C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACZ2_LEIMA

TriTrypDb:

LmjF.27.0150 , LMJLV39_270006700 , LMJSD75_270006500

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.753
DOC_CYCLIN_yClb1_LxF_4	55	61	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.631
DOC_PP2B_LxvP_1	140	143	PF13499	0.674
DOC_PP2B_LxvP_1	155	158	PF13499	0.474
DOC_PP2B_LxvP_1	165	168	PF13499	0.528
DOC_USP7_MATH_1	105	109	PF00917	0.695
DOC_USP7_MATH_1	122	126	PF00917	0.573
DOC_USP7_MATH_1	91	95	PF00917	0.711
DOC_USP7_UBL2_3	166	170	PF12436	0.641
DOC_WW_Pin1_4	109	114	PF00397	0.744
DOC_WW_Pin1_4	128	133	PF00397	0.714
DOC_WW_Pin1_4	72	77	PF00397	0.694
DOC_WW_Pin1_4	81	86	PF00397	0.645
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	107	111	PF00533	0.754
LIG_CtBP_PxDLS_1	121	125	PF00389	0.741
LIG_EVH1_1	140	144	PF00568	0.694
LIG_FHA_1	171	177	PF00498	0.593
LIG_FHA_1	21	27	PF00498	0.463
LIG_FHA_1	95	101	PF00498	0.722
LIG_LIR_Gen_1	150	160	PF02991	0.682
LIG_LIR_Gen_1	94	100	PF02991	0.491
LIG_LIR_Nem_3	150	155	PF02991	0.585
LIG_SH2_NCK_1	146	150	PF00017	0.603
LIG_SH2_STAT5	152	155	PF00017	0.687
LIG_SH2_STAT5	29	32	PF00017	0.329
LIG_SH2_STAT5	43	46	PF00017	0.328
LIG_SH3_1	145	151	PF00018	0.557
LIG_SH3_2	85	90	PF14604	0.746
LIG_SH3_3	107	113	PF00018	0.691
LIG_SH3_3	13	19	PF00018	0.610
LIG_SH3_3	138	144	PF00018	0.624
LIG_SH3_3	145	151	PF00018	0.534
LIG_SH3_3	70	76	PF00018	0.686
LIG_SH3_3	82	88	PF00018	0.685
LIG_TRFH_1	60	64	PF08558	0.577
LIG_WW_1	143	146	PF00397	0.579
MOD_CDC14_SPxK_1	112	115	PF00782	0.694
MOD_CDK_SPxK_1	109	115	PF00069	0.692
MOD_CK1_1	125	131	PF00069	0.697
MOD_CK1_1	75	81	PF00069	0.644
MOD_CK1_1	83	89	PF00069	0.601
MOD_CK1_1	92	98	PF00069	0.524
MOD_DYRK1A_RPxSP_1	109	113	PF00069	0.685
MOD_GlcNHglycan	124	127	PF01048	0.688
MOD_GlcNHglycan	128	131	PF01048	0.650
MOD_GlcNHglycan	91	94	PF01048	0.632
MOD_GSK3_1	105	112	PF00069	0.673
MOD_GSK3_1	120	127	PF00069	0.629
MOD_GSK3_1	170	177	PF00069	0.634
MOD_N-GLC_1	103	108	PF02516	0.725
MOD_NEK2_1	124	129	PF00069	0.695
MOD_NEK2_1	89	94	PF00069	0.643
MOD_PIKK_1	103	109	PF00454	0.714
MOD_PIKK_1	20	26	PF00454	0.344
MOD_PIKK_1	75	81	PF00454	0.732
MOD_PIKK_1	83	89	PF00454	0.729
MOD_ProDKin_1	109	115	PF00069	0.747
MOD_ProDKin_1	128	134	PF00069	0.713
MOD_ProDKin_1	72	78	PF00069	0.695
MOD_ProDKin_1	81	87	PF00069	0.642
TRG_ENDOCYTIC_2	152	155	PF00928	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I344	Leptomonas seymouri	74%	85%
A0A0S4ISK2	Bodo saltans	43%	84%
A0A1X0NLP8	Trypanosomatidae	47%	75%
A0A3S7X0C4	Leishmania donovani	97%	100%
A0A422NXG6	Trypanosoma rangeli	50%	68%
A4HFD3	Leishmania braziliensis	89%	84%
A4I361	Leishmania infantum	96%	100%
C9ZKV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	74%
E9AYR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DCD8	Trypanosoma cruzi	49%	68%