CAAX prenyl protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo- peptidase, Clan M- Family M48

Species:

Leishmania major

UniProt:

E9ACY1_LEIMA

TriTrypDb:

LmjF.27.0040 , LMJLV39_270005500 , LMJSD75_270005400

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ACY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016485	protein processing	5	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071586	CAAX-box protein processing	6	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	173	179	PF00089	0.289
CLV_NRD_NRD_1	245	247	PF00675	0.224
CLV_NRD_NRD_1	31	33	PF00675	0.272
CLV_NRD_NRD_1	362	364	PF00675	0.268
CLV_NRD_NRD_1	43	45	PF00675	0.340
CLV_PCSK_FUR_1	29	33	PF00082	0.356
CLV_PCSK_KEX2_1	245	247	PF00082	0.221
CLV_PCSK_KEX2_1	261	263	PF00082	0.181
CLV_PCSK_KEX2_1	31	33	PF00082	0.272
CLV_PCSK_KEX2_1	321	323	PF00082	0.506
CLV_PCSK_KEX2_1	362	364	PF00082	0.257
CLV_PCSK_KEX2_1	425	427	PF00082	0.400
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.224
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.506
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.400
CLV_PCSK_SKI1_1	153	157	PF00082	0.218
CLV_PCSK_SKI1_1	236	240	PF00082	0.303
CLV_PCSK_SKI1_1	262	266	PF00082	0.224
CLV_PCSK_SKI1_1	382	386	PF00082	0.234
CLV_PCSK_SKI1_1	45	49	PF00082	0.361
DEG_APCC_DBOX_1	135	143	PF00400	0.363
DEG_APCC_KENBOX_2	389	393	PF00400	0.467
DOC_CDC14_PxL_1	82	90	PF14671	0.201
DOC_CYCLIN_RxL_1	149	160	PF00134	0.457
DOC_CYCLIN_RxL_1	377	389	PF00134	0.495
DOC_CYCLIN_RxL_1	69	77	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.378
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.378
DOC_MAPK_gen_1	321	329	PF00069	0.163
DOC_MAPK_gen_1	382	388	PF00069	0.426
DOC_MAPK_MEF2A_6	10	18	PF00069	0.266
DOC_MAPK_MEF2A_6	153	161	PF00069	0.424
DOC_MAPK_MEF2A_6	180	187	PF00069	0.292
DOC_MAPK_MEF2A_6	274	283	PF00069	0.455
DOC_MAPK_MEF2A_6	292	300	PF00069	0.492
DOC_MAPK_MEF2A_6	330	338	PF00069	0.234
DOC_MAPK_RevD_3	16	32	PF00069	0.266
DOC_PP1_RVXF_1	166	173	PF00149	0.266
DOC_PP1_RVXF_1	313	320	PF00149	0.289
DOC_PP2B_LxvP_1	121	124	PF13499	0.324
DOC_PP2B_LxvP_1	198	201	PF13499	0.310
DOC_PP2B_LxvP_1	83	86	PF13499	0.324
DOC_PP2B_PxIxI_1	278	284	PF00149	0.379
DOC_PP4_FxxP_1	345	348	PF00568	0.282
DOC_SPAK_OSR1_1	370	374	PF12202	0.506
DOC_USP7_MATH_1	12	16	PF00917	0.287
DOC_USP7_UBL2_3	149	153	PF12436	0.427
DOC_WW_Pin1_4	1	6	PF00397	0.353
DOC_WW_Pin1_4	209	214	PF00397	0.460
