Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACZ4_LEIMA

TriTrypDb:

LmjF.27.0170 , LMJLV39_270006900 , LMJSD75_270006700

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9ACZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ4

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.550
CLV_NRD_NRD_1	161	163	PF00675	0.711
CLV_NRD_NRD_1	17	19	PF00675	0.625
CLV_NRD_NRD_1	95	97	PF00675	0.688
CLV_PCSK_FUR_1	15	19	PF00082	0.677
CLV_PCSK_KEX2_1	17	19	PF00082	0.632
CLV_PCSK_KEX2_1	358	360	PF00082	0.770
CLV_PCSK_KEX2_1	95	97	PF00082	0.688
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.770
CLV_PCSK_SKI1_1	18	22	PF00082	0.613

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF2	Leptomonas seymouri	64%	99%
A0A1X0NLR9	Trypanosomatidae	26%	86%
A0A3Q8ID84	Leishmania donovani	96%	100%
A0A422NXM8	Trypanosoma rangeli	29%	86%
A4HFD5	Leishmania braziliensis	84%	100%
A4I359	Leishmania infantum	96%	100%
C9ZKV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
E9AYR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BKT2	Trypanosoma cruzi	28%	86%

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