LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
CMGC/RCK protein kinase, putative
Species:
Leishmania major
UniProt:
E9ACY7_LEIMA
TriTrypDb:
LmjF.27.0100 , LMJLV39_270006100 * , LMJSD75_270006000
Length:
660

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9ACY7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY7

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0035556 intracellular signal transduction 3 2
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 6
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004707 MAP kinase activity 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 81 85 PF00656 0.312
CLV_NRD_NRD_1 147 149 PF00675 0.294
CLV_NRD_NRD_1 366 368 PF00675 0.633
CLV_NRD_NRD_1 438 440 PF00675 0.614
CLV_NRD_NRD_1 512 514 PF00675 0.689
CLV_NRD_NRD_1 55 57 PF00675 0.334
CLV_NRD_NRD_1 593 595 PF00675 0.671
CLV_NRD_NRD_1 618 620 PF00675 0.597
CLV_PCSK_FUR_1 591 595 PF00082 0.607
CLV_PCSK_KEX2_1 132 134 PF00082 0.334
CLV_PCSK_KEX2_1 326 328 PF00082 0.499
CLV_PCSK_KEX2_1 437 439 PF00082 0.656
CLV_PCSK_KEX2_1 512 514 PF00082 0.642
CLV_PCSK_KEX2_1 55 57 PF00082 0.334
CLV_PCSK_KEX2_1 593 595 PF00082 0.608
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.334
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.499
CLV_PCSK_PC1ET2_1 437 439 PF00082 0.656
CLV_PCSK_PC1ET2_1 593 595 PF00082 0.535
CLV_PCSK_SKI1_1 121 125 PF00082 0.348
CLV_PCSK_SKI1_1 138 142 PF00082 0.380
CLV_PCSK_SKI1_1 215 219 PF00082 0.373
CLV_PCSK_SKI1_1 247 251 PF00082 0.334
CLV_PCSK_SKI1_1 281 285 PF00082 0.370
CLV_PCSK_SKI1_1 326 330 PF00082 0.568
CLV_PCSK_SKI1_1 33 37 PF00082 0.334
CLV_PCSK_SKI1_1 409 413 PF00082 0.592
CLV_PCSK_SKI1_1 646 650 PF00082 0.540
CLV_PCSK_SKI1_1 92 96 PF00082 0.334
DEG_APCC_DBOX_1 120 128 PF00400 0.334
DEG_Nend_UBRbox_2 1 3 PF02207 0.423
DEG_SPOP_SBC_1 388 392 PF00917 0.622
DEG_SPOP_SBC_1 520 524 PF00917 0.658
DOC_AGCK_PIF_2 77 82 PF00069 0.334
DOC_CYCLIN_RxL_1 212 221 PF00134 0.334
DOC_CYCLIN_yClb1_LxF_4 73 79 PF00134 0.334
DOC_MAPK_DCC_7 378 387 PF00069 0.496
DOC_MAPK_gen_1 138 147 PF00069 0.333
DOC_MAPK_gen_1 181 190 PF00069 0.388
DOC_MAPK_gen_1 24 32 PF00069 0.388
DOC_MAPK_gen_1 651 659 PF00069 0.599
DOC_MAPK_HePTP_8 178 190 PF00069 0.388
DOC_MAPK_HePTP_8 375 387 PF00069 0.493
DOC_MAPK_JIP1_4 141 147 PF00069 0.388
DOC_MAPK_MEF2A_6 181 190 PF00069 0.384
DOC_MAPK_MEF2A_6 378 387 PF00069 0.539
DOC_MAPK_MEF2A_6 481 488 PF00069 0.581
DOC_USP7_MATH_1 267 271 PF00917 0.428
DOC_USP7_MATH_1 353 357 PF00917 0.646
