2	Leptomonas seymouri	64%	99%
A0A1X0NLR9	Trypanosomatidae	26%	86%
A0A3Q8ID84	Leishmania donovani	96%	100%
A0A422NXM8	Trypanosoma rangeli	29%	86%
A4HFD5	Leishmania braziliensis	84%	100%
A4I359	Leishmania infantum	96%	100%
C9ZKV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
E9AYR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BKT2	Trypanosoma cruzi	28%	86%