RING-CH-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-variant domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ACY9_LEIMA

TriTrypDb:

LmjF.27.0120 , LMJLV39_270006300 , LMJSD75_270006200

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 2
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9ACY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY9

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.681
CLV_NRD_NRD_1	296	298	PF00675	0.394
CLV_NRD_NRD_1	440	442	PF00675	0.303
CLV_PCSK_FUR_1	294	298	PF00082	0.364
CLV_PCSK_KEX2_1	296	298	PF00082	0.394
CLV_PCSK_KEX2_1	440	442	PF00082	0.310
CLV_PCSK_SKI1_1	190	194	PF00082	0.668
CLV_PCSK_SKI1_1	209	213	PF00082	0.558
CLV_PCSK_SKI1_1	267	271	PF00082	0.481
CLV_PCSK_SKI1_1	322	326	PF00082	0.449
CLV_PCSK_SKI1_1	377	381	PF00082	0.577
CLV_PCSK_SKI1_1	431	435	PF00082	0.331
CLV_PCSK_SKI1_1	499	503	PF00082	0.633
CLV_PCSK_SKI1_1	581	585	PF00082	0.683
CLV_PCSK_SKI1_1	61	65	PF00082	0.682
DEG_APCC_DBOX_1	266	274	PF00400	0.444
DEG_SCF_FBW7_1	140	145	PF00400	0.423
DEG_SPOP_SBC_1	142	146	PF00917	0.428
DEG_SPOP_SBC_1	20	24	PF00917	0.478
DOC_CYCLIN_RxL_1	475	487	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.389
DOC_MAPK_MEF2A_6	267	275	PF00069	0.444
DOC_MAPK_MEF2A_6	67	76	PF00069	0.448
DOC_PP1_RVXF_1	353	359	PF00149	0.691
DOC_PP2B_LxvP_1	409	412	PF13499	0.531
DOC_PP2B_LxvP_1	96	99	PF13499	0.383
DOC_PP2B_PxIxI_1	71	77	PF00149	0.288
DOC_USP7_MATH_1	142	146	PF00917	0.418
DOC_USP7_MATH_1	177	181	PF00917	0.462
DOC_USP7_MATH_1	20	24	PF00917	0.459
DOC_USP7_MATH_1	316	320	PF00917	0.708
DOC_USP7_MATH_1	327	331	PF00917	0.659
DOC_USP7_MATH_1	381	385	PF00917	0.759
DOC_USP7_MATH_1	6	10	PF00917	0.489
DOC_USP7_MATH_1	70	74	PF00917	0.475
DOC_WW_Pin1_4	138	143	PF00397	0.390
DOC_WW_Pin1_4	25	30	PF00397	0.650
DOC_WW_Pin1_4	445	450	PF00397	0.546
DOC_WW_Pin1_4	464	469	PF00397	0.567
LIG_14-3-3_CanoR_1	190	195	PF00244	0.452
LIG_14-3-3_CanoR_1	227	233	PF00244	0.402
LIG_14-3-3_CanoR_1	401	405	PF00244	0.551
LIG_14-3-3_CanoR_1	581	586	PF00244	0.422
LIG_Actin_WH2_2	485	501	PF00022	0.485
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	206	210	PF00533	0.413
LIG_BRCT_BRCA1_1	383	387	PF00533	0.643
LIG_BRCT_BRCA1_1	417	421	PF00533	0.573
LIG_BRCT_BRCA1_1	558	562	PF00533	0.494
LIG_BRCT_BRCA1_1	575	579	PF00533	0.342
LIG_BRCT_BRCA1_1	77	81	PF00533	0.445
LIG_Clathr_ClatBox_1	560	564	PF01394	0.436
LIG_deltaCOP1_diTrp_1	513	516	PF00928	0.461
LIG_eIF4E_1	206	212	PF01652	0.423
LIG_FHA_1	168	174	PF00498	0.516
LIG_FHA_1	283	289	PF00498	0.496
LIG_FHA_1	33	39	PF00498	0.363
LIG_FHA_1	394	400	PF00498	0.503
LIG_FHA_1	531	537	PF00498	0.429
LIG_FHA_1	582	588	PF00498	0.469
LIG_FHA_2	176	182	PF00498	0.475
LIG_FHA_2	236	242	PF00498	0.378
LIG_FHA_2	504	510	PF00498	0.409