DOC_WW_Pin1_4	215	220	PF00397	0.463
DOC_WW_Pin1_4	394	399	PF00397	0.408
LIG_14-3-3_CanoR_1	158	162	PF00244	0.355
LIG_14-3-3_CanoR_1	245	253	PF00244	0.442
LIG_14-3-3_CanoR_1	393	397	PF00244	0.457
LIG_14-3-3_CanoR_1	96	104	PF00244	0.310
LIG_Actin_WH2_2	144	160	PF00022	0.458
LIG_Actin_WH2_2	220	238	PF00022	0.467
LIG_APCC_ABBA_1	338	343	PF00400	0.393
LIG_BIR_II_1	1	5	PF00653	0.359
LIG_Clathr_ClatBox_1	316	320	PF01394	0.310
LIG_EH1_1	186	194	PF00400	0.179
LIG_eIF4E_1	221	227	PF01652	0.426
LIG_FHA_1	143	149	PF00498	0.538
LIG_FHA_1	152	158	PF00498	0.438
LIG_FHA_2	141	147	PF00498	0.424
LIG_FHA_2	210	216	PF00498	0.573
LIG_FHA_2	266	272	PF00498	0.467
LIG_FHA_2	46	52	PF00498	0.477
LIG_GBD_Chelix_1	300	308	PF00786	0.266
LIG_LIR_Apic_2	343	348	PF02991	0.289
LIG_LIR_Gen_1	126	133	PF02991	0.444
LIG_LIR_Gen_1	23	33	PF02991	0.435
LIG_LIR_Gen_1	399	410	PF02991	0.424
LIG_LIR_Gen_1	63	71	PF02991	0.469
LIG_LIR_LC3C_4	190	195	PF02991	0.244
LIG_LIR_Nem_3	122	128	PF02991	0.259
LIG_LIR_Nem_3	179	184	PF02991	0.211
LIG_LIR_Nem_3	218	224	PF02991	0.453
LIG_LIR_Nem_3	23	28	PF02991	0.310
LIG_LIR_Nem_3	343	349	PF02991	0.283
LIG_LIR_Nem_3	350	355	PF02991	0.251
LIG_LIR_Nem_3	399	405	PF02991	0.467
LIG_LIR_Nem_3	63	68	PF02991	0.445
LIG_PCNA_yPIPBox_3	166	180	PF02747	0.310
LIG_Pex14_2	177	181	PF04695	0.211
LIG_Pex14_2	341	345	PF04695	0.278
LIG_SH2_CRK	266	270	PF00017	0.411
LIG_SH2_CRK	402	406	PF00017	0.457
LIG_SH2_GRB2like	128	131	PF00017	0.457
LIG_SH2_GRB2like	297	300	PF00017	0.266
LIG_SH2_NCK_1	407	411	PF00017	0.424
LIG_SH2_PTP2	297	300	PF00017	0.266
LIG_SH2_STAP1	108	112	PF00017	0.328
LIG_SH2_STAP1	266	270	PF00017	0.423
LIG_SH2_STAT3	163	166	PF00017	0.310
LIG_SH2_STAT5	184	187	PF00017	0.261
LIG_SH2_STAT5	25	28	PF00017	0.294
LIG_SH2_STAT5	253	256	PF00017	0.420
LIG_SH2_STAT5	297	300	PF00017	0.266
LIG_SH2_STAT5	359	362	PF00017	0.434
LIG_SH2_STAT5	407	410	PF00017	0.467
LIG_SH2_STAT5	42	45	PF00017	0.506
LIG_SH2_STAT5	91	94	PF00017	0.378
LIG_SH3_3	200	206	PF00018	0.282
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.266
LIG_SUMO_SIM_anti_2	190	195	PF11976	0.310
LIG_SUMO_SIM_par_1	384	389	PF11976	0.426
LIG_TRAF2_1	48	51	PF00917	0.477
LIG_TYR_ITIM	264	269	PF00017	0.411
LIG_TYR_ITIM	88	93	PF00017	0.201
LIG_UBA3_1	161	168	PF00899	0.266
LIG_UBA3_1	269	274	PF00899	0.482
LIG_UBA3_1	385	390	PF00899	0.446
LIG_WRC_WIRS_1	349	354	PF05994	0.266
MOD_CDK_SPxxK_3	215	222	PF00069	0.482
MOD_CK1_1	244	250	PF00069	0.414
