Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACZ1_LEIMA

TriTrypDb:

LmjF.27.0140 , LMJLV39_270006500 , LMJSD75_270006400

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.524
CLV_NRD_NRD_1	135	137	PF00675	0.612
CLV_NRD_NRD_1	74	76	PF00675	0.557
CLV_PCSK_KEX2_1	107	109	PF00082	0.639
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.639
CLV_PCSK_SKI1_1	144	148	PF00082	0.658
CLV_PCSK_SKI1_1	182	186	PF00082	0.682
CLV_PCSK_SKI1_1	88	92	PF00082	0.571
DEG_Nend_UBRbox_1	1	4	PF02207	0.479
DOC_CKS1_1	147	152	PF01111	0.601
DOC_USP7_MATH_1	19	23	PF00917	0.636
DOC_USP7_MATH_1	54	58	PF00917	0.563
DOC_WW_Pin1_4	12	17	PF00397	0.733
DOC_WW_Pin1_4	121	126	PF00397	0.658
DOC_WW_Pin1_4	146	151	PF00397	0.601
LIG_14-3-3_CanoR_1	108	112	PF00244	0.678
LIG_14-3-3_CanoR_1	186	194	PF00244	0.598
LIG_BIR_III_4	114	118	PF00653	0.690
LIG_deltaCOP1_diTrp_1	159	165	PF00928	0.554
LIG_FHA_1	107	113	PF00498	0.625
LIG_FHA_2	154	160	PF00498	0.615
LIG_FHA_2	87	93	PF00498	0.569
LIG_FHA_2	97	103	PF00498	0.604
LIG_LIR_Nem_3	84	90	PF02991	0.679
LIG_Pex14_1	161	165	PF04695	0.554
LIG_SH2_CRK	87	91	PF00017	0.631
LIG_SH2_STAT5	200	203	PF00017	0.562
LIG_SH2_STAT5	79	82	PF00017	0.590
LIG_SH3_2	152	157	PF14604	0.509
LIG_SH3_3	149	155	PF00018	0.536
LIG_WRC_WIRS_1	162	167	PF05994	0.612
MOD_CDK_SPK_2	146	151	PF00069	0.601
MOD_CK1_1	12	18	PF00069	0.559
MOD_CK1_1	22	28	PF00069	0.568
MOD_CK2_1	153	159	PF00069	0.615
MOD_GlcNHglycan	11	14	PF01048	0.600
MOD_GlcNHglycan	114	118	PF01048	0.670
MOD_GlcNHglycan	24	27	PF01048	0.458
MOD_GSK3_1	115	122	PF00069	0.599
MOD_GSK3_1	161	168	PF00069	0.613
MOD_GSK3_1	178	185	PF00069	0.444
MOD_GSK3_1	77	84	PF00069	0.583
MOD_NEK2_1	106	111	PF00069	0.714
MOD_NEK2_1	165	170	PF00069	0.613
MOD_NEK2_1	177	182	PF00069	0.493
MOD_PKA_1	107	113	PF00069	0.625
MOD_PKA_2	107	113	PF00069	0.602
MOD_PKA_2	178	184	PF00069	0.523
MOD_PKA_2	19	25	PF00069	0.467
MOD_PKA_2	207	213	PF00069	0.537
MOD_PKA_2	54	60	PF00069	0.596
MOD_Plk_1	47	53	PF00069	0.635
MOD_Plk_2-3	96	102	PF00069	0.515
MOD_Plk_4	107	113	PF00069	0.781
MOD_Plk_4	115	121	PF00069	0.485
MOD_Plk_4	25	31	PF00069	0.567
MOD_ProDKin_1	12	18	PF00069	0.734
MOD_ProDKin_1	121	127	PF00069	0.658
MOD_ProDKin_1	146	152	PF00069	0.599
TRG_ENDOCYTIC_2	87	90	PF00928	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJK2	Leptomonas seymouri	40%	90%
A0A3Q8ID42	Leishmania donovani	92%	100%
A4I362	Leishmania infantum	94%	100%
E9AIS4	Leishmania braziliensis	72%	89%
E9AYR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	89%