LIG_LIR_Gen_1	129	140	PF02991	0.375
LIG_LIR_Gen_1	277	284	PF02991	0.445
LIG_LIR_Gen_1	319	327	PF02991	0.643
LIG_LIR_Gen_1	448	458	PF02991	0.576
LIG_LIR_Gen_1	559	570	PF02991	0.446
LIG_LIR_Gen_1	572	582	PF02991	0.405
LIG_LIR_Gen_1	603	612	PF02991	0.667
LIG_LIR_Gen_1	90	100	PF02991	0.431
LIG_LIR_Nem_3	129	135	PF02991	0.386
LIG_LIR_Nem_3	195	201	PF02991	0.433
LIG_LIR_Nem_3	277	282	PF02991	0.432
LIG_LIR_Nem_3	319	323	PF02991	0.650
LIG_LIR_Nem_3	448	453	PF02991	0.548
LIG_LIR_Nem_3	513	517	PF02991	0.442
LIG_LIR_Nem_3	559	565	PF02991	0.446
LIG_LIR_Nem_3	572	577	PF02991	0.381
LIG_LIR_Nem_3	603	608	PF02991	0.662
LIG_LIR_Nem_3	90	96	PF02991	0.387
LIG_LIR_Nem_3	97	103	PF02991	0.325
LIG_LYPXL_SIV_4	526	534	PF13949	0.485
LIG_MLH1_MIPbox_1	558	562	PF16413	0.471
LIG_NRBOX	553	559	PF00104	0.382
LIG_Pex14_1	585	589	PF04695	0.361
LIG_Pex14_2	477	481	PF04695	0.558
LIG_Pex14_2	579	583	PF04695	0.503
LIG_SH2_CRK	450	454	PF00017	0.576
LIG_SH2_STAP1	128	132	PF00017	0.452
LIG_SH2_STAP1	194	198	PF00017	0.451
LIG_SH2_STAP1	206	210	PF00017	0.453
LIG_SH2_STAP1	308	312	PF00017	0.677
LIG_SH2_STAP1	569	573	PF00017	0.454
LIG_SH2_STAT5	100	103	PF00017	0.336
LIG_SH2_STAT5	187	190	PF00017	0.440
LIG_SH2_STAT5	194	197	PF00017	0.402
LIG_SH2_STAT5	218	221	PF00017	0.408
LIG_SH2_STAT5	337	340	PF00017	0.716
LIG_SH2_STAT5	450	453	PF00017	0.567
LIG_SH2_STAT5	483	486	PF00017	0.412
LIG_SH2_STAT5	496	499	PF00017	0.341
LIG_SH2_STAT5	527	530	PF00017	0.380
LIG_SH3_2	364	369	PF14604	0.734
LIG_SH3_3	159	165	PF00018	0.417
LIG_SH3_3	298	304	PF00018	0.751
LIG_SH3_3	361	367	PF00018	0.742
LIG_SH3_3	452	458	PF00018	0.606
LIG_SUMO_SIM_anti_2	237	244	PF11976	0.332
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.579
LIG_SUMO_SIM_par_1	12	18	PF11976	0.585
LIG_SUMO_SIM_par_1	269	274	PF11976	0.485
LIG_SUMO_SIM_par_1	34	40	PF11976	0.411
LIG_TRAF2_1	388	391	PF00917	0.742
LIG_TYR_ITIM	98	103	PF00017	0.425
LIG_TYR_ITSM	446	453	PF00017	0.549
LIG_UBA3_1	211	216	PF00899	0.433
LIG_WRC_WIRS_1	276	281	PF05994	0.375
LIG_WRC_WIRS_1	317	322	PF05994	0.557
LIG_WRC_WIRS_1	602	607	PF05994	0.648
LIG_WRC_WIRS_1	612	617	PF05994	0.658
MOD_CK1_1	105	111	PF00069	0.449
MOD_CK1_1	274	280	PF00069	0.495
MOD_CK1_1	75	81	PF00069	0.418
MOD_CK1_1	84	90	PF00069	0.382
MOD_CK2_1	194	200	PF00069	0.453
MOD_CK2_1	372	378	PF00069	0.681
MOD_CK2_1	385	391	PF00069	0.746
MOD_CK2_1	534	540	PF00069	0.485
MOD_CK2_1	611	617	PF00069	0.644
MOD_GlcNHglycan	104	107	PF01048	0.641
MOD_GlcNHglycan	206	209	PF01048	0.579
MOD_GlcNHglycan	571	574	PF01048	0.631
MOD_GlcNHglycan	594	597	PF01048	0.408
MOD_GSK3_1	102	109	PF00069	0.385
MOD_GSK3_1	138	145	PF00069	0.402
MOD_GSK3_1	15	22	PF00069	0.635
MOD_GSK3_1	186	193	PF00069	0.405
MOD_GSK3_1	271	278	PF00069	0.460
MOD_GSK3_1	302	309	PF00069	0.698