MOD_CK1_1	60	66	PF00069	0.473
MOD_CK1_1	98	104	PF00069	0.271
MOD_CK2_1	123	129	PF00069	0.314
MOD_CK2_1	140	146	PF00069	0.363
MOD_CK2_1	265	271	PF00069	0.465
MOD_CK2_1	45	51	PF00069	0.451
MOD_GlcNHglycan	402	405	PF01048	0.257
MOD_GSK3_1	225	232	PF00069	0.453
MOD_GSK3_1	57	64	PF00069	0.459
MOD_GSK3_1	98	105	PF00069	0.262
MOD_N-GLC_1	33	38	PF02516	0.226
MOD_NEK2_1	157	162	PF00069	0.315
MOD_NEK2_1	187	192	PF00069	0.249
MOD_NEK2_1	265	270	PF00069	0.442
MOD_NEK2_1	308	313	PF00069	0.337
MOD_NEK2_1	371	376	PF00069	0.446
MOD_NEK2_1	405	410	PF00069	0.443
MOD_NEK2_1	74	79	PF00069	0.411
MOD_PKA_2	157	163	PF00069	0.324
MOD_PKA_2	244	250	PF00069	0.424
MOD_PKA_2	392	398	PF00069	0.426
MOD_PKA_2	95	101	PF00069	0.325
MOD_Plk_1	229	235	PF00069	0.410
MOD_Plk_1	60	66	PF00069	0.455
MOD_Plk_4	151	157	PF00069	0.448
MOD_Plk_4	187	193	PF00069	0.294
MOD_Plk_4	199	205	PF00069	0.195
MOD_Plk_4	265	271	PF00069	0.431
MOD_Plk_4	348	354	PF00069	0.279
MOD_Plk_4	38	44	PF00069	0.410
MOD_ProDKin_1	1	7	PF00069	0.347
MOD_ProDKin_1	209	215	PF00069	0.462
MOD_ProDKin_1	394	400	PF00069	0.408
TRG_ENDOCYTIC_2	128	131	PF00928	0.424
TRG_ENDOCYTIC_2	184	187	PF00928	0.265
TRG_ENDOCYTIC_2	221	224	PF00928	0.533
TRG_ENDOCYTIC_2	25	28	PF00928	0.427
TRG_ENDOCYTIC_2	266	269	PF00928	0.418
TRG_ENDOCYTIC_2	297	300	PF00928	0.266
TRG_ENDOCYTIC_2	324	327	PF00928	0.224
TRG_ENDOCYTIC_2	346	349	PF00928	0.310
TRG_ENDOCYTIC_2	402	405	PF00928	0.467
TRG_ENDOCYTIC_2	90	93	PF00928	0.323
TRG_ER_diArg_1	28	31	PF00400	0.489
TRG_ER_diLys_1	424	427	PF00400	0.530
TRG_NES_CRM1_1	230	242	PF08389	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC87	Leptomonas seymouri	60%	100%
A0A0S4J5R2	Bodo saltans	46%	100%
A0A1X0P508	Trypanosomatidae	46%	100%
A0A3S7X0A9	Leishmania donovani	96%	100%
A4HFC3	Leishmania braziliensis	77%	100%
A4I2K0	Leishmania infantum	96%	100%
C9ZYC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AYQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O75844	Homo sapiens	33%	90%
P40769	Bacillus subtilis (strain 168)	25%	100%
P47154	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	94%
Q10071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	90%
Q3Y6B8	Taenia solium	32%	90%
Q54FH7	Dictyostelium discoideum	35%	100%
Q6EPN8	Oryza sativa subsp. japonica	38%	100%
Q80W54	Mus musculus	33%	90%
Q8RX88	Arabidopsis thaliana	39%	100%
Q9XVE5	Caenorhabditis elegans	32%	97%
V5DQF4	Trypanosoma cruzi	46%	100%