DOC_USP7_MATH_1 400 404 PF00917 0.632
DOC_USP7_MATH_1 444 448 PF00917 0.707
DOC_USP7_MATH_1 472 476 PF00917 0.609
DOC_USP7_MATH_1 625 629 PF00917 0.592
DOC_USP7_UBL2_3 20 24 PF12436 0.334
DOC_USP7_UBL2_3 34 38 PF12436 0.334
DOC_WW_Pin1_4 101 106 PF00397 0.328
DOC_WW_Pin1_4 233 238 PF00397 0.334
DOC_WW_Pin1_4 338 343 PF00397 0.635
DOC_WW_Pin1_4 389 394 PF00397 0.701
DOC_WW_Pin1_4 401 406 PF00397 0.686
DOC_WW_Pin1_4 410 415 PF00397 0.753
DOC_WW_Pin1_4 476 481 PF00397 0.700
DOC_WW_Pin1_4 507 512 PF00397 0.651
DOC_WW_Pin1_4 521 526 PF00397 0.651
DOC_WW_Pin1_4 606 611 PF00397 0.610
DOC_WW_Pin1_4 639 644 PF00397 0.588
LIG_14-3-3_CanoR_1 253 257 PF00244 0.320
LIG_14-3-3_CanoR_1 291 298 PF00244 0.480
LIG_14-3-3_CanoR_1 354 361 PF00244 0.623
LIG_14-3-3_CanoR_1 594 604 PF00244 0.600
LIG_BIR_III_2 397 401 PF00653 0.569
LIG_BRCT_BRCA1_1 365 369 PF00533 0.556
LIG_eIF4E_1 183 189 PF01652 0.334
LIG_eIF4E_1 82 88 PF01652 0.334
LIG_FHA_1 105 111 PF00498 0.270
LIG_FHA_1 173 179 PF00498 0.388
LIG_FHA_1 219 225 PF00498 0.421
LIG_FHA_1 236 242 PF00498 0.417
LIG_FHA_1 24 30 PF00498 0.334
LIG_FHA_1 342 348 PF00498 0.507
LIG_FHA_1 428 434 PF00498 0.619
LIG_FHA_1 611 617 PF00498 0.650
LIG_FHA_1 652 658 PF00498 0.713
LIG_FHA_2 372 378 PF00498 0.594
LIG_FHA_2 39 45 PF00498 0.322
LIG_FHA_2 596 602 PF00498 0.599
LIG_IBAR_NPY_1 515 517 PF08397 0.604
LIG_LIR_Apic_2 180 186 PF02991 0.388
LIG_LIR_Apic_2 468 472 PF02991 0.714
LIG_LIR_Gen_1 2 10 PF02991 0.334
LIG_LIR_Nem_3 12 18 PF02991 0.348
LIG_LIR_Nem_3 161 165 PF02991 0.334
LIG_LIR_Nem_3 2 7 PF02991 0.334
LIG_LIR_Nem_3 255 259 PF02991 0.361
LIG_LIR_Nem_3 366 372 PF02991 0.575
LIG_LIR_Nem_3 75 80 PF02991 0.388
LIG_LYPXL_yS_3 113 116 PF13949 0.334
LIG_MYND_1 576 580 PF01753 0.580
LIG_NRBOX 644 650 PF00104 0.578
LIG_PTB_Apo_2 586 593 PF02174 0.641
LIG_PTB_Phospho_1 586 592 PF10480 0.640
LIG_SH2_CRK 254 258 PF00017 0.297
LIG_SH2_CRK 469 473 PF00017 0.729
LIG_SH2_STAP1 4 8 PF00017 0.373
LIG_SH2_STAT3 119 122 PF00017 0.334
LIG_SH2_STAT3 572 575 PF00017 0.608
LIG_SH2_STAT5 129 132 PF00017 0.382
LIG_SH2_STAT5 135 138 PF00017 0.382
LIG_SH2_STAT5 177 180 PF00017 0.384
LIG_SH2_STAT5 254 257 PF00017 0.334
LIG_SH2_STAT5 370 373 PF00017 0.593
LIG_SH2_STAT5 40 43 PF00017 0.334
LIG_SH2_STAT5 572 575 PF00017 0.608
LIG_SH3_1 494 500 PF00018 0.566
LIG_SH3_3 106 112 PF00018 0.282
LIG_SH3_3 213 219 PF00018 0.376
LIG_SH3_3 282 288 PF00018 0.334
LIG_SH3_3 377 383 PF00018 0.624
LIG_SH3_3 408 414 PF00018 0.655
LIG_SH3_3 43 49 PF00018 0.334
