LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ACY8_LEIMA
TriTrypDb:
LmjF.27.0110 , LMJLV39_270006200 , LMJSD75_270006100
Length:
85

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005739 mitochondrion 5 2
GO:0016020 membrane 2 6
GO:0020023 kinetoplast 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9ACY8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.420
CLV_PCSK_KEX2_1 3 5 PF00082 0.420
CLV_PCSK_SKI1_1 37 41 PF00082 0.415
DEG_Nend_Nbox_1 1 3 PF02207 0.661
LIG_14-3-3_CanoR_1 3 10 PF00244 0.670
LIG_CSL_BTD_1 75 78 PF09270 0.470
LIG_FHA_1 12 18 PF00498 0.706
LIG_FHA_1 46 52 PF00498 0.677
LIG_FHA_1 54 60 PF00498 0.454
LIG_LIR_Nem_3 40 46 PF02991 0.613
LIG_Pex14_2 39 43 PF04695 0.607
LIG_Pex14_2 58 62 PF04695 0.489
LIG_SH2_CRK 10 14 PF00017 0.677
LIG_SH2_STAT5 34 37 PF00017 0.637
LIG_SH3_3 10 16 PF00018 0.708
LIG_SH3_3 74 80 PF00018 0.443
MOD_CK1_1 38 44 PF00069 0.613
MOD_GlcNHglycan 66 69 PF01048 0.409
MOD_GlcNHglycan 72 75 PF01048 0.643
MOD_GSK3_1 45 52 PF00069 0.676
MOD_NEK2_1 2 7 PF00069 0.678
MOD_NEK2_1 9 14 PF00069 0.678
MOD_PIKK_1 38 44 PF00454 0.613
MOD_PKA_1 3 9 PF00069 0.700
MOD_PKA_2 2 8 PF00069 0.679
TRG_ENDOCYTIC_2 10 13 PF00928 0.657
TRG_ER_diArg_1 2 4 PF00400 0.629

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4T6 Leptomonas seymouri 84% 100%
A0A0S4ISG4 Bodo saltans 53% 91%
A0A3Q8ICG9 Leishmania donovani 99% 100%
A4HFD0 Leishmania braziliensis 89% 100%
A4I2K7 Leishmania infantum 99% 100%
C9ZKU9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
E9AYR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS