TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACX8_LEIMA

TriTrypDb:

LmjF.27.0010 , LMJLV39_270005200 , LMJSD75_270005100

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.606
CLV_NRD_NRD_1	35	37	PF00675	0.397
CLV_NRD_NRD_1	366	368	PF00675	0.503
CLV_PCSK_KEX2_1	134	136	PF00082	0.588
CLV_PCSK_KEX2_1	182	184	PF00082	0.524
CLV_PCSK_KEX2_1	200	202	PF00082	0.419
CLV_PCSK_KEX2_1	293	295	PF00082	0.439
CLV_PCSK_KEX2_1	35	37	PF00082	0.397
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.501
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.383
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.419
CLV_PCSK_SKI1_1	163	167	PF00082	0.413
CLV_PCSK_SKI1_1	189	193	PF00082	0.447
CLV_PCSK_SKI1_1	273	277	PF00082	0.537
CLV_PCSK_SKI1_1	35	39	PF00082	0.507
CLV_PCSK_SKI1_1	350	354	PF00082	0.413
CLV_PCSK_SKI1_1	367	371	PF00082	0.335
DEG_APCC_DBOX_1	254	262	PF00400	0.345
DEG_Nend_UBRbox_2	1	3	PF02207	0.535
DOC_CYCLIN_RxL_1	160	167	PF00134	0.485
DOC_CYCLIN_RxL_1	270	279	PF00134	0.536
DOC_MAPK_gen_1	365	374	PF00069	0.506
DOC_MAPK_MEF2A_6	365	374	PF00069	0.586
DOC_MAPK_MEF2A_6	4	11	PF00069	0.321
DOC_MAPK_MEF2A_6	51	59	PF00069	0.327
DOC_PP1_RVXF_1	271	278	PF00149	0.535
DOC_PP1_RVXF_1	292	299	PF00149	0.469
DOC_USP7_MATH_1	219	223	PF00917	0.456
DOC_USP7_UBL2_3	117	121	PF12436	0.469
DOC_USP7_UBL2_3	289	293	PF12436	0.447
DOC_WW_Pin1_4	189	194	PF00397	0.503
DOC_WW_Pin1_4	340	345	PF00397	0.358
LIG_14-3-3_CanoR_1	171	175	PF00244	0.585
LIG_APCC_ABBAyCdc20_2	88	94	PF00400	0.413
LIG_Clathr_ClatBox_1	274	278	PF01394	0.623
LIG_FHA_1	190	196	PF00498	0.592
LIG_FHA_1	21	27	PF00498	0.392
LIG_LIR_Gen_1	114	119	PF02991	0.489
LIG_LIR_Gen_1	128	137	PF02991	0.508
LIG_LIR_Gen_1	194	203	PF02991	0.407
LIG_LIR_Gen_1	268	277	PF02991	0.434
LIG_LIR_Gen_1	44	53	PF02991	0.418
LIG_LIR_Nem_3	110	115	PF02991	0.381
LIG_LIR_Nem_3	128	133	PF02991	0.534
LIG_LIR_Nem_3	194	199	PF02991	0.397
LIG_LIR_Nem_3	268	274	PF02991	0.419
LIG_LIR_Nem_3	39	45	PF02991	0.442
LIG_PDZ_Class_2	369	374	PF00595	0.510
LIG_PTB_Apo_2	86	93	PF02174	0.411
LIG_SH2_CRK	184	188	PF00017	0.453
LIG_SH2_CRK	271	275	PF00017	0.513
LIG_SH2_NCK_1	205	209	PF00017	0.417
LIG_SH2_SRC	299	302	PF00017	0.498
LIG_SH2_STAP1	22	26	PF00017	0.358
LIG_SH2_STAT5	10	13	PF00017	0.326
LIG_SH2_STAT5	22	25	PF00017	0.343
LIG_SH2_STAT5	299	302	PF00017	0.498
LIG_SH2_STAT5	85	88	PF00017	0.345
LIG_SH3_3	237	243	PF00018	0.457
LIG_SH3_3	278	284	PF00018	0.528
LIG_TRAF2_1	307	310	PF00917	0.460
LIG_TYR_ITIM	113	118	PF00017	0.420
LIG_UBA3_1	321	326	PF00899	0.350
MOD_CDK_SPxK_1	340	346	PF00069	0.353
MOD_CK2_1	117	123	PF00069	0.431
MOD_CK2_1	204	210	PF00069	0.473
MOD_Cter_Amidation	365	368	PF01082	0.457
MOD_GlcNHglycan	206	209	PF01048	0.488
MOD_GlcNHglycan	322	325	PF01048	0.465
MOD_GSK3_1	117	124	PF00069	0.547
MOD_NEK2_1	11	16	PF00069	0.374
MOD_PKA_2	170	176	PF00069	0.467
MOD_Plk_2-3	119	125	PF00069	0.328
MOD_Plk_4	125	131	PF00069	0.508
MOD_Plk_4	142	148	PF00069	0.423
MOD_ProDKin_1	189	195	PF00069	0.495
MOD_ProDKin_1	340	346	PF00069	0.353
MOD_SUMO_for_1	116	119	PF00179	0.458
MOD_SUMO_for_1	199	202	PF00179	0.423
MOD_SUMO_for_1	37	40	PF00179	0.457
MOD_SUMO_rev_2	114	122	PF00179	0.449
TRG_DiLeu_BaEn_1	310	315	PF01217	0.323
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.518
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.380
TRG_DiLeu_LyEn_5	310	315	PF01217	0.342
TRG_ENDOCYTIC_2	10	13	PF00928	0.335
TRG_ENDOCYTIC_2	115	118	PF00928	0.424
TRG_ENDOCYTIC_2	22	25	PF00928	0.384
TRG_ENDOCYTIC_2	271	274	PF00928	0.430
TRG_ENDOCYTIC_2	46	49	PF00928	0.403
TRG_ER_diArg_1	133	135	PF00400	0.598
TRG_ER_diArg_1	35	37	PF00400	0.416
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I333	Leptomonas seymouri	76%	90%
A0A0S4IVD3	Bodo saltans	44%	81%
A0A1X0NPF3	Trypanosomatidae	61%	86%
A0A3Q8IPL3	Leishmania donovani	96%	100%
A4HFC1	Leishmania braziliensis	89%	100%
A4I2J7	Leishmania infantum	96%	100%
C9ZPM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	88%
E9AYQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BCK8	Trypanosoma cruzi	61%	88%