LIG_SH3_3 474 480 PF00018 0.575
LIG_SH3_3 489 495 PF00018 0.614
LIG_SH3_3 505 511 PF00018 0.607
LIG_SH3_3 570 576 PF00018 0.659
LIG_SH3_5 173 177 PF00018 0.334
LIG_SUMO_SIM_anti_2 319 325 PF11976 0.512
LIG_SUMO_SIM_anti_2 50 55 PF11976 0.334
LIG_SUMO_SIM_par_1 207 213 PF11976 0.214
LIG_TRAF2_1 237 240 PF00917 0.334
LIG_TRAF2_1 41 44 PF00917 0.334
LIG_TYR_ITIM 111 116 PF00017 0.370
LIG_UBA3_1 123 132 PF00899 0.380
LIG_UBA3_1 371 376 PF00899 0.570
LIG_UBA3_1 87 95 PF00899 0.370
MOD_CDC14_SPxK_1 404 407 PF00782 0.620
MOD_CDC14_SPxK_1 510 513 PF00782 0.554
MOD_CDK_SPK_2 476 481 PF00069 0.628
MOD_CDK_SPK_2 507 512 PF00069 0.610
MOD_CDK_SPK_2 606 611 PF00069 0.610
MOD_CDK_SPxK_1 401 407 PF00069 0.629
MOD_CDK_SPxK_1 507 513 PF00069 0.556
MOD_CDK_SPxxK_3 639 646 PF00069 0.566
MOD_CK1_1 23 29 PF00069 0.365
MOD_CK1_1 341 347 PF00069 0.535
MOD_CK1_1 362 368 PF00069 0.685
MOD_CK1_1 392 398 PF00069 0.610
MOD_CK1_1 428 434 PF00069 0.677
MOD_CK1_1 440 446 PF00069 0.562
MOD_CK1_1 547 553 PF00069 0.591
MOD_CK1_1 561 567 PF00069 0.611
MOD_CK1_1 571 577 PF00069 0.583
MOD_CK1_1 596 602 PF00069 0.567
MOD_CK2_1 149 155 PF00069 0.309
MOD_CK2_1 233 239 PF00069 0.334
MOD_CK2_1 38 44 PF00069 0.322
MOD_CK2_1 564 570 PF00069 0.583
MOD_Cter_Amidation 435 438 PF01082 0.657
MOD_GlcNHglycan 150 154 PF01048 0.334
MOD_GlcNHglycan 261 264 PF01048 0.382
MOD_GlcNHglycan 313 316 PF01048 0.549
MOD_GlcNHglycan 474 477 PF01048 0.679
MOD_GlcNHglycan 488 491 PF01048 0.609
MOD_GlcNHglycan 528 531 PF01048 0.635
MOD_GlcNHglycan 560 563 PF01048 0.639
MOD_GlcNHglycan 598 601 PF01048 0.605
MOD_GlcNHglycan 634 638 PF01048 0.594
MOD_GlcNHglycan 654 657 PF01048 0.465
MOD_GSK3_1 100 107 PF00069 0.314
MOD_GSK3_1 172 179 PF00069 0.351
MOD_GSK3_1 229 236 PF00069 0.396
MOD_GSK3_1 353 360 PF00069 0.633
MOD_GSK3_1 383 390 PF00069 0.629
MOD_GSK3_1 425 432 PF00069 0.786
MOD_GSK3_1 440 447 PF00069 0.647
MOD_GSK3_1 472 479 PF00069 0.688
MOD_GSK3_1 519 526 PF00069 0.668
MOD_GSK3_1 564 571 PF00069 0.585
MOD_GSK3_1 606 613 PF00069 0.699
MOD_N-GLC_1 400 405 PF02516 0.711
MOD_N-GLC_1 587 592 PF02516 0.706
MOD_N-GLC_1 606 611 PF02516 0.697
MOD_NEK2_1 361 366 PF00069 0.646
MOD_NEK2_1 371 376 PF00069 0.526
MOD_NEK2_1 427 432 PF00069 0.750
MOD_NEK2_1 486 491 PF00069 0.630
MOD_NEK2_1 587 592 PF00069 0.646
MOD_PIKK_1 437 443 PF00454 0.609
MOD_PIKK_1 571 577 PF00454 0.648
MOD_PK_1 229 235 PF00069 0.334
MOD_PKA_1 437 443 PF00069 0.628
MOD_PKA_1 593 599 PF00069 0.602
MOD_PKA_2 252 258 PF00069 0.323
