Queuine tRNA-ribosyltransferase accessory subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

queuine tRNA-ribosyltransferase, putative

Species:

Leishmania major

UniProt:

E9ACY0_LEIMA

TriTrypDb:

LmjF.27.0030 , LMJLV39_270005400 , LMJSD75_270005300

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ACY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACY0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0101030	tRNA-guanine transglycosylation	7	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0008479	queuine tRNA-ribosyltransferase activity	5	9
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016763	pentosyltransferase activity	4	12
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.540
CLV_NRD_NRD_1	135	137	PF00675	0.254
CLV_PCSK_KEX2_1	13	15	PF00082	0.254
CLV_PCSK_KEX2_1	133	135	PF00082	0.244
CLV_PCSK_KEX2_1	280	282	PF00082	0.280
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.315
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.244
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.296
CLV_PCSK_SKI1_1	325	329	PF00082	0.434
CLV_PCSK_SKI1_1	67	71	PF00082	0.278
DEG_APCC_DBOX_1	283	291	PF00400	0.528
DEG_Nend_UBRbox_2	1	3	PF02207	0.642
DEG_SPOP_SBC_1	244	248	PF00917	0.426
DOC_MAPK_gen_1	111	121	PF00069	0.465
DOC_MAPK_gen_1	198	204	PF00069	0.558
DOC_MAPK_gen_1	96	103	PF00069	0.518
DOC_MAPK_MEF2A_6	233	241	PF00069	0.515
DOC_PP2B_LxvP_1	237	240	PF13499	0.540
DOC_PP2B_LxvP_1	8	11	PF13499	0.457
DOC_PP2B_PxIxI_1	205	211	PF00149	0.396
DOC_PP4_FxxP_1	46	49	PF00568	0.515
DOC_USP7_MATH_1	139	143	PF00917	0.491
DOC_USP7_MATH_1	214	218	PF00917	0.555
DOC_USP7_MATH_1	327	331	PF00917	0.503
DOC_USP7_MATH_1	81	85	PF00917	0.500
DOC_WW_Pin1_4	18	23	PF00397	0.461
DOC_WW_Pin1_4	193	198	PF00397	0.550
DOC_WW_Pin1_4	245	250	PF00397	0.460
LIG_14-3-3_CanoR_1	318	323	PF00244	0.460
LIG_14-3-3_CanoR_1	34	44	PF00244	0.452
LIG_14-3-3_CanoR_1	73	77	PF00244	0.504
LIG_14-3-3_CanoR_1	98	104	PF00244	0.465
LIG_BIR_III_2	175	179	PF00653	0.540
LIG_BRCT_BRCA1_1	182	186	PF00533	0.564
LIG_Clathr_ClatBox_1	238	242	PF01394	0.499
LIG_FHA_1	114	120	PF00498	0.536
LIG_FHA_1	199	205	PF00498	0.483
LIG_FHA_2	138	144	PF00498	0.504
LIG_FHA_2	227	233	PF00498	0.472
LIG_FHA_2	245	251	PF00498	0.509
LIG_FHA_2	290	296	PF00498	0.454
LIG_LIR_Apic_2	45	49	PF02991	0.496
LIG_LIR_Gen_1	181	192	PF02991	0.540
LIG_LIR_Gen_1	38	49	PF02991	0.495
LIG_LIR_Nem_3	104	109	PF02991	0.478
LIG_LIR_Nem_3	181	187	PF02991	0.540
LIG_LIR_Nem_3	58	63	PF02991	0.483
LIG_LIR_Nem_3	64	69	PF02991	0.411
LIG_LIR_Nem_3	74	79	PF02991	0.499
LIG_MYND_1	18	22	PF01753	0.465
LIG_NRBOX	286	292	PF00104	0.528
LIG_PDZ_Class_1	331	336	PF00595	0.514
LIG_SH2_CRK	60	64	PF00017	0.547
LIG_SH2_CRK	66	70	PF00017	0.532
LIG_SH2_SRC	173	176	PF00017	0.558
LIG_SH2_SRC	286	289	PF00017	0.445
LIG_SH2_STAP1	263	267	PF00017	0.509
LIG_SH2_STAT5	173	176	PF00017	0.495
LIG_SH2_STAT5	286	289	PF00017	0.462
LIG_SH2_STAT5	60	63	PF00017	0.557
LIG_SH3_3	248	254	PF00018	0.549
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.477
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.521
