Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACX2_LEIMA

TriTrypDb:

LmjF.02.0690 , LMJSD75_270033100

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ACX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.644
CLV_NRD_NRD_1	238	240	PF00675	0.556
CLV_NRD_NRD_1	58	60	PF00675	0.760
CLV_PCSK_KEX2_1	17	19	PF00082	0.657
CLV_PCSK_KEX2_1	238	240	PF00082	0.556
CLV_PCSK_KEX2_1	58	60	PF00082	0.740
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.598
CLV_PCSK_SKI1_1	152	156	PF00082	0.414
CLV_PCSK_SKI1_1	166	170	PF00082	0.399
CLV_PCSK_SKI1_1	239	243	PF00082	0.572
CLV_Separin_Metazoa	98	102	PF03568	0.663
DEG_Nend_UBRbox_3	1	3	PF02207	0.463
DEG_SPOP_SBC_1	136	140	PF00917	0.564
DOC_MAPK_gen_1	174	181	PF00069	0.573
DOC_MAPK_gen_1	283	290	PF00069	0.512
DOC_MAPK_MEF2A_6	265	272	PF00069	0.534
DOC_MAPK_NFAT4_5	265	273	PF00069	0.501
DOC_USP7_MATH_1	135	139	PF00917	0.590
DOC_USP7_MATH_1	36	40	PF00917	0.657
DOC_USP7_UBL2_3	123	127	PF12436	0.447
DOC_WW_Pin1_4	43	48	PF00397	0.692
LIG_14-3-3_CanoR_1	101	108	PF00244	0.632
LIG_14-3-3_CanoR_1	166	172	PF00244	0.433
LIG_14-3-3_CanoR_1	247	256	PF00244	0.420
LIG_14-3-3_CanoR_1	37	45	PF00244	0.784
LIG_FHA_1	193	199	PF00498	0.529
LIG_NRBOX	267	273	PF00104	0.460
LIG_PCNA_yPIPBox_3	174	185	PF02747	0.501
LIG_SH2_STAP1	130	134	PF00017	0.527
LIG_SH3_3	57	63	PF00018	0.501
LIG_SUMO_SIM_anti_2	267	274	PF11976	0.415
LIG_TRAF2_1	241	244	PF00917	0.573
MOD_CDK_SPxK_1	43	49	PF00069	0.771
MOD_CK1_1	138	144	PF00069	0.630
MOD_CK1_1	172	178	PF00069	0.568
MOD_CK1_1	190	196	PF00069	0.464
MOD_CK1_1	295	301	PF00069	0.674
MOD_CK1_1	39	45	PF00069	0.709
MOD_CK2_1	295	301	PF00069	0.674
MOD_CK2_1	37	43	PF00069	0.650
MOD_GlcNHglycan	124	127	PF01048	0.538
MOD_GlcNHglycan	146	149	PF01048	0.478
MOD_GlcNHglycan	156	159	PF01048	0.409
MOD_GlcNHglycan	31	34	PF01048	0.709
MOD_GSK3_1	292	299	PF00069	0.649
MOD_GSK3_1	37	44	PF00069	0.765
MOD_GSK3_1	82	89	PF00069	0.557
MOD_N-GLC_1	187	192	PF02516	0.496
MOD_NEK2_1	1	6	PF00069	0.648
MOD_NEK2_1	154	159	PF00069	0.484
MOD_NEK2_1	169	174	PF00069	0.422
MOD_NEK2_2	278	283	PF00069	0.508
MOD_PIKK_1	192	198	PF00454	0.523
MOD_PIKK_1	247	253	PF00454	0.349
MOD_PK_1	284	290	PF00069	0.491
MOD_PKA_2	100	106	PF00069	0.411
MOD_PKA_2	36	42	PF00069	0.772
MOD_PKB_1	35	43	PF00069	0.754
MOD_Plk_1	187	193	PF00069	0.528
MOD_Plk_1	284	290	PF00069	0.558
MOD_Plk_1	86	92	PF00069	0.538
MOD_Plk_2-3	82	88	PF00069	0.525
MOD_Plk_4	214	220	PF00069	0.609
MOD_Plk_4	284	290	PF00069	0.504
MOD_ProDKin_1	43	49	PF00069	0.694
MOD_SUMO_for_1	264	267	PF00179	0.595
MOD_SUMO_rev_2	147	157	PF00179	0.442
TRG_DiLeu_BaEn_1	267	272	PF01217	0.408
TRG_ER_diArg_1	18	20	PF00400	0.649
TRG_ER_diArg_1	34	37	PF00400	0.638
TRG_ER_diArg_1	58	60	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KPJ0	Bodo saltans	26%	96%
A0A1X0NJU7	Trypanosomatidae	35%	76%
A0A3S5H515	Leishmania donovani	93%	66%
A0A3S7X120	Leishmania donovani	94%	66%
A0A422NAX6	Trypanosoma rangeli	36%	74%
A4HG32	Leishmania braziliensis	79%	68%
C9ZJ54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	72%
E9ACE3	Leishmania major	99%	66%
E9AG19	Leishmania infantum	94%	66%
E9AG20	Leishmania infantum	94%	66%
E9AJN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	66%
V5BA51	Trypanosoma cruzi	37%	74%