MOD_PKA_2 290 296 PF00069 0.388
MOD_PKA_2 353 359 PF00069 0.669
MOD_PKA_2 437 443 PF00069 0.653
MOD_PKA_2 593 599 PF00069 0.646
MOD_PKA_2 610 616 PF00069 0.642
MOD_Plk_1 357 363 PF00069 0.612
MOD_Plk_1 444 450 PF00069 0.586
MOD_Plk_1 547 553 PF00069 0.661
MOD_Plk_1 587 593 PF00069 0.646
MOD_Plk_4 229 235 PF00069 0.334
MOD_Plk_4 568 574 PF00069 0.668
MOD_Plk_4 582 588 PF00069 0.598
MOD_ProDKin_1 101 107 PF00069 0.328
MOD_ProDKin_1 233 239 PF00069 0.334
MOD_ProDKin_1 338 344 PF00069 0.633
MOD_ProDKin_1 389 395 PF00069 0.702
MOD_ProDKin_1 401 407 PF00069 0.687
MOD_ProDKin_1 410 416 PF00069 0.753
MOD_ProDKin_1 476 482 PF00069 0.702
MOD_ProDKin_1 507 513 PF00069 0.652
MOD_ProDKin_1 521 527 PF00069 0.649
MOD_ProDKin_1 606 612 PF00069 0.608
MOD_ProDKin_1 639 645 PF00069 0.587
MOD_SUMO_for_1 140 143 PF00179 0.334
MOD_SUMO_for_1 532 535 PF00179 0.612
MOD_SUMO_rev_2 560 569 PF00179 0.601
TRG_DiLeu_BaEn_4 43 49 PF01217 0.334
TRG_DiLeu_BaLyEn_6 106 111 PF01217 0.334
TRG_DiLeu_BaLyEn_6 599 604 PF01217 0.585
TRG_ENDOCYTIC_2 113 116 PF00928 0.370
TRG_ENDOCYTIC_2 4 7 PF00928 0.363
TRG_ER_diArg_1 168 171 PF00400 0.279
TRG_ER_diArg_1 406 409 PF00400 0.586
TRG_ER_diArg_1 511 513 PF00400 0.630
TRG_ER_diArg_1 54 56 PF00400 0.334
TRG_NES_CRM1_1 296 309 PF08389 0.334
TRG_NLS_MonoExtC_3 436 442 PF00514 0.611
TRG_NLS_MonoExtN_4 247 254 PF00514 0.334
TRG_NLS_MonoExtN_4 435 441 PF00514 0.612
TRG_NLS_MonoExtN_4 591 597 PF00514 0.526

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4E3 Leptomonas seymouri 55% 98%
A0A3Q8IE25 Leishmania donovani 98% 100%
A0A3Q8IVR8 Leishmania donovani 33% 100%
A0A3S5H5U5 Leishmania donovani 24% 100%
A0A3S5H6C8 Leishmania donovani 26% 100%
A0A3S7WQK7 Leishmania donovani 26% 100%
A0A3S7X8Z8 Leishmania donovani 23% 100%
A4H4S9 Leishmania braziliensis 24% 100%
A4H5L7 Leishmania braziliensis 25% 100%
A4HD79 Leishmania braziliensis 23% 100%
A4HFC9 Leishmania braziliensis 82% 100%
A4HFF3 Leishmania braziliensis 24% 100%
A4HNT2 Leishmania braziliensis 33% 100%
A4HTV4 Leishmania infantum 26% 100%
A4HTV5 Leishmania infantum 26% 100%
A4I2K6 Leishmania infantum 98% 100%
A4IB02 Leishmania infantum 23% 100%
A4ICR2 Leishmania infantum 33% 100%
E9AET0 Leishmania major 24% 100%
E9AG71 Leishmania infantum 24% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AYR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q4QIV8 Leishmania major 24% 100%
Q5R754 Pongo abelii 30% 100%
Q92772 Homo sapiens 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS