SET domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ACZ3_LEIMA

TriTrypDb:

LmjF.27.0160 , LMJLV39_270006800 , LMJSD75_270006600

Length:

261

Annotations

LeishMANIAdb annotations

Homologous to human SMYD1, but contains an unexpected C-terminal tail-anchor segment. Localization: Inner nuclear membrane (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0016020	membrane	2	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ACZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.233
CLV_NRD_NRD_1	247	249	PF00675	0.552
CLV_PCSK_FUR_1	140	144	PF00082	0.300
CLV_PCSK_KEX2_1	142	144	PF00082	0.243
CLV_PCSK_KEX2_1	212	214	PF00082	0.290
CLV_PCSK_KEX2_1	247	249	PF00082	0.552
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.290
CLV_PCSK_SKI1_1	11	15	PF00082	0.242
CLV_PCSK_SKI1_1	205	209	PF00082	0.303
CLV_PCSK_SKI1_1	52	56	PF00082	0.233
DEG_Nend_UBRbox_3	1	3	PF02207	0.663
DOC_CKS1_1	60	65	PF01111	0.500
DOC_CYCLIN_RxL_1	69	78	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.412
DOC_MAPK_gen_1	140	147	PF00069	0.475
DOC_MAPK_gen_1	183	193	PF00069	0.410
DOC_MAPK_gen_1	224	233	PF00069	0.475
DOC_MAPK_MEF2A_6	125	132	PF00069	0.433
DOC_MAPK_MEF2A_6	226	235	PF00069	0.362
DOC_MAPK_RevD_3	234	248	PF00069	0.336
DOC_PP2B_LxvP_1	238	241	PF13499	0.412
DOC_SPAK_OSR1_1	134	138	PF12202	0.536
DOC_SPAK_OSR1_1	248	252	PF12202	0.399
DOC_USP7_MATH_1	149	153	PF00917	0.536
DOC_USP7_MATH_1	167	171	PF00917	0.536
DOC_WW_Pin1_4	59	64	PF00397	0.443
LIG_14-3-3_CanoR_1	72	77	PF00244	0.462
LIG_APCC_ABBA_1	145	150	PF00400	0.433
LIG_BRCT_BRCA1_1	114	118	PF00533	0.443
LIG_BRCT_BRCA1_1	77	81	PF00533	0.443
LIG_EH1_1	70	78	PF00400	0.457
LIG_FHA_1	108	114	PF00498	0.501
LIG_FHA_1	49	55	PF00498	0.433
LIG_FHA_2	60	66	PF00498	0.500
LIG_LIR_Gen_1	131	139	PF02991	0.536
LIG_LIR_Gen_1	165	176	PF02991	0.443
LIG_LIR_Gen_1	232	243	PF02991	0.283
LIG_LIR_Gen_1	53	63	PF02991	0.443
LIG_LIR_Gen_1	78	87	PF02991	0.433
LIG_LIR_Nem_3	115	121	PF02991	0.434
LIG_LIR_Nem_3	131	135	PF02991	0.428
LIG_LIR_Nem_3	165	171	PF02991	0.443
LIG_LIR_Nem_3	189	195	PF02991	0.433
LIG_LIR_Nem_3	232	238	PF02991	0.283
LIG_LIR_Nem_3	53	58	PF02991	0.443
LIG_LIR_Nem_3	78	84	PF02991	0.433
LIG_LRP6_Inhibitor_1	166	172	PF00058	0.336
LIG_Pex14_2	5	9	PF04695	0.646
LIG_PTB_Apo_2	170	177	PF02174	0.536
LIG_SH2_CRK	168	172	PF00017	0.443
LIG_SH2_CRK	60	64	PF00017	0.536
LIG_SH2_GRB2like	153	156	PF00017	0.433
LIG_SH2_SRC	153	156	PF00017	0.536
LIG_SH2_STAT3	121	124	PF00017	0.443
LIG_SH2_STAT5	153	156	PF00017	0.433
LIG_SH2_STAT5	245	248	PF00017	0.371
LIG_SH2_STAT5	31	34	PF00017	0.517
LIG_SH2_STAT5	68	71	PF00017	0.440
LIG_SH2_STAT5	83	86	PF00017	0.411
LIG_SH3_3	94	100	PF00018	0.433
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.433
LIG_SUMO_SIM_par_1	126	131	PF11976	0.433
LIG_SUMO_SIM_par_1	72	78	PF11976	0.536
LIG_TRAF2_1	62	65	PF00917	0.429
LIG_TYR_ITIM	166	171	PF00017	0.443
MOD_CK1_1	75	81	PF00069	0.453
MOD_CK1_1	82	88	PF00069	0.413
MOD_CK2_1	59	65	PF00069	0.484
MOD_Cter_Amidation	140	143	PF01082	0.233
MOD_GlcNHglycan	114	117	PF01048	0.243
MOD_GlcNHglycan	177	180	PF01048	0.233
MOD_GlcNHglycan	77	80	PF01048	0.260
MOD_GSK3_1	1	8	PF00069	0.759
MOD_GSK3_1	112	119	PF00069	0.438
MOD_GSK3_1	75	82	PF00069	0.447
MOD_N-GLC_1	1	6	PF02516	0.454
MOD_N-GLC_1	107	112	PF02516	0.313
MOD_N-GLC_1	154	159	PF02516	0.336
MOD_NEK2_1	1	6	PF00069	0.654
MOD_NEK2_1	175	180	PF00069	0.450
MOD_NEK2_1	216	221	PF00069	0.479
MOD_NEK2_2	167	172	PF00069	0.366
MOD_Plk_1	1	7	PF00069	0.742
MOD_Plk_1	116	122	PF00069	0.457
MOD_Plk_1	149	155	PF00069	0.480
MOD_Plk_1	162	168	PF00069	0.389
MOD_Plk_1	216	222	PF00069	0.484
MOD_Plk_2-3	117	123	PF00069	0.443
MOD_Plk_4	149	155	PF00069	0.536
MOD_Plk_4	229	235	PF00069	0.283
MOD_Plk_4	72	78	PF00069	0.472
MOD_ProDKin_1	59	65	PF00069	0.443
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.433
TRG_ENDOCYTIC_2	168	171	PF00928	0.443
TRG_ER_diArg_1	139	142	PF00400	0.475
TRG_ER_diArg_1	246	248	PF00400	0.351
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWF5	Leptomonas seymouri	90%	79%
A0A0S4IND3	Bodo saltans	57%	78%
A0A1X0NLS4	Trypanosomatidae	71%	78%
A0A3Q8IG56	Leishmania donovani	97%	100%
A0A422NXJ8	Trypanosoma rangeli	72%	78%
A4HFD4	Leishmania braziliensis	94%	100%
A4I360	Leishmania infantum	97%	100%
C9ZKV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	78%
E9AYR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BGA9	Trypanosoma cruzi	72%	72%