Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACY5_LEIMA

TriTrypDb:

LmjF.27.0080 , LMJLV39_270005900 , LMJSD75_270005800

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.696
CLV_NRD_NRD_1	124	126	PF00675	0.460
CLV_NRD_NRD_1	133	135	PF00675	0.575
CLV_NRD_NRD_1	137	139	PF00675	0.589
CLV_NRD_NRD_1	73	75	PF00675	0.429
CLV_PCSK_FUR_1	71	75	PF00082	0.323
CLV_PCSK_KEX2_1	111	113	PF00082	0.643
CLV_PCSK_KEX2_1	123	125	PF00082	0.463
CLV_PCSK_KEX2_1	133	135	PF00082	0.568
CLV_PCSK_KEX2_1	137	139	PF00082	0.583
CLV_PCSK_KEX2_1	73	75	PF00082	0.429
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.589
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.425
CLV_PCSK_PC7_1	133	139	PF00082	0.450
CLV_PCSK_SKI1_1	155	159	PF00082	0.572
CLV_PCSK_SKI1_1	73	77	PF00082	0.473
DOC_MAPK_RevD_3	60	74	PF00069	0.306
DOC_PP1_RVXF_1	72	79	PF00149	0.416
DOC_USP7_MATH_1	96	100	PF00917	0.462
DOC_WW_Pin1_4	61	66	PF00397	0.513
LIG_14-3-3_CanoR_1	159	163	PF00244	0.637
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_Clathr_ClatBox_1	28	32	PF01394	0.421
LIG_eIF4E_1	42	48	PF01652	0.422
LIG_FHA_1	57	63	PF00498	0.541
LIG_IBAR_NPY_1	130	132	PF08397	0.552
LIG_LIR_Apic_2	18	23	PF02991	0.521
LIG_LIR_LC3C_4	59	63	PF02991	0.391
LIG_LIR_Nem_3	176	182	PF02991	0.481
LIG_PTB_Apo_2	147	154	PF02174	0.498
LIG_SH2_CRK	20	24	PF00017	0.515
LIG_SH2_NCK_1	193	197	PF00017	0.578
LIG_SH2_STAT5	20	23	PF00017	0.660
LIG_SH2_STAT5	42	45	PF00017	0.437
LIG_SH3_3	59	65	PF00018	0.478
LIG_SUMO_SIM_anti_2	27	32	PF11976	0.427
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.387
LIG_SUMO_SIM_par_1	57	64	PF11976	0.396
MOD_CK2_1	12	18	PF00069	0.499
MOD_CK2_1	49	55	PF00069	0.421
MOD_Cter_Amidation	121	124	PF01082	0.560
MOD_GSK3_1	9	16	PF00069	0.574
MOD_NEK2_1	140	145	PF00069	0.546
MOD_PKA_2	158	164	PF00069	0.484
MOD_Plk_1	9	15	PF00069	0.584
MOD_Plk_4	49	55	PF00069	0.404
MOD_Plk_4	56	62	PF00069	0.355
MOD_ProDKin_1	61	67	PF00069	0.519
TRG_DiLeu_BaEn_2	135	141	PF01217	0.556
TRG_ER_diArg_1	110	112	PF00400	0.676
TRG_ER_diArg_1	124	126	PF00400	0.462
TRG_ER_diArg_1	132	134	PF00400	0.592
TRG_ER_diArg_1	70	73	PF00400	0.425
TRG_NLS_Bipartite_1	111	127	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0C3	Leishmania donovani	90%	100%
A4I2K4	Leishmania infantum	91%	100%