Cytochrome p450-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome p450-like protein

Species:

Leishmania major

UniProt:

E9ACY6_LEIMA

TriTrypDb:

LmjF.27.0090 , LMJLV39_270006000 , LMJSD75_270005900

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

E9ACY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY6

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004497	monooxygenase activity	3	12
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	4	1
GO:0020037	heme binding	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.495
CLV_C14_Caspase3-7	229	233	PF00656	0.435
CLV_C14_Caspase3-7	458	462	PF00656	0.527
CLV_NRD_NRD_1	157	159	PF00675	0.326
CLV_NRD_NRD_1	167	169	PF00675	0.326
CLV_NRD_NRD_1	317	319	PF00675	0.294
CLV_NRD_NRD_1	435	437	PF00675	0.238
CLV_PCSK_KEX2_1	157	159	PF00082	0.226
CLV_PCSK_KEX2_1	281	283	PF00082	0.236
CLV_PCSK_KEX2_1	317	319	PF00082	0.288

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0D1DMJ7	Ustilago maydis (strain 521 / FGSC 9021)	23%	95%
A0A0N1IIZ9	Leptomonas seymouri	78%	100%
A0A0N1PC71	Leptomonas seymouri	22%	100%
A0A0N9HT29	Sinopodophyllum hexandrum	21%	100%
A0A0S2IHL2	Kalopanax septemlobus	24%	100%
A0A0S4IUA7	Bodo saltans	53%	100%
A0A0S4KIN8	Bodo saltans	21%	100%
A0A161GJD5	Euphorbia lathyris	23%	100%
A0A179H0I7	Purpureocillium lilacinum	24%	100%
A0A1D6HSP4	Zea mays	22%	100%

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