MOD_GSK3_1	377	384	PF00069	0.639
MOD_GSK3_1	41	48	PF00069	0.374
MOD_GSK3_1	50	57	PF00069	0.426
MOD_GSK3_1	503	510	PF00069	0.478
MOD_GSK3_1	530	537	PF00069	0.369
MOD_GSK3_1	565	572	PF00069	0.527
MOD_GSK3_1	581	588	PF00069	0.353
MOD_GSK3_1	59	66	PF00069	0.423
MOD_GSK3_1	77	84	PF00069	0.242
MOD_N-GLC_1	157	162	PF02516	0.580
MOD_N-GLC_1	382	387	PF02516	0.488
MOD_N-GLC_1	41	46	PF02516	0.601
MOD_N-GLC_1	415	420	PF02516	0.381
MOD_N-GLC_1	534	539	PF02516	0.485
MOD_N-GLC_2	349	351	PF02516	0.471
MOD_NEK2_1	143	148	PF00069	0.428
MOD_NEK2_1	19	24	PF00069	0.540
MOD_NEK2_1	228	233	PF00069	0.329
MOD_NEK2_1	271	276	PF00069	0.441
MOD_NEK2_1	382	387	PF00069	0.727
MOD_NEK2_1	47	52	PF00069	0.413
MOD_NEK2_1	484	489	PF00069	0.498
MOD_NEK2_1	502	507	PF00069	0.347
MOD_NEK2_1	534	539	PF00069	0.454
MOD_NEK2_1	601	606	PF00069	0.609
MOD_NEK2_1	63	68	PF00069	0.361
MOD_NEK2_2	59	64	PF00069	0.515
MOD_NEK2_2	77	82	PF00069	0.227
MOD_PIKK_1	372	378	PF00454	0.689
MOD_PIKK_1	627	633	PF00454	0.679
MOD_PKA_2	400	406	PF00069	0.545
MOD_PKA_2	543	549	PF00069	0.642
MOD_PKB_1	125	133	PF00069	0.324
MOD_PKB_1	225	233	PF00069	0.392
MOD_Plk_1	377	383	PF00069	0.717
MOD_Plk_1	41	47	PF00069	0.401
MOD_Plk_1	534	540	PF00069	0.477
MOD_Plk_1	585	591	PF00069	0.308
MOD_Plk_1	84	90	PF00069	0.431
MOD_Plk_2-3	235	241	PF00069	0.439
MOD_Plk_2-3	613	619	PF00069	0.715
MOD_Plk_4	235	241	PF00069	0.405
MOD_Plk_4	271	277	PF00069	0.420
MOD_Plk_4	302	308	PF00069	0.678
MOD_Plk_4	382	388	PF00069	0.698
MOD_Plk_4	448	454	PF00069	0.574
MOD_Plk_4	469	475	PF00069	0.678
MOD_Plk_4	484	490	PF00069	0.365
MOD_Plk_4	534	540	PF00069	0.420
MOD_Plk_4	543	549	PF00069	0.668
MOD_Plk_4	556	562	PF00069	0.374
MOD_Plk_4	573	579	PF00069	0.296
MOD_Plk_4	6	12	PF00069	0.566
MOD_Plk_4	77	83	PF00069	0.421
MOD_ProDKin_1	138	144	PF00069	0.394
MOD_ProDKin_1	25	31	PF00069	0.647
MOD_ProDKin_1	445	451	PF00069	0.548
MOD_ProDKin_1	464	470	PF00069	0.565
TRG_DiLeu_BaEn_1	287	292	PF01217	0.647
TRG_ENDOCYTIC_2	100	103	PF00928	0.430
TRG_ENDOCYTIC_2	119	122	PF00928	0.344
TRG_ENDOCYTIC_2	198	201	PF00928	0.467
TRG_ENDOCYTIC_2	450	453	PF00928	0.549
TRG_ENDOCYTIC_2	483	486	PF00928	0.435
TRG_ENDOCYTIC_2	520	523	PF00928	0.344
TRG_ER_diArg_1	124	127	PF00400	0.428
TRG_ER_diArg_1	224	227	PF00400	0.414
TRG_ER_diArg_1	293	296	PF00400	0.699
TRG_ER_diArg_1	355	358	PF00400	0.635
TRG_ER_diArg_1	440	442	PF00400	0.492
TRG_NES_CRM1_1	552	564	PF08389	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS2	Leptomonas seymouri	55%	100%
A0A3Q8IHD5	Leishmania donovani	93%	100%
A0A3R7MRQ1	Trypanosoma rangeli	32%	97%
A4HFD1	Leishmania braziliensis	74%	100%
A4I364	Leishmania infantum	93%	100%
C9ZKV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
E9AYR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BGA4	Trypanosoma cruzi	33%	93%