LeishMANIAdb
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Dehydrogenase/oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Dehydrogenase/oxidoreductase-like protein
Gene product:
dehydrogenase/oxidoreductase-like protein
Species:
Leishmania major
UniProt:
E9ACX6_LEIMA
TriTrypDb:
LmjF.27.2650 , LMJLV39_270033400 , LMJSD75_270033600
Length:
128

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACX6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACX6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 124 126 PF00675 0.751
CLV_PCSK_KEX2_1 124 126 PF00082 0.745
CLV_PCSK_KEX2_1 41 43 PF00082 0.396
CLV_PCSK_PC1ET2_1 41 43 PF00082 0.396
CLV_PCSK_SKI1_1 117 121 PF00082 0.613
DEG_Nend_UBRbox_2 1 3 PF02207 0.658
DOC_MAPK_RevD_3 27 42 PF00069 0.396
DOC_USP7_MATH_1 98 102 PF00917 0.396
DOC_WW_Pin1_4 45 50 PF00397 0.527
LIG_BIR_III_2 18 22 PF00653 0.527
LIG_BRCT_BRCA1_1 33 37 PF00533 0.396
LIG_CtBP_PxDLS_1 62 66 PF00389 0.527
LIG_FHA_1 79 85 PF00498 0.527
LIG_FHA_2 46 52 PF00498 0.396
LIG_LIR_Gen_1 34 43 PF02991 0.457
LIG_LIR_Nem_3 34 40 PF02991 0.457
LIG_SUMO_SIM_anti_2 51 58 PF11976 0.396
MOD_CK1_1 89 95 PF00069 0.501
MOD_GSK3_1 103 110 PF00069 0.407
MOD_GSK3_1 78 85 PF00069 0.527
MOD_GSK3_1 86 93 PF00069 0.527
MOD_N-GLC_1 104 109 PF02516 0.532
MOD_NEK2_1 23 28 PF00069 0.369
MOD_NEK2_1 4 9 PF00069 0.595
MOD_NEK2_1 55 60 PF00069 0.396
MOD_NEK2_2 104 109 PF00069 0.488
MOD_PKA_2 4 10 PF00069 0.749
MOD_PKA_2 90 96 PF00069 0.527
MOD_Plk_1 98 104 PF00069 0.396
MOD_Plk_2-3 82 88 PF00069 0.396
MOD_Plk_4 82 88 PF00069 0.527
MOD_ProDKin_1 45 51 PF00069 0.527
TRG_DiLeu_BaEn_1 52 57 PF01217 0.396
TRG_ER_diArg_1 123 125 PF00400 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H517 Leishmania donovani 77% 71%
A4HRR8 Leishmania infantum 78% 71%
E9ACE7 Leishmania major 99% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS