Zinc finger protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania major

UniProt:

E9ACZ0_LEIMA

TriTrypDb:

LmjF.27.0130 , LMJLV39_270006400 , LMJSD75_270006300

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ACZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	17
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.507
CLV_PCSK_KEX2_1	9	11	PF00082	0.507
CLV_PCSK_SKI1_1	125	129	PF00082	0.260
DEG_Nend_UBRbox_4	1	3	PF02207	0.489
DOC_MAPK_gen_1	103	112	PF00069	0.474
DOC_PP4_MxPP_1	46	49	PF00568	0.433
DOC_USP7_MATH_1	17	21	PF00917	0.448
DOC_USP7_UBL2_3	105	109	PF12436	0.437
LIG_14-3-3_CanoR_1	136	142	PF00244	0.635
LIG_APCC_ABBA_1	110	115	PF00400	0.277
LIG_APCC_ABBAyCdc20_2	109	115	PF00400	0.277
LIG_FHA_2	76	82	PF00498	0.528
LIG_Integrin_isoDGR_2	86	88	PF01839	0.643
LIG_LIR_Apic_2	70	76	PF02991	0.303
LIG_LIR_Nem_3	78	83	PF02991	0.509
LIG_MYND_1	45	49	PF01753	0.302
LIG_Pex14_1	51	55	PF04695	0.303
LIG_SH2_GRB2like	83	86	PF00017	0.540
LIG_SH2_SRC	63	66	PF00017	0.338
LIG_SH2_STAT3	40	43	PF00017	0.525
LIG_SH2_STAT5	40	43	PF00017	0.541
LIG_SH2_STAT5	55	58	PF00017	0.325
LIG_SH2_STAT5	63	66	PF00017	0.302
LIG_SH3_3	42	48	PF00018	0.514
LIG_SUMO_SIM_anti_2	22	29	PF11976	0.479
LIG_SUMO_SIM_par_1	22	29	PF11976	0.479
MOD_CK1_1	19	25	PF00069	0.478
MOD_CK2_1	75	81	PF00069	0.521
MOD_GSK3_1	101	108	PF00069	0.543
MOD_GSK3_1	26	33	PF00069	0.479
MOD_GSK3_1	67	74	PF00069	0.367
MOD_N-GLC_1	29	34	PF02516	0.471
MOD_NEK2_1	28	33	PF00069	0.459
MOD_PIKK_1	137	143	PF00454	0.575
MOD_PIKK_1	17	23	PF00454	0.449
MOD_Plk_1	29	35	PF00069	0.472
MOD_SUMO_rev_2	54	61	PF00179	0.394
TRG_ER_diArg_1	8	10	PF00400	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E5	Leptomonas seymouri	83%	100%
A0A0S4IT37	Bodo saltans	47%	100%
A0A1X0NLL7	Trypanosomatidae	56%	100%
A0A3R7NZE2	Trypanosoma rangeli	55%	100%
A0A3S7X0B7	Leishmania donovani	96%	99%
A0A3S7X5L3	Leishmania donovani	47%	100%
A4HFD2	Leishmania braziliensis	94%	100%
A4HKG1	Leishmania braziliensis	46%	100%
A4I363	Leishmania infantum	96%	99%
A4I7Y9	Leishmania infantum	47%	100%
C9ZKV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
D0AA56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AYR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B2V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
Q4Q5A6	Leishmania major	49%	100%