Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACY4_LEIMA

TriTrypDb:

LmjF.27.0070 , LMJLV39_270005800 , LMJSD75_270005700

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ACY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.451
CLV_C14_Caspase3-7	294	298	PF00656	0.670
CLV_NRD_NRD_1	210	212	PF00675	0.691
CLV_NRD_NRD_1	213	215	PF00675	0.686
CLV_NRD_NRD_1	244	246	PF00675	0.533
CLV_PCSK_FUR_1	211	215	PF00082	0.680
CLV_PCSK_KEX2_1	194	196	PF00082	0.727
CLV_PCSK_KEX2_1	208	210	PF00082	0.644
CLV_PCSK_KEX2_1	212	214	PF00082	0.672
CLV_PCSK_KEX2_1	244	246	PF00082	0.533
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.751
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.689
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.713
CLV_PCSK_PC7_1	209	215	PF00082	0.705
CLV_PCSK_SKI1_1	279	283	PF00082	0.530
CLV_PCSK_SKI1_1	3	7	PF00082	0.634
CLV_PCSK_SKI1_1	77	81	PF00082	0.553
DEG_APCC_DBOX_1	2	10	PF00400	0.484
DEG_SPOP_SBC_1	122	126	PF00917	0.460
DEG_SPOP_SBC_1	134	138	PF00917	0.392
DOC_CKS1_1	111	116	PF01111	0.378
DOC_CKS1_1	160	165	PF01111	0.413
DOC_CKS1_1	256	261	PF01111	0.408
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.346
DOC_PP1_RVXF_1	1	8	PF00149	0.463
DOC_PP2B_LxvP_1	157	160	PF13499	0.388
DOC_PP2B_LxvP_1	23	26	PF13499	0.359
DOC_USP7_MATH_1	121	125	PF00917	0.327
DOC_USP7_MATH_1	79	83	PF00917	0.404
DOC_USP7_UBL2_3	208	212	PF12436	0.573
DOC_WW_Pin1_4	110	115	PF00397	0.393
DOC_WW_Pin1_4	159	164	PF00397	0.497
DOC_WW_Pin1_4	255	260	PF00397	0.317
DOC_WW_Pin1_4	281	286	PF00397	0.710
DOC_WW_Pin1_4	44	49	PF00397	0.278
LIG_14-3-3_CanoR_1	214	220	PF00244	0.554
LIG_14-3-3_CanoR_1	244	252	PF00244	0.447
LIG_14-3-3_CanoR_1	270	276	PF00244	0.505
LIG_14-3-3_CanoR_1	56	64	PF00244	0.413
LIG_14-3-3_CanoR_1	77	85	PF00244	0.432
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BIR_III_2	201	205	PF00653	0.415
LIG_EH1_1	175	183	PF00400	0.305
LIG_FHA_1	123	129	PF00498	0.328
LIG_FHA_1	149	155	PF00498	0.443
LIG_FHA_1	182	188	PF00498	0.406
LIG_FHA_1	256	262	PF00498	0.389
LIG_FHA_1	56	62	PF00498	0.371
LIG_FHA_1	78	84	PF00498	0.414
LIG_FHA_2	17	23	PF00498	0.534
LIG_FHA_2	292	298	PF00498	0.672
LIG_LIR_Nem_3	264	269	PF02991	0.420
LIG_LIR_Nem_3	63	67	PF02991	0.475
LIG_NRBOX	4	10	PF00104	0.557
LIG_Pex14_1	252	256	PF04695	0.460
LIG_Pex14_2	262	266	PF04695	0.469
LIG_SH2_CRK	131	135	PF00017	0.349
LIG_SH2_CRK	257	261	PF00017	0.403
LIG_SH2_NCK_1	30	34	PF00017	0.393
LIG_SH2_STAP1	176	180	PF00017	0.368
LIG_SH2_STAP1	273	277	PF00017	0.676
LIG_SH2_STAP1	30	34	PF00017	0.393
LIG_SH2_STAT5	110	113	PF00017	0.402
LIG_SH2_STAT5	127	130	PF00017	0.236