LIG_SUMO_SIM_anti_2	298	305	PF11976	0.495
LIG_SUMO_SIM_par_1	254	260	PF11976	0.537
LIG_SUMO_SIM_par_1	289	295	PF11976	0.454
LIG_SUMO_SIM_par_1	68	75	PF11976	0.455
LIG_TRAF2_1	240	243	PF00917	0.499
LIG_TRAF2_1	292	295	PF00917	0.444
LIG_WRC_WIRS_1	100	105	PF05994	0.558
MOD_CDC14_SPxK_1	196	199	PF00782	0.558
MOD_CDK_SPK_2	193	198	PF00069	0.558
MOD_CDK_SPxK_1	193	199	PF00069	0.558
MOD_CK1_1	217	223	PF00069	0.530
MOD_CK1_1	321	327	PF00069	0.503
MOD_CK1_1	82	88	PF00069	0.528
MOD_CK2_1	137	143	PF00069	0.536
MOD_CK2_1	217	223	PF00069	0.487
MOD_CK2_1	226	232	PF00069	0.478
MOD_CK2_1	244	250	PF00069	0.519
MOD_CK2_1	289	295	PF00069	0.444
MOD_CK2_1	36	42	PF00069	0.553
MOD_GlcNHglycan	163	166	PF01048	0.331
MOD_GlcNHglycan	320	323	PF01048	0.348
MOD_GlcNHglycan	333	336	PF01048	0.555
MOD_GlcNHglycan	63	66	PF01048	0.352
MOD_GlcNHglycan	81	84	PF01048	0.214
MOD_GSK3_1	137	144	PF00069	0.507
MOD_GSK3_1	146	153	PF00069	0.472
MOD_GSK3_1	155	162	PF00069	0.438
MOD_GSK3_1	327	334	PF00069	0.521
MOD_GSK3_1	61	68	PF00069	0.483
MOD_GSK3_1	79	86	PF00069	0.382
MOD_N-GLC_1	217	222	PF02516	0.340
MOD_NEK2_1	155	160	PF00069	0.567
MOD_NEK2_1	186	191	PF00069	0.538
MOD_NEK2_1	36	41	PF00069	0.515
MOD_NEK2_1	55	60	PF00069	0.506
MOD_NEK2_1	72	77	PF00069	0.471
MOD_NEK2_1	79	84	PF00069	0.434
MOD_OFUCOSY	274	279	PF10250	0.254
MOD_PKA_1	198	204	PF00069	0.558
MOD_PKA_2	113	119	PF00069	0.536
MOD_PKA_2	72	78	PF00069	0.540
MOD_Plk_1	180	186	PF00069	0.461
MOD_Plk_1	217	223	PF00069	0.540
MOD_Plk_4	141	147	PF00069	0.562
MOD_Plk_4	155	161	PF00069	0.524
MOD_Plk_4	217	223	PF00069	0.467
MOD_Plk_4	36	42	PF00069	0.445
MOD_Plk_4	65	71	PF00069	0.478
MOD_ProDKin_1	18	24	PF00069	0.461
MOD_ProDKin_1	193	199	PF00069	0.550
MOD_ProDKin_1	245	251	PF00069	0.460
TRG_DiLeu_BaEn_2	41	47	PF01217	0.558
TRG_DiLeu_BaEn_4	150	156	PF01217	0.558
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.540
TRG_ENDOCYTIC_2	184	187	PF00928	0.544
TRG_ENDOCYTIC_2	60	63	PF00928	0.541
TRG_ENDOCYTIC_2	66	69	PF00928	0.497
TRG_ER_diArg_1	134	136	PF00400	0.478
TRG_NLS_MonoCore_2	132	137	PF00514	0.454
TRG_NLS_MonoExtN_4	130	137	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE8	Leptomonas seymouri	67%	100%
A0A0S4IR14	Bodo saltans	36%	96%
A0A1X0NPI6	Trypanosomatidae	38%	100%
A0A3R7K861	Trypanosoma rangeli	39%	100%
A0A3S7X0A8	Leishmania donovani	93%	100%
A4HFC2	Leishmania braziliensis	83%	100%
A4I2J9	Leishmania infantum	93%	100%
B0WAN0	Culex quinquefasciatus	24%	78%
B3NCH1	Drosophila erecta	22%	80%
B3RNT0	Trichoplax adhaerens	23%	91%
B4H1X9	Drosophila persimilis	23%	81%
B4HL48	Drosophila sechellia	24%	80%
B4IXD3	Drosophila grimshawi	24%	80%
B4KXI8	Drosophila mojavensis	23%	81%
B4LFW2	Drosophila virilis	23%	81%
B4N549	Drosophila willistoni	23%	79%
B4PEV9	Drosophila yakuba	23%	80%
C9ZPM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AYQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q16RF5	Aedes aegypti	22%	80%
Q29EE9	Drosophila pseudoobscura pseudoobscura	25%	81%
Q7Q727	Anopheles gambiae	23%	78%
Q9VSZ6	Drosophila melanogaster	23%	80%
V5BCL2	Trypanosoma cruzi	40%	100%