LIG_SH2_STAT5	257	260	PF00017	0.378
LIG_SH3_2	160	165	PF14604	0.416
LIG_SH3_3	111	117	PF00018	0.382
LIG_SH3_3	157	163	PF00018	0.385
LIG_SH3_3	64	70	PF00018	0.355
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.564
LIG_SUMO_SIM_anti_2	38	44	PF11976	0.382
MOD_CDK_SPK_2	281	286	PF00069	0.664
MOD_CDK_SPxK_1	110	116	PF00069	0.375
MOD_CDK_SPxK_1	159	165	PF00069	0.387
MOD_CK1_1	284	290	PF00069	0.735
MOD_CK1_1	44	50	PF00069	0.329
MOD_CK1_1	75	81	PF00069	0.421
MOD_CK2_1	16	22	PF00069	0.555
MOD_GlcNHglycan	131	134	PF01048	0.622
MOD_GlcNHglycan	220	223	PF01048	0.662
MOD_GlcNHglycan	245	248	PF01048	0.679
MOD_GlcNHglycan	288	292	PF01048	0.564
MOD_GlcNHglycan	303	306	PF01048	0.460
MOD_GlcNHglycan	74	77	PF01048	0.520
MOD_GSK3_1	129	136	PF00069	0.327
MOD_GSK3_1	140	147	PF00069	0.409
MOD_GSK3_1	287	294	PF00069	0.778
MOD_GSK3_1	301	308	PF00069	0.680
MOD_GSK3_1	40	47	PF00069	0.317
MOD_GSK3_1	51	58	PF00069	0.298
MOD_GSK3_1	75	82	PF00069	0.398
MOD_GSK3_1	86	93	PF00069	0.374
MOD_N-GLC_1	56	61	PF02516	0.583
MOD_NEK2_1	1	6	PF00069	0.492
MOD_NEK2_1	123	128	PF00069	0.356
MOD_NEK2_1	139	144	PF00069	0.417
MOD_NEK2_1	223	228	PF00069	0.519
MOD_NEK2_1	271	276	PF00069	0.540
MOD_NEK2_1	49	54	PF00069	0.350
MOD_NEK2_1	55	60	PF00069	0.360
MOD_NEK2_1	7	12	PF00069	0.466
MOD_NEK2_1	72	77	PF00069	0.373
MOD_NEK2_2	236	241	PF00069	0.383
MOD_NEK2_2	51	56	PF00069	0.363
MOD_PKA_2	243	249	PF00069	0.407
MOD_PKA_2	55	61	PF00069	0.415
MOD_PKA_2	72	78	PF00069	0.374
MOD_Plk_1	148	154	PF00069	0.413
MOD_Plk_1	35	41	PF00069	0.388
MOD_Plk_1	56	62	PF00069	0.410
MOD_Plk_1	97	103	PF00069	0.322
MOD_Plk_4	123	129	PF00069	0.409
MOD_Plk_4	261	267	PF00069	0.399
MOD_Plk_4	7	13	PF00069	0.585
MOD_ProDKin_1	110	116	PF00069	0.391
MOD_ProDKin_1	159	165	PF00069	0.505
MOD_ProDKin_1	255	261	PF00069	0.317
MOD_ProDKin_1	281	287	PF00069	0.667
MOD_ProDKin_1	44	50	PF00069	0.279
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.398
TRG_ENDOCYTIC_2	131	134	PF00928	0.327
TRG_ENDOCYTIC_2	257	260	PF00928	0.403
TRG_ER_diArg_1	211	214	PF00400	0.482
TRG_ER_diArg_1	243	245	PF00400	0.345
TRG_NLS_Bipartite_1	194	216	PF00514	0.496
TRG_NLS_MonoCore_2	210	215	PF00514	0.505
TRG_NLS_MonoExtN_4	208	215	PF00514	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD93	Leptomonas seymouri	51%	100%
A0A1X0NLP1	Trypanosomatidae	31%	100%
A0A3R7RDJ4	Trypanosoma rangeli	28%	100%
A0A3S7X0B8	Leishmania donovani	90%	100%
A4HFC6	Leishmania braziliensis	72%	100%
A4I2K3	Leishmania infantum	90%	100%
C9ZKU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AYQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BKS2	Trypanosoma cruzi	28%	100%